Article
Oncology
Nnamdi I. Gwacham, Karolina A. Kilowski, Fernando O. Recio, Ahmad Awada, Theresa M. Kuhn, Jianbin Zhu, Ameya Patel, Sarfraz Ahmad, Nathalie D. McKenzie, James E. Kendrick, Robert W. Holloway
Summary: The study aimed to determine the prevalence of peritoneal cytologic contamination following robotic hysterectomy for endometrial cancer. The results showed that 13.1% of cases had pelvic contamination. Pelvic contamination was associated with factors such as myometrial invasion, tumor size, lymphovascular space invasion, and lymph node metastasis. Rating: 8 out of 10.
GYNECOLOGIC ONCOLOGY
(2023)
Article
Oncology
C. Uwins, H. Patel, G. Prakash Bhandoria, S. Butler-Manuel, A. Tailor, P. Ellis, J. Chatterjee
Summary: Minimally invasive surgery has multiple benefits for the treatment of endometrial and cervix cancer, but oncological efficacy and safety should be rigorously established when adopting new techniques, rather than assumed based on first principles.
Article
Surgery
Andrea Giannini, Javier F. Magrina, Paul M. Magtibay, Kristina A. Butler
Summary: The aim of this study was to investigate the feasibility and safety factors of same-day dismissal (SDD) in endometrial cancer patients undergoing robotic hysterectomy and staging. Retrospective chart review showed that 40% of the 292 patients had SDD, while 60% had non-SDD. Factors significantly associated with non-SDD included longer operating time, older age, and comorbidities such as cardiovascular diseases, anemia, and anticoagulant therapy. However, sentinel lymph node sampling was significantly associated with achieving SDD.
UPDATES IN SURGERY
(2023)
Article
Oncology
Giorgio Bogani, Violante Di Donato, Andrea Papadia, Alessandro Buda, Jvan Casarin, Francesco Multinu, Francesco Plotti, Ilaria Cuccu, Tullio Golia D'Auge, Maria Luisa Gasparri, Ciro Pinelli, Anna Myriam Perrone, Fabio Barra, Flavia Sorbi, Antonella Cromi, Giampaolo Di Martino, Innocenza Palaia, Giorgia Perniola, Simone Ferrero, Pierandrea De Iaco, Chiara Perrone, Roberto Angioli, Daniela Luvero, Ludovico Muzii, Fabio Ghezzi, Fabio Landoni, Michael D. Mueller, Pierluigi Benedetti Panici, Francesco Raspagliesi
Summary: This study evaluated the long-term survival of three different approaches of nodal assessment in endometrial cancer patients and found that sentinel lymph node mapping (SNM) provides similar long-term oncologic outcomes to lymphadenectomy (LND).
GYNECOLOGIC ONCOLOGY
(2022)
Article
Oncology
Giacomo Corrado, Enrico Vizza, Anna Myriam Perrone, Liliana Mereu, Vito Cela, Francesco Legge, Georgios Hilaris, Tina Pasciuto, Marco D'Indinosante, Eleonora La Fera, Camilla Certelli, Valentina Bruno, Stylianos Kogeorgos, Francesco Fanfani, Pierandrea De Iaco, Giovanni Scambia, Valerio Gallotta
Summary: This study evaluated the peri-operative and oncological outcomes of elderly endometrial cancer patients who underwent laparoscopic or robotic surgery, finding no significant differences in surgical and survival outcomes between the two groups. However, robotic surgery showed lower blood losses and longer operative times compared to laparoscopic surgery. Ultimately, neither approach demonstrated superiority in terms of survival outcomes, highlighting the need for individual evaluation to determine the best surgical approach.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Emanuele Perrone, Ilaria Capasso, Tina Pasciuto, Alessandro Gioe, Salvatore Gueli Alletti, Stefano Restaino, Giovanni Scambia, Francesco Fanfani
Summary: The study found that robotic-assisted surgery (RS) and laparoscopy (LPS) have similar efficacy and safety for endometrial cancer staging. The different surgical approaches did not significantly influence disease-free survival (DFS) or overall survival (OS). Age was found to be a significant factor for survival in high-risk endometrial cancer patients, independent of the minimally invasive approach.
JOURNAL OF GYNECOLOGIC ONCOLOGY
(2021)
Article
Oncology
Jonathan S. Berek, Xavier Matias-Guiu, Carien Creutzberg, Christina Fotopoulou, David Gaffney, Sean Kehoe, Kristina Lindemann, David Mutch, Endometrial Canc Staging Subcomm, FIGO Womens Canc Comm
Summary: Since the 2009 update of the FIGO staging system, there have been significant advances in understanding the pathologic and molecular features of endometrial cancer. The new staging system aims to better define prognostic groups and create substages to guide more appropriate treatment.
JOURNAL OF GYNECOLOGIC ONCOLOGY
(2023)
Article
Oncology
Celine Lechartier, Juliette Bernard, Marie-Claude Renaud, Marie Plante
Summary: This study retrospectively evaluated the outcome of robotic-assisted surgery for endometrial cancer in obese patients with a BMI >= 40 kg/m2. The study found that complications and outcomes were similar in both groups of patients.
GYNECOLOGIC ONCOLOGY
(2023)
Article
Medicine, General & Internal
Kyung Jin Eoh, Dae Woo Lee, Ji Hyun Lee, Eun Ji Nam, Sang Wun Kim, Young Tae Kim
Summary: The study found that robot-assisted staging surgery using three robotic arms and laparotomy for endometrial carcinoma had similar survival outcomes.
YONSEI MEDICAL JOURNAL
(2021)
Article
Health Care Sciences & Services
Ana Sofia Linhares Moreira, Vera Ribeiro, Giacomo Aringhieri, Salvatore Claudio Fanni, Lorenzo Tumminello, Lorenzo Faggioni, Dania Cioni, Emanuele Neri
Summary: This study aimed to assess the predictive value of apparent diffusion coefficient (ADC) measurements in determining the histological grade of endometrial cancer. The findings showed that ADC values were not effective in predicting the grade of endometrial cancer, despite good agreement between MRI interpretation and histopathology in staging the cancer.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Obstetrics & Gynecology
Jonathan Berek, Xavier Matias-Guiu, Carien Creutzberg, Christina Fotopoulou, David Gaffney, Sean Kehoe, Kristina Lindemann, David Mutch, Nicole Concin, Endometrial Canc Staging Subcomm, FIGO Womens Canc Comm
Summary: Since the last update of the FIGO staging system in 2009, significant advancements have been made in understanding the pathology and molecular features of endometrial cancer. The new staging system aims to better define prognostic groups and create substages that guide appropriate treatment options. The proposed system incorporates data from molecular and histological classifications, providing a more comprehensive understanding of the complex nature of endometrial carcinoma and its biological behavior.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Review
Medicine, General & Internal
Emma J. Crosbie, Sarah J. Kitson, Jessica N. McAlpine, Asima Mukhopadhyay, Melanie E. Powell, Naveena Singh
Summary: Endometrial cancer is the most common gynaecological cancer in high income countries, with a global rise in incidence. Obesity is the major underlying cause, posing challenges for diagnosis and treatment. Early presentation with postmenopausal bleeding ensures cure, but advanced cases have poor prognosis. Minimally invasive surgical staging and targeted chemotherapeutic strategies are important advances.
Article
Surgery
Linda Feldbruegge, Santiago Andres Ortiz Galindo, Oliver Frisch, Christian Benzing, Felix Krenzien, Anna Riddermann, Anika Kaestner, Nora Franziska Nevermann, Thomas Malinka, Wenzel Schoening, Johann Pratschke, Moritz Schmelzle
Summary: The study found that robotic liver surgery is safe and feasible for patients with prior abdominal surgeries, despite limited experience in the field. Baseline characteristics and perioperative outcomes in robotic liver resection showed no significant differences between patients with and without prior surgeries.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Surgery
Marcos Gomez Ruiz, Roberto Ballestero Diego, Patricia Tejedor, Carmen Cagigas Fernandez, Lidia Cristobal Poch, Natalia Suarez Pazos, Julio Castillo Diego
Summary: Radical resection beyond TME, sometimes by multi-visceral resection, is important for T4 rectal tumors and local recurrences of rectal cancer. The use of robotic surgery for these cases may offer advantages over laparoscopic surgery. This study analyzed the outcomes and oncological results of robotic surgery for locally advanced rectal cancer and LR.
UPDATES IN SURGERY
(2023)
Article
Oncology
Shinichi Togami, Mika Fukuda, Mika Mizuno, Shintaro Yanazume, Hiroaki Kobayashi
Summary: This study validates the surgical and oncologic outcomes of robotic surgery with sentinel node navigation surgery (SNNS) in endometrial cancer. It demonstrates that this approach has shorter operative time and less blood loss, high detection rate of pelvic sentinel lymph nodes, low recurrence rate, and excellent survival rates.
JOURNAL OF GYNECOLOGIC ONCOLOGY
(2023)
Article
Oncology
Hyang Sook Seol, Ju Hee Oh, Eunhye Choi, SangMin Kim, Hyunki Kim, Eun Ji Nam
Summary: This study aimed to establish a patient-derived organoid platform to evaluate the effects of chemotherapy, radiation therapy, and targeted therapy in cervical cancer. The results showed that patient-derived cervical cancer organoids can be used as a platform for drug and radiation sensitivity testing, potentially providing personalized treatment options for patients with different subtypes of cervical cancer.
JOURNAL OF GYNECOLOGIC ONCOLOGY
(2023)
Article
Oncology
Yong Jae Lee, Young Shin Chung, Jung-Yun Lee, Eun Ji Nam, Sang Wun Kim, Young Tae Kim, Sunghoon Kim
Summary: This study evaluated the usefulness of preoperative diagnostic laparoscopy in treatment planning for patients with advanced-stage ovarian cancer. The results showed that laparoscopy reduced the rate of suboptimal cytoreduction after primary debulking surgery and decreased the proportion of non-high-grade serous carcinoma patients undergoing neoadjuvant chemotherapy. Additionally, laparoscopy reduced postoperative morbidity without affecting survival outcomes.
JOURNAL OF GYNECOLOGIC ONCOLOGY
(2023)
Article
Obstetrics & Gynecology
Amany Abdelwadoud Makroum, Yong Jae Lee, Jung-Yun Lee, Eun Ji Nam, Sunghoon Kim, Sang Wun Kim, Young Tae Kim
Summary: This study compared the oncological outcomes of sentinel lymph node (SLN) biopsy and complete lymph node dissection in patients with early-stage endometrial carcinoma. The results showed no difference in progression-free survival and overall survival between the two groups.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2023)
Article
Oncology
Kyung Jin Eoh, Dae Woo Lee, Eun Ji Nam, Jae In Kim, Hanna Moon, Sang Wun Kim, Young Tae Kim
Summary: HOXA cluster antisense RNA 3 (HOXA-AS3) is associated with ovarian cancer progression and can be used as a prognostic marker and therapeutic target in epithelial ovarian cancer (EOC). The expression of HOXA-AS3 is higher in ovarian cancer tissues compared to normal ovarian tissues. Knockdown of HOXA-AS3 inhibits cell proliferation and migration in ovarian cancer cell lines, and HOXA-AS3 modulates the expression of epithelial-mesenchymal transition (EMT) markers.
Article
Medicine, General & Internal
Kyung Jin Eoh, Young Joo Lee, Eun Ji Nam, Hye In Jung, Young Tae Kim
Summary: This study aimed to evaluate the clinical relevance of vaginal cuff dehiscence following a hysterectomy. The incidence of vaginal cuff dehiscence was compared between minimally invasive and open hysterectomy, and clinical factors were analyzed. The results showed that the incidence of vaginal cuff dehiscence was 1.0% regardless of the surgical method. Surgical indications and obesity were identified as independent risk factors for vaginal cuff dehiscence, while the different modes of hysterectomy did not influence the risk.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Kyung Jin Eoh, Yoo-Na Kim, Eun Ji Nam, Sang Wun Kim, Young Tae Kim
Summary: In this study, the impact of uterine manipulation on endometrial cancer survival outcomes was investigated. Patients with endometrial cancer who underwent robot-assisted staging and open staging surgery between 2010 and 2020 were analyzed. Propensity score matching was performed to adjust for baseline characteristics. The results showed that robotic surgery using a uterine manipulator or vaginal tube did not compromise survival outcomes in endometrial cancer management.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Yoo-Na Kim, Kyunglim Lee, Eunhyang Park, Junsik Park, Yong Jae Lee, Eun Ji Nam, Sang Wun Kim, Sunghoon Kim, Young Tae Kim, Jung-Yun Lee
Summary: The purpose of this study was to investigate the genomic and immunohistochemical profiles, as well as immunotherapy outcomes, in patients with cervical cancer. The study identified clinical information and results from patients who underwent tumor next-generation sequencing (NGS) and received immunotherapy. The findings revealed differences in PD-L1 CPS and HER2 receptor expression based on histology, as well as common gene mutations such as PIK3CA, TP53, STK11, FAT1, and FBXW7 in patients with cervical squamous cell carcinoma.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Lee Kyung Kim, Sun-Ae Park, Eun Ji Nam, Young Tae Kim, Tae-Hwe Heo, Hee Jung Kim
Summary: In this study, it was confirmed that the upregulation of long non-coding RNA (lncRNA) SNHG4 is associated with lower survival rates in endometrial cancer patients. Knock-down of SNHG4 reduced cell proliferation, colonization, migration, invasion, and tumor growth of endometrial cancer. Moreover, the role of SNHG4 was mediated by the transcription factor SP-1. These findings suggest that SNHG4/SP-1 may serve as a potential therapeutic and prognostic biomarker for endometrial cancer.
Article
Oncology
Dahye Lee, Yoo-Na Kim, Sang Hyun Cho, Hye soo Yoon, Young Tae Kim, Sunghoon Kim, Sang Wun Kim
Summary: This study aimed to compare the oncologic outcomes of patients with endometrial cancer who underwent sentinel lymph node (SLN) biopsy without ultrastaging with those who underwent lymphadenectomy (LND). The study found that SLN biopsy without ultrastaging did not compromise survival outcomes and was associated with significantly reduced lymphatic complication rates.
JOURNAL OF GYNECOLOGIC ONCOLOGY
(2023)
Article
Surgery
Ki Eun Seon, Yong Jae Lee, Jung-Yun Lee, Eun Ji Nam, Sunghoon Kim, Young Tae Kim, Sang Wun Kim
Summary: This study compared the perioperative outcomes of conventional laparotomy (LT) and da Vinci SP robotic system (SP) in endometrial cancer patients. The results showed that although SP had a longer operation time, it had lower estimated blood loss, postoperative Hb change, postoperative complications rate, perioperative transfusion rate, and postoperative hospital stay compared to LT. Additionally, patients in the SP group had lower postoperative pain scores.
JOURNAL OF ROBOTIC SURGERY
(2023)