Journal
JOURNAL OF SURGICAL ONCOLOGY
Volume 97, Issue 2, Pages 132-135Publisher
WILEY-LISS
DOI: 10.1002/jso.20929
Keywords
gastric cancer; lymph node metastasis; n ratio; prognosis
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Background and Objectives: To determine the prognostic significance of the ratio between metastatic and dissected lymph nodes (n ratio) in gastric cancer patients. Methods: We retrospectively reviewed 777 advanced gastric cancer patients who had undergone curative gastrectomy at our hospital. Results: The n ratio was significantly greater in cases with a large tumor, undifferentiated tumor, lymphatic vessel invasion, or blood vessel invasion. Furthermore, the n ratio was significantly correlated with the depth of invasion, level of lymph node metastasis, and number of lymph node metastases. The prognosis for gastric cancer patients correlated well with the n ratio. Multivariate analysis indicated that the n ratio, but not the number of lymph node metastases, was an independent prognostic indicator. Moreover, the n ratio was an independent prognostic factor in NI, N2, and N3 patients defined by the Japanese Classification of Gastric Cancer (JCGC). Conclusions: The n ratio is useful for evaluating the status of lymph node metastasis in gastric cancer. Therefore, the addition of the n ratio to the N (nodal) category defined by the JCGC may be a useful strategy in the N-staging classification of gastric cancer.
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