Review
Biochemistry & Molecular Biology
Xianglin Hu, Zhengwang Sun, Fengfeng Li, Chaoyin Jiang, Wangjun Yan, Yangbai Sun
Summary: Burn injury is a potential cause of heterotopic ossification (HO), which can result in pain and joint dysfunction. The occurrence of burn-induced HO is associated with increased inflammation, contributions from the nervous system and calcium, highlighting the need for the development of effective biomarkers and therapeutic strategies.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2021)
Article
Orthopedics
Joseph S. Geller, Paul R. Allegra, Crystal S. Seldon, Benjamin O. Spieler, Lara L. Cohen, Spencer W. Barnhill, Samuel R. Huntley, Alberto De La Zerda, Stuart Samuels, Lora Wang, Derek Isrow, Aaron H. Wolfson, Raphael L. Yechieli
Summary: This study suggests that radiotherapy may be a safe and effective method for preventing heterotopic ossification of the elbow, both as primary prophylaxis and secondary prophylaxis. The study did not find any association between radiotherapy and radiation-induced sarcoma, but further research with larger patient populations and extended follow-up is needed to better understand high-risk populations.
JOURNAL OF ORTHOPAEDIC TRAUMA
(2022)
Article
Orthopedics
Hui Ben, Erica Kholinne, Chu Hui Zeng, Hood Alsaqri, Jun-Bum Lee, Sang-Pil So, Kyoung-Hwan Koh, In-Ho Jeon
Summary: This study retrospectively reviewed data from 205 patients who underwent elbow arthroscopy and found that HO was a minor complication with a prevalence rate of 6.3%. It was usually located in the medial compartment of the elbow. Younger age, longer tourniquet time, and longer surgical time were identified as risk factors for HO formation after elbow arthroscopy.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2023)
Article
Orthopedics
Ioannis Gkiatas, William Xiang, Allina A. Nocon, Mark P. Youssef, T. David Tarity, Peter K. Sculco
Summary: This study found a higher incidence of heterotopic ossification (HO) in patients undergoing revision total knee arthroplasty (TKA) for stiffness, with HO severity potentially affecting preoperative and postoperative range of motion (ROM). There is a need for a comprehensive classification system for HO to guide patient expectations.
JOURNAL OF ARTHROPLASTY
(2021)
Article
Pharmacology & Pharmacy
Dong Mao, Jingyi Mi, Xiaoyun Pan, Gang Zhao, Yongjun Rui
Summary: Through this study, we demonstrated the potential of Galunisertib as a prophylactic drug for the treatment of traumatic HO or other related diseases triggered by over-expressed TGF-beta.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Surgery
Yi Sun, Yuzhe Lin, Zenggan Chen, Andrew Breland, William C. Lineaweaver, Feng Zhang
Summary: Heterotopic ossification (HO) is a known complication of burns with a low incidence. The etiology is unclear, but early diagnosis and treatment are crucial for improving patient prognosis. This study summarizes relevant literature on potential pathogenic mechanisms, diagnosis, prophylaxis, and treatment measures of HO in burn patients.
ANNALS OF PLASTIC SURGERY
(2022)
Article
Orthopedics
Dheenadhayalan Jayamaraju, Aniruddha Sinha Sarkar, Sudipta Kumar Patra, Siva Kumar Palanivelayutham, Shanmuganathan Rajasekaran
Summary: Early surgical excision of posttraumatic HO of the elbow guided by a proposed surgical protocol resulted in significant improvement in elbow function and MEPS scores. The study demonstrated good functional outcomes for patients with both limited and global HO, as well as different types of associated fractures.
INDIAN JOURNAL OF ORTHOPAEDICS
(2021)
Review
Rehabilitation
George I. Vasileiadis, Apostolia A. Balta, Aikaterini Zerva, Vasileios Kontogiannopoulos, Dimitrios N. Varvarousis, Georgios Dimakopoulos, Avraam Ploumis
Summary: The role of kinesiotherapy in preventing heterotopic ossification is uncertain. A systematic review found that there is a lack of high-quality clinical trials in the literature. Passive exercises, such as continuous passive motion, initiated early and at a painless range of motion, were found to be effective in preventing neurogenic heterotopic ossification. However, for posttraumatic heterotopic ossification in the elbow and burn-associated heterotopic ossification in major joints, early active range of motion is recommended.
AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION
(2023)
Article
Cell Biology
Bing Tu, Juehong Li, Ziyang Sun, Tongtong Zhang, Hang Liu, Feng Yuan, Cunyi Fan
Summary: The presence of macrophage infiltration and activation of TGF-beta signaling are observed in traumatic heterotopic ossification (HO), and inhibiting macrophages or TGF-beta activity can effectively suppress ectopic bone formation. Additionally, M2 macrophages play a critical role in the development of HO.
Article
Cell Biology
Bing Tu, Bo Yu, Wei Wang, Juehong Li, Feng Yuan, Jing Zhu, Cunyi Fan
Summary: IL-17 promotes traumatic heterotopic ossification by activating beta-catenin signaling, while inhibition of IL-17 may serve as a potential therapeutic target for traumatic HO.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Orthopedics
Elizabeth P. Wahl, Peter M. Casey, Thomas Risoli, Cynthia L. Green, Marc J. Richard, David S. Ruch
Summary: The study found that the development of HO is specific to the type of injury and influenced by the involved soft tissues. Most CSDH and RH fractures, as well as the majority of elbow dislocations, developed HO in the collateral ligaments, while DH fractures mainly developed anterior capsule HO, OL fractures developed HO posteriorly, and EAPRU fractures developed proximal radioulnar synostosis.
EUROPEAN JOURNAL OF ORTHOPAEDIC SURGERY AND TRAUMATOLOGY
(2021)
Article
Rehabilitation
George Vasileiadis, Dimitrios N. Varvarousis, Ioannis Manolis, Avraam Ploumis
Summary: Heterotopic ossification refers to the formation of pathological bone in soft tissues. Continuous passive motion may play a role in halting the progression of heterotopic ossification, as demonstrated in a clinical case study of a patient with right hemiparesis. However, further investigation is needed to determine the effectiveness of continuous passive motion in selected cases.
AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION
(2021)
Article
Orthopedics
W. Liu, Z. Sun, H. Xiong, J. Liu, J. Lu, B. Cai, W. Wang, C. Fan
Summary: A prognostic nomogram was developed to predict the probability of gaining functional range of motion after open arthrolysis of the elbow in patients with post-traumatic elbow stiffness. The model showed good discrimination and calibration, making it a valuable tool for clinicians in counseling patients about treatment options.
BONE & JOINT JOURNAL
(2022)
Article
Orthopedics
Yousif Atwan, Irfan Abdulla, Ruby Grewal, Kenneth J. Faber, Graham J. W. King, George S. Athwal
Summary: This study found no significant difference between indomethacin and placebo in preventing heterotopic ossification after surgical treatment of elbow trauma, based on a randomized, double-blind, placebo-controlled trial.
JOURNAL OF SHOULDER AND ELBOW SURGERY
(2023)
Article
Immunology
Cassie J. Rowe, Uloma Nwaolu, Daniela Salinas, Jonathan Hong, Johanna Nunez, Jefferson L. Lansford, Conor F. McCarthy, Benjamin K. Potter, Benjamin H. Levi, Thomas A. Davis
Summary: This study suggests that FAK2 inhibition may be a novel strategy to dampen trauma-induced inflammation and attenuate HO in patients at high risk as a consequence of severe musculoskeletal polytrauma.
FRONTIERS IN IMMUNOLOGY
(2023)