Article
Pharmacology & Pharmacy
Abdullah A. Alamoudi, Osama A. A. Ahmed, Khalid M. El-Say
Summary: This study successfully enhanced the transdermal delivery and bioavailability of avanafil using optimized TPGS-based mixed micelle-loaded film design.
Review
Health Care Sciences & Services
Francesco Di Bello, Massimiliano Creta, Luigi Napolitano, Gianluigi Califano, Francesco Passaro, Simone Morra, Angelo di Giovanni, Giovanni Maria Fusco, Luigi Cirillo, Marco Abate, Vincenzo Morgera, Gianluigi Cacace, Luigi De Luca, Gianluca Spena, Claudia Colla Ruvolo, Francesco Paolo Calace, Celeste Manfredi, Roberto La Rocca, Giuseppe Celentano, Carmine Turco, Marco Capece, Carlo D'Alterio, Alessandro Giordano, Ernesto di Mauro, Francesco Trama, Ugo Amicuzi, Davide Arcaniolo, Ferdinando Fusco, Nicola Longo
Summary: Spinal cord injury (SCI) is a significant medical and social problem that often results in sexual dysfunction and fertility problems for patients. The best management strategies for ejaculatory disorders include penile vibratory stimulation (PVS) and electroejaculation (EEJ), while medical therapies and surgical options are available for treating erectile dysfunction.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Health Care Sciences & Services
John Zizzo, David R. Gater, Sigmund Hough, Emad Ibrahim
Summary: Spinal cord injury (SCI) has a significant impact on individuals' lives, raising various concerns and questions. However, advancements in SCI research have provided healthcare providers with evidence-based approaches to address these issues. Effective treatments are available for sexual function and reproductive health, and focusing on self-image, confidence, and communication is equally important for improving the quality of life after SCI.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Neurosciences
Wu Jiang, Fan He, Guoming Ding, Junsong Wu
Summary: This study aimed to investigate the protective effect of the novel mitochondria-targeted peptide EPT in spinal cord injury (SCI). The results showed that EPT improved locomotor functional recovery and reduced neuronal loss. EPT also inhibited NLRP3 inflammasome activation and elevated levels of pro-inflammatory cytokines. Furthermore, EPT alleviated mitochondrial dysfunction and reduced mitochondrial reactive oxygen species level. Therefore, EPT may protect against SCI by inhibiting pyroptosis.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Review
Plant Sciences
A. Anand Ganapathy, V. M. Hari Priya, Alaganandam Kumaran
Summary: This paper reviewed 97 medicinal plants with PDE5 inhibitory effect, of which 77 were selected based on their traditional use as aphrodisiacs. Isoflavones and biflavones were identified as the major active constituents responsible for action, while Icariin and Icariside II were found to be the most effective inhibitors from natural sources. Traditional medicines containing extracts of Ginkgo biloba, Kaempferia parviflora, Clerodendrum colebrookianum, Eurycoma longifolia, and Vitis vinifera were also found to inhibit the PDE5 enzyme.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ana Paula Magrini Iacopucci, Pamela da Silva Pereira, Dalila Andrade Pereira, Fabiano Beraldi Calmasini, Valeria Pittala, Leonardo Oliveira Reis, Arthur L. Burnett, Fernando Ferreira Costa, Fabio Henrique Silva
Summary: In this study, a mouse model was used to investigate the effect of intravascular hemolysis on corpus cavernosum smooth muscle relaxation and oxidative stress in the penis. The results showed that intravascular hemolysis promotes increased corpus cavernosum smooth muscle relaxation, accompanied by upregulation of HO-1 expression and oxidative stress. This study provides support for clinical studies that have shown a strong positive correlation between priapism and high levels of intravascular hemolysis in men with SCD.
Article
Physiology
Pamela da Silva Pereira, Dalila Andrade Pereira, Fabiano Beraldi Calmasini, Leonardo O. Reis, Nathan Brinkman, Arthur L. Burnett, Fernando Ferreira Costa, Fabio Henrique Silva
Summary: This study found that in sickle cell disease, decreased haptoglobin levels contribute to abnormal erectile function. Treatment with haptoglobin can improve erectile function by regulating the expression of key proteins involved in the control of penile erection. This suggests that haptoglobin treatment may be an additional strategy to prevent priapism in sickle cell disease.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Endocrinology & Metabolism
Biljana Musicki, Arthur L. Burnett
Summary: Hypogonadism is a common issue in men with sickle cell disease (SCD). Testicular failure is the primary cause, but other types of hypogonadism have also been observed. The underlying mechanism for primary hypogonadism involves increased oxidative stress in the testis. Hypogonadism in SCD affects various aspects of health, and treating it without affecting fertility is a challenge.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Health Care Sciences & Services
James Guest, Nilanjana Datta, George Jimsheleishvili, David R. Gater
Summary: The spinal cord serves as a communication conduit between the brain and the body, responsible for transmitting information and controlling various functions. Following a spinal cord injury, various complications can arise, including paralysis, pain, and autonomic dysfunction.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Abhinandan D. Hudwekar, Pankul Kotwal, Mohd. Ishaq Dar, Shilpi Balgotra, Ashish Dogra, Jaspreet Kour, Santosh S. Chobe, Utpal Nandi, Sajad Hussain Syed, Sanghapal D. Sawant
Summary: Continuing our research on sildenafil analogs as inhibitors of PDE5 for erectile dysfunction, we found that modifications at the N-methylpiperazine ring with hydrophobic region followed by hydrogen bond donor or acceptor region have potential. However, previously identified leads had limitations such as poor pharmacokinetic profile, low aqueous solubility, and poor bioavailability. Therefore, we designed, synthesized, and screened a new series of sildenafil based analogs. Compound 18 showed excellent in vitro activity with selectivity towards PDE5 isozyme, as well as excellent in vivo activity and pharmacokinetic profile. The compound also exhibited excellent cyp inhibition and CaCO2 permeability.
CHEMISTRY & BIODIVERSITY
(2023)
Article
Andrology
Ahmed S. Zaghloul, Abdelrahman M. El-Nashaar, Shady Z. Said, Ihab A. Osman, Taymour Mostafa
Summary: This study evaluated the effectiveness of platelet-rich plasma (PRP) combined with oral tadalafil in diabetic patients with erectile dysfunction (ED) who did not respond to PDE5 inhibitors. The results showed that PRP therapy significantly improved erectile function and erection hardness in these patients. Furthermore, the level of diabetic control was associated with treatment outcomes.
Review
Pharmacology & Pharmacy
Yasmeen Saeed
Summary: Spinal cord injury (SCI) is a challenging disorder without a standard treatment. Immune responses could enhance the injury sequel, but they are also necessary for healing. Immunotherapeutic strategies targeting SCI can benefit from the dual nature of immune responses. This study aims to provide an overview of previous research on immunotherapeutic strategies for functional recovery after SCI and address the limitations of DNA and cell-based vaccination strategies.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Zheng Wang, Yunyun Wang, Jiachao Xiong, Xinxin Gan, Yewei Bao, Aimin Jiang, Ye Zhou, Huangfu Zhao, Yiren Yang, Zhiyong Liu, Demeng Xia, Linhui Wang
Summary: A two-sample Mendelian randomization (MR) study revealed a positive causal link between hypertension and the risk of erectile dysfunction. Various MR methods consistently showed that hypertension is associated with an increased risk of erectile dysfunction. Therefore, more attention should be given to prevent or improve erectile function in the management of hypertension.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Kurt Miller, Uwe May, Wolf-Dietrich Beecken, Georgios Hatzichristodoulou, Michael Boehm, Stefan Fink
Summary: This study evaluated the benefits and risks of reclassifying tadalafil, a phosphodiesterase type 5 inhibitor, as an over-the-counter medication. The expert panel concluded that the benefits outweighed the risks and considered the risk mitigation strategies of packaging label and patient information leaflet to be sufficient.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Immunology
Jiansong Chen, Yiguo Shen, Xiaobo Shao, Weiliang Wu
Summary: Spinal cord injury (SCI) and spinal cord tumor cause significant damage to the spinal cord, leading to multiple impairments and high morbidity and mortality. The treatment options for these conditions are limited and the underlying molecular mechanisms remain unclear. In the review, the role of inflammasomes in SCI and spinal cord tumors is highlighted, and targeting inflammasomes is suggested as a potential therapeutic strategy.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Urology & Nephrology
Chiara Traini, Giulio Del Popolo, Massimo Lazzeri, Katia Mazzaferro, Federico Nelli, Laura Calosi, Maria Giuliana Vannucchi
Article
Urology & Nephrology
Giuseppe Lombardi, Stefania Musco, Thomas M. Kessler, Vincenzo Li Marzi, Michele Lanciotti, Giulio Del Popolo
Review
Urology & Nephrology
Marc P. Schneider, Tobias Gross, Lucas M. Bachmann, Bertil F. M. Blok, David Castro-Diaz, Giulio Del Popolo, Jan Groen, Rizwan Hamid, Gilles Karsenty, Jurgen Pannek, Lisette 't Hoen, Thomas M. Kessler
Review
Obstetrics & Gynecology
Giuseppe Lombardi, Enrico Finazzi Agro, Giulio Del Popolo
INTERNATIONAL UROGYNECOLOGY JOURNAL
(2015)
Review
Urology & Nephrology
Simone Crivellaro, Alessandro Morlacco, Giovanni Bodo, Enrico Finazzi Agro', Christian Gozzi, Donatella Pistolesi, Giulio Del Popolo, Vincenzo Ficarra
NEUROUROLOGY AND URODYNAMICS
(2016)
Article
Urology & Nephrology
Maurizio Serati, Luca Topazio, Giorgio Bogani, Elisabetta Costantini, Amelia Pietropaolo, Giovanni Palleschi, Antonio Carbone, Marco Soligo, Giulio Del Popolo, Vincenzo Li Marzi, Stefano Salvatore, Enrico Finazzi Agro
NEUROUROLOGY AND URODYNAMICS
(2016)
Article
Urology & Nephrology
G. Amarenco, M. Sutory, R. Zachoval, M. Agarwal, G. Del Popolo, R. Tretter, G. Compion, D. De Ridder
NEUROUROLOGY AND URODYNAMICS
(2017)
Article
Urology & Nephrology
Michael Kennelly, Roger Dmochowski, Heinrich Schulte-Baukloh, Karen Ethans, Giulio Del Popolo, Courtenay Moore, Brenda Jenkins, Steven Guard, Yan Zheng, Gilles Karsenty
NEUROUROLOGY AND URODYNAMICS
(2017)
Review
Clinical Neurology
G. Lombardi, S. Musco, J. J. Wyndaele, G. Del Popolo
Article
Urology & Nephrology
Jan Groen, Juergen Pannek, David Castro Diaz, Giulio Del Popolo, Tobias Gross, Rizwan Hamid, Gilles Karsenty, Thomas M. Kessler, Marc Schneider, Lisette 't Hoen, Bertil Blok
Article
Urology & Nephrology
Maria Paola Bertapelle, Mario Vottero, Giulio Del Popolo, Marco Mencarini, Edoardo Ostardo, Michele Spinelli, Antonella Giannantoni, Anna D'Ausilio
WORLD JOURNAL OF UROLOGY
(2015)
Article
Neurosciences
Stefania Musco, Donatella Giraudo, Elena Antoniono, Giuseppe Lombardi, Giulio Del Popolo, Vincenzo Li Marzi, Gianfranco Lamberti
Summary: The study found that the prevalence of nocturia in patients with a history of acquired brain injury (ABI) was 35%, and it was significantly associated with other storage urinary symptoms. Factors such as age, gender, duration of coma, cognitive impairment were not significantly associated with the occurrence of nocturia. Subarachnoid haemorrhage was identified as one of the main reasons for nocturia.
Article
Clinical Neurology
Erez James Cohen, Gabriele Righi, Claudia Conti, Claudia De Santis, Giorgia Sciarrone, Giulio Del Popolo
Summary: This study examines the use of a circle-tracing task to quantify hand functional recovery in cervical spinal cord injury patients. The results show significant differences in pen pressure profiles between initial assessment and 4-week assessment in the SCI patients, with lower pressure applied compared to controls. However, there were no significant correlations found between clinical assessments and pen pressure.
JOURNAL OF SPINAL CORD MEDICINE
(2022)
Article
Urology & Nephrology
Stephanie A. Stalder, Oliver Gross, Collene E. Anderson, Lucas M. Bachmann, Sarah Baumann, Veronika Birkhauser, Mirjam Bywater, Giulio del Popolo, Daniel S. Engeler, Enrico Finazzi Agro, Susanne Friedl, Nuno Grilo, Stephan Kiss, Miriam Koschorke, Lorenz Leitner, Martina D. Liechti, Ulrich Mehnert, Stefania Musco, Helen Sadri, Lara Stachele, Jure Tornic, Stephanie van Der Lely, Stephen Wyler, Thomas M. Kessler
Summary: This study protocol describes a randomized controlled trial investigating the efficacy and safety of transcutaneous tibial nerve stimulation (TTNS) for refractory neurogenic lower urinary tract dysfunction (NLUTD). The primary outcome is improvement in bladder diary variables at study end compared to baseline values. Secondary outcomes include urodynamic, neurophysiological, and bowel function measures, as well as safety assessments.
Article
Computer Science, Cybernetics
Tommaso Bagneschi, Domenico Chiaradia, Gabriele Righi, Giulio Del Popolo, Antonio Frisoli, Daniele Leonardis
Summary: We propose a new soft exoskeleton that actively supports hand closure and opening by using a unique tendon routing system. The design enhances stability, reduces slippage and detachment, and provides comfortable clenching effect. Additionally, the use of a single actuator and modular design improves adaptability to different hand sizes. Experimental evaluations have demonstrated positive results in terms of stability, deformation, inter-finger compliance, and grasping force. Initial evaluations with Spinal Cord Injury patients have provided valuable insights into the device's strengths and limitations in real-life scenarios.
IEEE TRANSACTIONS ON HAPTICS
(2023)