Journal
PHYTOTHERAPY RESEARCH
Volume 29, Issue 12, Pages 1950-1955Publisher
WILEY
DOI: 10.1002/ptr.5489
Keywords
bone histomorphometry; bone mineral density; menopause; rat; young coconut juice
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Funding
- JMS Bayer Schering Pharma Grant from the Japan Menopause Society
- Scientific Research Grant from Amano Foundation of Industrial Technology
- Grants-in-Aid for Scientific Research [24790080] Funding Source: KAKEN
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Young coconut juice (Cocos nucifera Linn.) (YCJ) has traditionally been consumed to alleviate symptoms associated with menopause by women in Southeast Asia. The aim of the present study was to determine the effects of YCJ on bone metabolism in ovariectomized rats. Female 10-week-old Wistar rats were randomly assigned to the following 4 groups: Baseline, Sham, Ovx, and Ovx + YCJ (n = 10 rats per group). Rats in the Baseline group were sacrificed immediately, and those in the other groups were subjected to either sham operation (Sham) or bilateral ovariectomy (Ovx and Ovx + YCJ). The Ovx + YCJ rats were administered 5x-concentrated YCJ at a dose of 10 mL/kg body weight per day. Six weeks after surgery, the rats were sacrificed, and indices of bone mass and bone histomorphometry were measured. The bone mineral density of the left femur was significantly higher in the Ovx + YCJ group compared with the Ovx group. In addition, the Ovx + YCJ group showed significantly higher measurements for bone formation rate compared with the Ovx group. These findings suggest that YCJ supplementation has a positive effect on bone metabolism and thus represents a possible intervention to slow the bone loss observed following menopause. Copyright (C) 2015 John Wiley & Sons, Ltd.
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