Article
Rheumatology
Jingru Tian, Dingyao Zhang, Xu Yao, Yaqing Huang, Qianjin Lu
Summary: This study estimated the epidemiology of SLE globally, finding variations in incidence and prevalence rates across different countries and regions. It also highlighted the impact of gender, age, and prevalence estimation method on the findings. SLE was found to occur more frequently in high-income countries.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Ali Duarte-Garcia, Mehmet Hocaoglu, Maria Valenzuela-Almada, Shirley-Ann Osei-Onomah, Jesse Y. Dabit, Alain Sanchez-Rodriguez, Stephanie Q. Duong, Rachel E. Giblon, Hannah E. Langenfeld, Graciela S. Alarcon, Charles G. Helmick, Cynthia S. Crowson
Summary: The incidence and prevalence of systemic lupus erythematosus (SLE) are increasing in the US population, potentially due to the rising ethnic diversity. However, the severity of SLE and the survival gap between SLE and the general population have remained unchanged over time.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
George C. Drosos, Daisy Vedder, Eline Houben, Laura Boekel, Fabiola Atzeni, Sara Badreh, Dimitrios T. Boumpas, Nina Brodin, Ian N. Bruce, Miguel Angel Gonzalez-Gay, Soren Jacobsen, Gyorgy Kerekes, Francesca Marchiori, Chetan Mukhtyar, Manuel Ramos-Casals, Naveed Sattar, Karen Schreiber, Savino Sciascia, Elisabet Svenungsson, Zoltan Szekanecz, Anne-Kathrin Tausche, Alan Tyndall, Vokko van Halm, Alexandre Voskuyl, Gary J. Macfarlane, Michael M. Ward, Michael T. Nurmohamed, Maria G. Tektonidou
Summary: This study developed recommendations for cardiovascular risk management in rheumatic and musculoskeletal diseases, emphasizing the importance of regular screening and management of modifiable CVR factors as well as patient education. The recommendations covered CVR prediction tools, interventions on traditional CVR factors, and interventions on disease-related CVR factors.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Dentistry, Oral Surgery & Medicine
Anne Isine Bolstad, Pria Sehjpal, Stein Atle Lie, Bjorg-Tilde Svanes Fevang
Summary: This study in Norway found that patients with SLE had a significantly higher risk of periodontitis compared to the control population, with the highest difference seen in young patients. This highlights the importance of focusing on dental health in SLE patients.
JOURNAL OF PERIODONTOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Shingo Nakayamada, Yoshiya Tanaka
Summary: The treatment of rheumatoid arthritis was revolutionized with the use of molecular-targeted drugs that target immunoregulatory molecules. The success of treatment with these drugs prompted the development of molecular-targeted drugs for systemic lupus erythematosus. However, systemic lupus erythematosus is a disease with high heterogeneous immune abnormalities, and diverse cells or molecules can be treatment targets. Thus, the identification of subpopulations based on immune abnormalities is essential for the development of effective treatment.
Article
Rheumatology
Bahar Moghaddam, Shelby Marozoff, Lingyi Li, Eric C. Sayre, J. Antonio Avina-Zubieta
Summary: This study demonstrates a persistent mortality gap in all-cause and cause-specific deaths in SLE patients compared with the general population.
Article
Biochemical Research Methods
Daniel Toro-Dominguez, Jordi Martorell-Marugan, Manuel Martinez-Bueno, Raul Lopez-Dominguez, Elena Carnero-Montoro, Guillermo Barturen, Daniel Goldman, Michelle Petri, Pedro Carmona-Saez, Marta E. Alarcon-Riquelme
Summary: This study developed MyPROSLE, an omic-based analytical workflow, to measure the molecular characteristics of individual patients and support therapeutic decisions. Through analysis of nearly 6100 lupus patients and 750 healthy samples, it was found that dysregulation of certain gene-modules is strongly associated with specific clinical manifestations, relapses, long-term remission, and drug response. Therefore, MyPROSLE can accurately predict these clinical outcomes.
BRIEFINGS IN BIOINFORMATICS
(2022)
Review
Medicine, General & Internal
Sigrid Reppe Moe, Hilde Haukeland, Oyvind Molberg, Karoline Lerang
Summary: Research on outcomes of Systemic Lupus Erythematosus (SLE) shows that the standardized mortality ratio ranges from 1.9 to 4.6, with cardiovascular disease being the most common cause of death and ESRD progressing in 5-11% of all SLE patients. There is currently no data supporting an increased incidence of cancer in SLE patients. Further population-based studies are needed, especially inception studies with control groups and follow-up times over 15 years.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Rheumatology
Alexandra Legge, Alicia Malone, John G. Hanly
Summary: The SLICC frailty index (SLICC-FI) has been validated in a prevalent cohort of individuals with longstanding SLE, showing that higher baseline SLICC-FI values are associated with increased mortality risk and damage accrual.
Article
Rheumatology
Lisa Zhu, Manpreet Singh, Sonia Lele, Lori Sahakian, Jennifer Grossman, Bevra Hahn, Maureen McMahon
Summary: This study assessed the validity of QRISK3 in predicting cardiovascular risk in SLE patients compared to other risk models. The results showed that both QRISK3 and PREDICTS performed better than traditional risk scoring methods in predicting cardiovascular disease risk in SLE patients.
LUPUS SCIENCE & MEDICINE
(2022)
Review
Rheumatology
Resit Yildirim, Tatiana Oliveira, David Alan Isenberg
Summary: In recent years, there have been efforts to improve the prognosis and outcome in patients with autoimmune inflammatory rheumatic diseases by using treat-to-target strategy and early intervention strategies with immunosuppressive agents. However, infectious complications due to medication side effects remain a major concern. Vaccination programmes and vaccine immunity play a crucial role in patients with SLE in terms of morbidity and mortality. Although research on vaccines' efficacy and immune response in immunosuppressed patients has increased, there is still a lack of data investigating these parameters for those receiving biological agents, leading to a lack of consensus on a vaccination policy for patients with SLE.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Medicine, General & Internal
Fanny Urbain, Maharajah Ponnaiah, Farid Ichou, Marie Lhomme, Clement Materne, Sophie Galier, Julien Haroche, Eric Frisdal, Alexis Mathian, Herve Durand, Micheline Pha, Miguel Hie, Anatol Kontush, Philippe Cluzel, Philippe Lesnik, Zahir Amoura, Maryse Guerin, Fleur Cohen Aubart, Wilfried Le Goff
Summary: This study uncovers the contribution of disturbed metabolism to the presence of coronary artery calcium and the associated risk of coronary heart disease in patients with systemic lupus erythematosus (SLE). Identification of novel lipid and metabolite biomarkers may help stratifying patients for reducing cardiovascular disease morbidity and mortality in SLE.
Article
Rheumatology
Gabriel Figueroa-Parra, Jose A. Meade-Aguilar, Cassondra A. Hulshizer, Tina M. Gunderson, Alanna M. Chamberlain, Uma Thanarajasingam, Kurt J. Greenlund, Kamil E. Barbour, Cynthia S. Crowson, Ali Duarte-Garcia
Summary: The study aimed to assess the prevalence and incidence of multimorbidity and its association with the SLICC/ACR damage index (SDI) among patients with SLE. The results showed that patients with SLE were more likely to have multimorbidity, both before and after the onset of the disease. Multimorbidity was driven by both SDI-related and unrelated conditions.
Article
Rheumatology
Lingxiao Xu, Jian Zhao, Qing Sun, Xue Xu, Lei Wang, Ting Liu, Yunjuan Wu, Jingfeng Zhu, Linyu Geng, Yun Deng, Alexander Awgulewitsch, Diane L. Kamen, Jim C. Oates, Prithvi Raj, Edward K. Wakeland, R. Hal Scofield, Joel M. Guthridge, Judith A. James, Bevra H. Hahn, Deborah K. McCurdy, Fang Wang, Miaojia Zhang, Wenfeng Tan, Gary S. Gilkeson, Betty P. Tsao
Summary: This research found two novel SAT1 LOF variants through whole exome sequencing in families with multiple siblings affected by systemic lupus erythematosus (SLE), demonstrating their association with SLE. The study highlights the pathogenic role of dysregulated polyamine catabolism in lupus.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Review
Immunology
Yao-Chin Wang, Muh-Shi Lin, Abel Po-Hao Huang, Chieh-Chen Wu, Woon-Man Kung
Summary: This systematic review and meta-analysis demonstrate an increased risk of dementia among participants with systemic rheumatic diseases (SRDs), except for rheumatoid arthritis (RA).
FRONTIERS IN IMMUNOLOGY
(2022)