Article
Infectious Diseases
Zohreh Rostami, Luca Cegolon, Nematollah Jonaidi Jafari, Nasrin Gholami, Seyed Vahid Mousavi, Fakhri Allahyari, Atena Azami, Mohammad Javanbakht
Summary: This case report described a 28-year-old male patient with granulomatosis with polyangiitis (GPA), tuberculosis infection, and cerebral venous thrombosis. Clinicians should be aware of potential multiple conditions as crescentic glomerulonephritis can progress to renal failure.
BMC INFECTIOUS DISEASES
(2021)
Review
Cell Biology
Wolfgang H. Goldmann
Summary: Wegener's granulomatosis is a form of systemic vasculitis characterized by inflammation, vasculitis, and glomerulonephritis. PR3-ANCAs are strongly associated with the disease, but their pathogenic significance in vivo is still unclear. Animal models have been used to study the autoimmune origin and pathophysiology of WG, with the goal of better understanding and treating the disease.
CELL BIOLOGY INTERNATIONAL
(2022)
Article
Rheumatology
Michele Iudici, Christian Pagnoux, Delphine S. Courvoisier, Pascal Cohen, Antoine Neel, Achille Aouba, Francois Lifermann, Marc Ruivard, Olivier Aumaitre, Bernard Bonnotte, Francois Maurier, Thomas Le Gallou, Eric Hachulla, Alexandre Karras, Chahera Khouatra, Noemie Jourde-Chiche, Jean-Francois Viallard, Claire Blanchard-Delaunay, Pascal Godmer, Alain Le Quellec, Thomas Quemeneur, Claire de Moreuil, Alexis Regent, Benjamin Terrier, Luc Mouthon, Loic Guillevin, Xavier Puechal
Summary: Patients with localized granulomatosis with polyangiitis (L-GPA) present with different clinical features compared to systemic GPA (S-GPA), with younger age, less frequent saddle nose deformity or subglottic stenosis, and lower PR3-ANCA positivity. Treatment strategies also vary, with less frequent use of CYC and more frequent use of a combination of MTX and glucocorticoids in L-GPA patients. Despite similar relapse risks between L-GPA and S-GPA, L-GPA patients have higher overall survival rates and more frequent relapses in the ENT and lung regions.
Review
Immunology
Claudio Galluzzo, Ilaria Chiapparoli, Ada Corrado, Francesco Paolo Cantatore, Carlo Salvarani, Nicolo Pipitone
Summary: This review focuses on the rare localized forms of idiopathic inflammatory myopathies. These forms are often challenging to diagnose due to their localized nature and can be misdiagnosed as tumors.
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
A. Gravos, K. Katsifa, P. Tselioti, V. Grammatikopoulou, K. Sakellaridis, S. Kanakaki, C. Tsapas, A. Destounis, H. Moschouris, I. Athanasiadou, F. Chatzivasiloglou, E. Ivanova, A. Prekates
Summary: Aneurysm formation is a rare complication of granulomatosis with polyangiitis, which requires urgent endovascular treatment and early initiation of immunosuppression therapy for optimal management.
JOURNAL OF MEDICAL CASE REPORTS
(2021)
Article
Rheumatology
Joana Martins-Martinho, Eduardo Dourado, Nikita Khmelinskii, Pablo Espinosa, Cristina Ponte
Summary: Localized vasculitides are rare conditions with varying clinical features depending on the affected organ. While aspects such as clinical manifestations and histologic findings have been extensively investigated, there is still a lack of robust data on pathogenesis, epidemiology, and treatment. Further research on treatment is needed due to the challenges in diagnosis and exclusion of systemic vasculitis.
CURRENT RHEUMATOLOGY REPORTS
(2021)
Letter
Allergy
Andrea Matucci, Susanna Bormioli, Luisa Bercich, Camilla E. Comin, Michela Bezzi, Emanuele Vivarelli, Alessandra Vultaggio
Summary: Type 2 cytokines play a key role in inflammatory processes in asthma and eosinophilic granulomatosis with polyangiitis, and biologic therapies present new treatment opportunities. Airway remodeling can impact therapeutic responses in severe asthmatic patients. Anti-IL-4/IL-13 strategy can help resolve goblet cell hyperplasia in severe asthmatic patients.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2021)
Article
Medicine, General & Internal
Jesus Rojas-Jaimes, Victor Hugo Rojas Figueroa, Rodrigo Corcuera-Ciudad, Jose Arenas, Julio Garcia-Reynoso
Summary: Granulomatosis with polyangiitis with nasal septal perforation can be confused with infectious diseases like mucosal leishmaniasis, so an in-depth study is necessary for correct treatment. Key characteristics to differentiate Wegener's granulomatosis from infectious diseases include vasculitis, lymphadenopathy, and sinusopathy.
CLINICAL CASE REPORTS
(2021)
Article
Mathematics, Applied
Veronica Danesi, Marco Sansottera, Simone Paleari, Tiziano Penati
Summary: This paper investigates the continuation with respect to a small parameter ε of spatially localized and time periodic solutions in 1-dimensional dNLS lattices. The study applies a normal form algorithm to explore the continuation and linear stability of degenerate localized periodic orbits on lower and full dimensional invariant resonant tori.
COMMUNICATIONS IN NONLINEAR SCIENCE AND NUMERICAL SIMULATION
(2022)
Article
Microbiology
Rhys Grinter, Faye C. Morris, Rhys A. Dunstan, Pok Man Leung, Ashleigh Kropp, Matthew Belousoff, Sachith D. Gunasinghe, Nichollas E. Scott, Simone Beckham, Anton Y. Peleg, Chris Greening, Jian Li, Eva Heinz, Trevor Lithgow
Summary: Acinetobacter baumannii is a high-risk pathogen with rapidly spreading multidrug-resistant lineages. The unique lipoprotein BonA, upregulated in response to polymyxin challenge, has distinct features, forms a decamer through unusual oligomerization, and plays a role in cell envelope function and cell motility. The transient nature of the BonA decamer suggests a dynamic role in A. baumannii's function and potential for new treatment strategies.
Article
Rheumatology
Naomi A. Amudala, Sara Boukhlal, Brittany Sheridan, Carol A. Langford, Abdallah Geara, Peter A. Merkel, Divi Cornec
Summary: Obinutuzumab appears to be a safe and efficacious therapy for patients with ANCA-associated vasculitis who have had refractory disease or a history of anaphylaxis to rituximab. Prospective studies comparing rituximab to obinutuzumab in ANCA-associated vasculitis patients are warranted.
Article
Otorhinolaryngology
Natasha J. Minaya, Vishwanatha Rao, Matthew R. Naunheim, Phillip C. Song
Summary: Although laryngeal manifestations of GPA are often described as subglottic disease presenting with respiratory symptoms, subsite analysis shows that only 25% of patients solely had subglottic disease, with similar rates of sole glottic disease. Different laryngeal subsites have distinct epithelial mucosa, function, and physiology, understanding the specific sites of involvement will determine symptoms and enable better analysis of the underlying mechanisms of disease.
Article
Medicine, General & Internal
Yannis Ahmad, Gabrielle Morawietz, Hatem Ksouri, Joerg C. Schefold, Patrick Zuercher
Summary: Severe intrapulmonary GPA can be present even in the absence of disease-specific radiological signs. Rapid diagnosis through confirmatory biopsy is crucial for initiating life-saving therapy.
CLINICAL CASE REPORTS
(2021)
Editorial Material
Critical Care Medicine
Jennifer A. Morin, Cory R. Gooch, Justin T. Stowell, Jorge M. Mallea, Liuyan Jiang, Mathew Thomas
Summary: This case presents a 71-year-old man with multiple medical conditions and recurrent left pleural effusion. He had been experiencing fevers, fatigue, cough, and weight loss for the past three years. Despite treatment with antibiotics and steroids, his symptoms persisted. The patient had sinus balloon sinuplasty and was receiving sublingual immunotherapy for respiratory allergies.
Article
Critical Care Medicine
Javaria Tehzeeb, Vadim Divilov, Arkar Htoo, Faye Sajjadi, Amit Chopra
Summary: A 21-year-old Hispanic woman with skin lesions, dyspnea, and hemoptysis underwent biopsy and initial treatment without improvement. She had no history of immunodeficiency, malignancies, recent international travel, or sick contacts.
