Editorial Material
Medicine, General & Internal
Yuanwei Liu, Peipei Hao
Summary: A 32-year-old woman presented with vaginal bleeding and an intrauterine mass with multiple cystic spaces was found on ultrasonography.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Medicine, General & Internal
Hirokazu Usui, Makio Shozu
Summary: This report presents a case of complete hydatidiform mole (CHM) with genomic DNA identical to the paternal somatic cells and no maternally derived nuclear DNA. The development of CHM into gestational trophoblastic neoplasia was resolved with chemotherapy. The case highlights the importance of accurate selection of round spermatids in assisted reproductive technology.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Medicine, Research & Experimental
Yuanyang Wang, Cheng Qin, Bangbo Zhao, Zeru Li, Tianyu Li, Xiaoying Yang, Yutong Zhao, Weibin Wang
Summary: This study found that EGR1 is highly expressed in pancreatic cancer and is associated with prognosis and cancer metastasis. EGR1 promotes migration and invasion ability of pancreatic cancer cells and is correlated with the epithelial-mesenchymal transition process. The study also revealed that EGR1 activates the SNAI2 gene through interaction with p300/CBP. In vivo experiments confirmed that EGR1 promotes liver metastasis of pancreatic cancer. Therefore, blocking the expression of EGR1 could be a new anticancer strategy for pancreatic cancer.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Ala Aiob, Karina Naskovica, Inna Amdur Zilberfarb, Avishalom Sharon, Jacob Bornstein, Lior Lowenstein
Summary: A retrospective study on molar pregnancy diagnosis revealed an increase in the incidence of partial molar pregnancies and a decrease in complete molar pregnancies. Additionally, typical presenting symptoms of molar pregnancy showed a decline.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yang Chen, Weilian Liang, Ke Liu, Zhengjun Shang
Summary: The study identified that FOXD1 is upregulated in oral squamous cell carcinoma, and higher expression is associated with poorer prognosis. Knocking down FOXD1 inhibits EMT and cell stemness, while overexpression promotes these processes. This suggests FOXD1 may be a potential marker for diagnosis and treatment of OSCC.
CELL AND BIOSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Xinran Qiao, Jingyu Lin, Jiajia Shen, Yang Chen, Liyun Zheng, Hangjiang Ren, Xiaoli Zhao, Hang Yang, Pengyu Li, Zhen Wang
Summary: FBXO28 is a crucial negative regulator of migration, invasion, and metastasis in HCC. It acts as an E3 ubiquitin ligase by directly binding to SNAI2 and degrading it through the ubiquitin proteasome system. Low FBXO28 or PRKACA expression is associated with poor prognosis in HCC patients.
Article
Biochemistry & Molecular Biology
Xue-Quan Fang, Mingyu Lee, Woo-Jin Lim, Seonghoon Lee, Chang-Hoon Lim, Ji-Hong Lim
Summary: PGC1 alpha is a critical transcriptional coactivator that maintains metabolic homeostasis and energy expenditure. Its deficiency promotes lung cancer metastasis through the cooperation with FOXA1 and ID1 in regulating EMT gene expression. Transforming growth factor beta1 regulates ID1 expression, which in turn affects the expression of EMT genes. The findings suggest that FOXA1 and PGC1 alpha-mediated ID1 expression is associated with the inhibition of TCF4 and TWIST1, which are involved in lung cancer metastasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Jain Ha, Sewoong Lee, Jiyoung Park, Jihye Seo, Eunjeong Kang, Haelim Yoon, Ba Reum Kim, Hyeon Kyu Lee, Seong Eon Ryu, Sayeon Cho
Summary: ADQ successfully suppressed carcinogenic activity by inhibiting the Akt signaling pathway and Twist1, suggesting it may be an efficient candidate for cancer drug development.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Enrico Capobianco, Vanessa McGaughey, Gerbenn Seraphin, John Heckel, Sandra Rieger, Thomas S. S. Lisse
Summary: Vitamin D and its receptor play an important role in inhibiting osteosarcoma metastasis and growth by regulating NMD-ROS-EMT signaling. This study reveals that vitamin D can inhibit the progression of osteosarcoma by suppressing the EMT pathway and exert its anti-tumor effects by regulating the NMD machinery.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Wai Kit Chia, Pik Yuen Chia, Nor Haslinda Abdul Aziz, Salwati Shuib, Muaatamarulain Mustangin, Yoke Kqueen Cheah, Teck Yee Khong, Yin Ping Wong, Geok Chin Tan
Summary: The general notion of complete hydatidiform moles is that they consist mostly of paternal DNA and do not express p57. This study explored other paternally imprinted genes that could aid in the diagnosis of hydatidiform moles. Immunohistochemical study revealed that TSSC3 and RB1 expression were present in partial moles and non-molar abortuses, but only in a small percentage of complete moles. DOG1 was consistently negative in all cases. Maternally imprinted genes were expressed in all cases except for one complete mole.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Lee Admoni-Elisha, Tzofit Elbaz, Anand Chopra, Guy Shapira, Mark T. Bedford, Christopher J. Fry, Noam Shomron, Kyle Biggar, Michal Feldman, Dan Levy
Summary: TWIST1 methylation plays a regulatory role in the expression of LINC-PINT, promoting EMT in glioma.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Obstetrics & Gynecology
Shiho Suzuki, Kenta Takahashi, Satoshi Obayashi, Masafumi Kitazawa, Hajime Kuroda, Ichio Fukasawa
Summary: A 27-year-old woman presented with acute abdominal pain and was diagnosed with an ectopic hydatidiform mole, treated with chemotherapy. This case highlights the importance of recognizing the potential for ectopic hydatidiform moles through abdominal pregnancy.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2021)
Article
Cell Biology
Reihaneh Alsadat Mahmoudian, Maryam Lotfi Gharaie, Mohammad Reza Abbaszadegan, Ali Alasti, Mohammad Mahdi Forghanifard, Atena Mansouri, Mehran Gholamin
Summary: This study investigated the expression of MMP-13, TWIST1, and CD44 in ESCC and found significant correlations with clinical features, such as tumor progression and invasion. The results suggest that the TWIST1-CD44-MMP-13 axis may be involved in tumor aggressiveness and could serve as diagnostic markers and therapeutic targets in ESCC.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Genetics & Heredity
Mohammad Hossein Izadpanah, Mohammad Mahdi Forghanifard
Summary: This study found that TWIST1 regulates the expression of cancer stem cell markers in human esophageal squamous cell carcinoma cells. These results may have important implications for understanding the self-renewal process of cancer stem cells and the potential of TWIST1 as a therapeutic target.
Article
Biochemistry & Molecular Biology
Nicoletta Cordani, Luca Mologni, Rocco Piazza, Pietro Tettamanti, Viola Cogliati, Mario Mauri, Matteo Villa, Federica Malighetti, Camillo Di Bella, Marta Jaconi, Maria Grazia Cerrito, Guido Cavaletti, Marialuisa Lavitrano, Marina Elena Cazzaniga
Summary: CDK4/6 inhibitors have shown significant improvement in the progression-free survival of hormone-receptor-positive and HER2-negative metastatic breast cancer. However, there is a high percentage of patients who are unresponsive or refractory to these inhibitors, and no reliable biomarkers have been identified to predict patients' response to treatment. This study focused on palbociclib, a selective CDK4/6 inhibitor, and found that TWIST1 could be a potential target for reversing resistance to palbociclib. This study provides new insights into the mechanisms of resistance to CDK4/6 inhibitors and identifies potential markers for patient follow-up during treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Letter
Surgery
Corrado Pedrazzani, Cristian Conti, Angelo Di Vittori, Giulia Turri, Laura Bernardoni, Andrea Mafficini, Claudio Luchini, Armando Gabbrielli, Aldo Scarpa, Alfredo Guglielmi
ASIAN JOURNAL OF SURGERY
(2023)
Article
Clinical Neurology
Roberto Latina, Giustino Varrassi, Ettore Di Biagio, Diana Giannarelli, Francesco Gravante, Antonella Paladini, Daniela D'Angelo, Laura Iacorossi, Cristina Martella, Rosaria Alvaro, Dhurata Ivziku, Nicola Veronese, Mario Barbagallo, Anna Marchetti, Paolo Notaro, Irene Terrenato, Gianfranco Tarsitani, Maria Grazia De Marinis
Summary: Opioids are effective in managing moderate or severe chronic pain. The use of invasive treatments and complementary therapy is associated with severe or moderate pain. The choice of a pain clinic is influenced by clinical parameters such as the nature of pain, multi-diagnosis, multiple sites of pain, treatments, and general practitioner.
Article
Biochemistry & Molecular Biology
Lydia Giannitrapani, Luigi Mirarchi, Simona Amodeo, Anna Licata, Maurizio Soresi, Francesco Cavaleri, Salvatore Casalicchio, Gregorio Ciulla, Maria Elena Ciuppa, Melchiorre Cervello, Mario Barbagallo, Nicola Veronese
Summary: The immune response to COVID-19 is important, but some patients experience persistent symptoms that lead to a global health and economic burden. This study investigates the potential role of IL-6 levels as a marker for long COVID. The analysis of 184 patients admitted to a hospital in Italy revealed that higher IL-6 levels were associated with a doubled risk of long COVID, mobility decline, and PTSD, indicating the significance of IL-6 in disease severity, unfavorable outcomes, and long COVID development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Marco Solmi, Trevor Thompson, Andres Estrade, Agorastos Agorastos, Joaquim Radua, Samuele Cortese, Elena Dragioti, Friedrich Leisch, Davy Vancampfort, Lau Caspar Thygesen, Harald Aschauer, Monika Schloegelhofer, Elena Aschauer, Andres Schneeberger, Christian G. Huber, Gregor Hasler, Philippe Conus, Kim Q. Do Cuenod, Roland von Kaenel, Gonzalo Arrondo, Paolo Fusar-Poli, Philip Gorwood, Pierre-Michel Llorca, Marie-Odile Krebs, Elisabetta Scanferla, Taishiro Kishimoto, Golam Rabbani, Karolina Skonieczna-Zydecka, Paolo Brambilla, Angela Favaro, Akihiro Takamiya, Leonardo Zoccante, Marco Colizzi, Julie Bourgin, Karol Kaminski, Maryam Moghadasin, Soraya Seedat, Evan Matthews, John Wells, Emilia Vassilopoulou, Ary Gadelha, Kuan-Pin Su, Jun Soo Kwon, Minah Kim, Tae Young Lee, Oleg Papsuev, Denisa Mankova, Andrea Boscutti, Cristiano Gerunda, Diego Saccon, Elena Righi, Francesco Monaco, Giovanni Croatto, Guido Cereda, Jacopo Demurtas, Natascia Brondino, Nicola Veronese, Paolo Enrico, Pierluigi Politi, Valentina Ciappolino, Andrea Pfennig, Andreas Bechdolf, Andreas Meyer-Lindenberg, Kai G. Kahl, Katharina Domschke, Michael Bauer, Nikolaos Koutsouleris, Sibylle Winter, Stefan Borgwardt, Istvan Bitter, Judit Balazs, Pal Czobor, Zsolt Unoka, Dimitris Mavridis, Konstantinos Tsamakis, Vasilios P. Bozikas, Chavit Tunvirachaisakul, Michael Maes, Teerayuth Rungnirundorn, Thitiporn Supasitthumrong, Ariful Haque, Andre R. Brunoni, Carlos Gustavo Costardi, Felipe Barreto Schuch, Guilherme Polanczyk, Jhoanne Merlyn Luiz, Lais Fonseca, Luana V. Aparicio, Samira S. Valvassori, Merete Nordentoft, Per Vendsborg, Sofie Have Hoffmann, Jihed Sehli, Norman Sartorius, Sabina Heuss, Daniel Guinart, Jane Hamilton, John Kane, Jose Rubio, Michael Sand, Ai Koyanagi, Aleix Solanes, Alvaro Andreu-Bernabeu, Antonia San Jose Caceres, Celso Arango, Covadonga M. Diaz-Caneja, Diego Hidalgo-Mazzei, Eduard Vieta, Javier Gonzalez-Penas, Lydia Fortea, Mara Parellada, Miquel A. Fullana, Norma Verdolini, Eva Andrlikova, Karolina Janku, Mark John Millan, Mihaela Honciuc, Anna Moniuszko-Malinowska, Igor Loniewski, Jerzy Samochowiec, Lukasz Kiszkiel, Maria Marlicz, Pawel Sowa, Wojciech Marlicz, Georgina Spies, Brendon Stubbs, Joseph Firth, Sarah Sullivan, Asli Enez Darcin, Hatice Aksu, Nesrin Dilbaz, Onur Noyan, Momoko Kitazawa, Shunya Kurokawa, Yuki Tazawa, Alejandro Anselmi, Cecilia Cracco, Ana Ines Machado, Natalia Estrade, Diego De Leo, Jackie Curtis, Michael Berk, Philip Ward, Scott Teasdale, Simon Rosenbaum, Wolfgang Marx, Adrian Vasile Horodnic, Liviu Oprea, Ovidiu Alexinschi, Petru Ifteni, Serban Turliuc, Tudor Ciuhodaru, Alexandra Bolos, Valentin Matei, Dorien H. Nieman, Iris Sommer, Jim van Os, Therese van Amelsvoort, Ching-Fang Sun, Ta-wei Guu, Can Jiao, Jieting Zhang, Jialin Fan, Liye Zou, Xin Yu, Xinli Chi, Philippe de Timary, Ruud van Winkel, Bernardo Ng, Edilberto Pena, Ramon Arellano, Raquel Roman, Thelma Sanchez, Larisa Movina, Pedro Morgado, Sofia Brissos, Oleg Aizberg, Anna Mosina, Damir Krinitski, James Mugisha, Dena Sadeghi-Bahmani, Farshad Sheybani, Masoud Sadeghi, Samira Hadi, Serge Brand, Antonia Errazuriz, Nicolas Crossley, Dragana Ignjatovic Ristic, Carlos Lopez-Jaramillo, Dimitris Efthymiou, Praveenlal Kuttichira, Roy Abraham Kallivayalil, Afzal Javed, Muhammad Iqbal Afridi, Bawo James, Omonefe Joy Seb-Akahomen, Jess Fiedorowicz, Andre F. Carvalho, Jeff Daskalakis, Lakshmi N. Yatham, Lin Yang, Tarek Okasha, Aicha Dahdouh, Bjoern Gerdle, Jari Tiihonen, Jae Il Shin, Jinhee Lee, Ahmed Mhalla, Lotfi Gaha, Takoua Brahim, Kuanysh Altynbekov, Nikolay Negay, Saltanat Nurmagambetova, Yasser Abu Jamei, Mark Weiser, Christoph U. Correll
Summary: The COH-FIT survey is a valid instrument to measure global mental health during the COVID-19 pandemic. The study confirmed the validity of COH-FIT items and the internal reliability of the co-primary outcome, the P-score. The survey has been translated into 30 languages and measures various mental health symptoms and factors.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Editorial Material
Endocrinology & Metabolism
Nicola Veronese, Shaun Sabico
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Geriatrics & Gerontology
Francesco Pollicino, Nicola Veronese, Ligia J. Dominguez, Mario Barbagallo
Summary: Mitochondria play a critical role in various energy processes and are important in the physiological response to stress, aging, and disease. The Mediterranean diet has been found to affect mitochondrial function, reducing the risk of negative health outcomes. Components of the Mediterranean diet, such as polyphenols, can limit free radicals and have anti-inflammatory effects, improving mitochondrial function. It is necessary to conduct further studies in humans to confirm these findings.
EXPERIMENTAL GERONTOLOGY
(2023)
Review
Geriatrics & Gerontology
Ligia J. Dominguez, Carolina Donat-Vargas, Carmen Sayon-Orea, Maria Barberia-Latasa, Nicola Veronese, Jimena Rey-Garcia, Fernando Rodriguez-Artalejo, Pilar Guallar-Castillon, Miguel Angel Martinez-Gonzalez, Mario Barbagallo
Summary: Frailty is a geriatric syndrome with increasing frequency and dire consequences due to population aging. Nutritional factors, particularly the Mediterranean diet, play a crucial role in its pathogenesis. A systematic review and meta-analysis confirmed a robust association between higher adherence to the Mediterranean diet and reduced incident frailty. Promoting the Mediterranean diet as a high-quality dietary pattern adapted to different regions offers an opportunity to counteract the spread of unhealthy eating and lifestyle models and reduce frailty incidence.
EXPERIMENTAL GERONTOLOGY
(2023)
Review
Nutrition & Dietetics
Maria del Carmen Macias Ruiz, Lorena Cuenca Bermejo, Nicola Veronese, Emiliano Fernandez Villalba, Ana Maria Gonzalez Cuello, Karolina Kublickiene, Valeria Raparelli, Colleen M. Norris, Alexandra Kautzky-Willer, Louise Pilote, Mario Barbagallo, Ligia Dominguez, Maria Trinidad Herrero
Summary: This article reviews the role of magnesium in health and illness, with emphasis on the elderly population with chronic kidney disease (CKD) and potential sex differences. It is found that magnesium can be used as an adjunctive treatment for CKD patients to improve glomerular filtration, but further research and characterization are needed for its clinical applications. Therefore, well-designed prospective clinical trials are needed to establish guidelines for magnesium supplementation, considering age and sex.
Correction
Clinical Neurology
Roberto Latina, Giustino Varrassi, Ettore Di Biagio, Diana Giannarelli, Francesco Gravante, Antonella Paladini, Daniela D'Angelo, Laura Iacorossi, Cristina Martella, Rosaria Alvaro, Dhurata Ivziku, Nicola Veronese, Mario Barbagallo, Anna Marchetti, Paolo Notaro, Irene Terrenato, Gianfranco Tarsitani, Maria Grazia De Marinis
Article
Nutrition & Dietetics
Nicola Veronese, Ai Koyanagi, Pinar Soysal, Francesco Bolzetta, Ligia J. J. Dominguez, Mario Barbagallo, Shaun Sabico, Nasser M. M. Al-Daghri, Lee Smith
Summary: This study found a significant association between DAO and the risk of falls in older adults, while dynapenia alone was not related to falls. This is important for fall prevention and control, and therefore deserves attention.
FRONTIERS IN NUTRITION
(2023)
Article
Geriatrics & Gerontology
Nicola Veronese, Ai Koyanagi, Pinar Soysal, Vitalba Sapienza, Francesco Saverio Ragusa, Francesco Bolzetta, Ligia J. Dominguez, Mario Barbagallo, Lee Smith
Summary: This study aimed to investigate the association between dynapenic abdominal obesity (DAO) at baseline and the development of multimorbidity over a 10-year follow-up period. The results showed that both abdominal obesity and DAO significantly increased the risk of multimorbidity. DAO was also associated with a higher risk of arthritis and diabetes.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2023)
Article
Surgery
Laura Maggino, Giuseppe Malleo, Stefano Crippa, Giulio Belfiori, Elisa Bannone, Gabriella Lionetto, Giulia Gasparini, Sara Nobile, Claudio Luchini, Paola Mattiolo, Marco Schiavo-Lena, Claudio Doglioni, Aldo Scarpa, Cristina Ferrone, Claudio Bassi, Carlos Fernandez-del Castillo, Massimo Falconi, Roberto Salvia
Summary: In this multicentre study, a modified staging system combining extrapancreatic invasion and tumour size was found to be associated with better prognostic stratification in patients undergoing postneoadjuvant pancreatectomy. This system allows identification of a subgroup of patients who might benefit from adjuvant therapy.
BRITISH JOURNAL OF SURGERY
(2023)
Article
Geriatrics & Gerontology
Francesco Saverio Ragusa, Luisa Solimando, Caterina Mandala, Roberta Masnata, Gregorio Ciulla, Stefano Ciriminna, Francesco La Blasca, Pasquale Mansueto, Nicola Veronese, Mario Barbagallo
Summary: The study found a positive association between higher multidimensional prognostic index (MPI) values, indicating frailty, and the prevalence of infectious diseases, including multidrug-resistant pathogens, resulting in increased antibiotic costs.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2023)
Review
Rheumatology
Sara Tenti, Olivier Bruyere, Sara Cheleschi, Jean-Yves Reginster, Nicola Veronese, Antonella Fioravanti
Summary: Osteoarthritis (OA) is a prevalent condition worldwide, causing pain, disability, reduced social activities, and impaired quality of life. The current therapeutic options are limited and focus mainly on managing symptoms, lacking disease-modifying drugs. Efforts have been made to find potential therapeutic targets for OA, repurposing existing drugs used for inflammatory rheumatic diseases. Unfortunately, the use of conventional and biologic drugs for hand osteoarthritis (HOA) has not been successful, highlighting the need for research on HOA molecular mechanisms and personalized treatment options.
THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE
(2023)
Article
Geriatrics & Gerontology
Marco Demaria, Beatrice Bertozzi, Nicola Veronese, Francesco Spelta, Edda Cava, Valeria Tosti, Laura Piccio, Dayna S. Early, Luigi Fontana
Summary: Long-term high-intensity endurance exercise can prevent the accumulation of senescent cells in cancer-prone tissues like colon mucosa, reducing the risk of colon adenoma and cardiometabolic dysfunction. This study is important for understanding the benefits of exercise on health and preventing the development of age-related diseases.
