Review
Biochemistry & Molecular Biology
Kozo Nakai, Daisuke Tsuruta
Summary: Oxygen in the atmosphere is vital for human life, but the metabolites ROS, produced in excess, can exacerbate skin aging and inflammation. Excessive exposure to air pollutants and other harmful substances can stimulate the production of ROS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Lingyu Ye, Yujia Huang, Xueqing Liu, Xinyu Zhang, Yang Cao, Xiangju Kong, Xiaolei Yuan, Jie Xu, Hui Zhu
Summary: The study revealed that women with preeclampsia had increased maternal apelin concentration but reduced APJ expression in the placenta. Treatment with apelin-13 could attenuate oxidative stress injury in placental trophoblasts through the activation of the PI3K/AKT signaling pathway.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Cell Biology
Joanna Nowaczyk, Barbara Poniedzialek, Piotr Rzymski, Dominika Sikora, Mariola Ropacka-Lesiak
Summary: This study aimed to evaluate platelet parameters in pregnant women with fetal growth restriction (FGR) and their relationship with hemodynamic abnormalities. The study found that FGR patients had impaired oxidative metabolism in platelets, which may lead to oxidative stress and impaired platelet function.
Article
Clinical Neurology
Moinay Kim, Joonho Byun, Yeongu Chung, Si Un Lee, Ji Eun Park, Wonhyoung Park, Jung Cheol Park, Jae Sung Ahn, Seungjoo Lee
Summary: Administering ROS scavengers to patients with acute ICH significantly reduced PHE volume, shortened time to reach target Richmond Agitation Sedation Scale, and reduced length of stay in the intensive care unit.
Article
Medicine, Research & Experimental
Caio Pupin Rosa, Thiago Caetano Andrade Belo, Natalia Cristina de Melo Santos, Evandro Neves Silva, Juciano Gasparotto, Patricia Paiva Corsetti, Leonardo Augusto de Almeida
Summary: Intracellular production of reactive oxygen species (ROS) plays a significant role in both the lethal effects on microorganisms and the regulation of inflammation and metabolism. Various microorganisms have been found to modulate the assembly or disruption of inflammasomes through ROS production. This process is a significant milestone in our understanding of the immunology of intracellular pathogens.
Article
Biochemistry & Molecular Biology
Anton G. Rogov, Tatiana N. Goleva, Khoren K. Epremyan, Igor I. Kireev, Renata A. Zvyagilskaya
Summary: Mitochondria are considered the primary source of ROS in cells, with ROS-induced ROS release triggered in cardiac myocytes under excessive oxidative stress. Using Dipodascus magnusii yeast cells, it was found that prooxidant-induced oxidative stress begins in mitochondria before spreading to the whole cell, with mitochondrial ROS leading to mitochondrial fragmentation.
Article
Engineering, Biomedical
Bijun Zhu, Jiangjiexing Wu, Tong Li, Songtao Liu, Junheng Guo, Yijun Yu, Xinyi Qiu, Yue Zhao, Haoran Peng, Jinli Zhang, Leiying Miao, Hui Wei
Summary: In this study, the use of MVF nanozyme as a precise regulator of ROS in periodontitis is proposed. By selectively eliminating H2O2, the most prominent ROS, MVF contributes to limiting inflammation, regulating immune microenvironment, promoting periodontal regeneration, and stimulating osteogenic differentiation of periodontal stem cells. MVF regulates ROS through the Nrf2/HO-1 pathway and promotes osteogenic differentiation through the PI3K/Akt pathway. Nanozymes have the potential to be an important precision medicine tool in periodontitis therapy.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Biochemistry & Molecular Biology
Yang Zhang, Mengqiu Hao, Xuyang Yang, Su Zhang, Junhong Han, Ziqiang Wang, Hai-Ning Chen
Summary: Colorectal cancer often requires adjuvant therapies to reduce tumor burden, and the efficacy of these therapies is significantly influenced by reactive oxygen species (ROS). ROS-mediated colorectal cancer adjuvant therapies involve multiple mechanisms, and preliminary clinical trials have shown the potential of ROS-manipulating therapy in enhancing treatment outcomes.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Review
Biochemistry & Molecular Biology
Masuko Ushio-Fukai, Dipankar Ash, Sheela Nagarkoti, Eric J. Belin de Chantemele, David J. R. Fulton, Tohru Fukai
Summary: Reactive oxygen species (ROS) and reactive nitrogen species (RNS) play important roles as signaling molecules at physiological levels, but excess levels are associated with cardiovascular disease. Cells regulate ROS and RNS levels by controlling metabolic pathways, with implications for disease treatment strategies.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Review
Biochemistry & Molecular Biology
Yoon-Seok Seo, Jung-Min Park, Jae-Hyeong Kim, Moo-Yeol Lee
Summary: Smoking is a significant risk factor for various diseases due to the production of excessive reactive oxygen species (ROS). This review focuses on how cigarette smoke promotes the formation of ROS and provides key mechanisms involved.
Article
Engineering, Environmental
Steven Lelieveld, Jake Wilson, Eleni Dovrou, Ashmi Mishra, Pascale S. J. Lakey, Manabu Shiraiwa, Ulrich Poeschl, Thomas Berkemeier
Summary: Air pollutants such as aerosols and ozone can cause the generation of reactive oxygen species in the human respiratory tract, leading to oxidative stress and adverse health effects.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Sulagna Dutta, Pallav Sengupta, Sanghamitra Das, Petr Slama, Shubhadeep Roychoudhury
Summary: Reactive nitrogen species (RNS) play important roles in male reproduction, but excessive levels can impair fertility by affecting testicular functions and compromising semen quality. High RNS levels lead to abnormalities in germ cells and gametes, and severely impact maturation and fertilization processes. Conventional semen analyses are not reliable predictors for assisted reproductive technology outcomes in cases of male infertility, highlighting the need for novel assessment and treatment methods.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Xiang-Qun Hu, Lubo Zhang
Summary: Hypoxia during gestation has significant impacts on maternal complications and fetal development. Mitochondrial ROS play a key role in placental dysfunction and pregnancy complications. Therapeutic approaches targeting mitochondrial ROS in placental cells are discussed for potential treatment strategies.
Article
Medicine, General & Internal
Ramana Vaka, Evangeline Deer, Mark Cunningham, Kristen M. McMaster, Kedra Wallace, Denise C. Cornelius, Lorena M. Amaral, Babbette LaMarca
Summary: Preeclampsia is associated with oxidative stress, placental ischemia, and autoantibodies to angiotensin II type I receptor. This study found that mitochondrial dysfunction plays a role in the pathophysiology of preeclampsia, particularly in affecting placental function. Antioxidants may not be an effective treatment for the oxidative stress in preeclampsia.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Prima Buranasin, Hiromi Kominato, Koji Mizutani, Risako Mikami, Natsumi Saito, Kohei Takeda, Takanori Iwata
Summary: Diabetes mellitus is associated with periodontal disease and affects the efficacy of periodontal treatment. Increased reactive oxygen species (ROS) production in periodontal tissues of diabetic patients contributes to insulin resistance and impairs wound healing and tissue repair. Antioxidants and insulin resistance ameliorants may improve wound healing by inhibiting ROS production. This review comprehensively examines the latest evidence on ROS generation in periodontal tissues, particularly related to microbial challenge and diabetes, and discusses the impact of oxidative stress on wound healing in periodontal and dental implant therapies, as well as the potential benefits of administering antioxidants and anti-insulin resistance medications to counteract ROS production and inflammation.
Article
Anatomy & Morphology
Masanori Tachikawa, Hidetoh Toki, Masahiko Watanabe, Masatoshi Tomi, Ken-ichi Hosoya, Tetsuya Terasaki
ANATOMICAL SCIENCE INTERNATIONAL
(2018)
Article
Pharmacology & Pharmacy
Tomohiro Nishimura, Kei Higuchi, Yuko Yoshida, Yuki Sugita-Fujisawa, Kazuaki Kojima, Maiko Sugimoto, Marie Santo, Masatoshi Tomi, Emi Nakashima
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2018)
Article
Chemistry, Multidisciplinary
Yu Takahashi, Tomohiro Nishimura, Kei Higuchi, Saki Noguchi, Yuma Tega, Toshiki Kurosawa, Yoshiharu Deguchi, Masatoshi Tomi
PHARMACEUTICAL RESEARCH
(2018)
Article
Developmental Biology
Christiane Albrecht, Larry Chamley, D. Stephen Charnock-Jones, Sally Collins, Hiroshi Fujiwara, Thaddeus Golos, Solene Grayo, Natalie Hannan, Lynda Harris, Kiyotake Ichizuka, Nicholas P. Illsley, Mitsutoshi Iwashita, Sampada Kallol, Abdulla Al-Khan, Gendie Lash, Takeshi Nagamatsu, Akitoshi Nakashima, Kaoru Niimi, Masataka Nomoto, Christopher Redman, Shigeru Saito, Kenji Tanimura, Masatoshi Tomi, Hirokazu Usui, Manu Vatish, Bryce Wolfe, Eiko Yamamoto, Perrie O'Tierney-Ginn
Article
Chemistry, Medicinal
Tomohiro Nishimura, Yuichiro Sano, Yu Takahashi, Saki Noguchi, Yasuo Uchida, Akinori Takagi, Takahiro Tanaka, Satomi Katakura, Emi Nakashima, Masanori Tachikawa, Tetsuo Maruyama, Tetsuya Terasaki, Masatoshi Tomi
JOURNAL OF PHARMACEUTICAL SCIENCES
(2019)
Article
Multidisciplinary Sciences
Mai Inagaki, Tomohiro Nishimura, Takeo Nakanishi, Hiroaki Shimada, Saki Noguchi, Shin-ichi Akanuma, Masanori Tachikawa, Ken-ichi Hosoya, Ikumi Tamai, Emi Nakashima, Masatoshi Tomi
Article
Pharmacology & Pharmacy
Ken Kurosawa, Koji Chiba, Saki Noguchi, Tomohiro Nishimura, Masatoshi Tomi
DRUG METABOLISM AND DISPOSITION
(2020)
Article
Pharmacology & Pharmacy
Saki Noguchi, Moeko Okochi, Hayumi Atsuta, Rika Kimura, Ayaka Fukumoto, Kyoko Takahashi, Tomohiro Nishimura, Masatoshi Tomi
Summary: OAT4 may play a role in the excretion of azilsartan, candesartan, carboxylosartan, and valsartan, as well as olmesartan. Only OAT4-mediated dianion transport is Cl- sensitive.
DRUG METABOLISM AND PHARMACOKINETICS
(2021)
Article
Pharmacology & Pharmacy
Saki Noguchi, Akinori Takagi, Takahiro Tanaka, Yu Takahashi, Xiaole Pan, Yuka Kibayashi, Ryo Mizokami, Tomohiro Nishimura, Masatoshi Tomi
Summary: The study revealed that ENT1 expression was higher than ENT2 in triple-negative breast cancer cell lines, but both transporters had minimal contribution to fluorouracil uptake and showed no correlation with fluorouracil sensitivity. It suggests that neither ENT1 nor ENT2 significantly affects the sensitivity of TNBC cell lines to fluorouracil.
BIOPHARMACEUTICS & DRUG DISPOSITION
(2021)
Article
Biochemistry & Molecular Biology
Xiaole Pan, Saki Noguchi, Misuzu Ando, Tomohiro Nishimura, Masatoshi Tomi
Summary: The study found that overexpression of miR-126 can inhibit the invasive ability of JEG-3 cells by targeting LIN28A, without affecting proliferation and migration. In addition, miR-126-mediated downregulation of LIN28A may contribute to the onset/deterioration of preeclampsia.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Meeting Abstract
Developmental Biology
Masatoshi Tomi, Takehiro Nomura, Saki Noguchi, Tomohiro Nishimura
Meeting Abstract
Pharmacology & Pharmacy
Tomohiro Nishimura, Yu Ishikawa, Saki Noguchi, Masatoshi Tomi
DRUG METABOLISM AND PHARMACOKINETICS
(2020)
Meeting Abstract
Pharmacology & Pharmacy
Saki Noguchi, Moeko Tobita, Hayumi Atsuta, Rika Kimura, Ayaka Fukumoto, Tomohiro Nishimura, Masatoshi Tomi
DRUG METABOLISM AND PHARMACOKINETICS
(2020)
Meeting Abstract
Developmental Biology
Minako Tanabe, Saki Noguchi, Tomohiro Nishimura, Masatoshi Tomi
Meeting Abstract
Developmental Biology
Tomohiro Nishimura, Masaya Takahashi, Hikari Araki, Saki Noguchi, Masatoshi Tomi