Article
Biochemistry & Molecular Biology
Ana Paula Magrini Iacopucci, Pamela da Silva Pereira, Dalila Andrade Pereira, Fabiano Beraldi Calmasini, Valeria Pittala, Leonardo Oliveira Reis, Arthur L. Burnett, Fernando Ferreira Costa, Fabio Henrique Silva
Summary: In this study, a mouse model was used to investigate the effect of intravascular hemolysis on corpus cavernosum smooth muscle relaxation and oxidative stress in the penis. The results showed that intravascular hemolysis promotes increased corpus cavernosum smooth muscle relaxation, accompanied by upregulation of HO-1 expression and oxidative stress. This study provides support for clinical studies that have shown a strong positive correlation between priapism and high levels of intravascular hemolysis in men with SCD.
Review
Marine & Freshwater Biology
Martin Gabriel Frias-Espericueta, Juan Carlos Bautista-Covarrubias, Carmen Cristina Osuna-Martinez, Carolina Delgado-Alvarez, Carolina Bojorquez, Marisela Aguilar-Juarez, Sarahi Roos-Munoz, Isidro Osuna-Lopez, Federico Paez-Osuna
Summary: Aquatic decapod crustaceans exhibit varied antioxidant defense strategies in response to metal-induced oxidative stress. Antioxidant enzymes may be induced or inhibited by metals depending on species, concentration, and exposure time. Superoxide dismutase, for example, shows increased activity at low metal levels and exposure durations, but is inhibited at higher concentrations and longer exposure times.
AQUATIC TOXICOLOGY
(2022)
Article
Health Care Sciences & Services
Andreea-Daniela Meca, Adina Turcu-Stiolica, Elena Camelia Stanciulescu, Ana Marina Andrei, Floarea Mimi Nitu, Ileana Monica Banita, Marius Matei, Catalina-Gabriela Pisoschi
Summary: Tuberculosis is a global infectious disease with a complex pathogenesis. Recent studies have shown changes in oxidative parameters and antioxidant status in TB patients after anti-tubercular therapy. Monitoring TB based on oxidative stress and antioxidant status may be beneficial in disease management and progression.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Mi Yang, Xiaofei Zhou, Xi Tan, Xincheng Huang, Lu Yuan, Zipeng Zhang, Yan Yang, Min Xu, Ying Wan, Zezhi Li
Summary: Alcohol dependence leads to oxidative stress in the body, as evident from the changes observed in the levels of oxidative stress biomarkers. This meta-analysis highlights the decreased activities of superoxide dismutase (SOD) and glutathione peroxidase (GPx) enzymes and lower levels of albumin, along with increased levels of malondialdehyde (MDA), vitamin B12, homocysteine, and bilirubin in patients with alcohol dependence.
Article
Medicine, Research & Experimental
Bedoor Qabazard, Mariam Yousif, Alyaa Mousa, Oludotun Adebayo Phillips
Summary: The study investigates the potential protective role of hydrogen sulfide in diabetes-induced erectile dysfunction, with findings suggesting that H2S may reduce corporal contraction and fibromuscular changes in diabetic penile tissue, as well as having a link with plasma/urinary levels. These findings indicate that H2S could be a new strategy for preventing and treating diabetes-induced ED.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Hyo Seong Ji, Seoung Gun Bang, Min-A Ahn, Gayeon Kim, Eunhui Kim, Seung Hee Eom, Tae Kyung Hyun
Summary: This study found that heat stress can induce the activities of Cu/ZnSODs, FeSODs, and MnSODs in garlic leaves, and the cloned AsSODs encode functional SOD enzymes belonging to the Cu/ZnSOD and MnSOD families. These results provide a solid foundation for an in-depth analysis of the physiological functions of the AsSOD family in garlic plants.
Article
Biochemistry & Molecular Biology
Victoriane Peugnet, Maggy Chwastyniak, Paul Mulder, Steve Lancel, Laurent Bultot, Natacha Fourny, Edith Renguet, Heiko Bugger, Olivia Beseme, Anne Loyens, Wilfried Heyse, Vincent Richard, Philippe Amouyel, Luc Bertrand, Florence Pinet, Emilie Dubois-Deruy
Summary: This study investigated the impact of mitochondria-targeted therapy on cardiac hypertrophy and found that MitoQ can reduce mitochondrial ROS and hypertrophy, but it may also affect mitochondrial structure and function by impairing mitochondrial respiration and mitophagy, particularly showing deleterious effects in cardiomyocytes.
Article
Engineering, Biomedical
Motika Geethika, Namrata Singh, Sagar Kumar, Somanathapura K. Naveen Kumar, Govindasamy Mugesh
Summary: The conversion of nitric oxide (NO) into peroxynitrite (ONOO-) in a superoxide (O-2(.-))-rich environment is a major cause of reduced NO levels in vascular walls, leading to cardiovascular complications. Superoxide dismutase (SOD) mimetics that can selectively catalyze the dismutation of O-2(.-) in the presence of NO are challenging to design but have therapeutic relevance. In this study, the authors show that SOD mimetic cerium vanadate (CeVO4) nanozymes effectively regulate the bioavailability of NO and O-2(.-) even in the absence of cellular SOD enzyme, leading to improved endothelial function and potential applications in biological treatments.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Estefania Bravo-Sanchez, Donovan Pena-Montes, Sarai Sanchez-Duarte, Alfredo Saavedra-Molina, Elizabeth Sanchez-Duarte, Rocio Montoya-Perez
Summary: The study showed that treatment with apocynin significantly improved blood glucose levels and insulin resistance in diabetic rats, attenuated oxidative stress responses, enhanced mitochondrial function and antioxidant defense. Apocynin has a protective effect against diabetic complications.
Article
Andrology
Hao Cheng, Guo-Xiong Liu, Fei Wang, Ke Wang, Li-Tao Ruan, Lin Yang
Summary: The study found that shear wave elastography can be used to evaluate the aging degree of the corpus cavernosum. With increasing age, the Young's modulus of the corpus cavernosum increases and erectile function decreases. Histological investigation revealed an increase in collagen content and a decrease in smooth muscle content of the corpus cavernosum with age.
ASIAN JOURNAL OF ANDROLOGY
(2022)
Review
Biochemistry & Molecular Biology
Maria Carmina Pau, Arduino Aleksander Mangoni, Elisabetta Zinellu, Gianfranco Pintus, Ciriaco Carru, Alessandro Giuseppe Fois, Pietro Pirina, Angelo Zinellu
Summary: The study found that whole blood SOD concentrations were significantly lower in patients with obstructive sleep apnoea, while serum/plasma SOD concentrations did not show a significant difference. This suggests an impaired antioxidant defence in OSA patients.
Article
Biochemistry & Molecular Biology
Sahar Golabi, Sheyda Ghasemi, Maryam Adelipour, Reza Bagheri, Katsuhiko Suzuki, Alexei Wong, Maryam Seyedtabib, Mahshid Naghashpour
Summary: This study compared the antioxidant and inflammatory responses between COVID-19 outpatients and healthy individuals, finding higher concentrations of superoxide dismutase (SOD) and glutathione peroxidase (GPx) in COVID-19 patients. These results suggest that targeting oxidative stress in COVID-19 could be a promising therapeutic approach.
Review
Biochemistry & Molecular Biology
Suming Dai, Zezhong Tian, Dan Zhao, Ying Liang, Meitong Liu, Zhihao Liu, Shanshan Hou, Yan Yang
Summary: This study summarized the impact of CoQ10 supplementation on oxidative stress status, showing that it can increase total antioxidant capacity (TAC) and reduce malondialdehyde (MDA) concentrations, especially beneficial for individuals with coronary artery disease or type 2 diabetes, with a dosage of 100-150 mg per day showing better effects.
Article
Multidisciplinary Sciences
LiangYu Zhao, Sha Han, HengChuan Su, JianYing Li, ErLei Zhi, Peng Li, ChenCheng Yao, RuHui Tian, HuiXing Chen, HuiRong Chen, JiaQiang Luo, ChenKun Shi, ZhiYong Ji, JianLin Hu, Gang Wu, WeiDong Zhou, YuXin Tang, YuZhuo Chen, GuiTing Lin, Tom F. Lue, DengLong Wu, Zheng Li
Summary: This study provides insights into the cellular heterogeneity and signalling networks of the human corpus cavernosum. It describes the spatial distribution of different cell types and identifies potential regulatory signalling pathways in erectile dysfunction.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Jing Zhu, Shangxin Song, Xinglian Xu, Guanghong Zhou, Chunbao Li
Summary: The study found that meat proteins induced higher oxidative stress in the liver compared to casein and soybean protein. White meat proteins, such as fish and chicken, showed higher antioxidant capacity by promoting hepatic superoxide dismutase activity and total antioxidant capacity, compared to soybean and red meat proteins. Therefore, intake of moderate white meat proteins was suggested to be more conducive to hepatic antioxidative status than soybean and red meat proteins.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Jose Britto-Junior, Andre Ribeiro, Luiz Ximenes, Antonio Tiago Lima, Felipe Fernandes Jacintho, Adriano Fregonesi, Fabiola Z. Monica, Edson Antunes, Gilberto De Nucci
Summary: The study found that alpha(1)-adrenergic receptor antagonists act as 6-ND receptor antagonists in the rat isolated epididymal vas deferens, suggesting that many actions attributed to noradrenaline may actually be due to 6-ND antagonism. This research provides the possibility of a common mechanism of therapeutic action for tricyclic antidepressants and alpha(1)-adrenergic receptor antagonists in the treatment of premature ejaculation, through the blockade of 6-ND receptors.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Review
Nutrition & Dietetics
F. B. Calmasini, F. H. Silva, E. C. Alexandre, E. Antunes
Summary: Resveratrol, a polyphenol found naturally in fruits and plants, has shown beneficial properties in improving metabolic and lipid profiles, as well as antioxidant, anti-inflammatory and anti-proliferative effects. In studies involving the urogenital tract, resveratrol has been tested as a therapeutic drug in various diseases, particularly lower urinary tract symptoms, non-cancerous prostatic disease, and erectile dysfunction. In vitro studies have shown that resveratrol reduces inflammation and oxidative stress, and improves endothelial function in UGT. Despite its low oral bioavailability, in vivo administration of resveratrol has been proven effective in improving UGT-related dysfunctions in animal models. However, there is still insufficient clinical evidence to establish its efficacy in human UGT-related diseases. Future clinical trials are necessary to further investigate the potential of resveratrol as a treatment option.
NUTRITION RESEARCH REVIEWS
(2023)
Article
Hematology
Guilherme Ruiz Leonardi, Caroline Honaiser Lescano, Jose Luiz Costa, Bruna Mazetto, Fernanda Andrade Orsi, Fabiola Zakia Monica
Summary: Platelet reactivity is significantly increased in patients with thrombotic antiphospholipid syndrome (t-PAPS), which may be related to the overexpression of P2Y(12) receptor and the lower levels of cAMP and cGMP.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Multidisciplinary Sciences
Andressa Kely Pinheiro, Dalila Andrade Pereira, Jean Leandro dos Santos, Fabiano Beraldi Calmasini, Eduardo Costa Alexandre, Leonardo Oliveira Reis, Arthur L. Burnett, Fernando Ferreira Costa, Fabio Henrique Silva
Summary: This study evaluated the effects of a hybrid compound RVT-FxMe on two murine models displaying priapism phenotype. The results showed that RVT-FxMe reversed the enhanced NO-cGMP-mediated corpus cavernosum relaxations in eNOS(-/-) mice, but not in SCD mice. The excess of plasma hemoglobin in SCD mice may interfere in the pharmacological activity of NO donors compounds.
Article
Biochemistry & Molecular Biology
Ana Paula Magrini Iacopucci, Pamela da Silva Pereira, Dalila Andrade Pereira, Fabiano Beraldi Calmasini, Valeria Pittala, Leonardo Oliveira Reis, Arthur L. Burnett, Fernando Ferreira Costa, Fabio Henrique Silva
Summary: In this study, a mouse model was used to investigate the effect of intravascular hemolysis on corpus cavernosum smooth muscle relaxation and oxidative stress in the penis. The results showed that intravascular hemolysis promotes increased corpus cavernosum smooth muscle relaxation, accompanied by upregulation of HO-1 expression and oxidative stress. This study provides support for clinical studies that have shown a strong positive correlation between priapism and high levels of intravascular hemolysis in men with SCD.
Article
Physiology
Pamela da Silva Pereira, Dalila Andrade Pereira, Fabiano Beraldi Calmasini, Leonardo O. Reis, Nathan Brinkman, Arthur L. Burnett, Fernando Ferreira Costa, Fabio Henrique Silva
Summary: This study found that in sickle cell disease, decreased haptoglobin levels contribute to abnormal erectile function. Treatment with haptoglobin can improve erectile function by regulating the expression of key proteins involved in the control of penile erection. This suggests that haptoglobin treatment may be an additional strategy to prevent priapism in sickle cell disease.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Andrology
Gabriela Reolon Passos, Guilherme Ruiz Leonardi, Mariana Goncalves de Oliveira, Erick de Toledo Gomes, Ana Carolina Ghezzi, Edson Antunes, Fernanda Andrade Orsi, Jose Luiz da Costa, Fabiola Zakia Monica
Summary: This study aimed to assess the effects of serum obtained from unvaccinated men with severe COVID-19 on isolated corpus cavernosum (CC) from mice. The results showed that the relaxation responses in CC incubated with COVID-19 serum were significantly reduced compared to the control serum. However, the relaxation induced by a specific activator was unaffected in CC stimulated with the COVID-19 serum. In addition, COVID-19 serum increased the expression of specific genes. These findings suggest that COVID-19 may lead to erectile dysfunction.
Article
Biochemistry & Molecular Biology
Matheus L. Medeiros, Akila L. Oliveira, Glaucia C. Mello, Edson Antunes
Summary: Exposure to methylglyoxal (MGO) increases inflammatory responses in mouse airways, but the use of metformin can reduce these effects. In this study, mice exposed to MGO showed increased levels of inflammatory cells and cytokines, as well as mucus production and collagen deposition. However, treatment with metformin reversed these effects and suppressed the activation of RAGE-ROS signaling. These findings suggest that metformin may be a potential adjuvant therapy for asthma in individuals with high MGO levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biology
Jose Britto-Junior, Lincoln Rangel Medeiros-Teixeira, Antonio Tiago Lima, Leticia Costa Dassow, Rodrigo alvaro Brandao Lopes-Martins, Rafael Campos, Manoel Odorico Moraes, Maria Elisabete A. Moraes, Edson Antunes, Gilberto De Nucci
Summary: The study found that 6-nitrodopamine is the major catecholamine released from rat isolated ventricles and is 1000 times more potent than dopamine and noradrenaline in increasing heart inotropism. It is selectively blocked by atenolol.
Article
Biology
J. Britto-Junior, A. T. Lima, J. S. Santos-Xavier, P. Gonzalez, F. Z. Monica, R. Campos, V. B. de Souza, A. A. Schenka, E. Antunes, G. De Nucci
Summary: This study investigated the release of 6-nitrodopamine in the thoracic aorta and pulmonary artery rings of marmosets. The results showed that 6-nitrodopamine is the major catecholamine released by marmoset vascular tissues. It acts as a potent and selective antagonist of dopamine D2-like receptors and induces vasodilation by releasing NO.
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
(2023)
Article
Multidisciplinary Sciences
Dalila Andrade Pereira, Danillo Andrade Pereira, Pamela da Silva Pereira, Tammyris Helena Rebecchi Silveira, Fabiano Beraldi Calmasini, Leonardo Oliveira Reis, Fernando Ferreira Costa, Fabio Henrique Silva
Summary: Hydroxyurea treatment is not effective for priapism associated with sickle cell disease (SCD). Excess plasma hemoglobin and reactive oxygen species in SCD may react with nitric oxide (NO) before it binds to guanylyl cyclases (GCs) in the smooth muscle of the corpus cavernosum, preventing the restoration of baseline NO/cGMP levels. Furthermore, downregulation of endothelial NO synthase in the penis may impair the pharmacological action of hydroxyurea at the endothelial level in SCD mice. Therefore, alternative therapeutic approaches for priapism in SCD that are not hindered by high plasma hemoglobin and reactive oxygen species levels need to be explored.
Article
Physiology
Akila L. Oliveira, Matheus L. Medeiros, Ana Carolina Ghezzi, Gabriel Alonso dos Santos, Glaucia Coelho Mello, Fabiola Z. Monica, Edson Antunes
Summary: High levels of MGO and AGEs, along with activation of the RAGE pathway, contribute to diabetes-associated bladder dysfunction. Treatment with the AGE breaker ALT-711 can reduce MGO levels and improve bladder function in diabetic mice.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2023)
