Journal
PHYTOMEDICINE
Volume 22, Issue 1, Pages 23-26Publisher
ELSEVIER GMBH, URBAN & FISCHER VERLAG
DOI: 10.1016/j.phymed.2014.10.007
Keywords
Diabetes; alpha-Glucosidase; alpha-Amylase; Cycas pectinata; Maiba-Maibi
Categories
Funding
- IBSD Imphal
- DBT, Govt. of India
Ask authors/readers for more resources
Bioactivity guided chemical investigation On active anti-diabetic constituents of the fruits of Cycas pectinata Griff. (FCP) characterized EAFr-5 as the most potent sub fraction which significantly reduced the blood glucose level to normal in STZ induced diabetic rats, It was shown to contain the biflavonoids amentoflavone (1) and 2,3-dihydroamentoflavone (2) which exhibited significantly high inhibitory potency against a-glucosidase (IC50 8.09 +/- 0.023 and 9.77 +/- 0.032 mu M, respectively) and alpha-amylase (IC50 73.6 +/- 0.48 and 39.69 +/- 0.39 mu M, respectively). This is the first report of bioactivity guided isolation of anti-diabetic constituents from the traditionally used fruits of Cycas pectinata Griff. (C) 2015 Elsevier GmbH. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available