Article
Oncology
Sicheng Zhou, Yujuan Jiang, Jianwei Liang, Qian Liu
Summary: This study evaluated the efficacy of lateral pelvic lymph node dissection (LPND) for rectal cancer patients and its impact on prognosis. The results showed that patients who underwent LPND had a significantly higher risk of distant metastasis. Patients with limited metastasis to internal iliac and obturator lymph nodes may benefit from LPND, while those with external and common iliac lymph node metastasis have a poor prognosis.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Jessica M. Keilson, Adriana C. Gamboa, Michael K. Turgeon, Lillias Maguire, Katherine Hrebinko, Jennifer Holder-Murray, Jason T. Wiseman, Aslam Ejaz, Alexander T. Hawkins, Ebunoluwa Otegbeye, Matthew Silviera, Shishir K. Maithel, Glen C. Balch
Summary: This study evaluates the need for adjuvant chemotherapy in patients with rectal adenocarcinoma who have pathologic lymph node (pLN)-negative disease after receiving neoadjuvant chemoradiation therapy. The results show that adjuvant chemotherapy does not appear to improve survival in patients with pLN-negative disease, while it is associated with improved survival in patients with pLN-positive disease.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Julio Garcia-Aguilar, Sujata Patil, Marc J. Gollub, Jin K. Kim, Jonathan B. Yuval, Hannah M. Thompson, Floris S. Verheij, Dana M. Omer, Meghan Lee, Richard F. Dunne, Jorge Marcet, Peter Cataldo, Blase Polite, Daniel O. Herzig, David Liska, Samuel Oommen, Charles M. Friel, Charles Ternent, Andrew L. Coveler, Steven Hunt, Anita Gregory, Madhulika G. Varma, Brian L. Bello, Joseph C. Carmichael, John Krauss, Ana Gleisner, Philip B. Paty, Martin R. Weiser, Garrett M. Nash, Emmanouil Pappou, Jose G. Guillem, Larissa Temple, Iris H. Wei, Maria Widmar, Sabrina Lin, Neil H. Segal, Andrea Cercek, Rona Yaeger, J. Joshua Smith, Karyn A. Goodman, Abraham J. Wu, Leonard B. Saltz
Summary: This study demonstrates that organ preservation is achievable in patients with locally advanced rectal cancer treated with total neoadjuvant therapy, without a decrease in survival.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Oncology
Koya Hida, Daisuke Nishizaki, Atsuhiko Sumii, Ryosuke Okamura, Yoshiharu Sakai, Tsuyoshi Konishi, Tomonori Akagi, Tomohiro Yamaguchi, Takashi Akiyoshi, Meiki Fukuda, Seiichiro Yamamoto, Shigeki Arizono, Mamoru Uemura, Hirotoshi Hasegawa, Kenji Kawada, Satoshi Morita, Masahiko Watanabe
Summary: Lateral pelvic node dissection (LPND) is beneficial for low rectal cancer patients with lateral pelvic nodes measuring 5mm or more, showing significant improvement in 5-year overall survival and recurrence-free survival. However, LPND is associated with a higher incidence of postoperative complications.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Jung Kyong Shin, Jung Wook Huh, Woo Yong Lee, Seong Hyeon Yun, Hee Cheol Kim, Yong Beom Cho, Yoon Ah Park
Summary: This study analyzed the predictive factors, recurrence patterns, oncologic outcomes, and prognostic factors of patients with pathologic complete response (pCR) in rectal cancer who underwent radical surgery after neoadjuvant chemoradiotherapy (nCRT). The study found that clinical node negativity, tumor size < 4 cm, and well differentiation were significant independent clinical predictors for achieving pCR. Patients with pCR had better long-term outcomes compared to those without pCR.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Francesco Marchegiani, Valeria Palatucci, Giulia Capelli, Mario Guerrieri, Claudio Belluco, Daniela Rega, Emilio Morpurgo, Claudio Coco, Angelo Restivo, Silvia De Franciscis, Carlo Aschele, Alessandro Perin, Michele Bonomo, Andrea Muratore, Antonino Spinelli, Salvatore Ramuscello, Francesca Bergamo, Giampaolo Montesi, Gaya Spolverato, Paola Del Bianco, Maria Antonietta Gambacorta, Paolo Delrio, Salvatore Pucciarelli
Summary: The short-term outcomes of rectum-preservation for locally advanced rectal cancer patients achieving major clinical response or complete clinical response after neoadjuvant therapy were reported in the study. Transanal local excision for patients achieving cCR or mCR is safe, with an increased cCR rate seen when there is a 12-week interval from chemoradiotherapy completion to LE. Performing LE after achieving cCR reduces the risk of ypT >.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Surgery
Jordan Wlodarczyk, Sean Dewberry, Dong Yoon, Christine Hsieh, Joongho Shin, Sang W. Lee, Kyle G. Cologne
Summary: This study retrospectively analyzed the medical records of 170 patients with rectal cancer and found that endoscopic tattooing can increase the number of collected lymph nodes without affecting surgical outcomes and treatment efficacy.
JOURNAL OF SURGICAL RESEARCH
(2023)
Article
Urology & Nephrology
Kai Yao, Yue Chen, Yunlin Ye, Zhiming Wu, Dong Chen, Hui Han, Zaishang Li, Zhuowei Liu, Yanjun Wang, Zike Qin, Yonghong Li, Zhiyong Li, Fangjian Zhou
Summary: The study provides a detailed map of pelvic lymph node metastasis in patients with penile carcinoma, showing that the external iliac and obturator packages are most commonly involved. Pelvic lymph node metastasis is associated with advanced T-stage. Some patients have crossover metastasis.
JOURNAL OF UROLOGY
(2021)
Article
Multidisciplinary Sciences
Jung Kyong Shin, Hee Cheol Kim, Woo Yong Lee, Seong Hyeon Yun, Yong Beom Cho, Jung Wook Huh, Yoon Ah Park
Summary: Intersphincteric resection (ISR) for low-lying rectal cancer aims to avoid abdominoperineal resection (APR). This study compared open and minimally invasive ISR, finding similar 5-year disease-free survival rates. Minimally invasive ISR showed advantages in postoperative outcomes like reduced surgical site infection and shorter hospital stay.
SCIENTIFIC REPORTS
(2021)
Article
Surgery
Patricio B. Lynn, Maxime J. M. Van der Valk, Yvette H. M. Claassen, Qian Shi, Maria Widmar, Ester Bastiaannet, Cornelis J. H. Van de Velde, Julio Garcia-Aguilar
Summary: This study compared the oncological outcomes of chemoradiotherapy and local excision (CRT + LE) with total mesorectal excision (TME) in patients with distal cT2NO rectal cancer. The results showed that the 5-year disease-free survival and overall survival were similar between the CRT + LE and TME groups, but the CRT + LE group had fewer complications. In terms of overall health-related quality of life, the CRT + LE group experienced a decrease, while the TME group showed improvement.
Article
Oncology
Po-Kuei Hsu, Yi-Chen Yeh, Ling- Chien, Chien-Sheng Huang, Han-Shui Hsu
Summary: Pathologic complete lymph node regression may be an indicator of sensitivity to neoadjuvant treatment and serves as a good prognostic factor in patients with esophageal squamous cell carcinoma.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Reinhard Ruppert, Theodor Junginger, Rainer Kube, Joachim Strassburg, Andreas Lewin, Joerg Baral, Christoph A. Maurer, Joerg Sauer, Johannes Lauscher, Guenther Winde, Rena Thomasmeyer, Sigmar Stelzner, Cornelius Bambauer, Soenke Scheunemann, Axel Faedrich, Daniel Wollschlaeger, Susanne Merkel
Summary: This study aimed to investigate whether neoadjuvant chemoradiotherapy can be restricted to high-risk patients with rectal cancer without compromising oncological outcomes. It was found that low-risk patients do not require neoadjuvant therapy, while high-risk patients should intensify their neoadjuvant therapy to improve prognosis.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Can Chen, Xi Chen, Jingting Jiang
Summary: The study aimed to determine the prognostic role of neoadjuvant radiotherapy (NRT) in patients with rectal mucinous adenocarcinoma (RMAC) using propensity-score matching (PSM). The results showed that NRT improved the survival rate of RMAC patients, particularly in stage II and III patients. This suggests that NRT has significant and positive implications for RMAC patients.
SCIENTIFIC REPORTS
(2023)
Article
Gastroenterology & Hepatology
Takeru Matsuda, Kimihiro Yamashita, Hiroshi Hasegawa, Naoki Urakawa, Shingo Kanaji, Taro Oshikiri, Tetsu Nakamura, Yoshihiro Kakeji
Summary: The 2-team method with transanal assistance is an efficient and safe approach for lateral pelvic lymph node dissection in patients with rectal cancer, reducing operative time and operator burden while ensuring a secure and effective dissection.
DISEASES OF THE COLON & RECTUM
(2021)
Article
Gastroenterology & Hepatology
Yuichiro Tsukada, Eric Rullier, Takuya Shiraishi, Maylis Capdepont, Takeshi Sasaki, Bertrand Celerier, Quentin Denost, Masaaki Ito
Summary: This study compared the outcomes of two different strategies for clinical T3 rectal cancer without enlarged lateral lymph nodes: preoperative chemoradiotherapy (CRT) followed by total mesorectal excision (TME) and TME with bilateral lateral pelvic lymph node dissection (LPLND). The results showed that disease-free survival and overall survival were similar between the two groups, but the TME + LPLND group had a slightly higher rate of local recurrence. The TME + LPLND group also had more complications, including obturator nerve injury, isolated pelvic abscess, and urinary complications.
COLORECTAL DISEASE
(2023)
Article
Oncology
Seo-Hyeon Hwang, Dong-Woo Kang, Mi-Kyung Lee, Ji Yong Byeon, Hanui Park, Dong-Hyuk Park, Kyung-Chul Kim, Seung-Tae Lee, Sang Hui Chu, Nam Kyu Kim, Justin Y. Jeon
Summary: This study aimed to explore genome-wide DNA methylation changes after 6-week exercise training in colorectal cancer survivors. Results showed significant methylation changes in 756 CpG sites in the exercise group, linked to biological processes such as immune response and transcription. These findings suggest that exercise intervention may have positive effects on epigenetic markers in colorectal cancer survivors.
ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Surgery
Ho Seung Kim, Han-Gil Kim, Seung Yoon Yang, Yoon Dae Han, Hyuk Hur, Byung Soh Min, Kang Young Lee, Nam Kyu Kim, Min Soo Cho
Summary: This study retrospectively analyzed the medical records of patients who underwent surgery for appendiceal mucocele between 2010 and 2018, comparing the perioperative and short-term outcomes of single-incision laparoscopic surgery (SILS) and conventional laparoscopic surgery (CLS), as well as evaluating the oncological safety of SILS. The results showed that SILS for appendiceal mucocele is feasible and safe perioperatively and in the short-term, with favorable oncological outcomes.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Oncology
Kyung Hwan Kim, Han Sang Kim, Seung-Seob Kim, Hyo Sup Shim, Andrew Jihoon Yang, Jason Joon Bock Lee, Hong In Yoon, Joong Bae Ahn, Jee Suk Chang
Summary: This study investigated the role of mutations in DNA damage repair genes on treatment outcomes after radiotherapy (RT). The results suggest that tumors with mutations in ATM and BRCA1/2 genes exhibit superior tumor response and local control after RT.
CANCER RESEARCH AND TREATMENT
(2022)
Article
Oncology
Joongyo Lee, Kangpyo Kim, Kyung Hwan Kim, Ki Chang Keum, Hye Ryun Kim, Min Hee Hong, Eun Chang Choi, Se-Heon Kim, Yoon Woo Koh, Chang Geol Lee
Summary: This study found that the treatment outcomes of primary surgery and primary radiotherapy were similar in HPV-positive tonsil cancer after adjusting for clinical factors. Primary radiotherapy may be considered as an alternative to surgery in patients with advanced pathological T stage. Deintensification of adjuvant radiotherapy should be considered in cases of pathological complete remission after induction chemotherapy.
RADIATION ONCOLOGY
(2022)
Article
Oncology
Seo Hee Choi, Andrew Jihoon Yang, Sun Och Yoon, Hye Ryun Kim, Min Hee Hong, Se-Heon Kim, Eun Chang Choi, Ki Chang Keum, Chang Geol Lee
Summary: This study analyzed the data of head and neck adenoid cystic carcinoma (HNACC) patients and found that postoperative radiotherapy (PORT) can significantly reduce local failure rate and improve survival in high-risk patients. Particularly, patients with positive margins, T2-4 stage disease, and minor salivary gland tumors benefited more from PORT.
RADIATION ONCOLOGY
(2022)
Article
Oncology
Ryoung-Eun Ko, Jaehyeong Cho, Min-Kyue Shin, Sung Woo Oh, Yeonchan Seong, Jeongseok Jeon, Kyeongman Jeon, Soonmyung Paik, Joon Seok Lim, Sang Joon Shin, Joong Bae Ahn, Jong Hyuck Park, Seng Chan You, Han Sang Kim
Summary: This study presents a new machine learning-based mortality prediction model for critically ill cancer patients admitted to the intensive care unit. The model, called CanICU, shows high sensitivity and specificity and uses nine easily obtainable variables. It offers improved performance compared to current prognostic models and can help physicians allocate ICU care for cancer patients based on objective mortality risk.
Article
Gastroenterology & Hepatology
Jihee Min, Ki-yong An, Hyuna Park, Wonhee Cho, Hye Jeong Jung, Sang Hui Chu, Minsoo Cho, Seung Yoon Yang, Justin Y. Jeon, Nam Kyu Kim
Summary: This study aimed to investigate the effects of postoperative exercise on the recovery of colorectal cancer patients. The results indicated that patients in the postoperative exercise group had shorter hospital stay, greater readiness for discharge, and increased muscle mass. Therefore, postoperative inpatient exercise may facilitate faster recovery and discharge after colorectal cancer surgery.
BMC GASTROENTEROLOGY
(2023)
Article
Oncology
Jeongseok Jeon, Da Bin Lee, Sang Joon Shin, Dai Hoon Han, Jee Suk Chang, Yoon Dae Han, Hyunwook Kim, Joon Seok Lim, Han Sang Kim, Joong Bae Ahn
Summary: This study found that high-frequency abdominopelvic computed tomography (AP-CT) testing is associated with a higher proportion of surgery plus chemo- or radiotherapy as postrecurrence treatment, but does not improve the 5-year overall survival rate of patients with stage II-III colon cancer.
CLINICAL COLORECTAL CANCER
(2023)
Article
Immunology
Han Sang Kim, Chang Gon Kim, Won Kyu Kim, Kyung-A Kim, Jinseon Yoo, Byung Soh Min, Soonmyung Paik, Sang Joon Shin, Hyukmin Lee, Kyungwon Lee, Hoguen Kim, Eui-Cheol Shin, Tae-Min Kim, Joong Bae Ahn
Summary: This study found that Fusobacterium nucleatum (FN) in colorectal cancer tissues is associated with immune regulation in the tumor microenvironment, and its infection is correlated with poor prognosis and altered distribution of immune cells.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Dongjin Seo, Han Sang Kim, Joong Bae Ahn, Yu Rang Park
Summary: This study aimed to evaluate the prognostic impact of initial status and trajectories of muscle and BMI on overall survival in colorectal cancer patients. The results indicated that the trajectories of muscle and BMI were related to overall survival, and increasing muscle mass was associated with better survival. Therefore, the changes in muscle and BMI can serve as important indicators for predicting survival in colorectal cancer patients.
JMIR PUBLIC HEALTH AND SURVEILLANCE
(2023)
Article
Health Care Sciences & Services
Si Won Lee, Jung Hye Kwon, Seung-hoon Beom, Sang Joon Shin, Hyo Song Kim, Sun Young Rha, Minkyu Jung, Joo Hyuk Sohn, Joong-Bae Ahn, Hyun Cheol Chung, Gun Min Kim, Hye Ryun Kim, Beodeul Kang, Youn Jung Hu, Hye Jin Choi
Summary: This study evaluated the first-year outcomes of patients admitted to an acute palliative care unit (APCU) at a tertiary hospital in Korea. The results showed that during their stay in the APCU, the overall symptoms of inpatients were reduced.
PALLIATIVE MEDICINE REPORTS
(2023)
Article
Multidisciplinary Sciences
Chinock Cheong, Jeonghyun Kang, Byung Soh Min, Nam Kyu Kim, Joong Bae Ahn, Kang Young Lee
Summary: This study investigated the impact of neoadjuvant imatinib on rectal GIST. The results showed that imatinib treatment can reduce tumor size, increase resectability, and help preserve the sphincter. The neoadjuvant group had a higher rate of levator ani muscle displacement and larger radiologic tumor size compared to the control group. However, there was no significant difference between the two groups in terms of postoperative complications, hospital stay, local recurrence, and disease-free survival.
Article
Oncology
Seung-Hoon Beom, Ki Beom Bae, Dae Young Zang, Joohee Bae, In Gyu Hwang, Hye Jin Kang, In Sook Woo, Byoung Yong Shim, Byung-Noe Bae, Jaekyung Cheon, Sang-Bo Oh, Joong-Bae Ahn
Summary: This regulatory post-marketing surveillance study aimed to evaluate the safety and effectiveness of regorafenib in Korean patients with CRC, GIST, and HCC. The study found no new safety concerns and the results were consistent with previous clinical trials.
Article
Medicine, General & Internal
Cristopher Varela, Manar Nassr, Nam Kyu Kim
Summary: Controversial surgical anatomical landmarks in the deep pelvis can be visualized and identified using current technologies. Performing the gate approach technique during deep lateral dissection for total mesorectal excision facilitates visualization of the pelvic neurovascular structures following simple dissection steps to preserve the pelvic autonomic nerves and avoid accidental vascular injuries.
YONSEI MEDICAL JOURNAL
(2022)
