Article
Medicine, General & Internal
Jihye Kim, Tae-Hwan Kim
Summary: This study comprehensively analyzed the risk factors for postoperative deep infection following instrumented spinal fusion surgery for degenerative spinal disease. The results provide clinicians with an acceptable tool for comprehensive risk assessment of postoperative deep infection in patients who will undergo this surgery.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Sung-ryul Choi, Ji-Won Kwon, Kyung-Soo Suk, Hak-Sun Kim, Seong-Hwan Moon, Si-Young Park, Seung-Eon Moon, Byung-Ho Lee
Summary: This retrospective study investigates the effectiveness of using a toothbrush for biofilm removal and infection control in spinal infections occurring after spinal fusion surgery. The study found that using a toothbrush resulted in a significantly lower rate of infection control failure and additional surgeries compared to not using a toothbrush. Additionally, the normalization of c-reactive protein levels occurred faster in the toothbrush group. Thus, using a toothbrush appears to have beneficial effects in treating spinal infections following spinal fusion surgery.
BIOENGINEERING-BASEL
(2023)
Review
Orthopedics
Yongjie Wang, Mingxue Che, Zhi Zheng, Jun Liu, Xue Ji, Yang Sun, Jingguo Xin, Weiquan Gong, Shibo Na, Yuanzhe Jin, Shuo Wang, Shaokun Zhang
Summary: This article provides a review of commonly used animal models for studying the mechanism and developing new anti-bacterial methods for postoperative implant-related spinal infections. Although the current models have limitations, future ideal models may assess bacterial load in real-time and better mimic human anatomy and surgical techniques. Evaluating other types of microbial infections and developing novel transgenic models based on genome editing are also important for future research.
ORTHOPAEDIC SURGERY
(2022)
Article
Orthopedics
Friederike Schoemig, Justus Buerger, Zhouyang Hu, Axel Pruss, Edda Klotz, Matthias Pumberger, Christian Hipfl
Summary: This study analyzed the risk factors for postoperative spinal implant infection and found that the intraoperative Hb-trend is a predictor for the development of PSII. Further investigation into strategies to reduce intraoperative blood loss in spine surgery is needed to prevent such infections.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2021)
Article
Clinical Neurology
Vikesh Kumar Gupta, Yuxuan Zhou, Jonathan Francis Manson, James Peter Watt
Summary: The spine adipose index is associated with deep surgical site infection, with a threshold value of 0.51 being ideal for preoperative risk stratification in patients undergoing posterior instrumented lumbar fusion surgery.
Article
Clinical Neurology
Ralph T. Schaer, C. Marvin Jesse, Matteo Montalbetti, Nicole Soell, Katharina Lutz, Valentin Steinsiepe, Mattia Branca, Andreas Raabe, Stefan Zimmerli
Summary: The study demonstrated that the use of suprafascially administered vancomycin powder in open instrumented spinal fusion surgery is safe with minimal systemic uptake, low rates of adverse events, and no nephrotoxicity or ototoxicity reported. Further data from the VANCO Trial are needed for conclusive evidence on the efficacy of vancomycin in preventing surgical site infections and its impact on wound healing.
Review
Engineering, Electrical & Electronic
Yazan Qiblawey, Muhammad E. H. Chowdhury, Farayi Musharavati, Erfan Zalnezhad, Amith Khandaka, Mohammad Tariqul Islam
Summary: The increase in elderly population has led to a greater demand for knee or hip implants. However, current implants have a short lifespan and affect surrounding human tissue. Instrumented implants can accurately monitor their status, but current systems are not yet able to effectively monitor implants during daily activities.
IEEE SENSORS JOURNAL
(2021)
Review
Clinical Neurology
Andrew Hersh, Robert Young, Zach Pennington, Jeff Ehresman, Andy Ding, Srujan Kopparapu, Ethan Cottrill, Daniel M. Sciubba, Nicholas Theodore
Summary: There is currently no consensus on whether implants should be removed in patients with surgical site infection after fusion surgery. Retention of implants may be preferred in early infections to maintain spine stability, while removal may be more suitable in late infections. Further high-quality evidence is needed to guide clinical practice in this area.
JOURNAL OF NEUROSURGERY-SPINE
(2021)
Article
Clinical Neurology
Cathleen C. Kuo, Ryan M. Hess, Asham Khan, John Pollina, Jeffrey P. Mullin
Summary: The study aimed to identify risk factors associated with prolonged hospital length of stay after anterior lumbar interbody fusion (ALIF). Factors such as age ≥65 years, preoperative benzodiazepine use, higher intraoperative blood loss, delayed mobilization, and lower 12-item Short Form mental component score were found to be independent predictors for extended LOS.
WORLD NEUROSURGERY
(2021)
Article
Computer Science, Interdisciplinary Applications
Shivam Saini, Nagaraj Manju Moger, Manish Kumar, Subrato Sarkar, Samarth Mittal, Syed Ifthekar, Kaustubh Ahuja, Indra Vir Singh, Pankaj Kandwal
Summary: Interbody fusions have become popular for achieving good fusion rates, and finite element studies have validated their clinical implications. The study found that interbody procedures significantly reduced the range of motion in extension and torsion, and bilateral screw fixation was biomechanically superior except in torsion.
MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING
(2023)
Review
Clinical Neurology
Yunsoo Lee, Tariq Z. Issa, Arun P. Kanhere, Mark J. Lambrechts, Kerri-Anne Ciesielka, James Kim, Alan S. Hilibrand, Christopher K. Kepler, Gregory D. Schroeder, Alexander R. Vaccaro, Jose A. Canseco
Summary: In general, current evidence does not support a connection between preoperative epidural corticosteroid injections and postoperative infection rates following lumbar fusion or decompression. Operative treatment should not be delayed due to preoperative steroid injections. However, there is still a lack of high-quality data in the literature evaluating the impact of preoperative injections on postoperative infection rates.
EUROPEAN SPINE JOURNAL
(2022)
Article
Clinical Neurology
Anne-Katrin Hickmann, Denis Bratelj, Tatiana Pirvu, Markus Loibl, Anne F. Mannion, Dave O'Riordan, Tamas Fekete, Deszo Jeszenszky, Nadia Eberhard, Marku Vogt, Yvonne Achermann, Daniel Haschtmann
Summary: The management of implant-associated surgical site infections in patients with posterior spinal instrumentation is challenging, but successful outcomes can be achieved with surgery and specific antibiotic treatment. An interdisciplinary approach is recommended, and loose implants should be replaced when necessary. Multiple revisions may be required in some cases, but overall patient satisfaction is high.
EUROPEAN SPINE JOURNAL
(2022)
Article
Clinical Neurology
Jennyfer A. Mitterer, Bernhard J. H. Frank, Susana Gardete-Hartmann, Lukas F. Panzenboeck, Sebastian Simon, Petra Krepler, Jochen G. Hofstaetter
Summary: This study analyzed the changes in microbiological spectrum and antibiotic resistance pattern in patients who underwent multiple revision surgeries for the treatment of postoperative spinal implant infections (PSII). The findings suggest that changes in microbiological spectrum and antibiotic resistance pattern can occur in severe PSII cases that require multiple revision surgeries. These findings are important for guiding antimicrobial treatment in PSII.
Article
Clinical Neurology
Tucker C. Callanan, Celeste Abjornson, Edward DiCarlo, Michael Henry, Andrew A. Sama, Federico P. Girardi, Josh Schroeder, Paul Kiely, Darren R. Lebl, Frank P. Cammisa
Summary: This study focused on presumed aseptic patients who had undergone instrumented spine surgery, aiming to determine occult infection rates upon removal of instrumentation. The results showed a 38% positive culture rate, with Propionibacterium acnes being the most prevalent organism. There was no significant difference in preoperative markers, age, or length of time between surgeries between culture-positive and culture-negative patients.
CLINICAL SPINE SURGERY
(2021)
Review
Clinical Neurology
Raymond Pranata, Michael Anthonius Lim, Rachel Vania, Tjokorda Gde Bagus Mahadewa
Summary: For the treatment of spinal metastases, MIS surgery was associated with lower complication rates, reduced blood loss, lower transfusion rates, and shorter hospital stays compared to COS surgery, while showing similar rates of neurological improvement and surgical duration.
WORLD NEUROSURGERY
(2021)