Article
Medicine, General & Internal
Riccardo Vinciguerra, Emanuela F. Legrottaglie, Costanza Tredici, Cosimo Mazzotta, Pietro Rosetta, Paolo Vinciguerra
Summary: This study demonstrates the ability of transepithelial cross-linking with iontophoresis (I-CXL) to slow down the progression of keratoconus in the majority of patients, while also improving high order and comatic aberrations. A progression rate of 26% was reported.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Gregg W. Stone, William T. Abraham, JoAnn Lindenfeld, Saibal Kar, Paul A. Grayburn, D. Scott Lim, Jacob M. Mishell, Brian Whisenant, Michael Rinaldi, Samir R. Kapadia, Vivek Rajagopal, Ian J. Sarembock, Andreas Brieke, Steven O. Marx, David J. Cohen, Federico M. Asch, Michael J. Mack, COAPT Investigators
Summary: Data from a 5-year follow-up of outcomes after transcatheter edge-to-edge repair of severe mitral regurgitation in patients with heart failure demonstrate that this procedure, in addition to medical therapy, leads to lower rates of hospitalization for heart failure and all-cause mortality compared to medical therapy alone.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Ophthalmology
Adi Einan-Lifshitz, Asaf Achiron, Shira Hed, Idan Hecht, Biana Dubinsky-Pertzov, Boris Knyazer
Summary: The study demonstrates that accelerated corneal collagen cross-linking (A-CXL) can improve visual function, reduce corneal astigmatism and Kmax, and decrease the thinnest corneal thickness in pediatric patients with keratoconus (KC) after three years of follow-up. A-CXL is non-inferior to standard CXL (S-CXL) in terms of best-corrected and uncorrected visual acuity, thinnest pachymetry, and astigmatism, but non-inferiority cannot be concluded for Kmax.
Article
Medicine, General & Internal
Weijun Jian, Mi Tian, Xiaoyu Zhang, Ling Sun, Yang Shen, Meiyan Li, Xingtao Zhou
Summary: ATE-CXL is a safe and effective method in stabilizing the progression of pediatric keratoconus, and changes in corneal biomechanical response consistent with stiffening were observed following the surgery.
FRONTIERS IN MEDICINE
(2021)
Article
Medicine, General & Internal
Belen Alfonso-Bartolozzi, Carlos Lisa, Luis Fernandez-Vega-Cueto, David Madrid-Costa, Jose F. Alfonso
Summary: The study evaluated the outcomes of implanting Neoring in PD-DALK procedure for moderate-advanced keratoconus, showing improved visual acuity and corneal conditions post-operatively. It suggests that Neoring implantation is a safe and effective option for patients with moderate-severe keratoconus to optimize post-operative results.
FRONTIERS IN MEDICINE
(2021)
Article
Ophthalmology
Tommy C. Y. Chan, Rachel W. Y. Tsui, Vanissa W. S. Chow, Jasmine K. M. Lam, Victoria W. Y. Wong, Kelvin H. Wan
Summary: This study analyzed the 5-year results of accelerated corneal collagen crosslinking (CXL) for progressive keratoconus and identified preoperative characteristics predictive of visual and topographic outcomes. The results showed that accelerated CXL significantly decreased Kmax in patients with progressive keratoconus. Patients with worse preoperative CDVA and higher Kmax were more likely to have an improvement in visual acuity and corneal flattening.
INDIAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Multidisciplinary Sciences
Jost B. Jonas, Yan Ni Yan, Qi Zhang, Rahul A. Jonas, Ya Xing Wang
Summary: The study found that highly myopic eyes are more prone to choroidal vessel shift in relation to retinal vessels, with some eyes experiencing both choroidal vessel shift and an increase in gamma zone size. Eyes without choroidal vessels in the gamma zone exhibited a larger choroidal vessel shift compared to eyes with large choroidal vessels in the gamma zone.
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
Alejandro N. Santos, Laurel Rauschenbach, Dino Saban, Bixia Chen, Annika Herten, Thiemo Florin Dinger, Yan Li, Stephan Tippelt, Adela Della Marina, Christian Dohna-Schwake, Boerge Schmidt, Ramazan Jabbarli, Karsten H. Wrede, Ulrich Sure, Philipp Dammann
Summary: This study investigated the natural course of cerebral cavernous malformations (CCM) in pediatric patients, highlighting a higher risk of intracerebral hemorrhage (ICH) in children with brain stem CCM and familial history of CCM. Over a 5-year follow-up, untreated pediatric patients had a similar risk of (re)hemorrhage compared to adults, with an increased probability over time, especially in cases with ICH or brain stem localization.
Article
Endocrinology & Metabolism
Andrea Lin, Jasmine A. Mack, Brittany Bruggeman, Laura M. Jacobsen, Amanda L. Posgai, Clive H. Wasserfall, Todd M. Brusko, Mark A. Atkinson, Stephen E. Gitelman, Peter A. Gottlieb, Matthew J. Gurka, Clayton E. Mathews, Desmond A. Schatz, Michael J. Haller
Summary: The study found that low-dose antithymocyte globulin (ATG) and granulocyte colony-stimulating factor (GCSF) immunotherapy can maintain C-peptide levels in some patients with type 1 diabetes over the long term, but after 5 years there were no significant differences compared to the placebo group. This emphasizes the importance of long-term follow-up in ongoing and completed phase 2 trials of low-dose ATG therapy for type 1 diabetes.
Article
Hematology
Philippe Armand, Pier Luigi Zinzani, Hun Ju Lee, Nathalie A. Johnson, Pauline Brice, John Radford, Vincent Ribrag, Daniel Molin, Theodoros P. Vassilakopoulos, Akihiro Tomita, Bastian von Tresckow, Margaret A. Shipp, Alex F. Herrera, Jianxin Lin, Eunhee Kim, Samhita Chakraborty, Patricia Marinello, Craig H. Moskowitz
Summary: This study demonstrates that Pembrolizumab provides durable antitumor activity in patients with relapsed or refractory classical Hodgkin lymphoma, and a second course of treatment can reinduce sustained responses after relapse from initial complete response.
Article
Medicine, General & Internal
Cosimo Mazzotta, Anna Pandolfi, Marco Ferrise
Summary: This study aims to assess the preliminary clinical results of a new method called Epi-On ACXL in the treatment of progressive keratoconus. The results show that this treatment can improve visual acuity and stabilize the progression of the disease.
FRONTIERS IN MEDICINE
(2023)
Article
Endocrinology & Metabolism
Cervantee E. K. Wild, Lisa E. Wynter, Christopher M. Triggs, Jose G. B. Derraik, Paul L. Hofman, Yvonne C. Anderson
Summary: This study aimed to determine the 5-year outcomes of a multidisciplinary lifestyle intervention program for children. Results showed that the intervention did not have long-term efficacy in reducing BMI standard deviation score (BMISDS), but factors such as attendance and age were important considerations for future interventions to achieve long-term BMI reduction.
Article
Engineering, Biomedical
I Simonini, A. Ni Annaidh, A. Pandolfi
Summary: The mechanical behavior of keratoconus and suspected keratoconus corneas were investigated using patient-specific finite element models. Diseased corneas showed more compliant behavior under intraocular pressure, with up to 44% increase in apex displacement compared to healthy corneas. Stress maps revealed a marked increase in maximum tensile stress on both anterior and posterior surfaces for keratoconus corneas.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2022)
Article
Oncology
Robert Flisiak, Dorota Zarebska-Michaluk, Ewa Janczewska, Tadeusz Lapinski, Magdalena Rogalska, Ewa Karpinska, Tomasz Mikula, Beata Bolewska, Jolanta Bialkowska, Katarzyna Flejscher-Stepniewska, Krzysztof Tomasiewicz, Kornelia Karwowska, Monika Pazgan-Simon, Anna Piekarska, Hanna Berak, Olga Tronina, Aleksander Garlicki, Jerzy Jaroszewicz
Summary: Treatment of hepatitis C virus (HCV) infections with direct-acting antivirals (DAA) has high efficacy and safety, but long-term monitoring is essential to assess the risk of hepatocellular carcinoma (HCC) development after treatment.
Article
Gastroenterology & Hepatology
Olympia E. Anastasiou, Florin A. Caruntu, Manuela G. Curescu, Kendal Yalcin, Ulus S. Akarca, Selim Gurel, Stefan Zeuzem, Andreas Erhardt, Stefan Lueth, George V. Papatheodoridis, Onur Keskin, Kerstin Port, Monica Radu, Mustafa K. Celen, Ramazan Idilman, Benjamin Heidrich, Ingmar Mederacke, Heiko von der Leyen, Julia Kahlhoefer, Maria von Karpowitz, Svenja Hardtke, Markus Cornberg, Cihan Yurdaydin, Heiner Wedemeyer
Summary: This study confirms that patients who undergo PEG-IFNa treatment and achieve HDV suppression have a lower risk of developing liver-related complications. Until alternative therapies become available, PEG-IFNa treatment should be recommended for patients with HDV infection.
LIVER INTERNATIONAL
(2023)