Journal
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
Volume 90, Issue 1, Pages 82-90Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.jri.2011.03.004
Keywords
Heparin; Assisted reproduction; Thrombophilia; Implantation failure; Thrombosis
Categories
Ask authors/readers for more resources
Despite significant improvements in treatment protocols and laboratory techniques, the baby take-home rate after assisted reproduction (ART) is disappointing, e.g. 20% in Germany. It is therefore understandable that various approaches are undertaken to improve the pregnancy and delivery rates after IVF and ICSI. Among others, the application of heparin is suggested to avoid implantation failure - partially irrespective of maternal thrombophilia. The applications of heparin for various indications are presented in this manuscript and critically discussed, taking into account current studies and meta-analyses. Furthermore, possible effects of heparin on the embryo-maternal dialogue and indications for heparin to prevent and treat thromboembolic disease during ART are summarized. A systematic literature search of the PubMed/Medline database was performed assessing all articles published before November 2010. IVF', ICSI, assisted reproduction, heparin, side effect, coagulation, thrombosis, thrombophilia, thrombophilic disorder, implantation, implantation failure and placenta were used as keywords. The available studies on heparin in assisted reproduction are characterized by heterogeneous inclusion criteria and a lack of proven effectiveness in special constellations. In conclusion, the application of heparin to improve ART outcome rates is not justified. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available