Article
Chemistry, Multidisciplinary
Jingyi Wang, Xuzhong Shen, Xu Chen, Yinwei Bao, Jian He, Zhan Lu
Summary: In this study, cobalt-catalyzed enantioconvergent cross-coupling of alpha-bromoketones with aryl zinc reagents was achieved, leading to the synthesis of chiral ketones with alpha-tertiary stereogenic centers. Ligand modification was found to be critical for improving the reactivity and selectivity of this transformation.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Infectious Diseases
Jin Seok Kim, Jin Kyung Yu, Su Jin Jeon, Sang-Hun Park, Sunghee Han, So Hyeon Park, Minji Kang, Jung Im Jang, Eun-Kyung Shin, Junyoung Kim, Chae-Kyu Hong, Jib-Ho Lee, Young Ok Hwang, Young-Hee Oh
Summary: Colistin, commonly used as a last-resort drug against multi-drug-resistant Gram-negative bacteria, has faced challenges with the acquisition of mobile colistin resistance (mcr) genes by carbapenem-resistant Enterobacterales (CRE). A study in Seoul, Republic of Korea, found that 2.2% of 3675 CRE strains carried mcr genes, showing diversity in mcr carriers and clonal spreading of some Enterobacter cloacae complex (ECC) strains. The study emphasized the urgent need for intervention to control and prevent the dissemination of mcr genes in CRE strains.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2021)
Article
Infectious Diseases
Shijun Sun, Qi Wang, Longyang Jin, Yifan Guo, Yuyao Yin, Ruobing Wang, Lei Bi, Renfei Zhang, Yungang Han, Hui Wang
Summary: This study identified novel subtypes and the spread of tmexCD-toprJ gene clusters. The research revealed that these gene clusters are mainly distributed in Pseudomonas spp. and Klebsiella spp. and can be transferred between Enterobacterales through plasmids.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Infectious Diseases
Thanawat Phuadraksa, Sineewanlaya Wichit, Siwaret Arikit, Napat Songtawee, Sakda Yainoy
Summary: The aim of this study was to characterize three strains of colistin-resistant E. coli isolated from feces samples of healthy individuals in Thailand. The study found that these strains exhibited multidrug-resistant phenotype and carried various antimicrobial resistance genes. It is the first report of the co-occurrence of mcr-2 and mcr-3 on the chromosome of E. coli. Strategic action plans are urgently needed to control and prevent the spread of mcr genes.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2022)
Article
Microbiology
Lijuan Wu, Tingting Xu, Yang Ji, Jingjie Song, Feiling Wang, Junxi Huang, Kai Zhou
Summary: This study investigates the occurrence of mobilized colistin resistance (mcr) genes in Gram-negative bacteria causing bloodstream infections in child inpatients in China. The findings show a high prevalence of mcr genes in the sampled isolates, indicating their dissemination in the community and/or hospitals over a long period. The study highlights the importance of rational use of colistin and effective measures to control the spread of mcr genes.
MICROBIOLOGY SPECTRUM
(2022)
Article
Multidisciplinary Sciences
Lijin Lian, Xuejuan Hu, Zhenhong Huang, Liang Hu, Lu Xu
Summary: The study focuses on detecting harmful algae through hyperspectral fluorescence imaging microscopy and proposes an optimization method of multivariate curve resolution for pigment analysis. The method accurately describes the location, concentration, and distribution of microalgae pigments, providing a rapid and cost-effective solution for water quality environmental issues.
Article
Microbiology
Cai-Yue Mei, Yue Jiang, Qin-Chun Ma, Meng-Jun Lu, Han Wu, Zhen-Yu Wang, Xinan Jiao, Jing Wang
Summary: This study investigated the prevalence and genomic characteristics of the colistin resistance gene mcr in Salmonella enterica in China. The study found a low prevalence of mcr in Salmonella strains, with plasmids playing an important role in mcr transmission and incomplete mcr-1 being able to be captured by chromosomes.
MICROBIOLOGY SPECTRUM
(2022)
Article
Chemistry, Analytical
John A. Adegoke, Amanda De Paoli, Isaac O. Afara, Kamila Kochan, Darren J. Creek, Philip Heraud, Bayden R. Wood
Summary: By combining UV/vis and NIR spectroscopy, this study successfully detected and quantified low-level ring-staged malaria-infected whole blood, demonstrating the potential for accurate diagnosis of malaria-infected patients.
ANALYTICAL CHEMISTRY
(2021)
Article
Infectious Diseases
Yasuhide Kawamoto, Norihito Kaku, Norihiko Akamatsu, Kei Sakamoto, Kosuke Kosai, Yoshitomo Morinaga, Norio Ohmagari, Koichi Izumikawa, Yoshihiro Yamamoto, Hiroshige Mikamo, Mitsuo Kaku, Kazunori Oishi, Katsunori Yanagihara
Summary: This study investigated the prevalence of colistin resistance and mcr gene carriage in ESBL and CRE isolates in Japan. The results showed that the frequency of colistin resistance and mcr-positive strains is not high in Japan, but continuous monitoring of mcr genes is necessary.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2022)
Article
Environmental Sciences
Niamh Cahill, Brigid Hooban, Kelly Fitzhenry, Aoife Joyce, Louise O'Connor, Georgios Miliotis, Francesca McDonagh, Liam Burke, Alexandra Chueiri, Maeve Louise Farrell, James E. Bray, Niall Delappe, Wendy Brennan, Deirdre Prendergast, Montserrat Gutierrez, Catherine Burgess, Martin Cormican, Dearbhaile Morris
Summary: The emergence and dissemination of mobile colistin resistance (mcr) genes poses a significant threat to public health, as colistin is one of the last line treatment options for multi-drug resistant infections. This study identified several bacteria carrying mcr genes, mainly in water sources and wastewater, along with other multi-drug resistance genes. These findings highlight the need for further research to understand the role of the environment in the persistence and dissemination of antimicrobial resistance.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Public, Environmental & Occupational Health
Yolandi Snyman, Andrew C. Whitelaw, Jo M. Barnes, Motlatji R. B. Maloba, Mae Newton-Foot
Summary: The study found colistin resistant Gram-negative bacteria and mcr genes in rivers and storm water in the Western Cape region, including mcr-5.1 and various mcr-3 gene variants. These genes were mainly present in water sources influenced by human activities, potentially leading to gene transfer to pathogenic bacteria.
ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL
(2021)
Article
Chemistry, Medicinal
Zhengnian Li, Ryosuke Ishida, Yan Liu, Jinhua Wang, Yina Li, Yang Gao, Jie Jiang, Jianwei Che, Jason M. Sheltzer, Matthew B. Robers, Tinghu Zhang, Kenneth D. Westover, Behnam Nabet, Nathanael S. Gray
Summary: This study describes a medicinal chemistry campaign to identify a CDK11 inhibitor. Through structure-guided medicinal chemistry modifications, a CDK11 probe ZNL-05-044 with improved selectivity was identified, which can arrest cell cycle and impact CDK11-dependent gene splicing in cells.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Polymer Science
Jinbao Xu, Weiguo Liang, Jie Zhang, Zhixian Dong, Caihong Lei
Summary: This study presents an organic base-catalyzed esterification reaction method for the direct synthesis of side-chain functionalized PCL, with wide substrate applicability and mild reaction conditions, offering a versatile and robust protocol for the preparation of functional PCL-based polymers with high potential for biological applications.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Infectious Diseases
Afaf Hamame, Bernard Davoust, Jean-Marc Rolain, Seydina M. Diene
Summary: This study identified an atypical multidrug-resistant Escherichia coli strain carrying both mcr-1 and mcr-3 genes in France. Genomic analysis revealed the presence of multiple resistance genes and determined that the strain belongs to the ST-843 clone. Given the potential for zoonotic transmission, there is an urgent need to monitor and prevent the spread of this strain to humans.
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2022)
Article
Chemistry, Multidisciplinary
Zhihui Wang, Lei Wang, Zhiming Wang, Pinhua Li, Yicheng Zhang
Summary: A practical synthesis method of alpha-bromo/iodo/chloroketones from olefins under visible-light irradiation conditions has been developed, achieving high yields without additional photocatalysts under sunlight irradiation.
CHINESE CHEMICAL LETTERS
(2021)
Article
Spectroscopy
Maryam Sabbaghan, Ashraf Sadat Shahvelayati, Kamelia Madankar
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2015)
Article
Materials Science, Ceramics
Maryam Sabbaghan, Ashraf Sadat Shahvelayati, Solmaz Banihashem
CERAMICS INTERNATIONAL
(2016)
Article
Materials Science, Ceramics
A. S. Delbari, S. A. Jafari Mohammadi, A. S. Shahvelayati, P. W. de Oliveira, S. H. Mousavi
CERAMICS INTERNATIONAL
(2016)
Article
Chemistry, Organic
Maryam Ghazvini, Ashraf Sadat Shahvelayati, Ali Sabri, Fatemeh Zeinali Nasrabadi
CHEMISTRY OF HETEROCYCLIC COMPOUNDS
(2016)
Article
Chemistry, Organic
Ashraf S. Shahvelayati, Akram Ashouri, Akram S. Delbari
LETTERS IN ORGANIC CHEMISTRY
(2016)
Article
Chemistry, Inorganic & Nuclear
Elnaz Ghasemi, Ashraf S. Shahvelayati, Issa Yavari
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
(2016)
Article
Chemistry, Multidisciplinary
Ashraf S. Shahvelayati, Maryam Sabbaghan, Solmaz Banihashem
MONATSHEFTE FUR CHEMIE
(2017)
Article
Biochemical Research Methods
Ashraf S. Shahvelayati, Maryam Ghazvini, Khadijeh Yadollahzadeh, Akram S. Delbari
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
(2018)
Article
Chemistry, Organic
Roya Hemati, Ashraf S. Shahvelayati, Khadijeh Yadollahzadeh
LETTERS IN ORGANIC CHEMISTRY
(2018)
Article
Chemistry, Multidisciplinary
Ashraf S. Shahvelayati, Issa Yavari, Akram S. Delbari
CHINESE CHEMICAL LETTERS
(2014)
Article
Environmental Sciences
Zahra Amini, Leila Hajiaghababaei, Asraf Sadat Shahvelayati
JOURNAL OF ELEMENTOLOGY
(2018)
Article
Chemistry, Multidisciplinary
Akram Sadat Delbari, Ashraf Sadat Shahvelayati, Vida Jodaian, Vahid Amani
JOURNAL OF THE IRANIAN CHEMICAL SOCIETY
(2015)
Article
Chemistry, Multidisciplinary
F. Sheikholeslami-Farahani, A. S. Shahvelayati
BULGARIAN CHEMICAL COMMUNICATIONS
(2015)
Article
Electrochemistry
Leila Hajiaghababaei, Ashraf Sadat Shahvelayati, Seyedeh Azam Aghili
ANALYTICAL & BIOANALYTICAL ELECTROCHEMISTRY
(2015)
Article
Biochemical Research Methods
Fatemeh Sheikholeslami-Farahani, Ashraf S. Shahvelayati
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
(2013)
Review
Chemistry, Multidisciplinary
Md. Azharul Arafath
Summary: Thiosemicarbazone Schiff base ligands have strong coordination and biological activity, and can form biologically active complexes with transition metals.
JOURNAL OF SULFUR CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Saeedeh Kamalinahad, Esmail Vessally
Summary: This study utilized DFT calculations to evaluate the interaction between the surface of a B-22 nanocluster decorated with Sc and Ti atoms and SO2 gas as a chemical sensor. The results showed that the decorated M/B-22 structure exhibited promising sensing properties for the detection of SO2 gas.
JOURNAL OF SULFUR CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Athandwe M. Paca, Saheed O. Benson, Amos A. Fatokun, Peter A. Ajibade
Summary: Four organoruthenium(II) arene dithiocarbamate complexes were synthesized and characterized. The complexes showed promising cytotoxic effects against human cervical cancer and human lung fibroblast cell lines. Two compounds, C1 and C3, exhibited potent cytotoxicity and demonstrated potential as anticancer agents.
JOURNAL OF SULFUR CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Emine Ozturk, Elif Subasi, Ece Su Cakmakci, Asli Sahiner, Betuel Sen Yuksel
Summary: A series of thiosemicarbazones containing benzothiophen moiety were synthesized and characterized. These compounds exhibited higher efficacy against gram-positive bacteria and lower antifungal activity against C. albicans.
JOURNAL OF SULFUR CHEMISTRY
(2024)
