Review
Immunology
Nupur Mukherjee, Richa Sharma, Deepak Modi
Summary: Recurrent implantation failure (RIF) can be caused by uterine factors, male factors, or embryo factors. It is associated with disrupted endometrial receptivity, altered gene expression, immunologic disturbances, and epigenetic alterations. RIF is a heterogeneous condition with varied immune responses, and personalized therapies based on the patient's immune status are being tested.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Sarah R. McCoski, Rebecca R. Cockrum, Alan D. Ealy
Summary: Exposure to maternal obesity during pregnancy can have significant effects on offspring development, which may not be apparent until adulthood. This study investigated how obesity influences gene expression in the endometrium during early pregnancy using a sheep model. The results showed that obesity affects gene expression related to the immune response, adhesion, and angiogenesis in the endometrium. These findings suggest that the peri-implantation endometrium is responsive to maternal obesity and changes in gene expression during early embryogenesis may contribute to developmental programming.
JOURNAL OF ANIMAL SCIENCE
(2022)
Review
Obstetrics & Gynecology
Awoniyi O. Awonuga, Olivia G. Camp, Husam M. Abu-Soud, Daniel A. Rappolee, Elizabeth E. Puscheck, Michael P. Diamond
Summary: The contributions of uterine endometrium and embryo in implantation success are still debated. Various measures, such as endometrial receptivity analysis (ERA), endometrial scratch (ES), endometrial microbiome, and intrauterine or intravenous measures, are recommended to improve implantation success. However, there is insufficient evidence to determine the relative importance of endometrium and embryo in implantation success and the utility of these measures, especially with euploid embryos. Evidence suggests that embryos can implant and develop on non-endometrium epithelium. The role of embryo euploidy in implantation success is currently underappreciated.
REPRODUCTIVE SCIENCES
(2023)
Article
Reproductive Biology
Mehmet Kose, Mustafa Hitit, Mehmet Salih Kaya, Mesut Kirbas, Sukru Dursun, Ilyas Alak, Mehmet Osman Atli
Summary: This study aimed to elucidate the expression pattern of miRNAs in the endometrium during peri-implantation in ewes. A total of 116 ovine-specific miRNAs were detected, with 19 differentially expressed in early pregnancy. The differentially expressed miRNAs targeted a total of 315 genes, with functional enrichment in the innate immune system and signaling pathways.
Article
Obstetrics & Gynecology
Genia Rozen, Peter Rogers, Wan Tinn Teh, Catharyn J. Stern, Alex Polyakov
Summary: RIF is a disorder with an imprecise definition lacking robust scientific basis, presenting significant challenges in diagnosis and treatment. The concept of 'Theoretical Cumulative Implantation Rate' is proposed to determine RIF diagnosis based on objective data. An updated and standardized definition is needed for patient counseling and research planning.
HUMAN REPRODUCTION
(2021)
Article
Biochemistry & Molecular Biology
Yuta Matsuno, Kazuya Kusama, Kazuhiko Imakawa
Summary: This study characterized the expression profile of lncRNAs during peri-implantation periods in sheep conceptuses. The analysis identified a total of 8808 lncRNAs, including 3423 novel lncRNAs. Gene ontology analysis revealed enrichment of lncRNA target genes in the respiratory electron transport chain (RETC). The findings suggest that lncRNAs may play a role in regulating RETC during conceptus development in sheep.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Cell Biology
Tao Zhang, Shuai Guo, Han Zhou, Zhimin Wu, Junfeng Liu, Changwei Qiu, Ganzhen Deng
Summary: The activation of YAP is crucial for early pregnancy in bovines, as it promotes cell proliferation and creates an immunosuppressive local environment facilitating conceptus implantation into the uterine epithelium.
CELL PROLIFERATION
(2021)
Article
Immunology
Shafat Ali, Sabhiya Majid, Md. Niamat Ali, Shahnaz Taing, Muneeb U. Rehman, Azher Arafah
Summary: Recurrent pregnancy loss (RPL) is a reproductive disease that involves two or more successive spontaneous abortions, with causes often related to dysfunction of endometrial cytokines and dysregulation of decidual cytokines. Cytokine modulatory therapies are considered promising for preventing RPL.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Endocrinology & Metabolism
Davoud Jafari-Gharabaghlou, Mostafa Vaghari-Tabari, Hajar Oghbaei, Laura Lotz, Reza Zarezadeh, Yeganeh Rastgar Rezaei, Mahnaz Ranjkesh, Mohammad Nouri, Amir Fattahi, Saba Nikanfar, Ralf Dittrich
Summary: This review highlights the role of various adipokines in embryo-maternal interactions, endometrial receptivity, and embryo implantation, as well as the underlying molecular mechanisms.
ENDOCRINE CONNECTIONS
(2021)
Article
Biochemistry & Molecular Biology
Natalya I. I. Tapilskaya, Alevtina M. M. Savicheva, Kira V. V. Shalepo, Olga V. V. Budilovskaya, Aleksandr M. M. Gzgzyan, Olesya N. N. Bespalova, Tatiana A. A. Khusnutdinova, Anna A. A. Krysanova, Kseniia V. V. Obedkova, Galina Kh. Safarian
Summary: The study examined the composition of vaginal and endometrial microbiota in reproductive-aged women with secondary infertility of unknown origin. It found that certain bacteria and viruses in the uterine cavity, such as Peptostreptococcus spp. and HPV, were associated with altered levels of cytokines in the endometrium. These findings emphasize the importance of determining local immune biomarkers to assess the significance of specific microorganisms as causative agents of infertility.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Hsien-Ming Wu, Tzu-Chi Lo, Chia-Lung Tsai, Liang-Hsuan Chen, Hong-Yuan Huang, Hsin-Shih Wang, John Yu
Summary: This study investigates the involvement of miR-138-5p and GPR124 in NLRP3 inflammasome activation during embryo implantation and early pregnancy. The results indicate that these factors play important roles in decidual programming and placentation, suggesting their potential as modulators in human pregnancy.
Article
Multidisciplinary Sciences
Rong Li, Xiaoqiu Wang, Zhenyao Huang, Jayani Balaji, Tae Hoon Kim, Tianyuan Wang, Lecong Zhou, Ashley Deleon, Molly E. Cook, Margeaux W. Marbrey, San-Pin Wu, Jae Wook Jeong, Ripla Arora, Francesco J. DeMayo
Summary: The loss of uterine epithelial progesterone receptor (PGR) is crucial for embryo implantation in both humans and mice. This study reveals that the two major isoforms PGRA and PGRB disrupt embryo implantation through FOXO1 pathways in uterine epithelium, and both regulate the LIF-SGK1-FOXO1 signaling pathway.
Article
Biochemistry & Molecular Biology
Kanako Takimoto, Hideto Yamada, Shigeki Shimada, Yoshiyuki Fukushi, Shinichiro Wada
Summary: The aim of this study was to evaluate the association between chronic endometritis and uterine endometrium microbiota with repeated implantation failures and recurrent pregnancy losses. The results suggest that chronic endometritis may be involved in the pathophysiology of recurrent pregnancy losses and repeated implantation failures. Lactobacillus iners and Ureaplasma species may be associated with the etiology of chronic endometritis.
Review
Biochemistry & Molecular Biology
Hsien-Ming Wu, Liang-Hsuan Chen, Le-Tien Hsu, Chyong-Huey Lai
Summary: Embryo-endometrial communication plays a critical role in successful embryo implantation and pregnancy establishment through the regulation of maternal immune responses. Recent research has highlighted the importance of extracellular vesicles (EVs) and microRNAs in this process, showing that they modulate maternal immune responses and promote cross-communication between the embryo and the endometrium. Exploring the functions and mechanisms of EVs in embryo implantation and pregnancy may provide valuable insights for reproductive medicine and infertility treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Reproductive Biology
Beenu Moza Jalali, Pawel Likszo, Karolina Lukasik
Summary: This study reveals the role of STAT3 phosphorylation in regulating extracellular matrix remodeling and angiogenesis in porcine endometrium to facilitate embryo implantation.
BIOLOGY OF REPRODUCTION
(2022)