Article
Dentistry, Oral Surgery & Medicine
Chihiro Kaneko, Tetsuo Kobayashi, Satoshi Ito, Noriko Sugita, Akira Murasawa, Hajime Ishikawa, Koichi Tabeta
Summary: The study found a positive correlation between periodontitis severity, anti-agalactosyl IgG titer, and rheumatoid arthritis disease activity in patients with RA. Supragingival scaling was shown to decrease the anti-agalactosyl IgG titer in these patients.
JOURNAL OF PERIODONTAL RESEARCH
(2021)
Article
Health Care Sciences & Services
Chiara Pellicano, Amalia Colalillo, Giuseppina Cusano, Andrea Palladino, Marica Pellegrini, Cinzia Anna Maria Calla, Giorgia Mazzuccato, Valeria Carnazzo, Stefano Pignalosa, Luigi Di Biase, Mariapaola Marino, Umberto Basile, Edoardo Rosato
Summary: This study assessed the serum immunoglobulin G (IgG) subclasses in systemic sclerosis (SSc) patients and their influence on the main complications of the disease. The results showed that SSc patients had lower levels of total IgG, IgG1, and IgG3 compared to healthy controls. Logistic regression analysis found that IgG3 was associated with diffusing capacity of the lung for carbon monoxide (DLco), modified Rodnan skin score (mRSS), and radiological interstitial lung disease (ILD).
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Immunology
Baolin Liao, Zhao Chen, Peiyan Zheng, Linghua Li, Jianfen Zhuo, Fang Li, Suxiang Li, Dingbin Chen, Chunyan Wen, Weiping Cai, Shanhui Wu, Yanhong Tang, Linwei Duan, Peilan Wei, Fangli Chen, Jinwei Yuan, Jinghong Yang, Jiaxin Feng, Jingxian Zhao, Jincun Zhao, Baoqing Sun, Airu Zhu, Yimin Li, Xiaoping Tang
Summary: Characterizing the serologic features of asymptomatic SARS-CoV-2 infection is crucial for diagnostics and control. This study found that asymptomatic infections exhibit weaker overall antibody responses, primarily inducing IgG antibody responses. Anti-S2-IgG shows better sensitivity in identifying asymptomatic infections early after infection compared to anti-RBD-IgG.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Rheumatology
Yuta Yamashita, Yasuhiko Yamano, Yoshinao Muro, Mariko Ogawa-Momohara, Takuya Takeichi, Yasuhiro Kondoh, Masashi Akiyama
Summary: Objective Anti-NOR90 antibodies are rarely found in clinics, but their detection through ELISA can be useful. This study found that anti-NOR90 antibodies were more frequently detected in patients with systemic scleroderma-spectrum disorders (SSDs) and systemic scleroderma (SSc). Additionally, the presence of anti-NOR90 antibodies in SSc and idiopathic interstitial pneumonia (IIP) patients may be associated with interstitial lung disease (ILD) and cancer. Further studies are needed to confirm these associations.
Article
Immunology
Sunhui Chen, Qiong Liang, Yanhang Zhuo, Qin Hong
Summary: In this study, high-affinity human antibodies fragments were selected using phage display technology for the diagnosis of systemic sclerosis. Three fragments were humanized and analyzed for their physicochemical properties and structural basis. The electrostatic potential of their CDR regions determined their affinity and expression levels. The 2A fragment showed the highest affinity and specificity for Scl-70 but with the lowest expression level, which may provide new diagnostic strategies for systemic sclerosis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Clinical Neurology
Tetsuya Akaishi, Toshiyuki Takahashi, Tatsuro Misu, Kimihiko Kaneko, Yoshiki Takai, Shuhei Nishiyama, Ryo Ogawa, Juichi Fujimori, Tadashi Ishii, Masashi Aoki, Kazuo Fujihara, Ichiro Nakashima
Summary: Intrathecal production of MOG-IgG may occur more frequently than that of AQP4-IgG, suggesting different properties of B-cell trafficking and antibody production between MOG-IgG-associated disease and AQP4-IgG-positive NMOSD.
Article
Medicine, General & Internal
Ajanee Mahakkanukrauh, Siraphop Suwannaroj, Ratanavadee Nanagara, Chingching Foocharoen
Summary: Around one-fifth of Thai SSc patients have detectable ANCA without features of vasculitis. The presence of ANCA is associated with inflammation and myocardial injury, but ANCA is not a specific antibody for vasculitis in SSc.
ARCHIVES OF MEDICAL SCIENCE
(2021)
Article
Immunology
Maya W. Keuning, Marloes Grobben, Merijn W. Bijlsma, Beau Anker, Eveline P. Berman-de Jong, Sophie Cohen, Mariet Felderhof, Anne-Elise de Groen, Femke de Groof, Maarten Rijpert, Hetty W. M. van Eijk, Khadija Tejjani, Jacqueline van Rijswijk, Maurice Steenhuis, Theo Rispens, Frans B. Plotz, Marit J. van Gils, Dasja Pajkrt
Summary: This study evaluated the feasibility of using saliva antibody assays for identifying SARS-CoV-2 humoral immunity in children. Results showed a slightly lower prevalence of S-specific IgG in saliva compared to serum, and differences in antibody levels were observed between girls and immunocompromised children.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Dermatology
Shintaro Saito, Yukie Endo, Mayu Nishio, Akihiko Uchiyama, Akihito Uehara, Sayaka Toki, Masahito Yasuda, Osamu Ishikawa, Yoshinao Muro, Sei-ichiro Motegi
Summary: This case report describes a male patient with overlap syndrome of multiple connective tissue diseases, involving multiple organ systems. The condition is complex and difficult to treat.
JOURNAL OF DERMATOLOGY
(2022)
Article
Medicine, General & Internal
Laura Martinez-Prat, Victor Martinez-Taboada, Cruz Santos, Marcos Lopez-Hoyos, Michael Mahler
Summary: This study evaluated the presence of anti-protein-arginine deiminase (PAD) 4 IgG and IgA in the sera of rheumatoid arthritis (RA) patients and disease controls. The results showed that anti-PAD4 IgG and IgA are associated with severe RA and can serve as important biomarkers for prognosis prediction and patient stratification.
Review
Immunology
Aurelien Chepy, Louisa Bourel, Vincent Koether, David Launay, Sylvain Dubucquoi, Vincent Sobanski
Summary: Systemic sclerosis (SSc) is a connective tissue disease characterized by extensive fibrosis of the skin and internal organs. Antinuclear antibodies (ANA) are found in almost all SSc patients, but the exact role they play in the disease remains unclear. However, studies have shown that ANA may be associated with disease subtypes, appear before disease onset, correlate with disease activity and severity, and have a response to B-cell targeting therapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Urology & Nephrology
Ying Zhang, Ping Chen, Baobao Wang, Xueqing Tang, Yong Wei, Wei Cao, Lijun Tang, Zunsong Wang, Na Zhao
Summary: This study found that the containing anti-PLA2R IgG antibody in patients with idiopathic membranous nephropathy might have a direct damaging effect on podocytes, leading to abnormal expression and structure, as well as increased podocyte apoptosis.
Article
Immunology
Claus-Juergen Bauer, Pantelis Karakostas, Nadine Weber, Charlotte Behning, Birgit Stoffel-Wagner, Peter Brossart, Ramona Dolscheid-Pommerich, Valentin Sebastian Schaefer
Summary: This study is the first to prospectively investigate the performance of two of today's most commonly applied anti-dsDNA testing methods head-to-head under real-world conditions, as well as their correlation with other clinical and serological disease parameters in SLE patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Hiraku Sasaki, Tomoko Fukunaga, Ai Asano, Kansuke Yamanaka, Kota Oikawa, Nobuto Shibata
Summary: In Japan, the coverage rate of monovalent mumps virus (MuV) vaccine among 18-20 year old participants was only 48%. Those with a medical history and more than two doses of vaccination had significantly higher antibody titers. Seropositivity against MuV infection was over 50% regardless of the number of vaccinations.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2021)
Article
Immunology
Wenbo Zhou, Michael Graner, Cheryl Beseler, Timothy Domashevich, Sean Selva, Gill Webster, Aurelie Ledreux, Zoe Zizzo, Max Lundt, Enrique Alvarez, Xiaoli Yu
Summary: We have developed a new method to use levels of IgG aggregates in the plasma of multiple sclerosis (MS) patients as biomarkers for the disease. Our study shows significantly higher levels of IgG1, IgG3, and total IgG antibodies in MS IgG aggregates, with IgG1 levels able to distinguish different types of MS. Importantly, we have also demonstrated a strong correlation between IgG antibodies and IgG aggregate-induced neuronal cytotoxicity.
CLINICAL IMMUNOLOGY
(2023)
Article
Oncology
Atsushi Enomoto, Takemichi Fukasawa, Hiroshi Terunuma, Keiichi Nakagawa, Ayumi Yoshizaki, Shinichi Sato, Kiyoshi Miyagawa
Summary: This study reveals that hyperthermia can inhibit cell proliferation and clonogenicity by regulating the expression levels of TAK1, RAF1, and MEKK2 in the MAPK signaling pathway. These findings provide potential molecular targets for hyperthermia.
INTERNATIONAL JOURNAL OF HYPERTHERMIA
(2022)
Article
Dermatology
Satoshi Ebata, Ayumi Yoshizaki, Takemichi Fukasawa, Asako Yoshizaki-Ogawa, Yoshihide Asano, Kosuke Kashiwabara, Koji Oba, Shinichi Sato
Summary: This study investigated whether B-cell responsiveness to rituximab is related to therapeutic effect in patients with systemic sclerosis-associated interstitial lung disease. The findings suggest that the rate of B-cell clearance after 2 weeks of treatment with rituximab may serve as a useful marker for subsequent improvement in SSc-ILD. Patients with less than 5% residual B cells at week 2 showed significant improvement in lung function compared to baseline.
JOURNAL OF DERMATOLOGY
(2022)
Article
Rheumatology
Ai Kuzumi, Shunki Mitsuo, Tomomi Miyake, Shinichi Sato, Ayumi Yoshizaki
Review
Immunology
Ayumi Yoshizaki, Takemichi Fukasawa, Satoshi Ebata, Asako Yoshizaki-Ogawa, Shinichi Sato
Summary: This article outlines the role of B cells in the development of systemic sclerosis (SSc), including their involvement in autoimmune abnormalities, pro-inflammatory actions, and inhibitory functions. Studies have found B-cell depletion therapy to be effective for SSc.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Medicine, General & Internal
Satoshi Ebata, Asako Yoshizaki-Ogawa, Shinichi Sato, Ayumi Yoshizaki
Summary: This paper outlines the latest advances in the treatment of systemic sclerosis (SSc), with a focus on the efficacy and safety of Nintedanib, Tocilizumab, and Rituximab.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Rheumatology
Satoshi Ebata, Ayumi Yoshizaki, Koji Oba, Kosuke Kashiwabara, Keiko Ueda, Yukari Uemura, Takeyuki Watadani, Takemichi Fukasawa, Shunsuke Miura, Asako Yoshizaki-Ogawa, Naoko Okiyama, Masanari Kodera, Minoru Hasegawa, Shinichi Sato
Summary: Rituximab is a safe and effective treatment option for improving skin thickening in patients with systemic sclerosis, with sustained benefits for at least 48 weeks.
LANCET RHEUMATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Teruyoshi Hisamoto, Hiraku Suga, Asako Yoshizaki-Ogawa, Shinichi Sato, Ayumi Yoshizaki
Summary: Atopic dermatitis is a common chronic skin disease characterized by Th2 inflammation. The cytokine TL1A has been found to play a role in chronic inflammatory diseases, but its role in atopic dermatitis is unclear.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Kazuki M. Matsuda, Hirohito Kotani, Kei Yamaguchi, Taishi Okumura, Eriko Fukuda, Masanori Kono, Teruyoshi Hisamoto, Ruriko Kawanabe, Yuta Norimatsu, Ai Kuzumi, Maiko Fukayama, Takemichi Fukasawa, Satoshi Ebata, Asako Yoshizaki-Ogawa, Tomohisa Okamura, Hirofumi Shoda, Keishi Fujio, Naoki Goshima, Shinichi Sato, Ayumi Yoshizaki
Summary: Cutaneous arteritis (CA) is a skin vasculitis that affects small to medium-sized arteries. The diagnosis relies on skin biopsy, which can be burdensome. The pathogenesis and treatment of CA are still unclear. In this study, anti-transcobalamin receptor (TCblR) antibodies were found in 24% of CA patients and were associated with skin-limited CA. These antibodies trigger interleukin-6 autocrine loop and induce periarterial inflammation. Methylcobalamin, a ligand of TCblR, can ameliorate inflammation caused by these antibodies. These findings suggest that anti-TCblR antibodies could be a diagnostic marker and a therapeutic target for CA.
JOURNAL OF AUTOIMMUNITY
(2023)
Article
Rheumatology
Takemichi Fukasawa, Satoshi Toyama, Atsushi Enomoto, Asako Yoshizaki-Ogawa, Yuta Norimatsu, Shoko Tateishi, Hiroko Kanda, Kiyoshi Miyagawa, Shinichi Sato, Ayumi Yoshizaki
Summary: This study found that nailfold capillary abnormalities in patients with psoriasis may be a predictive factor for the development of psoriatic arthritis (PsA), and the degree of abnormality may be indicative of disease severity.
Letter
Rheumatology
Takemichi Fukasawa, Asako Yoshizaki-Ogawa, Ayumi Yoshizaki, Shinichi Sato
Article
Rheumatology
Kazuki M. Matsuda, Ayumi Yoshizaki, Ai Kuzumi, Satoshi Toyama, Kentaro Awaji, Tomomi Miyake, Shinichi Sato
Summary: This study aims to summarize the current knowledge on the efficacy of IVIG against GI symptoms of SSc and identify future research directions. The results indicate that IVIG administration can lead to remarkable improvement in GI symptoms, including IPO, and previous reports also support its efficacy. However, further studies with objective and quantitative measures are needed to evaluate short-term outcomes.
Article
Dermatology
Ai Kuzumi, Satoshi Ebata, Takemichi Fukasawa, Kazuki M. Matsuda, Hirohito Kotani, Asako Yoshizaki-Ogawa, Shinichi Sato, Ayumi Yoshizaki
Summary: This cohort study found that long-term use of rituximab for systemic sclerosis improved skin and lung fibrosis, and a decrease in serum immunoglobulins was associated with better clinical response.
Article
Medicine, General & Internal
Mariko Hara, Rumi Ueha, Taku Sato, Takao Goto, Ayumi Yoshizaki, Hayakazu Sumida, Shinichi Sato, Tatsuya Yamasoba
Summary: Systemic sclerosis is often associated with dysphagia and esophageal dysmotility. This study evaluated the association between dysphagia and esophageal dysmotility in patients with systemic sclerosis and identified risk factors. The results showed that dysphagia was associated with autoantibody positivity and older age, while there were no identified risk factors for esophageal dysmotility. No correlation was found between dysphagia and esophageal dysmotility.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Oncology
Takemichi Fukasawa, Atsushi Enomoto, Asako Yoshizaki-Ogawa, Shinichi Sato, Kiyoshi Miyagawa, Ayumi Yoshizaki
Summary: DNA is constantly damaged, and cells have evolved DNA damage response mechanisms to preserve genomic integrity. Kinases play a central role in this response by transmitting the DNA damage signal to various cellular processes. Recently, the role of STK38 in DNA damage signaling has emerged.
Article
Medicine, General & Internal
Yuta Norimatsu, Kazuki Mitsuru Matsuda, Kei Yamaguchi, Chihiro Ono, Taishi Okumura, Emi Kogo, Hirohito Kotani, Teruyoshi Hisamoto, Ai Kuzumi, Takemichi Fukasawa, Asako Yoshizaki-Ogawa, Naoki Goshima, Shinichi Sato, Ayumi Yoshizaki
Summary: This study developed a new method for detecting SSc and DM autoantibodies (A-cube) and examined its validity. The A-cube method showed comparable or higher sensitivity and specificity compared to existing testing methods, and could potentially lead to re-consideration of diagnosis in certain cases. The quality of the A-cube was ensured, and its usefulness for comprehensive analysis was demonstrated.
