Article
Fisheries
Fang Li, Xiaohong Liu, Hailong Ge, Jing Huang, Yaoguang Zhang, Zhijian Wang
Summary: A study was conducted to analyze the immune response of Chinese sucker to Aeromonas hydrophila infection at the molecular level. Various immune-related genes were found to be involved in the antibacterial immune response.
Article
Immunology
Silvia Umeda Gallani, Gustavo Moraes Ramos Valladao, Lindomar de Oliveira Alves, Suzana Kotzent, Diogo Teruo Hashimoto, Geert Wiegertjes, Karina Kirsten, Luiz Carlos Kreutz, Fabiana Pilarski
Summary: The production of tambaqui fish has reached a milestone in South American continental waters, but its immunity remains poorly understood. This study established patterns of innate immunity for the species through two experiments, showing up-regulation of immune genes in infected fish in early and chronic phases of infection, except for HSP70 which showed down-regulation.
MICROBIAL PATHOGENESIS
(2021)
Article
Toxicology
Felipe Silva de Franca, Joel Jose Megale Gabrili, Laurence Mathieu, Francois Burgher, Joel Blomet, Denise V. Tambourgi
Summary: The study investigated the systemic events in human whole-blood model induced by Bothrops lanceolatus venom, revealing a strong inflammatory reaction characterized by complement activation and release of lipid mediators that may favor thrombi formation.
ARCHIVES OF TOXICOLOGY
(2021)
Article
Neurosciences
Pablo Garrido-Gil, Maria A. Pedrosa, Maria Garcia-Garrote, Ana Pequeno-Valtierra, Jorge Rodriguez-Castro, Daniel Garcia-Souto, Ana Rodriguez-Perez, Jose L. Labandeira-Garcia
Summary: Sex differences in microglial AT2 receptor expression are influenced by genomic factors and are associated with differential expression of cytokines in microglia.
Review
Biochemistry & Molecular Biology
Konstantinos Pantos, Sokratis Grigoriadis, Evangelos Maziotis, Kalliopi Pistola, Paraskevi Xystra, Agni Pantou, Georgia Kokkali, Athanasios Pappas, Maria Lambropoulou, Konstantinos Sfakianoudis, Mara Simopoulou
Summary: Recurrent implantation failure (RIF) is a complex condition affecting 10-15% of IVF couples. Dysregulation of interleukins (ILs), which are involved in immune responses, plays a crucial role in the pathogenesis of RIF. Further research is needed to understand the molecular mechanisms of ILs in order to provide evidence-based consultancy and decision making for RIF patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Maciej Idzik, Jakub Poloczek, Bronislawa Skrzep-Poloczek, Ewelina Drozdz, Elzbieta Chelmecka, Zenon Czuba, Jerzy Jochem, Dominika Stygar
Summary: This study evaluated the effects of a 21-day general rehabilitation program on selected interleukins and cytokines in osteoarthritis patients after hip or knee replacement. The results showed that most anti/pro-inflammatory markers increased after rehabilitation, while FGF basic decreased. Inflammatory cytokines remained stable, indicating a controlled inflammatory status. The findings suggest that moderate physical activity can have beneficial outcomes in osteoarthritis patients.
Article
Genetics & Heredity
Mayu Kurokawa, Ai Takeshita, Shu Hashimoto, Masayasu Koyama, Yoshiharu Morimoto, Daisuke Tachibana
Summary: This study assessed the effects of a human protein, CTRP6, on miscarriage, fetal and placental development. Results showed that administration of CTRP6 reduced the abortion rate and increased the weights of placenta and fetus.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2022)
Article
Biochemistry & Molecular Biology
Katalin Gombos, Bence Galik, Krisztina Ildiko Kalacs, Krisztina Godony, Akos Varnagy, Donat Alpar, Jozsef Bodis, Attila Gyenesei, Gabor L. Kovacs
Summary: The study presents a comprehensive workflow for clinically applicable strategy for NIPGT-A based on NGS technology, applied to detect chromosomal abnormalities in embryos; through wet- and dry-lab procedures, it can be completed within 48 hours, which is crucial for same-cycle blastocyst transfer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Sylwia Slucznowska-Glabowska, Weronika Jaworska, Marzena Staniszewska, Marta Tkacz, Krzysztof Safranow, Karolina Luczkowska, Edyta Zagrodnik, Iwona Stecewicz, Boguslaw Machalinski, Andrzej Pawlik
Summary: Psoriasis is a chronic inflammatory skin disease characterized by skin lesions and systemic symptoms. This study investigated the plasma concentrations of IL-36 alpha, IL-36 beta, and IL-37 in psoriasis patients and their correlations with disease activity parameters. The results showed decreased plasma concentrations of IL-36 beta and IL-37, and increased concentrations of IL-36 alpha in psoriasis patients compared to the control group. The plasma concentrations of IL-36 alpha and IL-36 beta were significantly correlated with disease activity parameters.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Shahab Shahgaldi, Fatemeh Rezaei Kahmini, Seyed Mohammad Moazzeni
Summary: Research shows that mesenchymal stem cell (MSC) therapy can improve recurrent miscarriage by inhibiting excessive complement activation and promoting the production of angiogenic factors. In a mouse model, MSC treatment reduces the rate of miscarriage and improves the intrauterine environment.
MOLECULAR IMMUNOLOGY
(2022)
Review
Reproductive Biology
Xinrui Sun, Ying Feng, Qianhong Ma, Yan Wang, Fang Ma
Summary: Infertility is a challenging health problem affecting 8-15% of couples worldwide. Protein glycosylation plays a crucial role in maternal-fetal crosstalk, involving multiple cellular communication and molecular pathways. Dysregulation of protein glycosylation can lead to adverse pregnancy outcomes, underscoring its importance in the diagnosis and treatment of female reproductive disorders.
BIOLOGY OF REPRODUCTION
(2023)
Article
Public, Environmental & Occupational Health
Fiona de Londras, Amanda Cleeve, Maria I. Rodriguez, Antonella F. Lavelanet
Summary: Grounds-based approaches to abortion regulation, which restrict access to abortion based on stipulated grounds, have negative implications for access to quality abortion and human rights. Enabling access to abortion on request would be more rights-enhancing than grounds-based approaches.
Review
Immunology
Suheil Albert Atallah-Yunes, Michael J. Robertson
Summary: Cytokines play a regulatory role in the immune responses to cancer. While they have shown antitumor activity in preclinical models, their success as single therapeutic agents in clinical trials of cancer immunotherapy has been limited. However, combining cytokines with other immune therapeutics and advancements in genetic engineering, synthetic biology, and cellular and immune therapy have revived interest in cytokines as anticancer agents.
FRONTIERS IN IMMUNOLOGY
(2022)
Editorial Material
Medicine, General & Internal
[Anonymous]
Summary: This article condemns the decision of the U.S. Supreme Court to reverse Roe v. Wade and abolish longstanding legal protections.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Review
Medicine, General & Internal
Josh Serchen, Shari Erickson, David Hilden
Summary: The Supreme Court decision in Dobbs v Jackson Women's Health Organization has had a significant impact on the legal landscape regarding access to reproductive health care services in the United States. Some states have introduced stringent restrictions and even bans on abortion, while others have aimed to protect and expand access. Criminal and civil penalties have been imposed on healthcare providers who offer evidence-based reproductive health care services, leading to new enforcement methods such as prohibiting crossing state lines for abortion care and allowing third-party civil lawsuits. The American College of Physicians (ACP) has updated its policy positions on abortion to address these changes and advocates for equitable access to reproductive health care services.
ANNALS OF INTERNAL MEDICINE
(2023)
Article
Pediatrics
Ninna Brix, Mia Glerup, Steffen Thiel, Clara Elbaek Mistegaard, Regitze Gyldenholm Skals, Lillemor Berntson, Anders Fasth, Susan Mary Nielsen, Ellen Nordal, Marite Rygg, Henrik Hasle, Birgitte Klug Albertsen, Troels Herlin
Summary: It is difficult to distinguish between acute lymphoblastic leukaemia with arthropathy and juvenile idiopathic arthritis based on clinical grounds. This study found that M-ficolin is a valuable marker to differentiate children with ALL from those with JIA, with a high level in the JIA group and normalization after ALL remission. The predictive model combining M-ficolin, platelets, and hemoglobin had a high accuracy in detecting ALL from JIA.
ARCHIVES OF DISEASE IN CHILDHOOD
(2022)
Article
Biochemistry & Molecular Biology
Letizia Lombardelli, Federica Logiodice, Ornela Kullolli, Herman Haller, Chiara Agostinis, Roberta Bulla, Daniel Rukavina, Marie-Pierre Piccinni
Summary: The role of IL-35 in human pregnancy was investigated. It was found that human trophoblast cells produced IL-35 and could polarize T cells. Low concentrations of IL-35 not only did not suppress Th cell proliferation but also stimulated IL-4 and IL-10 production. IL-35 was crucial for the differentiation of IL-35+, IL-10+, IL-4+ Th2-type cells in successful pregnancies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Yaseelan Palarasah, Anne Sofie L. ogstrup Henriksen, Steffen Thiel, Maiken Henriksen, Soren W. K. Hansen
Summary: The serine protease MASP-3 mediates the conversion of pro-factor D to mature factor D in the complement system. This discovery suggests that pattern recognition of pathogen/danger-associated molecular patterns may be a prior requirement for all complement activation.
MOLECULAR IMMUNOLOGY
(2022)
Article
Immunology
Beatrice Belmonte, Alessandro Mangogna, Alessandro Gulino, Valeria Cancila, Gaia Morello, Chiara Agostinis, Roberta Bulla, Giuseppe Ricci, Filippo Fraggetta, Marina Botto, Peter Garred, Francesco Tedesco
Summary: This study found that the expression of C1q in trophoblasts is defective in patients with pre-eclampsia, which affects the remodeling of maternal decidua blood vessels, leading to changes in placental function and structure. Additionally, the study also showed that the lectin pathway plays an important role in complement activation in pre-eclampsia.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Hematology
Julie Brogaard Larsen, Rasmus Pihl, Mathies Appel Aggerbeck, Kim Michael Larsen, Christine Lodberg Hvas, Nanna Johnsen, Mette G. Christensen, Helle Praetorius, Anne-Mette Hvas, Steffen Thiel
Summary: The study investigates the association between ITIH4 levels and sepsis-related coagulopathy, indicating that ITIH4 is not an acute-phase reactant during septic shock.
RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Biochemistry & Molecular Biology
Chiara Agostinis, Miriam Toffoli, Andrea Balduit, Alessandro Mangogna, Hadida Yasmin, Chiara Ragazzon, Silvia Pegoraro, Giuseppina Campisciano, Guglielmo Stabile, Gabriella Zito, Uday Kishore, Manola Comar, Federica Scrimin, Roberta Bulla, Giuseppe Ricci
Summary: Although only a small percentage of SARS-CoV-2 infections occur in children aged 0-9, pneumonia remains the leading cause of infant mortality worldwide. Vaccinated breastfeeding mothers produce antibodies against the spike protein of SARS-CoV-2, which can activate the complement pathway and potentially protect breastfed newborns against infection. A study involving vaccinated healthcare and school workers found that anti-S IgG antibodies were present in the serum and breast milk, capable of activating complement.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Allergy
Laura Barrett Ryo, Didde Haslund, Anne Bruun Rovsing, Rasmus Pihl, Wariya Sanrattana, Steven de Maat, Yaseelan Palarasah, Coen Maas, Steffen Thiel, Jacob Giehm Mikkelsen
Summary: This study investigates the trans-inhibitory effects of different SERPING1 variants on the expression, secretion, functionality, and intracellular localization of C1 inhibitor (C1INH) in HeLa cells. The findings suggest that different SERPING1 variants may drive the pathogenicity of hereditary angioedema through different and sometimes overlapping molecular disease mechanisms, with some variants acting as dominant-negative factors.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Alexey Ferapontov, Marjan Omer, Isabelle Baudrexel, Jesper Sejrup Nielsen, Daniel Miotto Dupont, Kristian Juul-Madsen, Philipp Steen, Alexandra S. Eklund, Steffen Thiel, Thomas Vorup-Jensen, Ralf Jungmann, Jorgen Kjems, Soren Egedal Degn
Summary: The binding between B cell receptors (BCRs) and antigens triggers a response in B cells and eventually leads to antibody production. However, it is still unclear how BCRs are distributed on naive B cells and how antigen binding initiates the first step of BCR signaling. Using DNA-PAINT super-resolution microscopy, it has been discovered that most BCRs exist as monomers, dimers, or loosely associated clusters on resting B cells, with a nearest-neighbor inter-Fab distance of 20-30nm. By engineering monoclonal model antigens with precise control over affinity and valency, researchers found that the antigen can activate the BCR in an agonistic manner as affinity and avidity increase.
NATURE COMMUNICATIONS
(2023)
Article
Immunology
Mads Lamm Larsen, Anne Troldborg, Erik J. M. Toonen, Lisa Hurler, Zoltan Prohaszka, Laszlo Cervenak, Annette Gudmann Hansen, Steffen Thiel
Summary: This study aims to differentiate between classical or lectin pathway-mediated complement activation in SLE patients by quantifying pathway-specific protein complexes. The classical pathway is activated in active SLE disease, whereas activation of the lectin pathway might be more specific to disease manifestations like lupus nephritis.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2023)
Meeting Abstract
Immunology
Andrea Balduit, Romana Vidergar, Paola Zacchi, Alessandro Mangogna, Chiara Agostinis, Micaela Grandolfo, Cristina Bottin, Francesco Salton, Paola Confalonieri, Andrea Rocca, Fabrizio Zanconati, Marco Confaloneri, Uday Kishore, Berhane Ghebrehiwet, Roberta Bulla
Meeting Abstract
Immunology
Andrea Balduit, Alessandro Mangogna, Valentina Vaira, Chiara Agostinis, Paola Rafaniello Raviele, Cristina Bottin, Francesco Salton, Francesco Nesa, Nicola Fusco, Stefano Ferrero, Fabrizio Zanconati, Marco Confalonieri, Roberta Bulla
Meeting Abstract
Immunology
Hadida Yasmin, Chiara Agostinis, Miriam Toffoli, Tamali Roy, Silvia Pegoraro, Andrea Balduit, Giuseppe Ricci, Taruna Madan, Uday Kishore, Roberta Bulla
Meeting Abstract
Immunology
Andrea Balduit, Alessandro Mangogna, Chiara Agostinis, Francesco Salton, Miriam Toffoli, Gabriella Zito, Federico Romano, Roberto Verardo, Marco Confalonieri, Giuseppe Ricci, Roberta Bulla
Article
Multidisciplinary Sciences
Moritz Lasse, Jamal El Saghir, Celine C. Berthier, Sean Eddy, Matthew Fischer, Sandra D. Laufer, Dominik Kylies, Arvid Hutzfeldt, Lena Lydie Bonin, Bernhard Dumoulin, Rajasree Menon, Virginia Vega-Warner, Felix Eichinger, Fadhl Alakwaa, Damian Fermin, Anja M. Billing, Akihiro Minakawa, Phillip J. McCown, Michael P. Rose, Bradley Godfrey, Elisabeth Meister, Thorsten Wiech, Mercedes Noriega, Maria Chrysopoulou, Paul Brandts, Wenjun Ju, Linda Reinhard, Elion Hoxha, Florian Grahammer, Maja T. Lindenmeyer, Tobias B. Huber, Hartmut Schlueter, Steffen Thiel, Laura H. Mariani, Victor G. Puelles, Fabian Braun, Matthias Kretzler, Fatih Demir, Jennifer L. Harder, Markus M. Rinschen
Summary: Kidney organoids are a promising model for studying kidney disease. By analyzing the proteome and transcriptome of the organoids, researchers found that older organoids deposit more extracellular matrix and express fewer glomerular proteins. Treatment with TNF-α resulted in differential expression of 322 proteins, including cytokines and complement components. Integration of transcriptomic data revealed that these proteins were associated with poorer clinical outcomes in proteinuric kidney disease patients. This study demonstrates the functional relevance of kidney organoids in modeling human kidney disease.
NATURE COMMUNICATIONS
(2023)
Meeting Abstract
Biochemistry & Molecular Biology
Andrea Balduit, Romana Vidergar, Paola Zacchi, Alessandro Mangogna, Chiara Agostinis, Micaela Grandolfo, Fabrizio Zanconati, Marco Confalonieri, Roberta Bulla
MOLECULAR IMMUNOLOGY
(2022)