Article
Peripheral Vascular Disease
Rong Ren, Ye Zhang, Linghui Yang, Yuan Shi, Naima Covassin, Xiangdong Tang
Summary: This study aimed to quantify the independent association between arousals during REM/NREM sleep and prevalent hypertension. The results showed a significant dose-response relationship between arousal index during REM sleep and hypertension, while arousal index during NREM sleep was not a significant predictor of hypertension.
JOURNAL OF HYPERTENSION
(2023)
Article
Clinical Neurology
Luc Masset, Milan Nigam, Anne Ladarre, Marie Vidailhet, Smaranda Leu-Semenescu, Philippe Fossati, Isabelle Arnulf, Jean-Baptiste Maranci
Summary: Dreams during REM sleep can help reduce negative emotions, as shown by the study on emotional dynamics. Previous studies were limited to dream reports, but by studying individuals with REM sleep behavior disorder (RBD), researchers gained direct access to observe emotional dream behaviors. Analysis of 17 participants with RBD and 39.7 hours of REM sleep video revealed that emotional behaviors follow a biphasic temporal course, with an initial increase in frequency followed by a progressive decrease. Negative emotional behaviors occurred earlier than positive and neutral behaviors, and rapid succession of emotions of opposite valence was observed to prevent prolonged periods of negative emotions.
Article
Endocrinology & Metabolism
Dong Hee Kim, Kwang Kon Kim, Tae Hwan Lee, Hyejin Eom, Jin Woo Kim, Jeong Woo Park, Jin Kwon Jeong, Byung Ju Lee
Summary: The study found a positive correlation between hypothalamic TonEBP and AVP production under dehydration conditions. TonEBP can directly bind to the upstream promoter regions of the AVP gene, regulating AVP gene transcription. Additionally, dehydration-induced reductions in body weight were rescued in TonEBP haploinsufficiency mice.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Clinical Neurology
Claudio Liguori, Vittorio Zuccarelli, Matteo Spanetta, Francesca Izzi, Nicola Biagio Mercuri, Fabio Placidi
Summary: The study found that patients with idiopathic rapid eye movement sleep behavior disorder exhibit dysregulation in the circadian sleep-wake rhythm, showing reduced relative amplitude and alterations in both sleep and wake. These patients also reported subjective sleep and wake complaints, as well as higher scores on the Beck Depression Inventory compared to controls.
JOURNAL OF SLEEP RESEARCH
(2021)
Article
Multidisciplinary Sciences
William T. Schneider, Szilvia Vas, Alister U. Nicol, A. Jennifer Morton
Summary: Research showed that in sheep with HD, transitions into wake were more sudden and accompanied by less reduction in slow wave power compared to normal sheep, indicating impaired readiness for waking. These abnormal dynamics of sleep transitions may potentially serve as an early biomarker for HD and could be applied to studying transition dynamics in other sleep disorders as well.
Article
Multidisciplinary Sciences
Tomoko Yamagata, Martin C. Kahn, Jose Prius-Mengual, Elise Meijer, Merima Sabanovic, Mathilde C. C. Guillaumin, Vincent van der Vinne, Yi-Ge Huang, Laura E. McKillop, Aarti Jagannath, Stuart N. Peirson, Edward O. Mann, Russell G. Foster, Vladyslav V. Vyazovskiy
Summary: The inhibitory neurons in the lateral preoptic area (LPO) of the hypothalamus play a role in regulating arousal levels, impacting both the quality of sleep and the accumulation of sleep pressure.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Pao-Huan Chen, Cheng-Chih Chung, Shuen-Hsin Liu, Yu-Hsun Kao, Yi-Jen Chen
Summary: Lithium treatment can improve cardiac dysfunction caused by REM sleep deprivation and alleviate fibrosis. The potential mechanisms may involve the regulation of TGF-β, angiotensin II, and Ca2+ signaling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Marcus O. Harrington, Jennifer E. Ashton, Hong-Viet V. Ngo, Scott A. Cairney
Summary: This study manipulated theta activity during sleep using auditory closed-loop stimulation, showing that stimulation led to a short-term increase in theta power followed by a prolonged suppression, as well as an increase in beta power. These results highlight the potential of auditory stimulation in investigating REM sleep electrophysiology and its impact on behavior.
Article
Multidisciplinary Sciences
Aditi Pophale, Kazumichi Shimizu, Tomoyuki Mano, Teresa L. Iglesias, Kerry Martin, Makoto Hiroi, Keishu Asada, Paulette Garcia Andaluz, Thi Thu Van Dinh, Leenoy Meshulam, Sam Reiter
Summary: Octopuses exhibit two stages of sleep, quiet sleep and active sleep. Active sleep is characterized by body movements and changes in skin patterning similar to wakefulness. Quiet sleep is characterized by brain activity and specific brain regions resembling mammalian sleep, suggesting convergent features of complex cognition.
Article
Biology
Brittany J. Bush, Caroline Donnay, Eva-Jenee A. Andrews, Darielle Lewis-Sanders, Cloe L. Gray, Zhimei Qiao, Allison J. Brager, Hadiya Johnson, Hamadi C. S. Brewer, Sahil Sood, Talib Saafir, Morris Benveniste, Ketema N. Paul, J. Christopher Ehlen
Summary: Resilience, the ability to overcome stressful conditions, varies significantly among individuals and is influenced by sleep amount and sleep regulation in the prefrontal cortex.
Article
Clinical Neurology
Cole D. Stang, Aidan F. Mullan, Mania Hajeb, Emanuele Camerucci, Pierpaolo Turcano, Peter Martin, Michelle M. Mielke, Keith A. Josephs, James H. Bower, Erik K. St Louis, Bradley F. Boeve, Rodolfo Savica
Summary: The study revealed that the prevalence of rapid eye movement (REM) sleep behavior disorder (RBD) increased over time in patients with alpha-synucleinopathies, with higher likelihood of developing RBD in male patients. However, RBD did not increase mortality risk within the cohort.
ANNALS OF NEUROLOGY
(2021)
Article
Multidisciplinary Sciences
Sasa Teng, Fenghua Zhen, Li Wang, Jose Canovas Schalchli, Jane Simko, Xinyue Chen, Hao Jin, Christopher D. Makinson, Yueqing Peng
Summary: This study identifies a population of glutamatergic neurons that control sleep state transitions in mice and uncovers an excitatory brainstem-hypothalamic circuit involved in these transitions.
NATURE COMMUNICATIONS
(2022)
Article
Clinical Neurology
Xiaowei Sun, Fenqin Xue, Jialin Wen, Limin Gao, Yang Li, Lijun Yang, Hong Cui
Summary: This study investigated the pathological response of sleep-wake states in neonatal rats with hypoxic-ischemic encephalopathy (HIE). The results showed that HIE caused changes in the sleep-wake states, but they gradually returned to normal levels over time.
NATURE AND SCIENCE OF SLEEP
(2022)
Review
Chemistry, Medicinal
Eric Murillo-Rodriguez, Astrid Coronado-Alvarez, Luis Angel Lopez-Mucino, Jose Carlos Pastrana-Trejo, Gerardo Viana-Torre, Juan Jose Barberena, Daniela Marcia Soriano-Nava, Fabio Garcia-Garcia
Summary: The sleep-wake cycle is influenced by multiple neurobiological network interactions, with dreams playing a significant role. Recent research suggests that drugs can impact dream generation, adding complexity to our understanding of the neurobiological mechanisms involved.
CURRENT TOPICS IN MEDICINAL CHEMISTRY
(2022)
Article
Clinical Neurology
Carlos M. O. de Almeida, Manuelina M. C. Brito, Nayanne B. Bosaipo, Angela V. Pimentel, Vitor Tumas, Antonio W. Zuardi, Jose A. S. Crippa, Jaime E. C. Hallak, Alan L. Eckeli
Summary: This study evaluated the efficacy and safety of CBD as an alternative therapy for RBD in patients with Parkinson's disease. While CBD did not show significant differences compared to placebo for primary outcomes, there was a transient improvement in sleep satisfaction observed with a 300mg dose.
MOVEMENT DISORDERS
(2021)
Letter
Surgery
Matteo Ravaioli, Giuliana Germinario, Matteo Cerri, Enrico Prosperi, Guido Fallani, Francesco Vasuri, Matteo Serenari, Federica Odaldi, Lorenzo Maroni, Antonio Siniscalchi, Matteo Cescon, Matteo Renzulli
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Physiology
Gianluca Sgarbi, Timna Hitrec, Roberto Amici, Alessandra Baracca, Alessia Di Cristoforo, Francesca Liuzzi, Marco Luppi, Giancarlo Solaini, Fabio Squarcio, Giovanni Zamboni, Matteo Cerri
Summary: The ability to induce hypothermia resembling natural torpor has significant benefits. Two pharmacological procedures based on central nervous manipulation have proven effective in lowering body temperature in non-hibernating rats. The role of mitochondria in centrally induced hypothermia in non-hibernators is still not well understood.
JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMS AND ENVIRONMENTAL PHYSIOLOGY
(2022)
Article
Neurosciences
Michael Ambler, Timna Hitrec, Andrew Wilson, Matteo Cerri, Anthony Pickering
Summary: Recent research has discovered that the preoptic area of the hypothalamus and the dorsomedial hypothalamus (DMH) are involved in the regulation of daily torpor in mice. Using activity-dependent genetic techniques, scientists were able to target and manipulate DMH neurons to promote or inhibit torpor. This study further supports the role of these neurons in controlling torpor.
JOURNAL OF NEUROSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Davide Martelli, Virginia L. L. Brooks
Summary: It is widely accepted that decreases in plasma leptin levels, such as during fasting, signal starvation and lead to increased hunger and decreased energy expenditure. These effects are mainly mediated by the suppression of leptin actions in the hypothalamus, particularly on orexigenic neuropeptide Y neurons and anorexic pro-opiomelanocortin neurons in the arcuate nucleus. However, this review explores whether increased leptin levels also play a significant role in long-term energy balance control, contrary to conventional wisdom. We focus on leptin's actions to decrease food intake, increase sympathetic nerve activity, and support the hypothalamic-pituitary-thyroid axis, with a particular emphasis on sex differences. We also discuss the impact of obesity-induced inflammation on leptin's actions during obesity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Alessandra Occhinegro, Robin M. M. McAllen, Michael J. J. McKinley, Davide Martelli
Summary: In this review, we argue that the immune system is regulated by an endogenous neural reflex, known as the inflammatory reflex, which suppresses the acute immune response during a systemic immune challenge. We examine the involvement of different sympathetic nerves as potential pathways of the inflammatory reflex. Additionally, we discuss the role of the adrenal glands in the reflex control of inflammation, highlighting how the release of catecholamines by neural means enhances the anti-inflammatory cytokine IL10, but does not inhibit the pro-inflammatory cytokine TNF. Ultimately, we conclude that the splanchnic anti-inflammatory pathway, involving sympathetic fibers targeting various organs such as the spleen and adrenal glands, serves as the efferent arm of the inflammatory reflex, independently regulating TNF and IL10 responses in distinct populations of leukocytes.
NEUROIMMUNOMODULATION
(2023)
Article
Physiology
Fabio Squarcio, Timna Hitrec, Emiliana Piscitiello, Matteo Cerri, Catia Giovannini, Davide Martelli, Alessandra Occhinegro, Ludovico Taddei, Domenico Tupone, Roberto Amici, Marco Luppi
Summary: The study reveals that synthetic torpor induces reversible hyperphosphorylation of Tau protein in the rat brain, involving various cellular and systemic factors. This process is accompanied by transient neuroinflammation.
FRONTIERS IN PHYSIOLOGY
(2023)
Letter
Multidisciplinary Sciences
Matteo Cerri, Jurgen Bereiter-Hahn, Gerhard Heldmaier, Alexander Chouker, Leopold Summerer
Article
Physiology
Timna Hitrec, Fabio Squarcio, Emiliana Piscitiello, Matteo Cerri, Davide Martelli, Alessandra Occhinegro, Ludovico Taddei, Domenico Tupone, Roberto Amici, Marco Luppi
Summary: A short-term sleep deprivation soon after regaining euthermia can enhance the reversibility of Tau protein hyperphosphorylation induced by torpor, possibly due to higher body temperature, melatonin levels, and resting phenotype of microglia. This finding suggests that sleep deprivation may boost a latent neuroprotective mechanism.
JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMS AND ENVIRONMENTAL PHYSIOLOGY
(2023)
Article
Clinical Neurology
Fabio Squarcio, Timna Hitrec, Marco Luppi, Davide Martelli, Alessandra Occhinegro, Emiliana Piscitiello, Ludovico Taddei, Domenico Tupone, Roberto Amici, Matteo Cerri
Summary: Rats emit a distress call of 22-kHz ultrasonic vocalisation to warn their group of danger. Surprisingly, this study found that rats can emit these vocalisations during REM sleep, but not during non-REM sleep. The emission occurs during the expiratory phase and can happen singularly or as a train. This is the first report to demonstrate rats vocalising during REM sleep.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Multidisciplinary Sciences
Anggraeini Puspitasari, Fabio Squarcio, Martina Quartieri, Cristina Totis, Timna Hitrec, Akihisa Takahashi, Yukari Yoshida, Kenji Hanamura, Tomoko Yako, Matteo Cerri, Palma Simoniello, Marco Durante, Walter Tinganelli
Summary: Hibernation or torpor is a potential method to protect astronauts from space radiation, and it involves reducing skin temperature and increasing survival rate. Synthetic torpor also delays DNA repair and suppresses radiation-induced mitotic catastrophe.
SCIENTIFIC REPORTS
(2022)
Meeting Abstract
Clinical Neurology
A. Occhinegro, R. Amici, M. Cerri, T. Hitrec, D. Martelli, E. Piscitiello, F. Squarcio, L. Taddei, D. Tupone, M. Luppi