Journal
JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY
Volume 53, Issue 2, Pages 459-465Publisher
SPRINGER
DOI: 10.1007/s10971-009-2114-z
Keywords
Aminosilane; Hydroxyapatite; Nanocomposite; Osteoblast; Biomaterials
Categories
Funding
- NC Biotech Center [2008-MRG-1108]
- NIDCR [K08DE018695]
- American Association of Orthodontists Foundation
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Aminosilane has been explored as an alternative chemical linker to facilitate the binding and solidification of hydroxyapatite-gelatin nanocomposite at room temperature, which was synthesized using co-precipitation method in the presence of gelatin. This aminosilane treatment was found effective at low concentration (similar to 25 mu L/mL) and the solidification and dehydration of hydroxyapatite-gelatin slurry completes within hours depending on the amount of aminosilane. The resulting sample exhibits compressive strength of 133 MPa, about 40% higher than glutaraldehyde treated samples, and shows good biocompatibility based on cell adhesion, proliferation, alkaline phosphate synthesis, and mineralization studies.
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