Review
Immunology
Peng Zhang, Yuwen Su, Siying Li, Hui Chen, Ruifang Wu, Haijing Wu
Summary: This paper reviews the different subtypes of T lymphocytes and their functions in psoriasis, as well as provides an overview of targeted therapies for treating psoriasis.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Svetlana Korinfskaya, Sreeja Parameswaran, Matthew T. Weirauch, Artem Barski
Summary: Runx proteins are key regulators of cellular differentiation, with different roles in blood cell and bone cell development. Recent studies show complex relationships between Runx proteins, chromatin-modifying machinery, the cytoskeleton and transcription factors in mature T cells, inflammation, and cancer, with many areas requiring further research.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Jack M. Shireman, Nikita Gonugunta, Lei Zhao, Akshita Pattnaik, Emily Distler, Skyler Her, Xiaohu Wang, Rahul Das, Jaques Galipeau, Mahua Dey
Summary: Age-related immune dysfunctions have close connections with pathologies like cancers and lack of vaccine efficacy among the elderly. An engineered fusokine, GIFT-7, has the potential to reverse aging-related lymphoid organ atrophy. In experiments using aged mouse models of glioblastoma, peripheral vaccination with GIFT-7TVax resulted in thymic regeneration, long-term antitumor immunity, increased pro-inflammatory cytokines, enhanced T-cell trafficking to the brain, and robust T-cell formation.
Article
Immunology
Florent Lemaitre, Negar Farzam-Kia, Ana Carmena Moratalla, Yves Carpentier Solorio, Marie-Laure Clenet, Olivier Tastet, Aurelie Cleret-Buhot, Jean Victor Guimond, Elie Haddad, Pierre Duquette, J. Marc Girard, Alexandre Prat, Catherine Larochelle, Nathalie Arbour
Summary: IL-27 alters immune functions of human astrocytes and shapes the profile and motility of encountered T lymphocytes.
JOURNAL OF NEUROINFLAMMATION
(2022)
Review
Immunology
Chen Dong
Summary: T lymphocytes play a key role in cellular immunity, with significant heterogeneity in CD4(+) T cells leading to the identification of various subsets with unique roles in immunity and pathology. Understanding cytokine regulation and function has provided innovative treatment options for many human diseases.
ANNUAL REVIEW OF IMMUNOLOGY, VOL 39
(2021)
Review
Immunology
Enitome E. Bafor, Julio C. Valencia, Howard A. Young
Summary: The immune regulation of female reproductive function plays a crucial role in fertility, disruptions in immune tolerance can lead to autoimmune subfertility or infertility. Double negative T regulatory cells (DNTregs) are emerging as effector cells capable of mediating immune tolerance in the female reproductive system, potentially providing a paradigm shift from the known roles of conventional regulatory T cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Hang Zou, Niu Zhou, Xiao Cheng, Yi Qiu, Wenhong Hou, Jianbo Sun
Summary: This study revealed that gingipains of Porphyromonas gingivalis are important virulence factors that downregulate B10 cells and alter immune responses.
MOLECULAR ORAL MICROBIOLOGY
(2023)
Article
Immunology
Angelina De Martin, Yves Stanossek, Mechthild Lutge, Nadine Cadosch, Lucas Onder, Hung-Wei Cheng, Joshua D. Brandstadter, Ivan Maillard, Sandro J. Stoeckli, Natalia B. Pikor, Burkhard Ludewig
Summary: Human tonsillar fibroblastic reticular cells undergo dynamic reprogramming during life and exhibit strong response to inflammation. The subset of PI16-expressing reticular cells plays a specialized role in mucosal immune responses.
Article
Gastroenterology & Hepatology
Martin J. Lett, Hema Mehta, Adrian Keogh, Tina Jaeger, Maxime Jacquet, Kate Powell, Marie-Anne Meier, Isabel Fofana, Hassan Melhem, Juerg Vosbeck, Gieri Cathomas, Andres Heigl, Markus H. Heim, Emanuel Burri, Kirsten D. Mertz, Jan Hendrik Niess, Otto Kollmar, Christoph J. Zech, Robert Ivanek, Urs Duthaler, Paul Klenerman, Deborah Stroka, Magdalena Filipowicz Sinnreich
Summary: This study reveals the significant roles of liver cells in the activation and antigen metabolism of MAIT cells. The presence of MAIT cell stimulatory antigens in the serum may contribute to the development of liver diseases.
Article
Immunology
David M. Koelle, Lichun Dong, Lichen Jing, Kerry J. Laing, Jia Zhu, Lei Jin, Stacy Selke, Anna Wald, Dana Varon, Meei-Li Huang, Christine Johnston, Lawrence Corey, Christine M. Posavad
Summary: HSV-2-specific T-RM cells are abundant in the female reproductive tract between episodes of recurrent genital herpes, provide protection, and maintain the ability to expand.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell Biology
Adrian Y. S. Lee
Summary: Although CD20 is primarily known as a B cell marker, it has been observed in a subset of T cells as well. These CD20(+)T cells appear to express more inflammatory cytokines and markers of effector function compared to CD20(-)T cells. The current understanding is that CD20 may be acquired from B cells through trogocytosis. CD20(+)T cells can be found in various diseases including autoimmune diseases, malignancies, and HIV infections. Multiple sclerosis is one of the best-studied diseases where CD20(+)T cells are found and therapeutic interventions targeting CD20 have shown promise in depleting these cells.
INFLAMMATION RESEARCH
(2022)
Article
Cell Biology
Xiaochen Wang, Jianchu Wang, Haiyuan Shen, Zongjiang Luo, Xiaojie Lu
Summary: This study found that TPX2 regulates the antitumor effect of CD8 + T cells in hepatocellular carcinoma (HCC) by modulating CXCR5. Overexpression of TPX2 enhances the anticancer function of CD8 + T cells and shows synergistic effects with anti-PD-1 therapy.
CELL DEATH & DISEASE
(2022)
Review
Oncology
S. Leenen, M. Hermens, P. J. de Vos van Steenwijk, R. L. M. Bekkers, E. M. G. van Esch
Summary: Endometriosis is a risk factor for certain types of ovarian carcinoma, and immunological factors play a key role in the clinical outcome of both conditions. Chronic inflammation in endometriosis may drive carcinogenesis in endometriosis-associated ovarian carcinoma, but the exact immunological pathways and cellular processes involved remain unknown and require further investigation.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Article
Fisheries
Hongfei Tian, Jing Xing, Xiaoqian Tang, Xiuzhen Sheng, Heng Chi, Wenbin Zhan
Summary: Cytokines are small molecular proteins secreted by immune cells to regulate cell growth, differentiation, and effects. T cells have been identified in fish and shown to be involved in the immune response. However, research on fish T cell identification and differentiation is still in its early stages and requires more effort.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2023)
Article
Immunology
Tiago R. Matos, Masahiro Hirakawa, Ana C. Alho, Lars Neleman, Luis Graca, Jerome Ritz
Summary: CD4(+) Regulatory T cells play a critical role in immune homeostasis, but their heterogeneity in different populations including newborns, healthy adults, and patients after allogeneic hematopoietic stem cell transplantation with or without chronic graft-versus-host disease has been compared. The study found that Treg heterogeneity is higher in adults and gradually increases in the first two years post-transplant, while patients with chronic graft-versus-host disease have significantly fewer distinct Treg subpopulations.
FRONTIERS IN IMMUNOLOGY
(2021)