Article
Neurosciences
Jiawen Li, Dong Luo, Feifei Peng, Qi Kong, Huawei Liu, Meiyuan Chen, Lusha Tong, Feng Gao
Summary: The novel ANAID-ICH nomogram, incorporating age, NIHSS score, anemia, infratentorial location, presence of DWILs, and prior ICH, may facilitate the identification of patients at higher risk for an unfavorable outcome.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Medicine, General & Internal
Jawed Nawabi, Sarah Elsayed, Andrea Morotti, Anna Speth, Melanie Liu, Helge Kniep, Rosalie McDonough, Gabriel Broocks, Tobias Faizy, Elif Can, Peter B. Sporns, Jens Fiehler, Bernd Hamm, Tobias Penzkofer, Georg Bohner, Frieder Schlunk, Uta Hanning
Summary: This study found that patients with oral anticoagulant-associated intracerebral hemorrhage (OAC-ICH) had lower levels of perihematomal edema (PHE) in the early stages compared to those with non-oral anticoagulant-associated intracerebral hemorrhage (NON-OAC-ICH), with NOAC patients also exhibiting significantly lower levels of edema expansion distance compared to NON-OAC-ICH patients. The increase in early PHE volume did not increase the likelihood of poor outcomes in OAC-ICH, but was independently associated with poor outcomes in NON-OAC-ICH.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Neurosciences
Hongxiu Guo, Mingfeng You, Jiehong Wu, Anqi Chen, Yan Wan, Xinmei Gu, Senwei Tan, Yating Xu, Quanwei He, Bo Hu
Summary: This article summarizes the current knowledge of genetic variations in spontaneous intracerebral hemorrhage (ICH), with a focus on location distribution and outcome. Investigations have shown that certain genetic variants are associated with lobar ICH or deep ICH, and some variations in genes may contribute to the outcome of ICH.
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Pharmacology & Pharmacy
Teng J. Peng, Catherine Viscoli, Pooja Khatri, Stacey Q. Wolfe, Nirav R. Bhatt, Tarun Girotra, Hooman Kamel, Kevin N. Sheth
Summary: Spontaneous intracerebral hemorrhage (ICH) is a type of stroke and survivors are at risk for recurrent hemorrhagic and ischemic cerebrovascular events, especially those with atrial fibrillation (AF). The decision to initiate or resume versus withhold anticoagulation in survivors of ICH with AF is a conundrum in the field of vascular neurology, neurosurgery, and cardiology.
Article
Clinical Neurology
Merih Irem Baharoglu, Jonathan M. Coutinho, Henk A. Marquering, Charles B. Majoie, Yvo B. Roos
Summary: This study found that patients with antithrombotic therapy after ICH have worse clinical outcomes. Patients using VKA and AP had higher risk of poor outcomes and mortality compared to those using DOAC, highlighting the need for effective therapies for ICH patients.
FRONTIERS IN NEUROLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Andrea Morotti, Giorgio Busto, Gregoire Boulouis, Elisa Scola, Alessandro Padovani, Ilaria Casetta, Enrico Fainardi
Summary: The combined analysis of non-contrast CT and CT perfusion markers improves the prediction of hematoma expansion and outcome in intracerebral hemorrhage.
EUROPEAN RADIOLOGY
(2023)
Article
Clinical Neurology
Maximilian Spruegel, Joji B. Kuramatsu, Stefan T. Gerner, Jochen A. Sembill, Dominik Madzar, Caroline Reindl, Tobias Bobinger, Tamara Mueller, Philip Hoelter, Hannes Luecking, Tobias Engelhorn, Hagen B. Huttner
Summary: This study examined the impact of age on bleeding characteristics and clinical outcomes in different types of intracerebral hemorrhage. Results showed that elderly patients had worse functional outcomes at three months, with oral anticoagulant patients having larger baseline hemorrhage volumes and hematoma enlargement compared to non-OAC patients.
INTERNATIONAL JOURNAL OF STROKE
(2021)
Article
Clinical Neurology
Yujian Li, Huiqing Zhou, Xiang Yang, Jun Zheng, Fan Zhang, Mangmang Xu, Hao Li
Summary: This study found that neck circumference is an independent predictor of 180-day functional outcome in ICH patients, and can predict poor functional outcome at 6 months.
FRONTIERS IN NEUROLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Zuhua Song, Zhuoyue Tang, Huan Liu, Dajing Guo, Jinhua Cai, Zhiming Zhou
Summary: This study developed and validated a clinical-radiomics nomogram based on NCCT to identify sICH patients with poor 90-day prognosis. The nomogram, consisting of six independent predictors, showed good predictive performance in different cohorts, providing accurate risk assessment for sICH patients.
EUROPEAN RADIOLOGY
(2021)
Article
Clinical Neurology
Nefeli Valyraki, Adrien Goujon, Marjorie Mateos, Adrien Lecoeuvre, Augustin Lecler, Igor Raynouard, Candice Sabben, Michael Obadia, Julien Savatovsky, Pierre Seners
Summary: The presence of MRI spot sign in patients with acute intracerebral hemorrhage is independently associated with hematoma expansion and poor functional outcome. The number of spot signs shows a dose-dependent effect on hematoma expansion and poor functional outcome.
JOURNAL OF NEUROLOGY
(2023)
Article
Medicine, General & Internal
Quanhong Chu, Lin Liao, Wenxin Wei, Ziming Ye, Li Zeng, Chao Qin, Yanyan Tang
Summary: The study found that malignancy, pulmonary circulation disease, coagulopathy, age >60 years old, and hospitalization time >16 days are independent risk factors for VTE in ICH patients, and anticoagulation therapy for VTE in ICH patients may be safe and effective. These findings need to be verified by more high-quality and well-designed randomized controlled trials.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2021)
Article
Critical Care Medicine
Julian N. Acosta, Audrey C. Leasure, Lindsey R. Kuohn, Cameron P. Both, Nils H. Petersen, Lauren H. Sansing, Charles C. Matouk, Fernando Testai, Carl D. Langefeld, Daniel Woo, Hooman Kamel, Santosh B. Murthy, Adnan Qureshi, Stephan A. Mayer, Kevin N. Sheth, Guido J. Falcone
Summary: The study found that higher hemoglobin levels are associated with better outcomes in intracerebral hemorrhage. However, there were no consistent associations between hemoglobin levels and hematoma volume or expansion.
CRITICAL CARE MEDICINE
(2021)
Article
Clinical Neurology
Ernst Mayerhofer, Livia Parodi, Savvina Prapiadou, Rainer Malik, Jonathan Rosand, Marios K. Georgakis, Christopher D. Anderson
Summary: Integrating a genetic risk score into a clinical risk score can improve risk stratification for anticoagulation-related intracerebral hemorrhage. A prediction score incorporating genomic information is superior to a clinical risk score alone for risk stratification in anticoagulant users.
Article
Immunology
Yihao Chen, Chenchen Qin, Jianbo Chang, Yixun Liu, Qinghua Zhang, Zeju Ye, Zhaojian Li, Fengxuan Tian, Wenbin Ma, Junji Wei, Ming Feng, Shengpan Chen, Jianhua Yao, Renzhi Wang
Summary: A deep learning model was used to automatically segment hematoma and perihematomal edema (PHE), and a new definition of delayed perihematomal edema expansion (DPE) was generated. The time course, risk factors, and clinical outcomes of DPE were analyzed. The study found that DPE was associated with worse outcomes, and larger initial hematoma volume was a significant risk factor for DPE formation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Neurosciences
Zhiming Zhou, Hongli Zhou, Zuhua Song, Yuanyuan Chen, Dajing Guo, Jinhua Cai
Summary: This study aimed to derive and validate a location-specific radiomics score (Rad-score) based on noncontrast computed tomography as a predictive tool for poor outcomes in deep and lobar spontaneous intracerebral hemorrhage (SICH). The results showed that the Rad-score, along with other factors such as Glasgow Coma Scale score and haematoma volume, can independently predict poor outcomes in SICH patients. Combining the Rad-score with other predictors in the model can improve the identification of high-risk patients.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Neurosciences
Adam Vacek, Grant Mair, Philip White, Philip M. Bath, Keith W. Muir, Rustam Al-Shahi Salman, Chloe Martin, David Dye, Francesca M. Chappell, Ruediger von Kummer, Malcolm Macleod, Nikola Sprigg, Joanna M. Wardlaw
Summary: This study evaluated the performance of e-ASPECTS software in delineating the extent of intracranial hemorrhage (ICH) on brain CT scans. The results showed that the software achieved excellent or good delineation of ICH extent in 71% of cases. However, it was more likely to over- or under-estimate the extent when ICH was more extensive, intraventricular, or extra-axial.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Mathias Jacobsen Bach, Audrone Jakubauskaite, Ian Law, Otto Molby Henriksen, Inger Havsteen, Alexander Cuculiza Henriksen, Sverre Rosenbaum, Lisbeth Marner
Summary: This study found that the rCBFacz value after ACZ challenge can serve as an important indicator for predicting future cerebrovascular events, with high accuracy and prognostic value.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Tak Kyu Oh, Saeyeon Kim, In-Ae Song
Summary: The study found that many survivors of nontraumatic intracranial hemorrhage in South Korea experience unemployment, decreased household income, and newly acquired disability after intensive care unit admission. However, these changes are not associated with 2-year all-cause mortality.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Eduardo Sousa de Melo, Rodrigo de Paiva Bezerra, Arthur Cesario de Holanda, Maria Junia Lira e Silva, Paloma Peter Travassos, Tayne Fernanda Lemos da Silva, Genova Maria de Azevedo Oliveira, Silvia Marinho Martins Alves, Carolina de Araujo Medeiros, Maria das Neves Dantas da Silveira Barros, Wilson Alves de Oliveira, Gisele Sampaio Silva, Luciana Patrizia Alves de Andrade Valenca
Summary: Cardiac involvement has been found to be the predominant factor correlated with stroke in Chagas disease. While atherosclerosis-related risk factors are prevalent, their influence on ischemic stroke in Chagas disease appears limited.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Pingping Zheng, Ning Zhang, Zixi Chen
Summary: This case presents a rare infectious cause of stroke and air embolism involving a pulmonary abscess and pulmonary vein thrombosis. Early detection, diagnosis, and appropriate treatment of infected systemic embolism in young patients are crucial to prevent serious complications.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Filippo Luca Gurgoglione, Luigi Vignali, Maria Alberta Cattabiani, Emilia Solinas, Giorgio Benatti, Iacopo Tadonio, Federico Barocelli, Chiara Dizdari, Domenico Tuttolomondo, Diego Ardissino, Francesco Nicolini, Giampaolo Niccoli
Summary: The incidence of recurrent ischemic neurological events after transcatheter patent foramen ovale closure is relatively low. Obesity, Risk of Paradoxical Embolism score < 7, and migraine are independent positive predictors of recurrent stroke or transient ischemic attack.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Angelo Cascio Rizzo, Ghil Schwarz, Amedeo Cervo, Giuditta Giussani, Chiara Ceresa, Antonella Gatti, Fausto De Angeli, Cristina Motto, Angelo Guccione, Rachele Tortorella, Giuseppe Granata, Claudia Rollo, Antonio Macera, Mariangela Piano, Guglielmo Pero, Elio Clemente Agostoni
Summary: This study aimed to evaluate the efficacy and safety of endovascular treatment (EVT) in primary and EVT-induced secondary medium-vessel occlusions (MeVO). The results showed that primary MeVO had poorer outcomes in terms of complications, EVT efficacy, and the proportion of patients with a modified Rankin Scale (mRS) of 0-2 at 3 months compared to exclusive large-vessel occlusion (LVO). However, EVT-induced secondary MeVO showed similar safety and efficacy outcomes as exclusive LVO and had better outcomes in terms of mRS 0-2 compared to primary MeVO.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Jing Zhang, Chenming Wei, Jian Wu
Summary: This case report describes a patient with Bloom syndrome who developed acute cerebral infarction along with elevated antiphospholipid antibodies, suggesting a possible association between immune and coagulation abnormalities caused by Bloom syndrome and the development of acute cerebral infarction.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Yunxia Zhou, Shenglan He, Yanhong Hu
Summary: Compared with clopidogrel, DAPT with ticagrelor plus aspirin was associated with significantly lower thromboembolic events without an increase in hemorrhagic events in the treatment of intracranial aneurysms, according to the one-year clinical outcome analysis. However, larger upcoming trials are needed to confirm the effectiveness and safety of ticagrelor-associated DAPT.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Edvania Andrade de Moura Silva, Ludmilla Ribeiro Batista, Marcela Aline Fernandes Braga, Luci Fuscaldi Teixeira-Salmela, Christina Danielli Coelho de Morais Faria, Iza Faria-Fortini
Summary: The study found that stroke severity is the best predictor of self-perceived manual ability at both three and six months after stroke. Age, although significant, contributes little to the prediction of manual ability.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Sidarrth Prasad, Erica M. Jones, Mehari Gebreyohanns, Veronica Aguilera, DaiWai M. Olson, Jane A. Anderson, Sean I. Savitz, Salvador C. Flores, Steven J. Warach, Charlotte E. Rhodes, Mark P. Goldberg, Nneka L. Ifejika
Summary: This study identified the barriers and facilitators to adopting tenecteplase (TNK) as a thrombolytic treatment for acute ischemic stroke (AIS) by conducting qualitative research with stroke clinicians in Texas. The findings suggest that providing evidence and identifying key change processes can help clinicians achieve consensus on adopting TNK for AIS treatment.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Jeshma Jayan, Sunil K. Narayan, Yasmin Nesha Haniffa, Navin Kumar
Summary: This study investigated the effects of transcranial electrical and magnetic stimulation on somatosensory evoked potentials in chronic ischemic stroke patients, finding that the real tDCS and rTMS combination results in significant improvement and is safe for use.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Phoebe M. Tran, Cenjing Zhu, William T. Harris II, Sajeesh K. Kamala Raghavan, Agricola Odoi, Liem Tran
Summary: This study assessed the geographic accessibility of stroke rehabilitation facilities in Tennessee. The study found that rural counties had significantly longer travel distances and times compared to urban counties. Counties with high and medium stroke prevalence also had higher travel times and distances compared to low stroke prevalence counties. Therefore, addressing transportation barriers and implementing tele-rehabilitation are crucial for improving access to stroke aftercare in these areas.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Lili Xu, Shuaiyu Chen, Jing Xu, Yanyan Shi, Zhihang Huang, Meng Wang, Ziqiao Wei, Hui Cao, Junshan Zhou, Wei Wang, Mingyang Du
Summary: This study found that the Chinese Visceral Adiposity Index (CVAI) is positively correlated with 90-day poor outcome in Chinese ischemic stroke patients after endovascular thrombectomy (EVT).
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Guangying Wu, Shuhua Li, Min Luo, Xiaotian Li, Xinghua Zhu, Junhuai Zhang, Qian He, Qian Yang, Guojiang Zhao, Shasha Luo, Zhijie Yang
Summary: The study aimed to investigate the relationship between serum alkaline phosphatase (ALP) levels and the severity and prognosis of intracerebral hemorrhage (ICH). The results showed that serum ALP levels in ICH patients were significantly elevated and correlated with hematoma volume and Glasgow coma scale (GCS) score. High serum ALP levels may serve as a potential predictor for the severity and unfavorable prognosis of ICH.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)