Article
Endocrinology & Metabolism
Noriaki Fukuhara, Takeo Iwata, Naoko Inoshita, Katsuhiko Yoshimoto, Masanobu Kitagawa, Hirokazu Fukuhara, Keita Tatsushima, Mitsuo Yamaguchi-Okada, Akira Takeshita, Junko Ito, Yasuhiro Takeuchi, Shozo Yamada, Hiroshi Nishioka
Summary: This study investigated whether immunohistochemistry could replace genetic analysis as an aid in determining the subtype diagnosis of craniopharyngioma. Results showed that immunohistochemistry can assist in distinguishing between adamantinomatous and papillary subtypes, reflecting significant differences in clinical features.
ENDOCRINE PATHOLOGY
(2021)
Article
Oncology
Sherwin Tavakol, Michael P. Catalino, David J. Cote, Xian Boles, Edward R. Laws, Wenya Linda Bi
Summary: A novel classification scheme for cystic sellar lesions based on the heterogeneity of the cyst wall/contents and the presence of a solid component on imaging was proposed. The study found that different types of cysts were associated with the diagnoses of Rathke cleft cyst and cystic pituitary adenoma, with higher cyst types, fluid-fluid level presence, symptomatic hyperprolactinemia, and obesity being predictors of cystic pituitary adenoma.
FRONTIERS IN ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Maikerly Reyes, Mohammad Taghvaei, Siyuan Yu, Anish Sathe, Sarah Collopy, Giyarpuram N. Prashant, James J. Evans, Michael Karsy
Summary: This review examines the molecular and genetic markers implicated in craniopharyngiomas (CPs) and their impact on tumorigenic pathways, prognosis, and treatment. Various markers, such as BRAF, CTNNB1, EGFR, and VEGF, show differential expression in different types of CP. Targeted treatment modalities and immunotherapy have shown promise in managing CP. Further clinical trials and targeted therapies are needed to improve patient outcomes.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2022)
Article
Multidisciplinary Sciences
Chuan Zhao, Ye Wang, Hongxing Liu, Xueling Qi, Zhongqing Zhou, Xianlong Wang, Zhixiong Lin
Summary: This study confirmed CTNNB1 mutations and detected CTNNB1 expression levels in cyst walls and solid bodies. The proliferative capacity and tumor stem cell niches were assessed to compare the differences between cyst walls and solid bodies. The effect of residual cyst wall on recurrence was also evaluated. The results showed that CTNNB1 mutations were identical in cyst walls and solid bodies, and there was no significant difference in CTNNB1 transcriptional levels between them. The cyst wall exhibited a stronger proliferative capacity and more β-catenin positive cells compared to the solid tumor. Residual cyst wall was significantly associated with tumor recurrence, and the prognosis differed between complete (GTR) and subtotal (STR) resection. The presence of tumor stem cell niches in cyst walls may contribute to recurrence.
SCIENTIFIC REPORTS
(2023)
Article
Endocrinology & Metabolism
Cheng Xu, Songhan Ge, Juanxian Cheng, Huabin Gao, Fenfen Zhang, Anjia Han
Summary: The study reveals the expression of TrkA in craniopharyngioma, especially in adult patients. Additionally, beta-catenin and BRAF V600E mutation can be used for histological classification of adamantinomatous craniopharyngioma (ACP), while Ki-67 can serve as a marker to predict craniopharyngioma recurrence.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Oncology
Shaoyang Li, Bowen Wu, Yingqun Xiao, Jie Wu, Le Yang, Chenxing Yang, Zhongjian Huang, Chengbin Pan, Minde Li, Youqing Yang, Bin Tang, Shenhao Xie, Xiao Wu, Suyue Zheng, Chunliang Wang, Tao Hong
Summary: This study investigated the relationships between craniopharyngiomas (CPs) and contiguous structures, as well as the origin of the tumor. The results showed that CPs only invade a certain part of the hypothalamic-pituitary axis, and the finger-like protrusions (FP) may be the tumor origin.
JOURNAL OF NEURO-ONCOLOGY
(2022)
Article
Clinical Neurology
Jesse W. L. Mendoza, Ben A. Strickland, Alexander Micko, Andrew Brunswick, Stefan Wolfsberger, Gabriel Zada
Summary: This study is the first to report an increased prevalence of coexisting PC and RCC, possibly due to an embryologic link or other propensity for intracranial cyst formation. Additional studies in more generalizable populations can further explore the relation between RCC and PC, or other cyst formation.
WORLD NEUROSURGERY
(2021)
Article
Endocrinology & Metabolism
Jose Italo Soares Mota, Rui Milton Patricio Silva-Junior, Clarissa Silva Martins, Ana Carolina Bueno, Luiz Eduardo Wildemberg, Ximene Lima da Silva Antunes, Jorge Guilherme Okanobo Ozaki, Fernanda Borchers Coeli-Lacchini, Carlos Garcia-Peral, Antonio Edson Rocha Oliveira, Antonio Carlos Santos, Ayrton Custodio Moreira, Helio Rubens Machado, Marcelo Volpon dos Santos, Leandro M. Colli, Monica R. Gadelha, Sonir Roberto R. Antonini, Margaret de Castro
Summary: This study evaluated the behavior of telomere length in adamantinomtous craniopharyngioma (aCP) and found that CTNNB1 mutations are associated with progressive disease and shorter telomeres in aCP.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Juan He, Zhen Zeng, Yuelong Wang, Jiaojiao Deng, Xin Tang, Fujun Liu, Jianhan Huang, Hongxu Chen, Ruichao Liang, Xin Zan, Zhiyong Liu, Aiping Tong, Gang Guo, Jianguo Xu, Xiaofeng Zhu, Liangxue Zhou, Yong Peng
Summary: The study revealed that craniopharyngioma (CP) has fewer somatic mutations compared to malignant tumors, and mutations in CTNNB1 in adamantinomatous-type CP (ACP) and BRAF V600E in papillary-type CP (PCP) are mutually exclusive. A novel mutation in exon 3 of CTNNB1 was identified, showing that it can activate the Wnt-signaling pathway by increasing beta-catenin stability and promoting cell proliferation through experimental validation.
Article
Clinical Neurology
Wanchun Zhu, Tianchi Tang, Shijun Yuan, Bowen Chang, Shiting Li, Ming Chen
Summary: This study explored the relationship between cystic performances and CTNNB1 mutation in pediatric cystic ACP patients, finding that CTNNB1 MUT PCACP patients often exhibit multiple cysts, irregular shape, and specific MRI features. The combination of these features can enhance diagnostic accuracy, offering valuable insights for preoperative management.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2021)
Review
Endocrinology & Metabolism
John Richard Apps, Hermann Lothar Muller, Todd Cameron Hankinson, Torunn Ingrid Yock, Juan Pedro Martinez-Barbera
Summary: Craniopharyngiomas are aggressive tumors that tend to recur after therapy. They are divided into two types based on histology and molecular features. Patients often experience symptoms related to the tumor location, such as increased intracranial pressure, endocrine deficiencies, and visual defects. Treatment options are diverse but mostly noncurative, including surgery and radiotherapy. Targeted therapies have been used in recent years, and clinical trials are ongoing. For patients at risk of hypothalamic syndrome, treatment strategies that spare the hypothalamus are recommended.
Article
Oncology
Nicolas Penel, Sylvie Bonvalot, Andre-Michel Bimbai, Alexandra Meurgey, Francois Le Loarer, Sebastien Salas, Sophie Piperno-Neumann, Christine Chevreau, Pascaline Boudou-Rouquette, Pascale Dubray-Longeras, Jean-Emmanuel Kurtz, Cecile Guillemet, Emmanuelle Bompas, Antoine Italiano, Axel Le Cesne, Daniel Orbach, Julien Thery, Marie-Cecile Le Deley, Jean-Yves Blay, Olivier Mir
Summary: This prospective nationwide cohort study aimed to investigate the outcomes of desmoid-type fibromatosis (DF), focusing on the prognostic value of CTNNB1 mutations. The results showed that CTNNB1 mutation profile was associated with unfavorable prognostic factors but was not a prognostic factor for event-free survival (EFS).
CLINICAL CANCER RESEARCH
(2022)
Article
Clinical Neurology
Xiejun Zhang, Jihu Yang, Yan Huang, Yufei Liu, Lei Chen, Fanfan Chen, Guodong Huang
Summary: Retrospectively analyzing cases, it was found that complete sucking out the cyst contents and partial resection of the cyst wall may be sufficient for treatment of symptomatic RCC with EES. Total resection of the cyst wall is associated with a higher incidence of complications.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Hiroki Yamada, Ryo Ueda, Hiroyuki Ozawa, Masahiro Toda
Summary: Endoscopic endonasal cyst fenestration is an effective treatment for symptomatic RCC, resulting in symptom improvement in the majority of patients. Appropriate sellar floor reconstruction after surgery reduces the risk of cerebrospinal fluid leakage without impacting cyst regrowth.
WORLD NEUROSURGERY
(2022)
Article
Immunology
Yilamujiang Ainiwan, Yiguang Chen, Chaofu Mao, Junxiang Peng, Siyuan Chen, Songtao Wei, Songtao Qi, Jun Pan
Summary: In this study, a reliable animal model of adamantinomatous craniopharyngioma (ACP) cyst fluid-induced hypothalamic injury was established. It was found for the first time that ACP cyst fluid can trigger inflammatory activation of microglia to damage the hypothalamus, which may be related to the upregulation of the CD74-APP interaction and deposition of beta-amyloid, implying that there may be a similar mechanism between ACP cyst fluid damage to the hypothalamus and neurodegenerative diseases.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Pathology
Umberto Malapelle, Francesco Pepe, Pasquale Pisapia, Annalisa Altimari, Claudio Bellevicine, Hans Brunnstrom, Rossella Bruno, Reinhard Buttner, Luis Cirnes, Carlos E. De Andrea, Dario de Biase, Catherine Dumur, Kajsa Ericson Lindquist, Gabriella Fontanini, Eugenio Gautiero, David Gentien, Paul Hofman, Veronique Hofman, Antonino Iaccarino, Maria Dolores Lozano, Clara Mayo-de-Las-Casas, Sabine Merkelbach-Bruse, Fabio Pagni, Ruth Roman, Fernando C. Schmitt, Janna Siemanowski, Sinchita Roy-Chowdhuri, Giovanni Tallini, Francesc Tresserra, Sara Vander Borght, Philippe Vielh, Elena Vigliar, Giulia Anna Carmen Vita, Birgit Weynand, Rafael Rosell, Miguel Angel Molina Vila, Giancarlo Troncone
Summary: Gene fusion assays are crucial for personalized treatments of advanced human cancers. This study developed and validated gene fusion reference standards using cell line slides, finding that better results were obtained with Pap staining and amplicon-based assays. Further optimization is required for MGG stained cells and hybridisation-based approaches.
JOURNAL OF CLINICAL PATHOLOGY
(2023)
Article
Endocrinology & Metabolism
Agnese Orsatti, Antonio De Leo, Federico Chiarucci, Giulia Simoncini, Nadia Cremonini, Adele Fornelli, Luca Amorosa, Thais Maloberti, Dario de Biase, Giovanni Tallini
Summary: Multifocal fibrosing thyroiditis is a rare thyroid disease characterized by fibrotic scar-like lesions and atypical follicular cells. It is often associated with other thyroid conditions such as lymphocytic thyroiditis, nodular hyperplasia, and hyperthyroidism. It is also linked to papillary thyroid carcinoma.
ENDOCRINE PATHOLOGY
(2022)
Review
Oncology
Johan M. Kros, Elisabeth Rushing, Aime L. Uwimana, Aurelio Hernandez-Lain, Alex Michotte, Maysa Al-Hussaini, Franck Bielle, Christian Mawrin, Gianluca Marucci, C. Mircea S. Tesileanu, Roger Stupp, Brigitta Baumert, Martin van den Bent, Pim J. French, Thierry Gorlia
Summary: The histologic parameters, especially the mitotic count, provide additional prognostic value in IDH mutant astrocytomas. The mitotic count significantly affects the PFS and marginally the OS. Furthermore, the mitotic count also affects the PFS of tumors with CDKN2A/B homozygous deletion.
Article
Biochemistry & Molecular Biology
Antonio De Leo, Daniela Serban, Thais Maloberti, Viviana Sanza, Sara Coluccelli, Annalisa Altimari, Elisa Gruppioni, Federico Chiarucci, Angelo Gianluca Corradini, Andrea Repaci, Alessandra Colapinto, Margherita Nannini, Maria A. Pantaleo, Dario de Biase, Giovanni Tallini
Summary: BRAF non-V600E mutations are uncommon in thyroid carcinoma, typically found in indolent follicular-patterned tumors, but can also be found in tumors with metastatic potential concomitant with other molecular alterations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Valentina Opancina, Silvia Esposito, Francesco Di Meco, Eleonora Bruno, Marco Moscatelli, Ignazio G. Vetrano, Luisa Chiapparini, Miljan Opancina, Mariangela Farinotti, Nebojsa Zdravkovic, Bianca Pollo, Gianluca Marucci, Fabio M. Doniselli
Summary: The purpose of this study is to summarize the typical and atypical MRI findings of pediatric isolated-not NF1-related pilocytic astrocytomas (pPAs) and correlate specific MRI patterns with clinical variables. The results showed that typical MRI findings of pediatric pPAs include well-defined contours, hypo- and hyperintense signals on T1-wi and T2-wi, hyperintense signals on FLAIR, and heterogeneous signals on T1-wi and T2-wi sequences. Additionally, a positive correlation was found between pPA location and age, while the degree of connection between pPA location and gender was small.
NEUROLOGICAL SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Maria Vittoria Marvi, Irene Neri, Camilla Evangelisti, Giulia Ramazzotti, Sofia Asioli, Matteo Zoli, Diego Mazzatenta, Niccolo Neri, Luca Morandi, Caterina Tonon, Raffaele Lodi, Enrico Franceschi, James A. McCubrey, Pann-Ghill Suh, Lucia Manzoli, Stefano Ratti
Summary: Phospholipases are crucial enzymes that hydrolyze phospholipids, the most abundant species in the biological membranes of healthy human brain cells. They generate lipid mediators that play essential roles in intra- and inter-cellular signaling, regulating various cellular mechanisms involved in tumor progression and aggressiveness.
Article
Medicine, General & Internal
Dario de Biase, Thais Maloberti, Angelo Gianluca Corradini, Francesca Rosini, Marco Grillini, Martina Ruscelli, Sara Coluccelli, Annalisa Altimari, Elisa Gruppioni, Viviana Sanza, Daniela Turchetti, Andrea Galuppi, Martina Ferioli, Susanna Giunchi, Giulia Dondi, Marco Tesei, Gloria Ravegnini, Francesca Abbati, Daniela Rubino, Claudio Zamagni, Pierandrea De Iaco, Donatella Santini, Claudio Ceccarelli, Anna Myriam Perrone, Giovanni Tallini, Antonio De Leo
Summary: This study compares the new ESGO/ESTRO/ESP risk stratification system with the previous 2016 recommendations for endometrial carcinoma patients. The results show that the new system provides more accurate identification of low-risk and high-risk patients, potentially allowing a more specific selection of patients for post-operative adjuvant therapy.
FRONTIERS IN MEDICINE
(2023)
Editorial Material
Medicine, General & Internal
Dario de Biase, Enrico Franceschi, Gianluca Marucci
FRONTIERS IN MEDICINE
(2023)
Article
Medicine, General & Internal
Matilde Taddei, Silvia Esposito, Gianluca Marucci, Alessandra Erbetta, Paolo Ferroli, Laura Grazia Valentini, Chiara Pantaleoni, Stefano D'Arrigo, Veronica Saletti, Bianca Pollo, Rosina Paterra, Daria Riva, Sara Bulgheroni
Summary: In this study, the cognitive and behavioral outcomes of children with low-grade CNS tumors treated with surgical intervention were analyzed retrospectively. The results showed that the sample had normal cognitive abilities and behavioral functioning, but weaknesses were observed in verbal working memory and processing speed. Factors such as younger age at symptoms' onset, glioneuronal histological type, cortical location with preoperative seizures, timing of surgery, and seizure control after surgery were found to be associated with cognitive and behavioral functioning. Timely treatment and regular assessment are important for the global outcome and daily functioning of these patients.
Article
Health Care Sciences & Services
Martina Ruscelli, Thais Maloberti, Angelo Gianluca Corradini, Francesca Rosini, Giulia Querzoli, Marco Grillini, Annalisa Altimari, Elisa Gruppioni, Viviana Sanza, Alessia Costantino, Riccardo Ciudino, Matteo Errani, Alessia Papapietro, Sara Coluccelli, Daniela Turchetti, Martina Ferioli, Susanna Giunchi, Giulia Dondi, Marco Tesei, Gloria Ravegnini, Francesca Abbati, Daniela Rubino, Claudio Zamagni, Emanuela D'Angelo, Pierandrea De Iaco, Donatella Santini, Claudio Ceccarelli, Anna Myriam Perrone, Giovanni Tallini, Dario de Biase, Antonio De Leo
Summary: This study aims to evaluate the impact of integrated molecular and pathologic risk stratification in the clinical practice of endometrial carcinoma (EC). It found that molecular classes and risk groups were correlated with disease-free survival. The study supports the prognostic importance of EC molecular classification and the essential role of histopathologic assessment in patients' management.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Clinical Neurology
Roberta Di Giacomo, Alessandra Burini, Elisa Visani, Fabio Martino Doniselli, Valeria Cuccarini, Rita Garbelli, Gianluca Marucci, Dalia De Santis, Giuseppe Didato, Francesco Deleo, Chiara Pastori, Andrea Stabile, Flavio Villani, Michele Rizzi, Luca Girardi, Marco de Curtis
Summary: This study describes the clinical, diagnostic, and neuropathological findings of 12 patients with temporal encephaloceles and epilepsy, compared with a control group of 26 patients with temporal lobe epilepsy. The study found that encephaloceles have distinct characteristics including later epilepsy onset, higher prevalence of psychiatric comorbidities, no history of febrile convulsions, and differences in seizure semiology. Neuropathological examination revealed four different patterns of encephaloceles.
NEUROLOGICAL SCIENCES
(2023)
Article
Medicine, General & Internal
Pier Paolo Mattogno, Matteo Zoli, Quintino Giorgio DAlessandris, Daniele Bongetta, Valerio Maria Caccavella, Mario Rigante, Giuseppe Maria Della Pepa, Diego Mazzatenta, Liverana Lauretti, Alessandro Olivi, Giannantonio Spena, Cesare Zoia
Summary: The study aimed to assess the role of the Endoscopic Endonasal Approach (EEA) in the ultra-early management of selected neurosurgical emergencies. The results showed that EEA is a safe and effective technique with good outcomes in centers with adequate experience.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Neurosciences
Alessandro Carretta, Matteo Zoli, Federica Guaraldi, Giacomo Sollini, Arianna Rustici, Sofia Asioli, Marco Faustini-Fustini, Ernesto Pasquini, Diego Mazzatenta
Summary: The role of the endoscopic transplanum-transtuberculum approach (ETTA) in the treatment of pituitary adenomas/PitNETs (PAs) is feasible but associated with higher morbidity compared to the conventional endoscopic approach.
Meeting Abstract
Pathology
C. Ravaioli, F. Ambrosi, M. Lambertini, B. Corti, M. Fiorentino, G. Tallini, D. De Biase, E. Dika, C. Ricci