Article
Immunology
Svenja Schrader, Laura Unverdorben, Stefan Hutter, Julia Knabl, Elisa Schmoeckel, Sarah Meister, Alaleh Zati Zehni, Susanne Beyer, Theresa Vilsmaier, Sven Mahner, Udo Jeschke, Thomas Kolben, Christina Buschmann, Lucia Keilmann
Summary: This study provides evidence for the involvement of galectins in chronic inflammation during pregnancy with gestational diabetes mellitus.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2022)
Article
Cell Biology
Li Zhang, Xinyang Yu, Yue Wu, Huijia Fu, Ping Xu, Yangxi Zheng, Li Wen, Xiaotao Yang, Fumei Zhang, Mingyu Hu, Hao Wang, Xiyao Liu, Juan Qiao, Chuan Peng, Rufei Gao, Richard Saffery, Yong Fu, Hongbo Qi, Chao Tong, Mark D. Kilby, Philip N. Baker
Summary: The study found that GDM is associated with impaired glycolysis, AMPK activity, GLUT3 expression, and cell survival in the placenta. Hyperglycemia induced similar changes in trophoblasts, and these changes were rescued by AMPK activation. AMPK activation upregulates trophoblast glucose uptake by stimulating GLUT3 translocation, which is beneficial for viability.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Food Science & Technology
Yan Yang, Zixin Cai, Jingjing Zhang
Summary: The study suggests that pregnant women with GDM are more likely to have higher folate levels. Furthermore, high maternal folate levels may predict a higher risk of GDM. Further large population studies are needed to confirm these findings.
FOOD SCIENCE & NUTRITION
(2021)
Review
Health Care Sciences & Services
Ladan Safiee, Daniel John Rough, Heather Whitford
Summary: This systematic literature review highlights the challenges faced by health professionals and women with gestational diabetes mellitus (GDM) when using GDM self-management systems. The usability of GDM systems emerges as a primary challenge, while convenience, consistent monitoring, and optimization of self-management are important facilitators. Overall, eHealth technologies have the potential to support GDM self-management but need to address usability issues.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Ishai Heusler, Tal Biron-Shental, Sivan Farladansky-Gershnabel, Yael Pasternak, Debora Kidron, Inna Vulih-Shuitsman, Yael Einbinder, Keren Cohen-Hagai, Sydney Benchetrit, Tali Zitman-Gal
Summary: The study evaluated the expression of Gal-3 in maternal blood and placental tissue of women with GDM, and found that Gal-3 expression was higher in GDM patients but lower in cord blood. This highlights the important role of the placenta in protecting the fetus from potential Gal-3 damage.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Review
Cell Biology
Yan-ping Zhang, Sha-zhou Ye, Ying-xue Li, Jia-li Chen, Yi-sheng Zhang
Summary: Gestational diabetes mellitus (GDM) refers to abnormal glucose tolerance that occurs during pregnancy and has serious impacts on maternal and neonatal health. Molecular markers for early prediction and diagnosis of GDM are currently lacking. This article focuses on the potential role of circRNA in the pathophysiology of GDM and its potential as early molecular markers for GDM diagnosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Nadia Abu Samra, Herbert F. Jelinek, Habiba Alsafar, Farah Asghar, Muhieddine Seoud, Shahad M. Hussein, Hisham M. Mubarak, Siddiq Anwar, Mashal Memon, Nariman Afify, Ridda Manzoor, Zahrah Al-Homedi, Wael Osman
Summary: Gestational diabetes mellitus is a common complication during pregnancy, caused by genetic, epigenetic, and environmental factors. However, its underlying mechanisms are still unclear, and molecular research in this field is lagging. Early detection of metabolic changes and related genetic and epigenetic factors is crucial for predicting adverse pregnancy outcomes and future pathologies in GDM women and their children.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Jie Wen, Xiaoxia Bai
Summary: The study demonstrated that miR-520h was upregulated in the serum of GDM patients and GDM cell models, positively correlated with FBG levels. High glucose inhibited cell viability and decreased mTOR expression, while miR-520h inhibitor reversed these effects. mTOR was identified as a target gene of miR-520h in the GDM cell model.
ACTA BIOCHIMICA POLONICA
(2021)
Article
Endocrinology & Metabolism
Yunyu Chen, Danping Huang, Jinrong Liu, Fangling Zeng, Guoyi Tang, Wenjia Lei, Haiyu Wang, Yanmin Jiang, Weihui Shentu, Hongying Wang
Summary: Endothelial dysfunction in fetuses of women with gestational diabetes mellitus is associated with subsequent cardiovascular events. This study assessed fetal vascular endothelial function in GDM patients using color M-mode derived aortic propagation velocity (APV) and found a significant correlation between APV and vWF levels. The novel metric of APV could aid in early recognition of vascular functional alterations and potential risk factor surveillance and modification.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Qiaoli Zeng, Taili Yang, Wenfeng Wei, Dehua Zou, Yue Wei, Fengqiong Han, Jieyun He, Jinzhi Huang, Runmin Guo
Summary: The study found that GLO1 rs1130534 was associated with an increased susceptibility to GDM and higher blood glucose levels, while GLO1 rs4746 was associated with a decreased risk of GDM. The rs1781735 variant was linked to maternal glyoxal accumulation and subsequent weight gain in neonates.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Louise Fritsche, Martin Heni, Sabine S. Eckstein, Julia Hummel, Anette Schurmann, Hans-Ulrich Haring, Hubert Preissl, Andreas L. Birkenfeld, Andreas Peter, Andreas Fritsche, Robert Wagner
Summary: This study aimed to investigate the incretin response during an oral glucose tolerance test (OGTT) in pregnant women. The results showed that insulin secretion was lower in women with gestational diabetes mellitus (GDM), but the increase in GLP-1 was only associated with insulin secretion in GDM women. Additionally, postprandial GLP-1 levels were negatively associated with birth weight.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Medicine, General & Internal
Xinyang Yu, Zhengfei Liu, Jie Fang, Hongbo Qi
Summary: miR-96-5p plays a significant role in diagnosing gestational diabetes mellitus (GDM), with decreased levels in both placenta and plasma samples of patients with GDM. It can serve as a diagnostic biomarker for GDM with high sensitivity and specificity, and may participate in the pathogenesis of GDM by affecting the viability of trophoblasts.
Article
Endocrinology & Metabolism
S-S Tong
Summary: The study found that serum betatrophin concentration was significantly increased in GDM patients, and positively correlated with BMI, TG, TC, FSI, and HOMA-IR. Insulin resistance may be a mechanism involved in the overexpression of serum betatrophin in GDM patients, suggesting that serum betatrophin could potentially be used as a biochemical indicator for predicting GDM.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2021)
Article
Endocrinology & Metabolism
Colm Mcelwain, Samprikta Manna, Andrea Musumeci, Isaac Sylvester, Chloe Rouchon, Anne Marie O'Callaghan, Mustafa Abdalla Bakhit Ebad, Fergus Mccarthy, Cathal Mccarthy
Summary: This study finds that GDM-obese pregnancies are characterized by inadequate VAT remodeling and dysfunctional molecular signaling, which contribute to insulin resistance and hinder metabolic health.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Medicine, General & Internal
Ermioni Tsarna, Anna Eleftheriades, Efthymia Tsomi, Georgia Ziogou, Panagiotis Vakas, Theodoros Panoskaltsis, Panagiotis Christopoulos
Summary: This study found that there was no association between certain food categories and gestational diabetes mellitus (GDM) diagnosis. However, intake of cereals and fruits and vegetables appeared to have a protective effect against GDM, while frequent tea consumption was linked to a higher risk. These results highlight the importance of changing dietary habits during pregnancy to adjust one's risk of metabolic pregnancy complications, such as GDM.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Theresa Vilsmaier, Helene Hildegard Heidegger, Lennard Schroeder, Elisabeth Trapp, Alaleh Zati Zehni, Brigitte Rack, Wolfgang Janni, Sven Mahner, Tobias Weissenbacher, Udo Jeschke, Jan-Niclas Mumm
Summary: The study aimed to evaluate specific cytokine profiles as potential prognostic markers for breast cancer patients, finding that increased IL-15 serum levels are associated with worse survival outcomes, while elevated eotaxin levels in CTC-negative patients are linked to better survival outcomes, suggesting potential inhibitory effects on CTCs.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2021)
Article
Biochemistry & Molecular Biology
Alaleh Zati Zehni, Falk Batz, Aurelia Vattai, Till Kaltofen, Svenja Schrader, Sven-Niclas Jacob, Jan-Niclas Mumm, Helene Hildegard Heidegger, Nina Ditsch, Sven Mahner, Udo Jeschke, Theresa Vilsmaier
Summary: This study aimed to evaluate the prognostic value of steroid hormone receptor expression in breast cancer patients, focusing on the retinoid X receptor (RXR) and thyroid hormone receptors (THRs). The analysis showed significant correlations between RXR and THRs expression and survival in different breast cancer entities. The findings suggest the need for further investigation into molecular therapies targeting steroid hormone receptors in breast cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Lin Peng, Huixia Yang, Yao Ye, Zhi Ma, Christina Kuhn, Martina Rahmeh, Sven Mahner, Antonis Makrigiannakis, Udo Jeschke, Viktoria von Schonfeldt
Summary: PPARs play vital roles in pregnancy, and dysfunctions of PPARs may lead to various related pregnancy diseases such as recurrent miscarriage and preeclampsia. This review discusses the impact of regulating PPARs on trophoblast physiological conditions and explores the underlying mechanisms of PPARs in controlling pregnancy-related processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Bastian Czogalla, Alexandra Partenheimer, Susann Badmann, Elisa Schmoeckel, Doris Mayr, Thomas Kolben, Susanne Beyer, Anna Hester, Alexander Burges, Sven Mahner, Udo Jeschke, Fabian Trillsch
Summary: The study revealed that high nuclear expression of Enolase-1/MBP-1 in epithelial ovarian cancer is associated with improved overall survival, while showing a negative correlation with tumor grading and other clinical parameters.
TRANSLATIONAL ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Anna Trebo, Nina Ditsch, Tom Degenhardt, Christina Kuhn, Martina Rahmeh, Elisa Schmoeckel, Doris Mayr, Bastian Czogalla, Thomas Kolben, Sarah Meister, Sven Mahner, Udo Jeschke, Anna Hester
Summary: This study found that Siglec-8 is expressed in breast cancer cells and is correlated with known clinical and prognostic parameters, possibly regulated via PPAR gamma. Gal-7 and TA-MUC1 are clinical prognosticators only in the group expressing high levels of Siglec-8.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Qun Wang, Aurelia Vattai, Theresa Vilsmaier, Till Kaltofen, Alexander Steger, Doris Mayr, Sven Mahner, Udo Jeschke, Helene Hildegard Heidegger
Summary: This study identified 22 immune-related genes significantly associated with survival of cervical cancer through analysis of data from TCGA and ImmPort databases. These genes actively participate in the JAK-STAT pathway. A prognostic model based on 10 novel genes was established, showing stable predictive performance in SCC patients. These findings provide important insights for personalized treatment of cervical cancer patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Sanja Loeb, Aurelia Vattai, Christina Kuhn, Elisa Schmoeckel, Sven Mahner, Achim Woeckel, Thomas Kolben, Christiane Keil, Udo Jeschke, Theresa Vilsmaier
Summary: This study revealed significant changes in the expression of PZP and GdA in decidual tissue in patients experiencing spontaneous miscarriage and recurrent miscarriage, with a negative correlation between the two proteins. A balanced expression of GdA and PZP in the decidua appears crucial for successful ongoing pregnancy.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Nadine Ansorge, Christian Dannecker, Udo Jeschke, Elisa Schmoeckel, Doris Mayr, Helene H. Heidegger, Aurelia Vattai, Maximiliane Burgmann, Bastian Czogalla, Sven Mahner, Sophie Fuerst
Summary: The study found that the expression of COX-2 and PPAR gamma in vulvar cancer tissues is associated with survival rate, with cytoplasmic expression leading to reduced survival and nuclear expression associated with better survival. The combined expression of both COX-2 and PPAR gamma in the cytoplasm is considered an independent negative prognostic factor for vulvar cancer patients.
Article
Immunology
Sanja Loeb, Niklas Amann, Christina Kuhn, Elisa Schmoeckel, Achim Woeckel, Alaleh Zati Zehni, Till Kaltofen, Simon Keckstein, Jan-Niclas Mumm, Sarah Meister, Thomas Kolben, Sven Mahner, Udo Jeschke, Theresa Vilsmaier
Summary: The study found a significant upregulation of IL-1 beta in the decidua of recurrent miscarriage specimens, as well as in the decidua of spontaneous abortion cases, suggesting its potential role in early pregnancy loss. Double-immunofluorescence revealed that decidual stroma cells are the major IL-1 beta expressing cells at the fetomaternal interface.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2021)
Article
Oncology
Anna Buchholz, Aurelia Vattai, Sophie Furst, Theresa Vilsmaier, Christina Kuhn, Elisa Schmoeckel, Doris Mayr, Christian Dannecker, Sven Mahner, Udo Jeschke, Helene H. Heidegger
Summary: EP4 was found to be commonly expressed in vulvar cancer tissue, with significant correlations to tumor size and FIGO classification, as well as poorer overall survival and disease-free survival. EP4 was identified as an independent prognostic factor, and it was shown in vitro to attenuate viability and proliferation of vulvar cancer cells. Further research on the influence of EP4 in the tumor microenvironment and its potential as a therapeutic target is needed.
Article
Biochemistry & Molecular Biology
Lin Peng, Anca Chelariu-Raicu, Yao Ye, Zhi Ma, Huixia Yang, Hellen Ishikawa-Ankerhold, Martina Rahmeh, Sven Mahner, Udo Jeschke, Viktoria von Schoenfeldt
Summary: The study investigates the potential pathological mechanism of the EP4 receptor in regulating extravillous trophoblast cells in women with unexplained recurrent miscarriage. The results show that decreased expression of EP4 in EVT is associated with uRM, leading to inhibition of proliferation and induction of apoptosis in vitro. Additionally, reductions in hCG, progesterone, and IL-6 were observed, likely due to the activation of the cAMP-PKA-pCREB pathway. These findings provide insight into the role of EP4 in trophoblast function during early pregnancy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Tilman L. R. Vogelsang, Aurelia Vattai, Elisa Schmoeckel, Till Kaltofen, Anca Chelariu-Raicu, Mingjun Zheng, Sven Mahner, Doris Mayr, Udo Jeschke, Fabian Trillsch
Summary: High expression of TAAR1 in ovarian cancer patients is positively correlated with overall survival, especially enhanced in low-grade serous carcinomas. The potential prognostic relevance of TAAR1 in signal transduction of thyroid hormone derivatives in epithelial ovarian cancer warrants further investigation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Huixia Yang, Zhi Ma, Lin Peng, Christina Kuhn, Martina Rahmeh, Sven Mahner, Udo Jeschke, Viktoria von Schoenfeldt
Summary: The study showed differences in global H3K4me3 modification between ICSI and IVF, as well as between boys and girls. ICSI boys had more genes with differentially enriched H3K4me3 compared to ICSI girls, IVF girls, and IVF boys. Oxygen conditions, Polr2A, and KDM5A were found to regulate H3K4me3. This study provides insights into ART-associated epigenetic alterations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Mingjun Zheng, Junyu Long, Anca Chelariu-Raicu, Heather Mullikin, Theresa Vilsmaier, Aurelia Vattai, Helene Hildegard Heidegger, Falk Batz, Simon Keckstein, Udo Jeschke, Fabian Trillsch, Sven Mahner, Till Kaltofen
Summary: In this study, a prognostic 11-gene signature for advanced serous ovarian cancer was developed using lasso regression on tumor microenvironment-related genes. The established risk score showed improved accuracy in predicting the prognosis of ovarian cancer patients and the potential response to immunotherapy. This model was also found applicable to other cancer types, suggesting its broad usability in predicting biological responses to immunotherapy.
Review
Medicine, General & Internal
Fabian Garrido, Carl Mathis Wild, Johanna Mittelberger, Franziska Dobler, Mariella Schneider, Nadine Ansorge, Melitta Koepke, Annamarie Strieder, Nina Ditsch, Udo Jeschke, Christian Dannecker
Summary: Chemokines play a key role in activating immune checkpoints in cervical cancer progression, affecting prognosis in various aspects. Understanding chemokines and immune checkpoint modulators is crucial for effective treatment of the disease.
MEDICINA-LITHUANIA
(2021)
