Article
Medicine, General & Internal
Monika Ostrowska, Emil Michalski, Piotr Gietka, Malgorzata Manczak, Magdalena Posadzy, Iwona Sudol-Szopinska
Summary: This study compared MRI findings between patients clinically suspected of Juvenile Idiopathic Arthritis (JIA) and patients with ankle arthralgia of unknown cause. The results showed that inflammatory features were observed on MRI, with tenosynovitis being significantly more common in JIA patients. However, the MRI summarized score did not effectively differentiate between JIA and non-JIA patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Iwona Sudol-Szopinska, Nele Herregods, Andrea S. Doria, Mihra S. Taljanovic, Piotr Gietka, Nikolay Tzaribachev, Andrea Sabine Klauser
Summary: Over the past decade, imaging techniques for inflammatory arthritis in juvenile arthropathies have significantly improved, allowing for more accurate assessment and diagnosis. Ultrasound and magnetic resonance imaging have seen advancements in resolution, sensitivity, and diagnostic possibilities.
Article
Rheumatology
Naveen Ravichandran, Shivika Guleria, Namita Mohindra, Amita Aggarwal
Summary: This study assessed the long-term functional outcomes in ERA patients from China and found that delay in diagnosis was the sole predictor of poor functional outcome.
Article
Medicine, General & Internal
Monika Ostrowska, Piotr Gietka, Malgorzata Manczak, Emil Michalski, Iwona Sudol-Szopinska
Summary: The study aimed to differentiate between hip arthritis in JIA and hip arthralgia of unknown etiology using MRI. MRI is effective in distinguishing between the two conditions, with good specificity in confirming a diagnosis of JIA.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Health Care Sciences & Services
Nienke J. Kleinrensink, Wouter Foppen, Iris ten Katen, Emmerik F. A. Leijten, Pim A. de Jong, Julia Spierings
Summary: This study evaluated the application of HEMRIS in patients with SpA and psoriasis, showing that some patients had changes in HEMRIS in a one-year interval, but these changes were not associated with changes in clinical disease activity.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Medicine, General & Internal
Lovro Lamot, Marijana Miler, Rudolf Vukojevic, Mandica Vidovic, Mirta Lamot, Ivana Trutin, Nora Nikolac Gabaj, Miroslav Harjacek
Summary: The study found that ERA patients had significantly higher levels of gut inflammation compared to other JIA patients, and this gut inflammation may be related to disease activity and abnormal sacroiliac joint MRI findings. Although NSAID use did not affect fCAL levels, there was a correlation between treatment duration and fCAL concentration.
FRONTIERS IN MEDICINE
(2021)
Article
Rheumatology
Jelena Vojinovic, Ivan Foeldvari, Joke Dehoorne, Violeta Panaviene, Gordana Susic, Gerd Horneff, Valda Stanevicha, Katarzyna Kobusinska, Zbigniew Zuber, Bogna Dobrzyniecka, Jonathan Akikusa, Tadej Avcin, Cecilia Borlenghi, Edmund Arthur, Svitlana Y. Tatulych, Chuanbo Zang, Vassilis Tsekouras, Bonnie Vlahos, Alberto Martini, Nicolino Ruperto
Summary: CLIPPER2 is an 8-year study on the safety and efficacy of etanercept in patients with juvenile idiopathic arthritis (JIA). The study found that etanercept treatment was well tolerated and effective in these patients.
Article
Rheumatology
Selcan Demir, Fatma Bilge Ergen, Onur Taydas, Erdal Sag, Yelda Bilginer, Ustun Aydingoz, Seza Ozen
Summary: The study evaluated the frequency and spectrum of MRI findings of spine involvement in patients with JIA, finding that both ERA and non-ERA patients can have spinal involvement despite clinical symptoms or lack thereof.
RHEUMATOLOGY INTERNATIONAL
(2022)
Review
Medicine, General & Internal
Shi Huan Tay, Joo Guan Yeo, Jing Yao Leong, Salvatore Albani, Thaschawee Arkachaisri
Summary: Juvenile spondyloarthritis (JSpA) is a diverse spectrum of immune-mediated inflammatory arthritides that typically onset in late childhood and adolescence. It is characterized by a strong association with HLA-B27, enthesitis, and bone resorption.
FRONTIERS IN MEDICINE
(2021)
Article
Dentistry, Oral Surgery & Medicine
D. de F. C. Leite, A. L. F. Costa, S. Appenzeller, P. S. F. Campos, M. Q. S. Soares, J. S. Martins, G. D. Prado, F. K. Panzarella
Summary: This study compared inflammatory and structural damage in the temporomandibular joint of patients with juvenile idiopathic arthritis (JIA) and healthy patients, and evaluated the correlations between different classifications. The results showed that JIA patients had more severe signs of inflammation and structural changes, and appropriate management of inflammation may reduce the potential for structural damage to the joint.
INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2022)
Review
Immunology
Arash Maleki, Priya D. D. Patel, C. Steven Foster
Summary: Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatologic disease in children, with uveitis being the most common extra-articular manifestation. This review covers the epidemiology, risk factors, clinical presentation, laboratory tests, treatment options, and complications of JIA and JIA-associated uveitis. The discussion also includes the course of the disease, functional outcome, and quality of life for patients with JIA and JIA-associated uveitis.
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Zi-Yang Fan, Yan-Wei Lin, Ruo-Yang Shi, Ling-Zhan Yu, Rui Wu, Qiu-Ying Yao, Luke D. Wesemann, Jiani Hu, Qi Liu, Yan Zhou, Sheng Chen, Lian-Ming Wu
Summary: Creatine distribution in myocardial segments of idiopathic inflammatory myopathy (IIM) patients was measured using cardiovascular magnetic resonance (CMR) chemical exchange saturation transfer (CEST) creatine mapping. CEST showed increased sensitivity in detecting subclinical myocardial changes compared to conventional CMR mapping sequences, making it a promising CMR sequence for screening subclinical myocardial damage.
EUROPEAN RADIOLOGY
(2023)
Article
Medicine, General & Internal
Tarimobo M. Otobo, Mirkamal Tolend, Arthur B. Meyers, Iwona Sudol-Szopinska, Sayali Joshi, Jennifer Stimec, Nele Herregods, Jacob L. Jaremko, Shirley M. L. Tse, Nigil Haroon, Rahim Moineddin, Nikolay Tzaribachev, Simone Appenzeller, Michal Znajdek, Manuela Perez, Aloysius E. Ligha, Lennart Jans, Emilio Inarejos J. Clemente, Pamela Weiss, Olympia Papakonstantinou, Eva Kirkhus, Marion A. J. van Rossum, Dax G. Rumsey, John Carrino, Jonathan D. Akikusa, Philip G. Conaghan, Andrea S. Doria
Summary: This study used an adaptive multicriteria decision analysis to determine the relative weights of items in the JAMRIS-SIJ scoring system for juvenile idiopathic arthritis. Experts completed a conjoint analysis survey, comparing hypothetical patient profiles to determine the point value of the measurement items. The study found differences in relative weights among the JAMRIS-SIJ measurement items and validated the weighted scoring system.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Mateusz Kotecki, Piotr Gietka, Magdalena Posadzy, Iwona Sudol-Szopinska
Summary: This study evaluated the frequency of cervical spine lesions in 34 children with JIA, finding that 35% of patients were affected. X-ray was found to be superior in diagnosing AAS and SAS despite the advantages of MRI in imaging the atlanto-axial region.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
V. D. Vo Chieu, V. Vo Chieu, F. Dressler, N. Kornemann, A. Pfeil, J. Boettcher, F. Streitparth, L. D. Berthold, M. Dohna, D. M. Renz, S. Hellms
Summary: This study compares unenhanced and enhanced knee joint MRI in evaluating the disease activity of JIA. The results suggest that an augmented MRI protocol with PD-weighted sequences can be used in JIA patients without the need for contrast agent application.
EUROPEAN RADIOLOGY
(2023)
Letter
Rheumatology
Ilaria Maccora, Gabriele Simonini
Article
Oncology
Francesco Pegoraro, Donatella Lasagni, Sandra Trapani, Maria V. Mastrolia, Gabriele Simonini, Giuseppe Indolfi, Massimo Resti
Summary: This retrospective study evaluated MIS-C patients admitted to a children's hospital in Italy and found that thromboembolic events are rare complications of MIS-C. Most patients received anticoagulation and prophylactic anticoagulation was associated with cardiac involvement and higher ferritin levels. This study provides insights into the relationship between MIS-C and thromboembolic events and suggests that established risk factors for pediatric thromboembolism may also apply to MIS-C patients.
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
(2023)
Letter
Oncology
Antonio Scarcella, Edoardo Marrani, Maria Luisa Coniglio, Gabriele Simonini, Elena Sieni
PEDIATRIC BLOOD & CANCER
(2023)
Article
Rheumatology
Ilaria Maccora, Teodoro Oliverio, Ilaria Pagnini, Edoardo Marrani, Maria Vincenza Mastrolia, Gabriele Simonini
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Immunology
Anna Vanni, Alessio Mazzoni, Roberto Semeraro, Manuela Capone, Patrick Maschmeyer, Giulia Lamacchia, Lorenzo Salvati, Alberto Carnasciali, Parham Farahvachi, Teresa Giani, Gabriele Simonini, Giovanni Filocamo, Micol Romano, Francesco Liotta, Mir-Farzin Mashreghi, Lorenzo Cosmi, Rolando Cimaz, Alberto Magi, Laura Maggi, Francesco Annunziato
Summary: Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic condition in childhood, with T cells playing a key role in its pathogenesis. The expression of PD-1 on CD4+ and CD8+ T cells in JIA indicates their active contribution in sustaining chronic inflammation. Targeting PD-1 could be an effective therapeutic strategy for JIA.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Review
Immunology
Ilaria Maccora, Edoardo Marrani, Ilaria Pagnini, Maria Vincenza Mastrolia, Cinzia de Libero, Roberto Caputo, Gabriele Simonini
Summary: Childhood uveitis is a serious condition that can lead to blindness if not properly recognized and treated. This review discusses the main causes, diagnostic approach, risk factors, and difficulties in eye examination for childhood uveitis. The treatment options for childhood uveitis are also discussed in terms of choice, timing, and withdrawal.
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
(2023)
Editorial Material
Immunology
Ilaria Maccora, Preston Land, Virginia Miraldi Utz, Sheila T. Angeles-Han
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
(2023)
Editorial Material
Pediatrics
Francesca Miselli, Maria Vincenza Mastrolia, Gabriele Simonini, Sandra Trapani, Giovanni Battista Calabri
Summary: Among 365 children diagnosed with Kawasaki disease, only 5 (1.4%) had splenomegaly, with 2 of them complicated by macrophage activation syndrome and 3 ultimately diagnosed with alternative systemic illness. Splenomegaly is an atypical manifestation in Kawasaki disease and may indicate underlying complications such as macrophage activation syndrome or other diagnoses.
JOURNAL OF PEDIATRICS
(2023)
Article
Rheumatology
Mohamed-Yacine Khitri, Alessandra Bartoli, Georgina Maalouf, Alban Deroux, Carlo Salvarani, Giacomo Emmi, Omer Karadag, Gerard Espinosa, Mathilde Leclercq, Gabriele Simonini, Mathieu Vautier, Patrice Cacoub, David Saadoun
Summary: This study evaluated the efficacy of tocilizumab in patients with refractory Behcet disease. The results showed that 83% of patients responded to tocilizumab, with 60% achieving complete response and 23% achieving partial response. Tocilizumab also significantly reduced steroid dosage and the need for concomitant disease-modifying antirheumatic drugs. However, a small number of patients experienced mild to moderate side effects and serious adverse events.
JOURNAL OF RHEUMATOLOGY
(2023)
Article
Ophthalmology
Ilaria Maccora, Catherine Guly, Cinzia de Libero, Roberto Caputo, Athimalaipet Ramanan, Gabriele Simonini
Summary: This study reports the demographic, clinical characteristics, and outcomes of children with idiopathic non-infectious uveitis (iNIU) in a multicentric retrospective study. The results show that the majority of patients have a significant improvement in vision at 3 years, but 1 in 6 had impaired vision or blindness in their worse eye.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Review
Genetics & Heredity
Ilaria Maccora, Valerio Maniscalco, Silvia Campani, Simona Carrera, Giulia Abbati, Edoardo Marrani, Maria Vincenza Mastrolia, Gabriele Simonini
Summary: Deficiency of adenosine deaminase 2 (DADA2) is a rare monogenic autoinflammatory disease with a highly variable phenotype. A systematic review identified 90 publications describing 378 patients with DADA2. The most common clinical characteristics included cutaneous manifestations, hematological manifestations, recurrent fever, stroke and polyneuropathy, immunological abnormalities, arthralgia/arthritis, splenomegaly, abdominal involvement, hepatomegaly, recurrent infections, myalgia, and kidney involvement. Early diagnosis and treatment are crucial due to the significant morbidity and mortality associated with this disease.
ORPHANET JOURNAL OF RARE DISEASES
(2023)
Article
Medicine, General & Internal
Sara Immacolata Orsini, Edoardo Marrani, Ilaria Pagnini, Giovanni Taccetti, Vito Terlizzi, Gabriele Simonini
Summary: Patients with cystic fibrosis can also have juvenile idiopathic arthritis, and this report describes the first pediatric case of a patient with cystic fibrosis, Basedow's disease, and juvenile idiopathic arthritis who received treatment with elexacaftor/tezacaftor/ivacaftor (ELX/TEZ/IVA) and anti-tumor necrosis factor alpha (anti-TNF alpha). The report suggests that this combination treatment is safe and effective for these patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Ilaria Maccora, Cinzia De Libero, Matilde Peri, Gioia Danti, Alessio Rossi, Edoardo Marrani, Roberta Pasqualetti, Ilaria Pagnini, Maria Vincenza Mastrolia, Gabriele Simonini
Summary: This study attempted to use laser flare photometry (LFP) in the clinical practice of childhood chronic non-infectious uveitis (cNIU). The results showed a good correlation between LFP measurements and slit lamp evaluation (SLE) results, and LFP values were positively correlated with the presence of complications. This suggests that LFP may be a reliable objective modality to monitor intraocular inflammation in children with cNIU.
Letter
Rheumatology
M. V. Mastrolia, S. I. Orsini, E. Marrani, I. Maccora, I. Pagnini, G. Simonini
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2023)
Article
Pediatrics
Maria Vincenza Mastrolia, Silvia Boscia, Luisa Galli, Lorenzo Lodi, Laura Pisano, Ilaria Maccora, Silvia Ricci, Ilaria Pagnini, Edoardo Marrani, Chiara Azzari, Gabriele Simonini
Summary: Leishmaniasis is linked to HLH, and the measurement of CD8(+) CD38(high)/HLA-DR+ T cells is crucial in distinguishing HLH from sepsis or healthy individuals in children presenting with shock and organ failure.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)