Journal
JOURNAL OF RHEUMATOLOGY
Volume 39, Issue 6, Pages 1238-1240Publisher
J RHEUMATOL PUBL CO
DOI: 10.3899/jrheum.111467
Keywords
SYSTEMIC LUPUS ERYTHEMATOSUS; AUTOANTIBODIES; INTERFERONS; GENETICS
Categories
Funding
- Wake Forest University Health Sciences Center for Public Health Genomics
- US National Institutes of Health (NIH) [AR62277, AR42460, AI53747, AI31584, DE15223, RR20143, AI24717, AI62629, AR48940, AI83194, AR49084]
- US Department of Veterans Affairs, Alliance for Lupus Research, and Rheuminations Inc. [NIH R01 AR060861, NIH K08 AI083790, NIH P30 DK42086]
- National Institute of Allergy and Infectious Diseases [AI071651]
- NIH CTSA
- CTSA [UL1 RR024999]
- Lupus Research Institute
- Alliance for Lupus Research Target Identification in Lupus
- Arthritis National Research
- Foundation Eng Tan
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Objective. To investigate and refine the relationships among systemic lupus erythematosus (SLE) and related autoantibodies, interferon-alpha (IFN-alpha), and various ancestral backgrounds. Methods. We investigated quantitatively defined genetic ancestry through principal component analysis in place of self-reported ancestry. Results. African ancestry was found to be associated with presence of anti-RNP antibody (p = 0.0026), and anti-RNP was correlated with high levels of IFN-alpha (p = 2.8 x 10(-5)). Conclusion. Our data support a model in which African ancestry increases the likelihood of SLE-associated autoantibody formation, which subsequently results in higher levels of serum IFN-alpha. (First Release April 15 2012; J Rheumatol 2012;39:1238-40: doi:10.3899/jrheum.111467)
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