Article
Rheumatology
Hao-Guang Li, Dan-Min Wang, Feng-Cai Shen, Shu-Xin Huang, Zhi-Duo Hou, Ling Lin, Zheng-Yu Xiao
Summary: Peripheral involvement is common in juvenile-onset non-radiographic axial spondyloarthritis, and risk factors associated with progression to juvenile-onset ankylosing spondylitis include inflammatory back pain, buttock pain, enthesitis, elevated baseline CRP levels, and sacroiliac joint-MRI positivity.
Review
Rheumatology
Priyanka Iyer, Mark Hwang, Lauren Ridley, Michael M. Weisman
Summary: Increasing evidence suggests that mechanotransduction plays a pivotal role in the initiation and propagation of spondyloarthritis. This review examines the evidence and explores the unsolved question of how biomechanical forces contribute to the development and progression of ankylosing spondylitis.
Article
Rheumatology
Samantha S. R. Crossfield, Helena Marzo-Ortega, Sarah R. Kingsbury, Mar Pujades-Rodriguez, Philip G. Conaghan
Summary: This study found that the incidence of ankylosing spondylitis decreased between 1998 and 2007, then increased from 2007 to 2017. The rising prevalence may indicate improved patient survival. However, there is a persisting delay in rheumatology referral and diagnosis, particularly in women.
Article
Rheumatology
Anne Boel, Victoria Navarro-Compan, Annelies Boonen, Philip Mease, Uta Kiltz, Maxime Dougados, Robert Landewe, Desiree van der Heijde
Summary: Through a 3-round Delphi survey, patients and axSpA experts identified the most relevant disease domains to be considered for the core set for axSpA.
JOURNAL OF RHEUMATOLOGY
(2021)
Article
Multidisciplinary Sciences
Sahar Gelfman, Arden Moscati, Santiago Mendez Huergo, Rujin Wang, Veera Rajagopal, Neelroop Parikshak, Vijay Kumar Pounraja, Esteban Chen, Michelle Leblanc, Ralph Hazlewood, Jan Freudenberg, Blerta Cooper, Ann J. Ligocki, Charles G. Miller, Tave Van Zyl, Jonathan Weyne, Carmelo Romano, Botir Sagdullaev, Olle Melander, Aris Baras, Eli A. Stahl, Giovanni Coppola
Summary: In this study, the authors performed genome-wide association analysis and whole-exome analysis to uncover the underlying genetics of HLA-B*27 positive and negative forms of anterior uveitis (AU).
NATURE COMMUNICATIONS
(2023)
Article
Dermatology
Alina I. Marusina, Antonio Ji-Xu, Stephanie T. Le, Atrin Toussi, Lam C. Tsoi, Qinyuan Li, Guillaume Luxardi, Jordan Nava, Lauren Downing, Annie R. Leal, Nikolay Y. Kuzminykh, Olga Kruglinskaya, Marie-Charlotte Bruggen, Iannis E. Adamopoulos, Alexander A. Merleev, Johann E. Gudjonsson, Emanual Maverakis
Summary: ERAP1, ERAP2, and LNPEP, which are aminopeptidases, play a role in autoimmune diseases. The expression of ERAP2 is increased while ERAP1 is decreased in psoriasis patients with autoimmune-linked variants of ERAP. Different layers of skin cells show different expression patterns of aminopeptidases, and in psoriasis, basal keratinocytes also express CCL2 and IL-15. In addition, ERAP2-high skin fibroblasts also express more CXCL14.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Rheumatology
Kenji Kishimoto, Shuji Asai, Mochihito Suzuki, Nobunori Takahashi, Kenya Terabe, Yoshifumi Ohashi, Kyosuke Hattori, Toshihisa Kojima, Shiro Imagama
Summary: This study examined the age at onset and initial symptoms of ankylosing spondylitis in Japanese patients. The average age at onset was 28.9 years, with approximately one-third of patients experiencing onset before the age of 20. The most common initial symptoms were in the back, hip, knee, and buttocks, and younger patients were more likely to have extra-axial involvement.
MODERN RHEUMATOLOGY
(2023)
Article
Rheumatology
Anne Boel, Victoria Navarro-Compan, Desiree van der Heijde
Summary: The study aimed to assess the test-retest reliability of candidate instruments for the mandatory domains of the Assessment of Spondyloarthritis international Society (ASAS)-Outcome Measures in Rheumatology core set for axial spondyloarthritis (axSpA). The results showed good reliability for most instruments in evaluating disease activity in axSpA patients, with composite measures demonstrating higher reliability than single-item measures.
Article
Rheumatology
Mark C. Hwang, MinJae Lee, Lianne S. Gensler, Matthew A. Brown, Amirali Tahanan, Mohammad H. Rahbar, Theresa Hunter, Mingyan Shan, Mariko L. Ishimori, John D. Reveille, Michael H. Weisman, Thomas J. Learch
Summary: This study identified four distinct patterns of spinal disease progression in ankylosing spondylitis patients. Factors associated with higher spinal disease burden groups include male gender, longer disease duration, elevated CRP and smoking history. Independent confirmation in other AS cohorts is needed to confirm these radiographic patterns.
Article
Immunology
Zongchao Yu, Xiaoping Hong, Xiaoli Zhang, Fengping Zheng, Fanna Liu, Huixuan Xu, Chengxin Zhu, Wanxia Cai, Dongzhou Liu, Lianghong Yin, Bo Hu, Donge Tang, Yong Dai
Summary: This study investigated potential pathways involved in the pathogenesis of new-onset ankylosing spondylitis (AS) through systematic proteomic and phosphorylation analyses, and identified proteins that could be used as candidate markers for AS diagnosis and new therapeutic targets.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Jian-xiong Wang, Yue Shen, Xi-le Wang, Lin-li Ma, Sheng-qian Xu
Summary: This study used mendelian randomized analysis (MR) to investigate the causal relationship between clinical phenotypes of endometriosis and ankylosing spondylitis (AS). The study found a causal relationship between infertile endometriosis and AS, but no causal relationship between ovarian endometriosis, pelvic peritoneum endometriosis, rectovaginal endometriosis and AS.
SCIENTIFIC REPORTS
(2023)
Article
Rheumatology
Zhixiu Li, Mohammad Kazim Khan, Sjef M. van der Linden, Bjorn Winkens, Peter M. Villiger, Heinz Baumberger, Hermine van Zandwijk, Muhammad Asim Khan, Matthew A. Brown
Summary: This study found that patients with ankylosing spondylitis (AS) have a higher mortality rate compared to the general population, and healthy individuals carrying the HLA-B27 gene also have a similar risk. Additionally, female patients have a lower life expectancy. However, in the overall European population, the presence of the HLA-B27 gene does not affect survival or the risk of death from cardiovascular disease.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Matilda Morin, Karin Hellgren, Ulf Lindstroem, Thomas Frisell
Summary: This study aims to identify the risk factors for ankylosing spondylitis (AS) during perinatal and early life, while controlling for family-shared confounding using a sibling comparison design. The study found that having older siblings and a history of tonsillectomy in childhood were independently associated with the development of AS, even after adjusting for family-shared factors in a sibling comparison analysis.
Article
Multidisciplinary Sciences
Minkai Song, Xiangyu Wang, Jiawen Gao, Weizhou Jiang, Enguang Bi, Taixue An, Ting Wang, Zishuo Chen, Weilu Liu, Zhanjun Shi, Jun Xiao, Chao Zhang
Summary: This study reveals that the increased expression of circular RNA (circRNA) circIFNGR2 in peripheral blood mononuclear cells is associated with the severity of ankylosing spondylitis (AS). In vitro experiments show that circIFNGR2 promotes macrophage proliferation, regulates M1/M2 macrophage polarization and NF-kB/Akt pathways. Furthermore, circIFNGR2 enhances the expression of iNOS/TNFa and M1 polarization, and inhibits M2 polarization by sponging miR-939. The RNA-binding protein eIF4A3 is found to enhance the production of circIFNGR2. Importantly, miR-939 attenuates joint damage in collagen-induced arthritis mice, while circIFNGR2 reverses this effect. These findings highlight the pro-inflammatory roles of eIF4A3-induced circIFNGR2 in AS by modulating macrophage-associated inflammation through miR-939.
Article
Rheumatology
Diego Benavent, Dafne Capelusnik, Sofia Ramiro, Anna Molto, Clementina Lopez-Medina, Maxime Dougados, Victoria Navarro-Compan
Summary: Female gender is associated with less favorable outcomes in patients with spondyloarthritis, especially in terms of BASDAI, while ASDAS is only associated with gender in pSpA and PsA.