Lack of Association with Rheumatoid Arthritis of Selected Polymorphisms in 4 Candidate Genes: CFH, CD209, Eotaxin-3, and MHC2TA

Objective. To investigate associations with rheumatoid arthritis (RA) of single-nucleotide polymorphisms (SNP) in 4 candidate genes, complement factor H (CFH), CD209 or DC-SIGN, eotaxin-3, and the MHC class II Transactivator (MHC2TA) genes. These SNP have been reported as important for RA (eotaxin-3 and MHC2TA) or for other immune-mediated diseases (CFH and CD209). Methods. Genotypes for the 7 selected SNP were obtained from 1587 patients with RA and 1570 controls of Spanish ancestry. Analyses were carried out after stratification for sex, erosions, rheumatoid factor, shared epitope, anti-cyclic citrullinated peptide antibodies, and the R620W PTPN22 SNP. Results. None of the comparisons between patients with RA and controls or between the different strata of patients according to disease features was significant. Conclusion. None of the SNP in CFH and CD209 showed evidence of association with RA. We (lid not replicate the association of eotaxin-3 with RA described in Koreans, or that of the MHC2T SNP. (First Release July 1 2009; J Rheumatol 2009;36:1590-5.- doi: 10.3899/jrheum.090022)