High Preoperative Plasma Fibrinogen Levels Are Associated With Distant Metastases and Impaired Prognosis After Curative Resection in Patients With Colorectal Cancer

Background: The purpose of this study was to evaluate the association between preoperative plasma fibrinogen levels on clinicopathologic parameters and overall survival in patients after curative resection with colorectal cancer Methods: Preoperative plasma fibrinogen levels were examined in 341 patients who underwent curative resection for colorectal cancer Preoperative plasma fibrinogen levels were correlated with clinicopathologic findings and disease-specific overall survival Results: Mean (+/- SD) preoperative plasma fibrinogen levels were 369 9 mg/dl (+/- 69 1 mg/dl) Elevated plasma fibrinogen levels were associated with advanced tumor stage (P = 0 008). venous invasion (P = 0 006). and postoperative distant metastases (P < 0 001). but not with histologic grade (P = 0 232), invasion depth (P = 0 253). and lymph node involvement (P = 0 136) Multivariate analysis showed that preoperative plasma fibrinogen levels (P = 0 029). histologic grade (P = 0 001). and lymph node involvement = () 0(11) were defined as independent prognostic factors Conclusions: High preoperative plasma fibrinogen levels are associated with distant metastases and impaired prognosis after curative resection in patients with colorectal cancer J Surg Oncol 2010, 102 428-432 (C) 2010 Wiley-Liss. Inc