Article
Urology & Nephrology
Daniela Egli-Spichtig, Ahmad Kamal Hamid, Eva Maria Pastor Arroyo, Markus Ketteler, Andrzej Wiecek, Alexander R. Rosenkranz, Andreas Pasch, Horst Lorenz, Burkhard Hellmann, Michael Karus, Richard Ammer, Isabel Rubio-Aliaga, Carsten A. Wagner
Summary: This study aimed to assess the effects of combined treatment with nicotinamide modified release (NAMR) and phosphate binders (PB) on serum phosphate, FGF23, inflammation, and iron metabolism in ESKF patients. The results showed that iFGF23 was a better predictor of serum phosphate changes induced by NAMR and PB treatment. Furthermore, serum phosphate and iPTH were the best predictors of FGF23. These findings suggest that lowering serum phosphate in ESKF patients may highly depend on iFGF23.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Jonatan Warme, Martin O. Sundqvist, Marcus Hjort, Stefan Agewall, Olov Collste, Christina Ekenback, Mats Frick, Loghman Henareh, Claes Hofman-Bang, Jonas Spaak, Peder Sorensson, Shams Y-Hassan, Per Svensson, Bertil Lindahl, Robin Hofmann, Per Tornvall
Summary: Helicobacter pylori (Hp) infection is associated with protein biomarkers of inflammation and cardiovascular disease (CVD) in patients with myocardial infarction (MI) irrespective of the presence of obstructive coronary artery disease (CAD).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Urology & Nephrology
Qing-xiu Huang, Jie Pang, Chuan-ke Shi, Xiao-wen Huang, Xiao-fang Chen, Yan-feng Luo, Hai-wen An, Jian-lin Jian, Linna Liu, Yan-lin Li
Summary: In nondiabetic hemodialysis patients with severe hyperparathyroidism, parathyroidectomy is associated with improvements in biochemical measures and patient-level outcomes compared to nonoperative treatment.
Article
Nutrition & Dietetics
Francisco Hevilla, Marina Padial, Maria Blanca, Guillermina Barril, Tamara Jimenez-Salcedo, Mercedes Ramirez-Ortiz, Angel Nogueira, Adriana Gentile, Eva Garcia-Escobar, Silvana Y. Y. Romero-Zerbo, Gabriel Olveira
Summary: This study aimed to investigate the effects of oral nutritional supplements (ONS) and probiotics on nutritional status and biomarkers of inflammation/oxidation in malnourished hemodialysis patients. The results showed that ONS significantly increased protein and calorie intake, improved body weight and fat-free mass, and had significant effects on some inflammation/oxidation biomarkers. The addition of probiotics may have a synergistic effect with ONS on these biomarkers.
FRONTIERS IN NUTRITION
(2023)
Article
Medicine, General & Internal
Chiara Donadei, Andrea Angeletti, Valeria Pizzuti, Fulvia Zappulo, Diletta Conte, Maria Cappuccilli, Anna Laura Chiocchini, Anna Scrivo, Delia Apuzzo, Maria Addolorata Mariggio, Lorenzo Gasperoni, Gabriele Donati, Gaetano La Manna
Summary: Hemodialysis treatment has a significant impact on the patient's immune system, reshaping acquired immune components and causing an imbalance of T cell counterparts. CD3 cells are impaired while CD4 and CD8 cells increase and produce pro-inflammatory factors. B cells, monocytes, and NK cells are not affected by the dialysis procedure.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medical Laboratory Technology
Rasmus Bo Hasselbalch, Bashir Alaour, Jonas Henrik Kristensen, Liam S. Couch, Thomas E. Kaier, Ture Lange Nielsen, Louis Lind Plesner, Nina Strandkjaer, Morten Schou, Casper Rydahl, Jens P. Goetze, Henning Bundgaard, Michael Marber, Kasper Karmark Iversen
Summary: This study compared the concentration and prognostic ability of high sensitivity cardiac troponin T (hs-cTnT) and I (hs-cTnI) and cardiac myosin-binding protein C (cMyC) among stable hemodialysis patients. The results showed that hs-cTnT concentration was above the 99th percentile in almost all patients, while cMyC and hs-cTnI had lower proportions. High concentrations of hs-cTnT and hs-cTnI were associated with increased mortality risk, but cMyC concentration was not. These findings are important for the management of hemodialysis patients.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Fuyu Zhu, Peng Li, Yanhui Sheng
Summary: This article summarizes the mechanism and harmful outcomes of myocardial interstitial fibrosis in pathological myocardial hypertrophy, discusses the biomarkers that can be used to identify this lesion, and reviews the currently available and potential future treatments for individualized management of patients with pathological myocardial hypertrophy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Geriatrics & Gerontology
Nikolas Wada, Elizabeth C. Breen, Wendy S. Post, Valentina Stosor, Bernard J. Macatangay, Joseph B. Margolick
Summary: This study observed higher concentrations of CRP in men living with HIV compared to HIV-negative men at different ages, and men with detectable HIV RNA showed faster increases in CRP with age.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Mona Alshahawey, Radwa El Borolossy, Lamia El Wakeel, Tamer Elsaid, Nagwa Ali Sabri
Summary: Cholecalciferol has shown to be an effective and well-tolerated treatment option for overcoming vitamin D deficiency among hemodialysis patients, with a potential modulating effect on fetuin-A levels. No adverse effects were reported in the treatment group.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Article
Cardiac & Cardiovascular Systems
Roland Klingenberg, Soheila Aghlmandi, Baris Gencer, David Nanchen, Lorenz Raber, David Carballo, Sebastian Carballo, Barbara E. Stahli, Ulf Landmesser, Nicolas Rodondi, Francis Mach, Stephan Windecker, Heiner C. Bucher, Arnold von Eckardstein, Thomas F. Loscher, Christian M. Matter
Summary: The study found that patients with persistently elevated hsCRP after ACS have a higher risk of combined adverse events, highlighting the need for anti-inflammatory intervention trials in RIR patients.
Article
Dermatology
Daphne S. Bakker, Maria M. van der Wal, Lukas E. M. Heeb, Barbara Giovannone, Mindy Asamoah, Eveline M. Delemarre, Julia Drylewicz, Stefan Nierkens, Onur Boyman, Marjolein S. de Bruin-Weller, Judith L. Thijs, Femke van Wijk
Summary: The study shows that Dupilumab treatment rapidly and stably inhibits IL-4Rα, exerting an early strong immunological effect specifically on skin-homing T cells without affecting long-term skewing of T helper type cells.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Multidisciplinary Sciences
Aaron J. Velasquez-Mao, Mark A. Velasquez, Zhengxiong Hui, Denise Armas-Ayon, Jingshen Wang, Moriel H. Vandsburger
Summary: This study found that specific proteolytic regulators and fibrotic factors were elevated in plasma and platelets of ESRD patients during hemodialysis, leading to exacerbated platelet dysfunction and tissue dysregulation correlated with blood flow rate and dialysis vintage. The correlation between regulatory factors and fibrotic factors produced by platelets during hemodialysis directly contributes to a pro-fibrotic environment in ESRD patients.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Edoardo Pasqui, Gianmarco de Donato, Elisa Lazzeri, Cecilia Molino, Giuseppe Galzerano, Michele Giubbolini, Giancarlo Palasciano
Summary: The aim of this study was to investigate the predictive role of the preoperative neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in vascular access malfunctioning in hemodialysis patients. The results showed that NLR and PLR can be useful markers for stratifying vascular access failure, with the advantages of low cost and easy availability.
Article
Cardiac & Cardiovascular Systems
Bernard R. Chaitman, Karen P. Alexander, Derek D. Cyr, Jeffrey S. Berger, Harmony R. Reynolds, Sripal Bangalore, William E. Boden, Renato D. Lopes, Marcin Demkow, Gian Piero Perna, Robert K. Riezebos, Edward O. McFalls, Subhash Banerjee, Akshay Bagai, Gilbert Gosselin, Sean M. O'Brien, Frank W. Rockhold, David D. Waters, Kristian A. Thygesen, Gregg W. Stone, Harvey D. White, David J. Maron, Judith S. Hochman
Summary: The ISCHEMIA trial showed that an initial invasive strategy did not reduce cardiovascular events or all-cause mortality in patients with stable ischemic heart disease. Procedural MI rates were higher with the invasive strategy compared to conservative strategy, with the use of the secondary MI definition.
Article
Clinical Neurology
Nicholas Bakewell, Caroline A. Sabin, Riya Negi, Alejandro Garcia-Leon, Alan Winston, Memory Sachikonye, Nicki Doyle, Susan Redline, Patrick W. G. Mallon, Ken M. Kunisaki
Summary: This study investigated the associations between sleep measures and inflammatory profiles in people living with HIV. The results do not support a strong association between sleep and inflammation in HIV-positive individuals.
Article
Pharmacology & Pharmacy
PauloC Gregorio, Regiane S. da Cunha, Gilson Biagini, Bruna Bosquetti, Julia Budag, Alberto Ortiz, Maria Dolores Sanchez-Nino, Fellype C. Barreto, Andrea E. M. Stinghen
Summary: COVID-19 pandemic continues with limited antiviral agents available. Chloroquine, despite showing in vitro antiviral activity, had disappointing results in clinical trials and may harm outcomes. The adverse effects of chloroquine on endothelial cells were mitigated by agalsidase-beta treatment, suggesting a potential role of endothelial cell injury in the failure of chloroquine therapy for COVID-19.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2021)
Editorial Material
Urology & Nephrology
Melani Custodio
JORNAL BRASILEIRO DE NEFROLOGIA
(2021)
Review
Medicine, General & Internal
Murilo Guedes, Roberto Pecoits-Filho
Summary: Diabetic kidney disease (DKD) is a major cause of chronic kidney disease (CKD) worldwide, placing a significant burden on patient outcomes. Recent interventions and guidelines emphasize multidimensional approaches for optimal clinical management. Challenges lie in implementing these approaches to improve clinical outcomes and address residual risk in DKD.
JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Chemistry, Analytical
Andressa Flores Santos, Elberth Manfron Schiefer, Guilherme Lanzi Sassaki, Leociley Menezes, Renato Fonseca, Regiane Cunha, Wesley Souza, Roberto Pecoits-Filho, Andrea E. M. Stinghen
Summary: The study found that there was no significant difference in the clearance rates of metabolites between high flux HD and HDF in a single treatment session, but in the long-term evolution, 16 metabolites were identified that differentiated the two modalities. Most of these metabolites are involved in important metabolic pathways related to UTs and cardiovascular disease development. HDF samples showed stable concentrations of CKD-relevant metabolites and associated pathologies over a six-month period, suggesting that HDF enhances long-term stability.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2022)
Letter
Urology & Nephrology
Murilo Guedes, Bruce Robinson, Brian Bieber, Roberto Pecoits-Filho
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Physiology
Paulo C. Gregorio, Gilson Biagini, Regiane S. da Cunha, Julia Budag, Ana Maria Martins, Lara Valino Rivas, Elberth M. Schiefer, Maria Dolores Sanchez-Nino, Alberto Ortiz, Andrea E. M. Stinghen, Fellype C. Barreto
Summary: Inflammation and endothelial damage play a pivotal role in Fabry disease manifestations. Traditional biomarkers of target organ injury provide no information about inflammation and endothelial damage. This study found that the serum levels of 3-nitrotyrosine, growth differentiation factor-15, and syndecan-1 were associated with cardiac and renal involvement in Fabry disease patients on enzyme replacement therapy.
KIDNEY & BLOOD PRESSURE RESEARCH
(2022)
Review
Urology & Nephrology
Toby Humphrey, Mogamat Razeen Davids, Mogamat-Yazied Chothia, Roberto Pecoits-Filho, Carol Pollock, Glen James
Summary: This study provides a comprehensive overview of the epidemiology of hyperkalaemia, including its prevalence and incidence in different populations, healthcare settings, and continents. The prevalence of hyperkalaemia in adults is 6.3%, with an incidence of 2.8 cases per 100 person years. In the general population, the prevalence is 1.3%, with an incidence of 0.4 cases per 100 person years. Prevalence varies by sex and the definition/threshold used. Patients with end-stage kidney disease, kidney transplant patients, and patients with acute kidney injury have the highest prevalence of hyperkalaemia.
CLINICAL KIDNEY JOURNAL
(2022)
Article
Food Science & Technology
Regiane Stafim da Cunha, Carolina Amaral Bueno Azevedo, Carlos Alexandre Falconi, Fernanda Fogaca Ruiz, Sophie Liabeuf, Marcela Sorelli Carneiro-Ramos, Andrea Emilia Marques Stinghen
Summary: Uremic toxins are molecules that accumulate in the body due to chronic kidney disease (CKD), and are associated with kidney dysfunction and comorbidity development. Drugs may interact with protein-bound uremic toxins (PBUTs) and cell membrane transporters, affecting toxin levels and elimination. This review explores the interaction mechanisms between uremic toxins, albumin, and membrane transporters in relation to clinical drug use.
Editorial Material
Urology & Nephrology
Murilo Guedes, Roberto Pecoits-Filho
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Review
Urology & Nephrology
Murilo Guedes, Robin W. M. Vernooij, Andrew Davenport, Martin K. Kuhlmann, Fabienne Aregger, Roberto Pecoits-Filho
Summary: This article reviews the practical aspects of implementing HDF and discusses its impact on various biochemical, patient-reported, and clinical outcomes. It emphasizes the delivery of high-volume HDF therapy and its effects on solute clearance, inflammation, hemodynamic stability, cardiac outcomes, nutrition, quality of life, morbidity, and mortality.
SEMINARS IN DIALYSIS
(2022)
Article
Urology & Nephrology
Glen James, Juan Jose Garcia Sanchez, Juan Jesus Carrero, Supriya Kumar, Roberto Pecoits-Filho, Hiddo J. L. Heerspink, Stephen Nolan, Carolyn S. P. Lam, Hungta Chen, Eiichiro Kanda, Naoki Kashihara, Matthew Arnold, Mikhail N. Kosiborod, Mitja Lainscak, Carol Pollock, David C. Wheeler
Summary: According to the KDIGO classification, as urinary albumin increases, the prevalence of heart failure, hypertension, and type 2 diabetes increases; with declining baseline eGFR, the incidence of mortality and adverse cardiovascular and renal outcomes increases.
KIDNEY INTERNATIONAL REPORTS
(2022)
Article
Medicine, Research & Experimental
Bartholomeus J. A. Willigers, Mario Ouwens, Andrew Briggs, Hiddo J. L. Heerspink, Carol Pollock, Roberto Pecoits-Filho, Navdeep Tangri, Csaba P. P. Kovesdy, David C. C. Wheeler, Juan Jose Garcia Sanchez
Summary: To minimize uncertainty in projecting long-term outcomes in clinical trials, researchers developed a novel method that incorporates expert opinion in a Bayesian analysis. The results showed that using expert opinion in Bayesian analysis produced a smaller range of survival values compared to frequentist methods.
ADVANCES IN THERAPY
(2023)
Article
Urology & Nephrology
Murilo Guedes, Junhui Zhao, Brian LaMoreaux, Brad Marder, Barry Gorlitsky, Vinicius Domingues, Matthew B. Rivara, Susie Lew, Bruce Robinson, Roberto Pecoits-Filho, Angelo Karaboyas, Ali Alaradi, Pieter Evenepoel, Michel Jadoul, Manish Sood, Rita Suri, Xiaonong Chen, Yuqing Chen, Fanfan Hou, Xinling Liang, Zhaohui Ni, Li Zuo, Christian Combe, Fitsum Guebre-Egziabher, Pablo Antonio Urena Torres, Werner Kleophas, Elke Schaeffner, Thomas Weinreich, Giuliano Brunori, Loreto Gesualdo, Francesco Locatelli, Masafumi Fukagawa, Masaaki Inaba, Masaomi Nangaku, Kosaku Nitta, Kazuhiko Tsuruya, Saeed Al-Ghamdi, Mohammed Al Ghonaim, Fayez Hejaili, Ayman Karkar, Faissal Shaheen, Jamal Al Wakeel, Naser Alkandari, Anas Alyousef, Bassam Al Helal, Issa Alsalmi, Yacoub Al Maimani, Fadwa Al Ali, Abdulla Hamad, Aleix Cases, Almudena Vega Martinez, Patricia de Sequera, Anders Christensson, Stefan Jacobson, Samra Abouchacra, Mohamed Hassan, Ali Abdulkarim Al Obaidli, Mona Al Rukhaimi, Abdul Kareem Saleh, Elham Asgari, Indranil Dasgupta, Hugh Rayner, David Johnson, Jeffrey Perl, Mauricio Sanabria, Hideki Kawanishi, Yong-Lim Kim, Talerngsak Kanjanabuch, Simon Davies, Ronald Pisoni, Bruce Robinson, Jenny Shen
Summary: The prevalence of gout is high in patients with kidney disease and its association with outcomes in hemodialysis and peritoneal dialysis populations in North America is unknown.
Article
Transplantation
Roberto Pecoits-Filho, John Larkin, Carlos Eduardo Poli-de-Figueiredo, Americo Lourenco Cuvello-Neto, Ana Beatriz Lesqueves Barra, Priscila Bezerra Goncalves, Shimul Sheth, Murilo Guedes, Maggie Han, Viviane Calice-Silva, Manuel Carlos Martins de Castro, Peter Kotanko, Thyago Proenca de Moraes, Jochen G. Raimann, Maria Eugenia F. Canziani
Summary: In this study, the effects of high-volume online hemodiafiltration (HDF) on physical activity (PA) in dialysis patients were investigated. Despite achieving a high convective volume and positive impact on solute removal, HDF did not have a statistically significant treatment effect on PA compared to high-flux hemodialysis (HD). However, there were modest treatment effects observed, particularly in the hours following dialysis, which may warrant further investigation into the clinical significance.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Article
Medicine, General & Internal
Climerio Pereira Nascimento, Sergio Samir Arap, Melani Ribeiro Custodio, Ledo Mazzei Massoni Neto, Marilia D'Elboux Guimaraes Brescia, Rosa Maria Affonso Moyses, Vanda Jorgetti, Fabio Luiz de Menezes Montenegro
Summary: After total parathyroidectomy and autograft, dialysis patients exhibit four distinct patterns of graft function, each requiring varied therapeutic management. These patterns include stable function, early function with later failure, graft recurrence, and complete graft failure. Patterns of parathormone levels become statistically different after 36 months, highlighting the importance of long-term monitoring.
REVISTA DA ASSOCIACAO MEDICA BRASILEIRA
(2021)