Biosynthesis and biotechnological production of anti-cancer drug Camptothecin

Co-overexpression of geraniol-10-hydroxylase and strictosidine synthase improves anti-cancer drug camptothecin accumulation in Ophiorrhiza pumila

(2015) Lijie Cui et al.   Scientific Reports

Effects of methyl jasmonate and salicylic acid on tanshinone production and biosynthetic gene expression in transgenicSalvia miltiorrhizahairy roots

(2014) Xiaolong Hao et al.   BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY

Increased accumulation of the cardio-cerebrovascular disease treatment drug tanshinone in Salvia miltiorrhiza hairy roots by the enzymes 3-hydroxy-3-methylglutaryl CoA reductase and 1-deoxy-d-xylulose 5-phosphate reductoisomerase

(2014) Min Shi et al.   FUNCTIONAL & INTEGRATIVE GENOMICS

Camptothecin-producing endophytic fungus Trichoderma atroviride LY357: isolation, identification, and fermentation conditions optimization for camptothecin production

(2013) Xiang Pu et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Isolation of endophytic bacteria producing the anti-cancer alkaloid camptothecine from Miquelia dentata Bedd. (Icacinaceae)

(2013) S. Shweta et al.   PHYTOMEDICINE

Isolation and characterization of endophytic fungi from Camptotheca acuminata

(2013) Xiaowei Ding et al.   WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY

Molecular mechanism of elicitor-induced tanshinone accumulation in Salvia miltiorrhiza hairy root cultures

(2012) Guoyin Kai et al.   ACTA PHYSIOLOGIAE PLANTARUM

Endophytic fungi: novel sources of anticancer lead molecules

(2012) Sheela Chandra   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Expression of Monstera deliciosa agglutinin gene (mda) in tobacco confers resistance to peach-potato aphids

(2012) Guoyin Kai et al.   Integrative Biology

Enhancing the production of tropane alkaloids in transgenic Anisodus acutangulus hairy root cultures by over-expressing tropinone reductase I and hyoscyamine-6β-hydroxylase

(2012) Guoyin Kai et al.   Molecular BioSystems

Suppression of camptothecin biosynthetic genes results in metabolic modification of secondary products in hairy roots of Ophiorrhiza pumila

(2012) Takashi Asano et al.   PHYTOCHEMISTRY

Overexpression of ORCA3 and G10H in Catharanthus roseus Plants Regulated Alkaloid Biosynthesis and Metabolism Revealed by NMR-Metabolomics

(2012) Qifang Pan et al.   PLoS One

Molecular cloning and expression analysis of a gene encoding 3-hydroxy-3-methylglutaryl-CoA synthase from Camptotheca acuminata

(2012) G. Y. Kai et al.   RUSSIAN JOURNAL OF PLANT PHYSIOLOGY

Genetically transformed roots: from plant disease to biotechnological resource

(2012) Milen I. Georgiev et al.   TRENDS IN BIOTECHNOLOGY

An endophytic Neurospora sp. from Nothapodytes foetida producing camptothecin

(2011) S. Rehman et al.   APPLIED BIOCHEMISTRY AND MICROBIOLOGY

Micropropagation and hairy root culture of Ophiorrhiza alata Craib for camptothecin production

(2011) Pornwilai Ya-ut et al.   BIOTECHNOLOGY LETTERS

Molecular cloning and characterization of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase (CaHDR) from Camptotheca acuminata and its functional identification in Escherichia coli

(2011) Qian Wang et al.   BMB Reports

Co-expression of AaPMT and AaTRI effectively enhances the yields of tropane alkaloids in Anisodus acutangulus hairy roots

(2011) Guoyin Kai et al.   BMC BIOTECHNOLOGY

Pyrosequencing of the Camptotheca acuminata transcriptome reveals putative genes involved in camptothecin biosynthesis and transport

(2011) Yongzhen Sun et al.   BMC GENOMICS

Expression profile of jasmonic acid-induced genes and the induced resistance against the root-knot nematode (Meloidogyne incognita) in tomato plants (Solanum lycopersicum) after foliar treatment with methyl jasmonate

(2011) Taketo Fujimoto et al.   JOURNAL OF PLANT PHYSIOLOGY

Metabolic engineering tanshinone biosynthetic pathway in Salvia miltiorrhiza hairy root cultures

(2011) Guoyin Kai et al.   METABOLIC ENGINEERING

Effects of different elicitors on yield of tropane alkaloids in hairy roots of Anisodus acutangulus

(2011) Guoyin Kai et al.   MOLECULAR BIOLOGY REPORTS

Molecular cloning and expression analysis of a new putative gene encoding 3-hydroxy-3-methylglutaryl-CoA synthase from Salvia miltiorrhiza

(2010) Lin Zhang et al.   ACTA PHYSIOLOGIAE PLANTARUM

Inactivation of PI3k/Akt signaling pathway and activation of caspase-3 are involved in tanshinone I-induced apoptosis in myeloid leukemia cells in vitro

(2010) Jia-Jun Liu et al.   ANNALS OF HEMATOLOGY

Tanshinone biosynthesis in Salvia miltiorrhiza and production in plant tissue cultures

(2010) Jian Wen Wang et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Cell-specific expression of tryptophan decarboxylase and 10-hydroxygeraniol oxidoreductase, key genes involved in camptothecin biosynthesis in Camptotheca acuminata Decne (Nyssaceae)

(2010) Alessio Valletta et al.   BMC PLANT BIOLOGY

Biosynthetic system of camptothecin: An anticancer plant product

(2010) Mami Yamazaki et al.   PURE AND APPLIED CHEMISTRY

Molecular cloning, characterization and expression analysis of a new gene encoding 3-hydroxy-3-methylglutaryl coenzyme A reductase from Salvia miltiorrhiza

(2009) Pan Liao et al.   ACTA PHYSIOLOGIAE PLANTARUM

Elicitation with methyl-jasmonate stimulates peruvoside production in cell suspension cultures of Thevetia peruviana

(2009) Mario Arias Zabala et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-PLANT

An Endophytic Fungus fromCamptotheca acuminataThat Produces Camptothecin and Analogues

(2009) Souvik Kusari et al.   JOURNAL OF NATURAL PRODUCTS

Comparative studies and identification of camptothecin produced by an endophyte at shake flask and bioreactor

(2009) Suriya Rehman et al.   NATURAL PRODUCT RESEARCH

Endophytic fungal strains of Fusarium solani, from Apodytes dimidiata E. Mey. ex Arn (Icacinaceae) produce camptothecin, 10-hydroxycamptothecin and 9-methoxycamptothecin

(2009) S. Shweta et al.   PHYTOCHEMISTRY

In vitro plant regeneration from leaf explants of Ophiorrhiza japonica

(2008) G.-Y. Kai et al.   BIOLOGIA PLANTARUM

Optimization of induction and culture conditions and tropane alkaloid production in hairy roots of Anisodus acutangulus

(2008) Li Li et al.   BIOTECHNOLOGY AND BIOPROCESS ENGINEERING

Molecular characterization and expression analysis of a new cDNA encoding strictosidine synthase from Ophiorrhiza japonica

(2008) Yang Lu et al.   MOLECULAR BIOLOGY REPORTS

Molecular cloning, expression profiling and functional analysis of a DXR gene encoding 1-deoxy-d-xylulose 5-phosphate reductoisomerase from Camptotheca acuminata

(2007) Hongyan Yao et al.   JOURNAL OF PLANT PHYSIOLOGY