Review
Nutrition & Dietetics
Fredzzia Graterol Torres, Maria Molina, Jordi Soler-Majoral, Gregorio Romero-Gonzalez, Nestor Rodriguez Chitiva, Maribel Troya-Saborido, Guillem Socias Rullan, Elena Burgos, Javier Paul Martinez, Marina Urrutia Jou, Carles Canameras, Josep Riera Sadurni, Anna Vila, Jordi Bover
Summary: Despite advancements in patient care and treatment for chronic kidney disease (CKD), the incidence of malnutrition disorders in CKD has remained unchanged. The increased production of proinflammatory cytokines and oxidative stress contribute to a proinflammatory environment in CKD patients, leading to increased morbidity and mortality. Nutritional-inflammatory biomarkers have been explored as predictors of malnutrition, but further standardization is needed.
Article
Nutrition & Dietetics
Angel Nogueira, Graciela Alvarez, Guillermina Barril
Summary: The functional capacity of chronic kidney disease (CKD) patients is influenced by their nutrition-inflammation status. This study evaluates the functional capacity of advanced chronic kidney disease (ACKD) patients and the impact of nutrition-inflammation status on it. The findings suggest that nutritional status and body composition play a role in determining the functional capacity of patients with ACKD.
Article
Nutrition & Dietetics
Shona Mckirdy, Ben Nichols, Sarah Williamson, Konstantinos Gerasimidis
Summary: This study established handgrip strength centile charts in healthy children and explored the utility of handgrip strength z-scores in assessing body composition and screening malnutrition risk in sick children. The results showed that handgrip strength z-scores can help identify sick children in need of further dietetic intervention and are predictive of fat free mass.
CLINICAL NUTRITION
(2021)
Article
Nutrition & Dietetics
Ping-Huang Tsai, Hsiu-Chien Yang, Chin Lin, Chih-Chien Sung, Pauling Chu, Yu-Juei Hsu
Summary: In advanced chronic kidney disease patients, higher serum phosphate levels are associated with indicators of sarcopenia, specifically low handgrip strength. The optimal serum phosphate cutoff for predicting low handgrip strength is 3.65 mg/dL, indicating a negative correlation between serum phosphate and handgrip strength in this population.
Article
Urology & Nephrology
Pablo E. Pergola, Diogo Belo, Paul Crawford, Moustafa Moustafa, Wenli Luo, Alexander Goldfarb-Rumyantzev, Youssef M. K. Farag
Summary: This study investigated the long-term efficacy and safety of different FC dosing regimens for treating anemia in nondialysis-dependent CKD patients. Both twice daily and three times daily FC treatments were found to be safe and effective in improving hemoglobin levels in this population, suggesting potential dosing flexibility with FC.
AMERICAN JOURNAL OF NEPHROLOGY
(2021)
Article
Transplantation
Ahmed A. Awan, Carl P. Walther, Peter A. Richardson, Maulin Shah, Wolfgang C. Winkelmayer, Sankar D. Navaneethan
Summary: In patients with chronic kidney disease and anemia, absolute and functional iron deficiency anemia were associated with various clinical covariates. Functional IDA was linked to an increased risk of mortality and cardiovascular hospitalization, while absolute IDA was only associated with a higher risk of hospitalization.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Article
Biochemistry & Molecular Biology
Anderson Castro Ribeiro, Robson Eugenio Silva, Patricia Braga Issa Justino, Eliziaria Cardoso Santos, Reggiani Vilela Goncalves, Romulo Dias Novaes
Summary: Hemodialysis patients are exposed to various risk factors, including malnutrition and cardio-metabolic issues. A longitudinal study found that while anthropometric and nutritional factors remained stable over time, biomarkers such as adipokines and cytokines showed high variability. Factors such as fat mass, creatinine, and urea were found to be predictive markers of this variability.
Article
Nutrition & Dietetics
Pascal Tribolet, Nina Kaegi-Braun, Carla Gressies, Annic Baumgartner, Karl-Heinz Wagner, Zeno Stanga, Philipp Schuetz
Summary: Handgrip strength (HGS) is a practical measure to assess muscle strength, and its association with 180-day all-cause mortality in cancer patients has been investigated. The study found that lower HGS values were associated with a higher mortality rate in cancer patients.
Article
Cardiac & Cardiovascular Systems
Maria Serena Lonardo, Nunzia Cacciapuoti, Martina Chiurazzi, Mariastella Di Lauro, Bruna Guida, Simona Damiano, Mauro Cataldi
Summary: This study investigated the role of hemoglobin concentration and handgrip strength in identifying CKD patients at risk of undernutrition. The results showed that these parameters can distinguish patients with different nutritional status and disease severity.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2023)
Article
Nutrition & Dietetics
Maria Amasene, Ariadna Besga, Maria Medrano, Miriam Urquiza, Ana Rodriguez-Larrad, Ignacio Tobalina, Julia Barroso, Jon Irazusta, Idoia Labayen
Summary: The study reveals that over half of hospitalized older adults are at risk of malnutrition or malnourished, and the majority of older inpatients have poor physical performance. Handgrip strength and SPPB are recommended as alternative measures of muscle mass for malnutrition management in this population.
CLINICAL NUTRITION
(2021)
Article
Geriatrics & Gerontology
Panpan He, Ziliang Ye, Mengyi Liu, Huan Li, Yuanyuan Zhang, Chun Zhou, Qimeng Wu, Yanjun Zhang, Sisi Yang, Chengzhang Liu, Xianhui Qin
Summary: The study found that handgrip strength and walking pace were inversely associated with the risk of chronic kidney disease (CKD). Increasing handgrip strength and faster walking pace were found to lower the risk of incident CKD, based on data from the UK Biobank.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Biochemistry & Molecular Biology
Mirko Luketin, Maja Mizdrak, Dijana Boric-Skaro, Dinko Martinovic, Daria Tokic, Marino Vilovic, Daniela Supe-Domic, Tina Ticinovic Kurir, Josko Bozic
Summary: The study revealed significantly higher plasma CST levels in HD patients compared to healthy controls, with a significant positive correlation between CST and AGEs. Additionally, there were positive correlations between plasma CST levels, Dialysis Malnutrition Score, and Malnutrition-Inflammation Score.
Article
Multidisciplinary Sciences
Mahder Asefa, Amene Abebe, Behailu Balcha, Daniel Baza
Summary: The study found a high prevalence of undernutrition among chronic kidney disease patients, especially in those with diabetic nephropathy, low serum albumin levels, recent diagnosis of diabetes mellitus, and stage V chronic kidney disease.
Article
Neurosciences
Tirapoot Jatupornpoonsub, Paramat Thimachai, Ouppatham Supasyndh, Yodchanan Wongsawat
Summary: End-stage renal disease (ESRD) is associated with cerebral complications due to malnutrition and inflammation, known as malnutrition-inflammation complex syndrome (MICS). The severity of MICS is assessed using the malnutrition-inflammation score (MIS), which is invasive and inconvenient. Quantitative electroencephalogram (QEEG) can be used to evaluate cerebral diseases in ESRD patients and potentially reflect the severity of MICS. QEEG patterns may be associated with the severity of MICS and can be used to differentiate ESRD patients with and without MICS. These QEEG features could noninvasively monitor MICS in clinical practice.
FRONTIERS IN HUMAN NEUROSCIENCE
(2023)
Article
Medicine, General & Internal
Ji Hye Kim, Young Youl Hyun, Kyu-Beck Lee, Sung Woo Lee, Hayne Cho Park, Wookyung Chung, Joongyub Lee, Yun Kyu Oh, Kook-Hwan Oh, Dong-Wan Chae, Curie Ahn
Summary: This study found that for adults with chronic kidney disease, an adequate amount of moderate-vigorous physical activity is associated with a lower risk of all-cause death, cardiovascular events, and end-stage kidney disease. Age and sex also play a role in modifying the relationships between physical activity and clinical outcomes. Physical activity plans should be tailored for individual adults with CKD.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Urology & Nephrology
Juan J. Carrero, David Severs, Didier Aguilera, Enrico Fiaccadori, Martin G. Gonzalez, Christoph C. Haufe, Daniel Teta, Pablo Molina, Wesley Visser
Summary: Hemodialysis for patients with chronic kidney disease is associated with high morbidity and mortality rates, as well as low quality of life. Poor nutritional status is a predictor of these risks, so maintaining optimal nutrition in patients on hemodialysis is critical. Intravenous delivery of nutrition during hemodialysis sessions has been proposed as another way to support nutrition. In this review, experienced clinicians provide guidance on when to use intravenous nutrition, which patients may benefit from it, practical delivery strategies, and monitoring methods.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Clinical Neurology
Alessandro Bosi, Laura Ceriani, Carl-Gustaf Elinder, Rino Bellocco, Catherine M. M. Clase, Mikael Landen, Juan-Jesus Carrero, Bjorn Runesson
Summary: This study assessed the monitoring of creatinine and lithium in patients with bipolar disorder receiving lithium therapy in Sweden. The results revealed that only a small proportion of patients underwent annual monitoring of these biomarkers as recommended by guidelines.
Article
Urology & Nephrology
Juan-Jesus Carrero, Edouard L. Fu, Yingying Sang, Shoshana Ballew, Marie Evans, Carl-Gustaf Elinder, Peter Barany, Lesley A. Inker, Andrew S. Levey, Josef Coresh, Morgan E. Grams
Summary: Routine cystatin C testing provides real-world evidence about the differences between estimated glomerular filtration rate based on cystatin C and creatinine, and their association with various clinical outcomes. This observational study in Sweden found that patients with lower eGFR(cys) than eGFR(cr) had a higher risk of kidney failure, acute kidney injury, atherosclerotic cardiovascular disease, heart failure, and death.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2023)
Article
Urology & Nephrology
Patrizia Natale, Manfred Hecking, Amelie Kurnikowski, Nicole Scholes-Robertson, Juan Jesus Carrero, Germaine Wong, Giovanni Strippoli, Allison Jaure
Summary: There is a gender disparity in access to kidney transplantation, with women being 20% less likely to receive a transplant compared to men across different backgrounds and socioeconomics. Nephrologists perceive that this disparity is exacerbated by gender norms, stigma, prejudice, and educational and financial disadvantages faced by women.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Urology & Nephrology
Nanbo Zhu, Hong Xu, Tyra Lagerberg, Kristina Johnell, Juan Jesus Carrero, Zheng Chang
Summary: Antidepressant treatment may be associated with short-term adverse reactions in CKD patients, but not with long-term outcomes.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Medicine, General & Internal
Yang Xu, Marie Evans, Faizan Mazhar, Johan Arnlov, Elinor Cockburn, Peter Barany, Juan-Jesus Carrero
Summary: Chinese patients with chronic kidney disease (CKD) receiving primary care often face limited awareness and treatment options for managing anemia, a common complication. This study found that a significant number of patients did not receive timely treatment after developing anemia, and anemia was associated with adverse cardiovascular events and death.
JOURNAL OF INTERNAL MEDICINE
(2023)
Letter
Urology & Nephrology
Anne-Laure Faucon, Juan-Jesus Carrero
KIDNEY INTERNATIONAL
(2023)
Article
Transplantation
Edouard L. Fu, Andrew S. Levey, Josef Coresh, Morgan E. Grams, Anne-Laure Faucon, Carl-Gustaf Elinder, Friedo W. Dekker, Pierre Delanaye, Lesley A. Inker, Juan-Jesus Carrero
Summary: This study evaluated the performance of various equations to estimate glomerular filtration rate in a Swedish cohort. The eGFRcr-cys equations performed the best, showing minimal variation among equations. They also performed well in patients with liver disease, cancer, and heart failure.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Neurosciences
Tyra Lagerberg, Anthony A. Matthews, Nanbo Zhu, Seena Fazel, Juan-Jesus Carrero, Zheng Chang
Summary: Concerns have been raised about the impact of SSRIs on suicidal behavior. By using the target trial framework, this study found that SSRI treatment following a depression diagnosis increased the risk of suicidal behavior, particularly among individuals under the age of 25.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Urology & Nephrology
Ane Emilie Friis Vestergaard, Simon Kok Jensen, Uffe Heide-Jorgensen, Kasper Adelborg, Henrik Birn, Juan-Jesus Carrero, Christian Fynbo Christiansen
Summary: This nationwide cohort study investigated the association between the use of DOACs and the risks of kidney complications in patients with atrial fibrillation compared to VKAs.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Urology & Nephrology
Xiejia Li, Abdul Rashid Qureshi, Mohamed E. Suliman, Olof Heimburger, Peter Barany, Peter Stenvinkel, Bengt Lindholm
Summary: This study examined the association of interleukin-6 (IL-6) and albumin levels with outcomes in chronic kidney disease (CKD) patients, using the IL-6 to albumin ratio (IAR) as a predictor of death risk in incident dialysis patients. The results showed that IAR had a higher discrimination for predicting all-cause mortality compared to IL-6 and albumin alone. Additionally, high and middle IAR tertiles were significantly associated with an increased risk of all-cause mortality.
AMERICAN JOURNAL OF NEPHROLOGY
(2023)
Review
Urology & Nephrology
Fabiola Martin-del-Campo, Carla Maria Avesani, Peter Stenvinkel, Bengt Lindholm, Alfonso M. Cueto-Manzano, Laura Cortes-Sanabria
Summary: Protein-energy wasting (PEW) is common in patients with chronic kidney disease (CKD) and is associated with increased morbidity and mortality, and lower quality of life. Gut dysbiosis plays an important role in inflammation and uremic toxin retention, contributing to the development of PEW. Understanding the interactions between gut microbiota and the host may lead to the development of new strategies to improve nutrition and clinical outcomes in CKD patients.
JOURNAL OF NEPHROLOGY
(2023)
Review
Urology & Nephrology
Carla Maria Avesani, Aline Miroski de Abreu, Heitor S. Ribeiro, Torkel B. Brismar, Peter Stenvinkel, Alice Sabatino, Bengt Lindholm
Summary: Muscle fat infiltration (MFI), also known as myosteatosis, refers to the accumulation of lipids in the skeletal muscle. MFI is usually assessed using imaging methods like CT, MRI, and ultrasound, primarily in the legs, arms, and trunk muscle groups. MFI is considered a marker of muscle quality, where higher fat deposition in the muscle leads to decreased contraction power and force production per unit of muscle mass.
JOURNAL OF NEPHROLOGY
(2023)
Review
Urology & Nephrology
Nicholas C. Chesnaye, Juan Jesus Carrero, Manfred Hecking, Kitty J. Jager
Summary: Improved understanding of gender differences in kidney disease epidemiology, management, and outcomes is crucial to provide better care to patients. Women have a higher prevalence of early-stage chronic kidney disease, while men have a higher risk of kidney function decline, kidney failure, and cardiovascular disease. However, the protective effect of female sex diminishes with disease progression. Women are less likely to be diagnosed and treated for kidney disease and have lower health-related quality of life. They face more barriers to access the transplant waiting list but have better survival after transplantation.
NATURE REVIEWS NEPHROLOGY
(2023)
Article
Urology & Nephrology
Xiejia Li, Bengt Lindholm
Summary: Cardiovascular disease is a major complication of chronic kidney disease, even in its early stages. Accurate risk prediction models are important in identifying high-risk individuals and improving prognosis in CKD patients.
AMERICAN JOURNAL OF NEPHROLOGY
(2023)
