Article
Rheumatology
Emma Swardh, Christina Opava, Nina Brodin
Summary: Physical activity (PA) in rheumatoid arthritis (RA) is considered a lifelong behavior influenced by the disease. Patients perceive the impact of the disease on their health and engage in PA by increasing awareness, enhancing body awareness, and seeking social support. This meta-synthesis provides insights for tailoring PA support to individual drivers and determinants in clinical practice, benefiting both health professionals and RA patients.
Review
Immunology
Zongpan Li, Xue-Qiang Wang
Summary: Exercise is effective for treating rheumatoid arthritis (RA) but the mechanism of its effectiveness is still unclear.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Rehabilitation
Ayse A. Kucukdeveci, Burak K. Turan, Chiara Arienti, Stefano Negrini
Summary: The aim of this study was to provide an overview of Cochrane Systematic Reviews (CSRs) on rehabilitation interventions for rheumatoid arthritis (RA). The study found that physical activity and exercises are effective non-pharmacological interventions for hand function, muscle strength, and fatigue in RA patients. Psychosocial interventions show a small beneficial effect on fatigue. Celecoxib has similar analgesic effects with traditional NSAIDs but fewer gastric adverse events. There is a need for well-designed studies to determine the effects of these interventions on different outcomes and physiological mechanisms in RA.
EUROPEAN JOURNAL OF PHYSICAL AND REHABILITATION MEDICINE
(2023)
Article
Rheumatology
James M. Gwinnutt, Husain Alsafar, Kimme L. Hyrich, Mark Lunt, Anne Barton, Suzanne M. M. Verstappen
Summary: The study found that a significant proportion of patients with early RA reduced or stopped their physical activity levels over the first year of MTX treatment. Factors such as smoking, higher disability, and greater socioeconomic deprivation were associated with stopping physical activity.
Article
Orthopedics
Akira Onishi, Mie Torii, Yu Hidaka, Ryuji Uozumi, Yohei Oshima, Hiroki Tanaka, Hideo Onizawa, Takayuki Fujii, Koichi Murata, Kosaku Murakami, Masao Tanaka, Shuichi Matsuda, Akio Morinobu, Hidenori Arai, Motomu Hashimoto
Summary: This study aims to examine the efficacy of individualized exercise therapy on physical function in elderly patients with rheumatoid arthritis (RA) who are at a high risk for sarcopenia. The study is a single-center, parallel-group, two-arm, healthcare provider- and outcome assessor-blinded, superiority randomized controlled trial. The primary endpoint will be physical function assessed using the Short Physical Performance Battery (SPPB) at 4 months.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Management
Laura Ramos-Petersen, Jonatan Garcia-Campos, George Banwell, Ana Belen Ortega-Avila, Gabriel Gijon-Nogueron, Andres Reinoso-Cobo
Summary: The aim of this study was to explore the experiences of people with rheumatoid arthritis during and after COVID-19-induced quarantine in terms of physical activity and health status. The results indicate that although physical activity is considered essential for these patients, most of them significantly reduced their levels of physical activity during the pandemic. It is recommended to promote physical activity in people even in difficult times to improve disease outcomes, well-being, and mental health.
JOURNAL OF NURSING MANAGEMENT
(2022)
Article
Rheumatology
Vanessa L. Kronzer, Ryan J. Lennon, Jeffrey A. Sparks, Elena Myasoedova, John M. Davis, Cynthia S. Crowson
Summary: This study aimed to evaluate the association of physical activity and dietary factors with the risk of rheumatoid arthritis (RA). The results showed that high-intensity work physical activity was associated with an increased risk of RA, while leisure activity was not. The consumption of high-fat food and fruits/vegetables showed non-significant associations with RA risk.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2022)
Article
Rehabilitation
Chun-De Liao, Hung-Chou Chen, Shih-Wei Huang, Tsan-Hon Liou
Summary: Exercise therapy effectively increased muscle mass in patients with rheumatoid arthritis, but the treatment effects may be attenuated in those who have had the disease for a relatively long time. Meta-regression analyses indicated significant variance in treatment effects across studies, with disease duration as a significant explanatory factor.
CLINICAL REHABILITATION
(2022)
Review
Rehabilitation
Christina Merete Tvede Madsen, Sara Kjaer Bisgaard, Jette Primdahl, Jeanette Reffstrup Christensen, Cecilie von Bulow
Summary: The study aimed to assess the effect of job loss prevention interventions on persons with inflammatory arthritis. Six randomized controlled trials were included, showing significant improvements in work ability, absenteeism reduction, and job loss prevention among individuals with IA. Despite some inconsistent results, further high-quality studies on this topic are recommended.
JOURNAL OF OCCUPATIONAL REHABILITATION
(2021)
Article
Medicine, General & Internal
Ahmad M. Osailan, George S. Metsios, Joan L. Duda, George D. Kitas, Jet J. C. S. Veldhuijzen van Zanten, Ragab K. Elnaggar
Summary: The reduced chronotropic response (CR) in patients with rheumatoid arthritis (RA) is associated with several cardiovascular disease (CVD) risk factors, inflammatory markers, and cardiorespiratory fitness. Future studies should investigate the effects of controlling these associated variables on CR in patients with RA.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Rheumatology
Roswitha Dietzel, Sabine Wiegmann, Diana Borucki, Christian Detzer, Kim Nikola Zeiner, Desiree Schaumburg, Bjoern Buehring, Frank Buttgereit, Gabriele Armbrecht
Summary: In patients with rheumatoid arthritis (RA), chronic inflammation can lead to muscle depletion. The study found that sarcopenia is more common in RA patients and is associated with factors such as body weight, BMI, inflammation markers, and disease duration.
Article
Medicine, General & Internal
Ewa Zelnio, Mihra Taljanovic, Malgorzata Manczak, Iwona Sudol-Szopinska
Summary: The hand and wrist are frequently involved in rheumatic diseases, and this study aimed to identify the distinguishing radiographic characteristics of psoriatic arthritis (PsA), seropositive rheumatoid arthritis (RA), and seronegative RA, especially in the early stages. The analysis of radiographic hand findings on 180 seropositive RA patients, 154 PsA patients, and 36 seronegative RA patients revealed that symmetric distribution of lesions was more suggestive of seropositive or seronegative RA, while lesions affecting PIP joints, wrist, or styloid process of the radius were more common in patients with seropositive RA. PsA was more likely to be suggested by DIP joints' involvement and proliferative bone changes. Furthermore, there were differences in the types of bone lesions and their distribution between seropositive RA, seronegative RA, and PsA, with ulnar styloid involvement more commonly seen in seronegative RA patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Rheumatology
Farzin Khosrow-Khavar, Seoyoung C. Kim, Hemin Lee, Su Been Lee, Rishi J. Desai
Summary: The study did not find evidence of increased cardiovascular risk with tofacitinib in patients with RA in a real-world setting. However, tofacitinib was associated with an increased risk of cardiovascular outcomes, although statistically non-significant, in patients with RA with cardiovascular risk factors.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Pharmacology & Pharmacy
Merel A. A. Opdam, Sophie Benoy, Lise M. Verhoef, Sandra Van Bijnen, Femke Lamers-Karnebeek, Rene A. M. Traksel, Petra Vos, Alfons A. den Broeder, Jasper Broen
Summary: Patients with inflammatory rheumatic diseases do not have an increased risk for COVID-19 compared to the general population. Older age and obesity are major risk factors for hospitalization for COVID-19 in patients with IRD, while the use of methotrexate may have a protective effect in reducing the risk of hospitalization.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Pharmacology & Pharmacy
Susan J. Keam
Summary: Ozoralizumab (Nanozora (R)), a trivalent anti-TNF alpha NANOBODY (R) compound, has gained approval in Japan for the treatment of inadequately managed rheumatoid arthritis. This article provides an overview of the development milestones leading to this approval, including its development by Taisho Pharmaceutical Co. Ltd.
