Article
Biochemistry & Molecular Biology
Ana Paula Magrini Iacopucci, Pamela da Silva Pereira, Dalila Andrade Pereira, Fabiano Beraldi Calmasini, Valeria Pittala, Leonardo Oliveira Reis, Arthur L. Burnett, Fernando Ferreira Costa, Fabio Henrique Silva
Summary: In this study, a mouse model was used to investigate the effect of intravascular hemolysis on corpus cavernosum smooth muscle relaxation and oxidative stress in the penis. The results showed that intravascular hemolysis promotes increased corpus cavernosum smooth muscle relaxation, accompanied by upregulation of HO-1 expression and oxidative stress. This study provides support for clinical studies that have shown a strong positive correlation between priapism and high levels of intravascular hemolysis in men with SCD.
Article
Biotechnology & Applied Microbiology
Wende Yang, Chen Qiu, Jiancheng Zhai, Wei Zhang, Chengwu Huang, Jun Shao, Jingke Zhang, Shigao Chen, Xiaoyan Miao, Peng Chen, Bo Wei, Jie Ren, Hongbo Wei
Summary: In this study, an innovative liposomal microbubble (MB) loaded with both Sildenafil (one of PDE5i) and NO was designed. Ultrasound-targeted MB destruction (UTMD)-mediated efficient release and integration erectogenic agents into corpus cavernosum with high biosafety. The coordinated intervention of the multifunctional MB-cooperated UTMD reversed the abnormal structural remodeling and promoted the recovery of functional erection.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Bedoor Qabazard, Mariam Yousif, Alyaa Mousa, Oludotun Adebayo Phillips
Summary: The study investigates the potential protective role of hydrogen sulfide in diabetes-induced erectile dysfunction, with findings suggesting that H2S may reduce corporal contraction and fibromuscular changes in diabetic penile tissue, as well as having a link with plasma/urinary levels. These findings indicate that H2S could be a new strategy for preventing and treating diabetes-induced ED.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Andrology
Hao Cheng, Guo-Xiong Liu, Fei Wang, Ke Wang, Li-Tao Ruan, Lin Yang
Summary: The study found that shear wave elastography can be used to evaluate the aging degree of the corpus cavernosum. With increasing age, the Young's modulus of the corpus cavernosum increases and erectile function decreases. Histological investigation revealed an increase in collagen content and a decrease in smooth muscle content of the corpus cavernosum with age.
ASIAN JOURNAL OF ANDROLOGY
(2022)
Article
Multidisciplinary Sciences
LiangYu Zhao, Sha Han, HengChuan Su, JianYing Li, ErLei Zhi, Peng Li, ChenCheng Yao, RuHui Tian, HuiXing Chen, HuiRong Chen, JiaQiang Luo, ChenKun Shi, ZhiYong Ji, JianLin Hu, Gang Wu, WeiDong Zhou, YuXin Tang, YuZhuo Chen, GuiTing Lin, Tom F. Lue, DengLong Wu, Zheng Li
Summary: This study provides insights into the cellular heterogeneity and signalling networks of the human corpus cavernosum. It describes the spatial distribution of different cell types and identifies potential regulatory signalling pathways in erectile dysfunction.
NATURE COMMUNICATIONS
(2022)
Article
Cell Biology
Rafael Sobrano Fais, Rafael Menezes da Costa, Allan Carvalho Mendes, Fabiola Mestriner, Simon Gabriel Comerma-Steffensen, Rita C. Tostes, Ulf Simonsen, Fernando Silva Carneiro
Summary: In this study, it was hypothesized that stimulation of endothelin receptors ETA and ETB leads to NLRP3 activation through increased calcium and ROS formation. The experiments conducted on mice demonstrated that ET-1 reduced intracavernosal pressure and the CC ACh and SNP-induced relaxation, while increasing caspase-1 expression. The use of receptor antagonists, genetic deletion, and ROS inhibitors reversed these effects, indicating that ET-1-induced erectile dysfunction involves the activation of NLRP3 via Ca2+-dependent ROS generation mediated by ETA- and ETB-receptors.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Article
Andrology
Mariana Goncalves de Oliveira, Gabriela Reolon Passos, Erick de Toledo de Gomes, Guilherme Ruiz Leonardi, Adriana Zapparoli, Edson Antunes, Fabiola Zakia Monica
Summary: MK571 inhibiting MRPs promotes the accumulation of cGMP in obese mice smooth muscle cells, thereby improving smooth muscle relaxation and erectile function.
Article
Pharmacology & Pharmacy
Miguel A. Olivencia, Erika Esposito, Vincenzo Brancaleone, Sigismondo Castaldo, Giuseppe Cirino, Francisco Perez-Vizcaino, Raffaella Sorrentino, Roberta d'Emmanuele di Villa Bianca, Emma Mitidieri
Summary: This study explores the regulation of the redox state of soluble guanylate cyclase (sGC) by endogenous hydrogen sulfide (H2S). Lack of endogenous H2S disrupts the eNOS/NO/sGC/PDE pathway in CSE-/- mice, resulting in a significant reduction in the relaxant response to the sGC redox-dependent stimulator riociguat. However, the response to the sGC redox-independent activator cinaciguat remains unaltered.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Engineering, Biomedical
Li Liang, Yi Shen, Zhifeng Dong, Xin Gu
Summary: In this study, PDNPs-incorporated hydrogels were developed for sustained release of adipose stem cell-derived exosomes (EXO) and restoration of erectile function. The PDNPs in the hydrogels exhibited excellent photoacoustic performance, enabling accurate delivery into the tunica albuginea.
BIOACTIVE MATERIALS
(2022)
Article
Physiology
Pamela da Silva Pereira, Dalila Andrade Pereira, Fabiano Beraldi Calmasini, Leonardo O. Reis, Nathan Brinkman, Arthur L. Burnett, Fernando Ferreira Costa, Fabio Henrique Silva
Summary: This study found that in sickle cell disease, decreased haptoglobin levels contribute to abnormal erectile function. Treatment with haptoglobin can improve erectile function by regulating the expression of key proteins involved in the control of penile erection. This suggests that haptoglobin treatment may be an additional strategy to prevent priapism in sickle cell disease.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Andrology
Onder Kayigil, Yucel Altay, Emrah Okulu
Summary: This study investigated the use of CC-EMG recording as a diagnostic tool for identifying PAD in patients with LUTS and concurrent ED. Fifty patients were included in the study, and the findings were compared with urodynamic parameters and ultrasound results. The results showed that patients without PAD had significantly lower values for PVR, P det Q(max), and P det compliance compared to those with PAD. The study also found that increased electrical bursts and decreased relaxation responses on CC-EMG indicated an increase in bladder sphincter contractility.
Review
Medicine, General & Internal
Guangying Wang, Dayue Shen, Xilan Zhang, Monica G. Ferrini, Yuanping Li, Hui Liao
Summary: In this study, bioinformatics analyses were conducted to identify key biomarkers for potential clinical applications in the treatment of erectile dysfunction caused by DMED and CNIED. Common EFPs were identified in both models, and PPI results showed differences in hub genes between DMED and CNIED.
Article
Andrology
Joo Yong Lee, Dae Chul Jung, Seungsoo Lee, Nam Gyu Kang, Young Taik Oh, Kyunghwa Han
Summary: Using SWE to quantitatively measure the Young's modulus of the corpus cavernosum may be an objective technique for assessing penile erectile rigidity and the vascular subtype in patients with ED.
WORLD JOURNAL OF MENS HEALTH
(2021)
Article
Endocrinology & Metabolism
Dong Fang, Xiao-Hui Tan, Wen-Peng Song, Yang-Yang Gu, Jian-Cheng Pan, Xiao-Qing Yang, Wei-Dong Song, Yi-Ming Yuan, Jing Peng, Zhi-Chao Zhang, Zhong-Cheng Xin, Xue-Song Li, Rui-Li Guan
Summary: This study assessed the cellular heterogeneity of human corpus cavernosum in patients with severe erectile dysfunction (ED) at the single-cell level. It identified disease-related heterogeneity of cell types, including endothelial cells, smooth muscle cells, fibroblasts, and immune cells. Fibroblasts showed the highest cellular heterogeneity and may compromise the expansion of corpus cavernosum due to fibrosis. The study also indicated the crucial role of inflammation in the development of ED through robust cell-cell communication among different cell populations.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cell Biology
Kota Fujimoto, Daiki Hashimoto, Kenichi Kashimada, Shinji Kumegawa, Yuko Ueda, Taiju Hyuga, Tsuyoshi Hirashima, Norimitsu Inoue, Kentaro Suzuki, Isao Hara, Shinichi Asamura, Gen Yamada
Summary: This study establishes an explant system that allows direct visualization of the sinusoidal lumen in the penis, enabling the evaluation of dynamic movements during erection. The system provides unique information for investigating the novel regulations of erectile function and analyzing the pathology of erectile dysfunction (ED), ultimately aiding in the development of new treatments.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Andrology
Taymour Mostafa, Nashaat Nabil, Laila Rashed, Ahmed F. Abo-Sief, Hadier H. Eissa
Article
Cell Biology
Eman Mohamed Faruk, Ola Elsayed Nafea, Hanan Fouad, Usama Fouad Ahmed Ebrahim, Rehab Abd Allah Hasan
JOURNAL OF MOLECULAR HISTOLOGY
(2020)
Letter
Urology & Nephrology
Adham Zaazaa, Taymour Mostafa
JOURNAL OF SEXUAL MEDICINE
(2020)
Article
Andrology
Sherine H. Abd El Rahman, Laila A. Rashed, Essam M. Akl, Taymour Mostafa
Article
Medicine, Research & Experimental
Eman Mohamed Faruk, Wardah Abdullah Alasmari, Hanan Fouad, Ola Elsayed Nafea, Rehab Abd Allah Hasan
Summary: This study demonstrated the therapeutic potential of extracellular vesicles derived from bone marrow mesenchymal stem cells (BMSC-EVs) against fluoride-induced adrenal toxicity. BMSC-EVs effectively repaired damaged adrenal tissue and recovered its function following NaF consumption, reversing the toxic effects of fluoride and reprogramming injured adrenal cells by activating regenerative processes.
Correction
Medicine, Research & Experimental
Eman Mohamed Faruk, Wardah Abdullah Alasmari, Hanan Fouad, Ola Elsayed Nafea, Rehab Abd Allah Hasan
Article
Anatomy & Morphology
Hanan Fouad, Eman Mohamed Faruk, Wardah Abdullah Alasmari, Eman Hassan Nadwa, Usama Fouad Ahmed Ebrahim
Summary: The study evaluated the potential beneficial effects of MSCs and resveratrol in alleviating BPA-induced uterine damage in rats. Treatment with resveratrol, MSCs, or a combination of both significantly enhanced histological findings, restored gonadal hormone levels, and decreased oxidative stress markers and apoptosis genes. Combined treatment of resveratrol and MSCs showed more significant therapeutic effects compared to individual treatments with either MSCs or resveratrol.
Article
Andrology
Taymour Mostafa, Abd El-Aziz I. El-Taweel, Laila Ahmed Rashed, Nayera A. M. Mohammed, Essam Mohamed Akl
Summary: Varicocele has been linked to male infertility, and improvements in sperm parameters post-varicocelectomy support this association. Cystatin C has been associated with cellular changes common in male infertility cases related to varicocele. This preliminary study found that seminal Cys C levels were significantly higher in infertile OAT men with varicocele compared to fertile men, and decreased post-operatively, suggesting a potential role of Cys C in varicocele-induced infertility.
Review
Obstetrics & Gynecology
Taymour Mostafa, Ibrahim Abdel-Hamid, Mai Taymour, Omar Ali
Summary: This systematic review examined the association between genetic factors and varicocele-related male infertility (VRMI). The findings suggest that there is no clear evidence of a strong association between specific genetic polymorphisms and VRMI. However, several studies identified a higher frequency of the polymorphic genotype for the rs1799983 polymorphism of the NOS3 gene in varicocele patients. Further efforts are needed to standardize reporting, explore complementary study designs, and utilize GWAS technology to replicate these early findings.
Article
Multidisciplinary Sciences
Marwa Sayed Abdel-Tawab, Hanan Fouad, Asmaa M. Othman, Ragaey A. Eid, Marwa Abdeltawab Mohammed, Ahmed Hassan, Hoda Ramadan Reyad
Summary: This study assessed the association of PLEKHS1, AADAC, and CDKN3 genes with GC and found that their gene expressions were correlated with tumor stage, grade, and other clinicopathological features. PLEKHS1 gene was downregulated, while AADAC and CDKN3 genes were upregulated in GC group. The expression of AADAC gene was positively correlated with tumor grade and stage. These gene expressions can be used as diagnostic, predictive, and prognostic biomarkers of GC.
Article
Anatomy & Morphology
Eman Mohamed Faruk, Hanan Fouad, Rehab Abd Allah Hasan, Neama Mahmoud Taha, Amal Mahmoud El-Shazly
Summary: This study evaluated the therapeutic potential of soybean nano-isoflavone extract and bone marrow mesenchymal stem cells derived extracellular exosomes in experimentally induced neurodegenerative diseases in rats. The results showed that both treatments repaired damaged cerebral tissue and recovered its function greatly, with favorable therapeutic utility against D-galactose-induced neurodegenerative disease.
Article
Immunology
Wardah Abdullah Alasmari, Eman Faruk, Hanan Fouad, Rabab Radi, Dalia Ibrahim El-wafaey
Summary: This study evaluated the anti-inflammatory role of adipose tissue-derived stem cells (ASCs) and adipose stem cell-derived extracellular vesicles (ADSCs-EVs) in cardiorenal syndrome. The results showed that both ADSCs-EVs and ASCs significantly improved the histological findings, showed anti-inflammatory effects, and decreased markers of cardiac dysfunction in the experimental-induced cardiorenal syndrome type III.
TRANSPLANT IMMUNOLOGY
(2022)
Article
Anatomy & Morphology
Wardah Abdullah Alasmari, Somaya Hosny, Hanan Fouad, Khalid Al Quthami, Essa Abdulaziz Mohammed Althobiany, Eman Mohamed Faruk
Summary: Cardiorenal syndrome (CRS) is a medical condition in which kidney problems are accompanied by heart problems. In this study, the effects of adipose-derived stem cell extracellular vesicles (ADSCs-EVs) and adipose stem cells (ADSCs) were evaluated on an experimental model of CRSIII. The results showed that both ADSCs-EVs and ADSCs reversed induced CRSIII and reprogramed injured cells by activating regenerative processes. These findings are of great significance in protecting the heart from the deleterious effects of acute renal injury.
Article
Andrology
Mohamed Wael Ragab, Mina Saad, Zeinab Nour, Hamed Abdallah Hamed, Taymour Mostafa, Ahmed M. El-Guindi
Summary: This study aimed to evaluate the predictive role of seminal testis expressed protein (TEX101) in sperm recovery in infertile men with nonobstructive azoospermia (NOA) after microsurgical varicocelectomy. The results showed that NOA patients with higher preoperative TEX101 levels had successful sperm recovery in their semen. Additionally, NOA patients without seminal sperm recovery had higher levels of serum follicle-stimulating hormone (FSH) and luteinizing hormone (LH). Therefore, preoperative seminal TEX101 may serve as a biomarker for predicting sperm recovery in NOA patients with varicocele.
Review
Andrology
Ramy Abou Ghayda, Rossella Cannarella, Aldo E. Calogero, Rupin Shah, Amarnath Rambhatla, Wael Zohdy, Parviz Kavoussi, Tomer Avidor-Reiss, Florence Boitrelle, Taymour Mostafa, Ramadan Saleh, Tuncay Toprak, Ponco Birowo, Gianmaria Salvio, Gokhan Calik, Shinnosuke Kuroda, Raneen Sawaid Kaiyal, Imad Ziouziou, Andrea Crafa, Nguyen Ho Vinh Phuoc, Giorgio I. Russo, Damayanthi Durairajanayagam, Manaf Al-Hashimi, Taha Abo-Almagd Abdel-Meguid Hamoda, Germar-Michael Pinggera, Ricky Adriansjah, Israel Maldonado Rosas, Mohamed Arafa, Eric Chung, Widi Atmoko, Lucia Rocco, Haocheng Lin, Eric Huyghe, Priyank Kothari, Jesus Fernando Solorzano Vazquez, Fotios Dimitriadis, Nicolas Garrido, Sheryl Homa, Marco Falcone, Marjan Sabbaghian, Hussein Kandil, Edmund Ko, Marlon Martinez, Quang Nguyen, Ahmed M. Harraz, Ege Can Serefoglu, Vilvapathy Senguttuvan Karthikeyan, Dung Mai BaTien, Sunil Jindal, Sava Micic, Marina Bellavia, Hamed Alali, Nazim Gherabi, Sheena Lewis, Hyun Jun Park, Mara Simopoulou, Hassan Sallam, Liliana Ramirez, Giovanni Colpi, Ashok Agarwal
Summary: Artificial intelligence (AI) has made significant progress in the field of medicine and has been applied to various areas. Advances in computer science, medical informatics, robotics, and personalized medicine have facilitated AI's role in modern healthcare. In andrology and reproductive medicine, AI applications such as machine learning, artificial neural networks, and deep learning have shown great potential in diagnosing and treating male infertility, as well as improving patient care.
WORLD JOURNAL OF MENS HEALTH
(2023)
