Article
Oncology
Christopher S. Chandler, Meghan M. Bell, Sebastian K. Chung, Darren R. Veach, Edward K. Fung, Blesida Punzalan, Daniela Burnes Vargas, Mitesh Patel, Hong Xu, Hong-fen Guo, Brian H. Santich, Pat B. Zanzonico, Sebastien Monette, Garrett M. Nash, Andrea Cercek, Achim Jungbluth, Neeta Pandit-Taskar, Nai Kong Cheung, Steven M. Larson, Sarah M. Cheal
Summary: This study tests a treatment method for peritoneal carcinomatosis that targets GPA33 using intracompartmental pretargeted radioimmunotherapy. The results show that this method effectively prolongs the survival of tumor patients without significant radiotoxicity.
MOLECULAR CANCER THERAPEUTICS
(2022)
Article
Oncology
Eeeln Buckarma, Cornelius A. Thiels, Zhaohui Jin, Travis E. Grotz
Summary: CRS and HIPEC with paclitaxel and cisplatin is well tolerated and associated with favorable oncologic and perioperative outcomes.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Soo Yeun Park, Jun Seok Park, Hye Jin Kim, Jong Gwang Kim, Byung Woog Kang, Jin Ho Baek, Hyeong Rok Kim, Chang Hyun Kim, Young Jin Kim, Gyu-Seog Choi
Summary: This study found that mitomycin C-IPC after CRS was associated with improved survival outcomes in patients with resectable peritoneal metastasis of colorectal cancer. IPC had beneficial effects regarding peritoneal progression-free survival in patients with both peritoneal and extraperitoneal metastases.
JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Gastroenterology & Hepatology
Eyal Mor, Dan Assaf, Shachar Laks, Efrat Keren Gilat, David Hazzan, Einat Shacham-Shmueli, Ofer Margalit, Naama Halpern, Tamar Beller, Ben Boursi, Ofer Purim, Daria Perelson, Douglas Zippel, Mohammad Adileh, Aviram Nissan, Almog Ben-Yaacov
Summary: This study investigates the impact of pelvic peritonectomy on the outcomes of patients with colorectal peritoneal metastasis. The results show that pelvic peritonectomy during CRS/HIPEC is associated with higher morbidity and worse oncological outcomes.
JOURNAL OF GASTROINTESTINAL SURGERY
(2023)
Article
Oncology
Andrei Nikiforchin, Armando Sardi, Mary Caitlin King, Ekaterina Baron, Felipe Lopez-Ramirez, Luis Felipe Falla-Zuniga, Philipp Barakat, Sergei Iugai, Kathleen Pawlikowski, Carol Nieroda, Vadim Gushchin
Summary: This study aimed to assess the recurrence patterns of low-grade and high-grade appendiceal cancer. The results showed that low-grade appendiceal cancer mainly recurred intraperitoneally, while high-grade appendiceal cancer recurred both intra- and extraperitoneally. Understanding the recurrence patterns of appendiceal cancer can help to understand its biology and plan follow-up and post-relapse management.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Wei-Chun Chen, Ting-Chang Chang, Hung-Hsueh Chou, Mei-Hsiu Cheng, Jun-Jie Hong, Yi-Shan Hsieh, Chao-Min Cheng
Summary: This study investigated the changes in miRNA and cytokine expression in the peritoneal fluid of OVCA patients after receiving HIPEC during CRS. The results showed immediate down-regulation of miR-320a-3p and miR-663-a, followed by upregulation after 24 hours. Additionally, six other miRNAs and several cytokines demonstrated significant changes in expression post-HIPEC. Further research is needed to understand the role of HIPEC in these changes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Se Ik Kim, Ji Hyun Kim, Sanghee Lee, Hyunsoon Cho, Willemien J. van Driel, Gabe S. Sonke, Robert E. Bristow, Sang-Yoon Park, Christina Fotopoulou, Myong Cheol Lim
Summary: This study systematically evaluated the value of hyperthermic intraperitoneal chemotherapy (HIPEC) in cytoreductive surgery (CRS) for epithelial ovarian cancer (EOC). The results showed that HIPEC improved progression-free survival (PFS) and overall survival (OS) in the recent chemotherapy exposure group, but had no significant effect in the non-recent chemotherapy exposure group.
GYNECOLOGIC ONCOLOGY
(2022)
Article
Surgery
Duran-Martinez Manuel, Gomez-Duenas Gonzalo, Rodriguez-Ortiz Lidia, Sanchez-Hidalgo Juan Manuel, Gordon-Suarez Antonio, Casado-Adam Angela, Rufian-Pena Sebastian, Valenzuela-Molina Francisca, Rufian-Andujar Blanca, Vazquez-Borrego Maria Carmen, Romero-Ruiz Antonio, Briceno-Delgado Javier, Arjona-Sanchez Alvaro
Summary: This study compared the short-term outcomes of laparoscopic approach and open approach for interval cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS+HIPEC) in patients with advanced epithelial ovarian cancer (EOC). The results showed that the laparoscopic approach was associated with shorter hospital stay and time to return to systemic chemotherapy, while achieving similar oncological results compared to the open approach.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Review
Oncology
S. Kim, J-W Kim
Summary: Ovarian cancer is often diagnosed at an advanced stage, but combining surgery with Hyperthermic Intraperitoneal Chemotherapy (HIPEC) can improve patients' survival outcomes.
Article
Oncology
An Shang, Shuang Wang, Yongping Yang, Liping Li, Zeyun Zhao, Donglin Li, Yu Guo, Min Wang
Summary: This study found that surgery plus IOC resulted in a favorable prognosis for stage III CRC patients, while no side effects were observed for stage II patients when the dosage of lobaplatin was 0.1g/L. IOC therapy is a new, safe, and simple procedure that is easily performed and does not require any special devices or techniques, making it a promising therapeutic strategy for CRC patients.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Medicine, Research & Experimental
Mohammad Breakeit, Daniel Liu, Adrian Cheng, Hyerim Suh, Shoma Barat, Amer Matar, Nayef Alzahrani, David L. Morris
Summary: This study retrospectively analyzed stoma closure surgery in patients with peritoneal carcinomatosis of appendiceal or colorectal origin and compared them with patients who had known recurrence. The results showed a significant proportion of patients had peritoneal recurrence at the time of stoma closure. The time between the first and second surgery, as well as the peritoneal cancer index, were found to have an important impact on the occurrence of peritoneal recurrence.
Article
Oncology
Shachar Laks, Gal Schtrechman, Mohammad Adileh, Almog Ben-Yaacov, Ofer Purim, Vyacheslav Ivanov, Dan Aderka, Einat Shacham-Shmueli, Naama Halpern, Shani Goren, Daria Perelson, Aviram Nissan
Summary: Repeat CRS/HIPEC for CRPM patients shows a positive impact on survival rates compared to initial procedures, with no significant differences in complications and hospital stay. PCI and DFS are important factors influencing patient outcomes, and repeat procedures are safe and effective in appropriately selected patients.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Robert A. Nagourney, Steven Evans, Peter H. Tran, Adam J. Nagourney, Paul H. Sugarbaker
Summary: Patients with colon cancer who have received specific drug treatments are more likely to exhibit resistance to oxaliplatin, reducing the efficacy of heated intraperitoneal chemotherapy (HIPEC).
Review
Oncology
Louis Choon Kit Wong, Zhenyue Li, Qiao Fan, Joey Wee-Shan Tan, Qiu Xuan Tan, Jolene Si Min Wong, Chin-Ann Johnny Ong, Claramae Shulyn Chia
Summary: Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy may improve outcomes in patients with peritoneal sarcomatosis, although there are associated complications and longer hospital stays.
Review
Oncology
Ruby M. van Stein, Arend G. J. Aalbers, Gabe S. Sonke, Willemien J. van Driel
Summary: Hyperthermic intraperitoneal chemotherapy (HIPEC) shows potential efficacy in treating peritoneal metastases from epithelial ovarian and colorectal cancer with limited toxic effects. Further research is needed to determine the optimal patient selection, timing, and regimens for improving the effectiveness of HIPEC.
