Article
Gastroenterology & Hepatology
Rakhi Maiwall, Samba Siva Rao Pasupuleti, Ashini Kumar Hidam, Archana Rastogi, Sherin Thomas, Guresh Kumar, Anupam Kumar, Shiv Kumar Sarin
Summary: This study aimed to evaluate urinary neutrophil gelatinase-associated lipocalin (NGAL) and renal tubular epithelial cells (RTEC) as risk factors for non-resolution of acute kidney injury (AKI-NR) and chronic kidney disease (CKD) in critically ill patients with cirrhosis. The study found that RTEC and NGAL, as well as AKI-NR, were independent predictors of CKD development.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Review
Medicine, General & Internal
Abdulrahman Alwagdani, Alaa S. Awad, Emaad M. Abdel-Rahman
Summary: Acute kidney injury is a serious problem that requires optimal coordinated care post-hospital discharge. There are currently no specific guidelines for the best care of AKI patients post-hospital discharge.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Nutrition & Dietetics
Dorothee Bedock, Julie Couffignal, Pierre Bel Lassen, Leila Soares, Alexis Mathian, Jehane P. Fadlallah, Zahir Amoura, Jean-Michel Oppert, Pauline Faucher
Summary: This study found that 28.6% of COVID-19 patients were malnourished 30 days after discharge, compared to 42.3% at admission. Early nutritional management helped some malnourished patients recover a normal nutritional status after discharge, but being transferred to intensive care units and high oxygen requirement during hospitalization were strong predictors of poor nutritional outcome.
Review
Oncology
Dominika Mekal, Jacek Sobocki, Anna Badowska-Kozakiewicz, Katarzyna Sygit, Elzbieta Cipora, Ewa Bandurska, Aleksandra Czerw, Andrzej Deptala
Summary: Malnutrition, cachexia, and sarcopenia are common problems in pancreatic cancer patients and are associated with increased toxicity, shorter survival, and reduced quality of life. Early diagnosis of nutritional problems is crucial for proper management in pancreatic cancer patients. It is important for healthcare professionals and patients to understand the significance of nutritional status and its impact on clinical outcomes and quality of life.
Review
Medicine, General & Internal
Xiang Yu, Zhe Feng
Summary: This review examines the definition, diagnosis, and pathophysiological characteristics of perioperative AKI, analyzes the main risk factors, and proposes preventive and curative measures to reduce the risk of AKI. The goal is to increase clinicians' attention to perioperative AKI and promote early assessment and intervention.
FRONTIERS IN MEDICINE
(2021)
Article
Nutrition & Dietetics
Wei Li, Xiaojun Huang, Jieying Liu, Limin Liang, Lina Wei, Jiamei Lu Mns
Summary: The objective of this study was to construct a set of scientific, comprehensive, and feasible indicators for evaluating the quality of nutrition management in patients with nasopharyngeal carcinoma during peri-radiotherapy. The study aims to provide a unified reference basis for objective nutritional evaluation and insights to clinical treatment and care.
Article
Multidisciplinary Sciences
Xiaojiang Guo, Xiguang Qi, Peihao Fan, Michael Gilbert, Andrew D. La, Zeyu Liu, Richard Bertz, John A. Kellum, Yu Chen, Lirong Wang
Summary: The study aimed to identify medications that could potentially reduce mortality in patients with acute kidney injury in the intensive care unit. Ondansetron was found to be associated with lower mortality among AKI patients, with its therapeutic effect possibly elicited through the NF-KB pathway and JAK-STAT pathway, as confirmed by gene expression signature comparison.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Bowen Wang, Mengjia Peng, Hui Wei, Chang Liu, Juan Wang, Liheng Jiang, Fei Fang, Yuliang Wang, Yuandi Shen
Summary: Patients with AKI at high altitudes undergoing CRRT show poorer outcomes with longer treatment duration and faster disease progression. However, early initiation of CRRT can improve survival rate and promote renal recovery in high-altitude patients.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Nina Kaegi-Braun, Marlena Mueller, Philipp Schuetz, Beat Mueller, Alexander Kutz
Summary: This cohort study showed that nutritional support was associated with reduced mortality among patients with malnutrition in clinical practice. The findings align with previous randomized clinical trials and provide valuable information for patients, clinicians, and authorities.
Article
Multidisciplinary Sciences
Lishan Tan, Li Chen, Yan Jia, Lingyan Li, Jinwei Wang, Xiaoyan Huang, Qiong Luo, Li Yang, Zuying Xiong
Summary: This study investigated the impact of diabetes mellitus (DM) on patients with acute kidney injury (AKI) in China. The results showed that DM was associated with longer hospital stay and higher costs in AKI patients, but did not significantly increase the risk of failed renal recovery and in-hospital mortality.
Article
Medicine, General & Internal
Nathan Axel Bianchi, Louis Leon Stavart, Marco Altarelli, Tatiana Kelevina, Mohamed Faouzi, Antoine Guillaume Schneider
Summary: This cohort study found that oliguria lasting more than 12 hours (KDIGO stage 2 or 3) has significant diagnostic implications for AKI and is associated with outcomes irrespective of sCr elevations.
Article
Medicine, Research & Experimental
Siyao Li, Man J. Livingston, Zhengwei Ma, Xiaoru Hu, Lu Wen, Han-Fei Ding, Daohong Zhou, Zheng Dong
Summary: Cisplatin, a commonly used chemotherapy drug, induces kidney diseases. The study found that persistent induction of tubular senescence plays an important role in promoting cisplatin-induced kidney disease. Targeting senescent tubular cells can improve kidney repair and the treatment of cisplatin-induced kidney disease.
Article
Multidisciplinary Sciences
Changwei Wu, Yun Zhang, Sheng Nie, Daqing Hong, Jiajing Zhu, Zhi Chen, Bicheng Liu, Huafeng Liu, Qiongqiong Yang, Hua Li, Gang Xu, Jianping Weng, Yaozhong Kong, Qijun Wan, Yan Zha, Chunbo Chen, Hong Xu, Ying Hu, Yongjun Shi, Yilun Zhou, Guobin Su, Ying Tang, Mengchun Gong, Li Wang, Fanfan Hou, Yongguo Liu, Guisen Li
Summary: This study developed a deep learning model to predict the risk of in-hospital death and dialysis for patients with acute kidney injury (AKI) during hospitalization. The model showed consistent predictive performance in both internal and external validation cohorts.
NATURE COMMUNICATIONS
(2023)
Article
Nutrition & Dietetics
Dimitra Rafailia Bakaloudi, Androniki Papaemmanouil, Andreas Vadarlis, Dimitrios Makrakis, Georgios Germanidis, Eleni Timotheadou, Michail Chourdakis
Summary: With the increasing incidence of cancer and the recognition of the importance of nutrition support for patients, there is a need for the development of nutritional clinical practice guidelines and consensus papers (CPGs). This systematic review aims to compare the content of existing CPGs and evaluate their quality using the AGREE-II tool.
CLINICAL NUTRITION
(2023)
Review
Biochemistry & Molecular Biology
Xiaoqin Zhang, Ewud Agborbesong, Xiaogang Li
Summary: Mitochondrial dysfunction plays a critical role in the pathogenesis of kidney diseases such as AKI and CKD, leading to renal microvascular loss, oxidative stress, and apoptosis. Understanding the molecular events governing mitochondrial functions in these diseases is crucial for developing novel therapeutic strategies. Targeting mitochondrial dysfunction may offer potential therapeutic options to ameliorate renal injury and delay disease progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Transplantation
Christophe Mariat, Geir Mjoen, Bruno Watschinger, Mehmet Sukru Sever, Marta Crespo, Licia Peruzzi, Gabriel C. Oniscu, Daniel Abramowicz, Luuk Hilbrands, Umberto Maggiore
Summary: The KDIGO guidelines serve as the most recent international framework for the evaluation and care of living kidney donors, but there are issues with the recommendations regarding pre-donation GFR adequacy. There is a need for a more basic and demanding GFR evaluation to enhance the efficiency of selecting potential kidney donors.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Letter
Surgery
Umberto Maggiore, Leonardo V. Riella, Jamil Azzi, Paolo Cravedi
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Urology & Nephrology
Valentina Pistolesi, Federica Artegiani, Anteo Di Napoli, Laura Zeppilli, Francesca Santoboni, Sara Somma, Francesca Di Mario, Giuseppe Regolisti, Enrico Fiaccadori, Santo Morabito
Summary: The study retrospectively analyzed AKI patients in a tertiary care hospital, finding that most cases occurred within 48 hours and were classified as severe. The in-hospital mortality rate was 43.3%, while early kidney function recovery was closely associated with patient survival.
Article
Transplantation
Francesca Di Mario, Giuseppe Regolisti, Umberto Maggiore, Maria Chiara Pacchiarini, Brenda Menegazzo, Paolo Greco, Caterina Maccari, Cristina Zambrano, Chiara Cantarelli, Valentina Pistolesi, Santo Morabito, Enrico Fiaccadori
Summary: In ICU patients, Kidney Replacement Therapy (KRT) can lead to hypophosphatemia. This study aimed to analyze the incidence of hypophosphatemia during Sustained Low-Efficiency Dialysis (SLED) in ICU patients and evaluate the determinants of post-SLED serum phosphate level (s-P) and the relationship between s-P, phosphate supplementation, and ICU mortality. The results showed that hypophosphatemia is a common complication in critically ill patients undergoing SLED and phosphate supplementation is strongly associated with reduced ICU mortality.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Medicine, General & Internal
Giuseppe Regolisti, Umberto Maggiore, Francesca Di Mario, Micaela Gentile, Giuseppe Daniele Benigno, Ilaria Gandolfini, Valentina Pistolesi, Santo Morabito, Maria Barbagallo, Edoardo Picetti, Enrico Fiaccadori
Summary: Acute kidney injury, electrolyte, and acid-base disorders are common complications in critically ill patients with COVID-19 and are associated with poor outcomes. The severity of clinical conditions at admission in the ICU may affect the impact of these conditions on mortality.
FRONTIERS IN MEDICINE
(2022)
Review
Medicine, General & Internal
Paolo Molinari, Carlo Maria Alfieri, Deborah Mattinzoli, Mariarosaria Campise, Angela Cervesato, Silvia Malvica, Evaldo Favi, Piergiorgio Messa, Giuseppe Castellano
Summary: Renal transplantation often leads to mineral and bone disorders (MBD) in patients, which can significantly affect their health and quality of life. However, there is a lack of clear guidelines for the treatment of post-RTx MBD. More research and international guidelines are needed to provide more specific treatment options.
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, General & Internal
Silvia De Rosa, Marita Marengo, Stefano Romagnoli, Marco Fiorentino, Vito Fanelli, Enrico Fiaccadori, Nicola Brienza, Santo Morabito, Vincenzo Pota, Fabrizio Valente, Giacomo Grasselli, Piergiorgio Messa, Antonino Giarratano, Vincenzo Cantaluppi
Summary: This Italian survey study reveals discrepancies in the recognition and management of acute kidney injury (AKI) during the COVID-19 pandemic, particularly among intensivists. Differences also exist in the use of specific types of renal replacement therapy, especially extracorporeal blood purification therapies for immune modulation and organ support, indicating the need for standardized clinical guidelines.
FRONTIERS IN MEDICINE
(2022)
Article
Transplantation
Mehmet Sukru Sever, Raymond Vanholder, Gabriel Oniscu, Daniel Abramowicz, Wim Van Biesen, Umberto Maggiore, Bruno Watschinger, Christophe Mariat, Jadranka Buturovic-Ponikvar, Marta Crespo, Geir Mjoen, Peter Heering, Licia Peruzzi, Ilaria Gandolfini, Rachel Hellemans, Luuk Hilbrands
Summary: This study reviewed transplantation practice during the COVID-19 pandemic and provided guidance for transplantation strategies in future disasters. It suggests continuing transplantation programs with appropriate operational circumstances and implementing preventative measures to minimize risks. Patient education and adherence to ethical rules are also important.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Immunology
Roberta Campagna, Laura Mazzuti, Giuliana Guerrizio, Chiara Nonne, Giuseppe Migliara, Corrado De Vito, Ivano Mezzaroma, Sabina Chiaretti, Caterina Fimiani, Valentina Pistolesi, Santo Morabito, Ombretta Turriziani
Summary: Patients with frailty are at higher risk of severe infection from SARS-CoV-2. Vaccination is an effective strategy, but the antibody levels decline over time, especially in frail patients. Healthcare workers have a better antibody response to the vaccine. The lack of T-cell response in about 50% of participants highlights the importance of booster doses.
Article
Transplantation
Francesca Di Mario, Alice Sabatino, Giuseppe Regolisti, Maria Chiara Pacchiarini, Paolo Greco, Caterina Maccari, Giuseppe Vizzini, Chiara Italiano, Valentina Pistolesi, Santo Morabito, Enrico Fiaccadori
Summary: The study evaluated the efficacy and safety of a simplified regional citrate anticoagulation (RCA) protocol in preventing KRT-related hypophosphatemia and optimizing acid-base balance in patients undergoing various forms of kidney replacement therapy. The results showed that the protocol was effective and safe in maintaining normal phosphate levels and acid-base balance without citrate accumulation.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Biochemistry & Molecular Biology
Giuseppe Regolisti, Paola Rebora, Giuseppe Occhino, Giulia Lieti, Giulio Molon, Alessandro Maloberti, Michela Algeri, Cristina Giannattasio, Maria Grazia Valsecchi, Simonetta Genovesi
Summary: The study aimed to investigate the relationship between the urea-to-creatinine ratio (UCR) and in-hospital death in COVID-19 patients with hyponatremia. It was found that a 5-unit increase in UCR during hospital stays was associated with an 8% increase in all-cause death hazard. In patients with a UCR > 40 at baseline, a > 10 mmol/L increase in serum sodium within the first week of hospitalization was associated with higher odds of in-hospital death.
Article
Urology & Nephrology
Silvia De Rosa, Marita Marengo, Marco Fiorentino, Vito Fanelli, Nicola Brienza, Enrico Fiaccadori, Giacomo Grasselli, Santo Morabito, Vincenzo Pota, Stefano Romagnoli, Fabrizio Valente, Vincenzo Cantaluppi, SIAARTI-SIN Joint Commission
Summary: Sepsis-associated acute kidney injury (AKI) is a life-threatening condition with high morbidity and mortality in critically ill patients. Despite the development of various extracorporeal blood purification therapies for sepsis and sepsis-associated AKI, there are still unresolved questions regarding the indications and timing of renal replacement therapy, optimal dialysis dose, and rationale for using these therapies in septic patients without AKI. There is also growing interest in novel blood purification therapies using adsorption devices for specific mediators clearance and antibiotic removal. A joint commission of the Italian Society of Anesthesiology and Critical Care and the Italian Society of Nephrology addressed these issues, proposed recommendations, and developed a framework for future research in this field.
JOURNAL OF NEPHROLOGY
(2023)
Review
Surgery
Matteo Abinti, Evaldo Favi, Carlo Maria Alfieri, Francesca Zanoni, Silvia Armelloni, Mariano Ferraresso, Vincenzo Cantaluppi, Giuseppe Castellano
Summary: Kidney transplantation is the best treatment for end-stage kidney disease, but early diagnosis of graft injury and improving graft outcomes remain challenging. Extracellular vesicles have shown potential as precise markers of damage and therapeutic targets in the field of kidney transplantation. They can be used to determine organ quality and aging, identify transplant-related pathologies, and are suitable for drug delivery and therapy development.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Article
Hematology
Gianluca Villa, Antonio Fioccola, Gaia Mari, Matteo Cecchi, Diego Pomare Montin, Caterina Scire-Calabrisotto, Silvia De Rosa, Zaccaria Ricci, Rodney Alexander Rosalia, Marco Vittorio Resta, Fiorenza Ferrari, Francesco Patera, Massimiliano Greco, Claudio Ronco, Stefano Romagnoli
Summary: This multicenter prospective study aims to preliminary describe the incidence, associated factors, and clinical consequences of premature circuit clotting in adult critically ill septic patients treated with EBP using a high biocompatible heparin-coated hemodiafilter. Results showed that hematocrit, serum procalcitonin, and anticoagulation strategy were independent predictors of circuit clotting. Patients with nonpremature circuit clotting showed more rapid recovery.
BLOOD PURIFICATION
(2022)
Article
Medicine, General & Internal
Luca Nardelli, Antonio Scalamogna, Piergiorgio Messa, Maurizio Gallieni, Roberto Cacciola, Federica Tripodi, Giuseppe Castellano, Evaldo Favi
Summary: Kidney transplantation is the best treatment option for end-stage renal disease, but limited organ supply leads to prolonged dialysis for most candidates. A personalized and flexible approach may be more appropriate, and current data supports the use of peritoneal dialysis over hemodialysis in patients awaiting kidney transplantation.
MEDICINA-LITHUANIA
(2022)
