Article
Chemistry, Applied
Man Hyung Koo, Hae-Jung Chae, Jun Hyuck Lee, Sung-Suk Suh, Ui Joung Youn
Summary: Phytochemical and biological studies of methanolic extracts from Ganoderma lucidum led to the discovery of a new lanostane triterpenoid, ganosidone A, and eight known derivatives. The compounds showed potential for cancer chemoprevention by inhibiting nitric oxide production in vitro, with compounds 4 and 7 exhibiting significant inhibition rates at a concentration of 50 μM.
NATURAL PRODUCT RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Xueqing Zhang, Xiaoxu Gao, Guoqing Long, Yongcheng Yang, Gang Chen, Guoli Hou, Xuting Huo, Jingming Jia, Anhua Wang, Gaosheng Hu
Summary: This study isolated and identified 10 undescribed lanostane triterpenoids and 21 known compounds from statically cultured mycelial mat of G. lucidum. The hepatoprotective activities of these compounds in H2O2-induced HepG2 cells were evaluated, and the structure-activity relationship was discussed.
Article
Biochemistry & Molecular Biology
Da-Wei Li, Min Liu, Yue-Qi Leng, Jin-Fang Hu, Sa Deng, Ai-Jing Leng, Xiao-Chi Ma, Ruo-Yu Wang, Jian Zhou, Chao Wang
Summary: This study investigated the bioactive phytochemicals in Ganoderma lucidum and found that its triterpenoids showed inhibitory effects on the enzyme FAAH, indicating their potential for treating neuroinflammation.
Article
Biochemistry & Molecular Biology
Zhen-Zhu Zhao, Bao-Yu Ji, Zhen-Zhen Wang, Ying-Ying Si, Yan-Jun Sun, Hui Chen, Wei-Sheng Feng, Xiao-Ke Zheng, Ji-Kai Liu
Summary: Eight new lanostane triterpenoids and nine known ones were discovered in the fruiting bodies of Ganoderma lingzhi S.H. Wu, Y. Cao & Y.C. Dai. Their structures were determined using spectroscopic data and quantum chemical calculations. Among them, ganoderane GL-1, containing a hydrogenated tetramethylsphenanthraquinone, is the first example in the lanostane nor-triterpenoid group. In terms of biological activity, ganoderanes GL-2 and GL-3, which have a rare 1,11-epoxy moiety, showed significant inhibition against nitric oxide production induced by lipopolysaccharide in RAW264.7 macrophage cells, while ganoderanes GL-4 and GL-8 exhibited bifunctional activities of anti-proliferation and anti-inflammation.
Review
Pharmacology & Pharmacy
Haoyuan Peng, Lei Zhong, Lin Cheng, Lu Chen, Rongsheng Tong, Jianyou Shi, Lan Bai
Summary: Ganoderma lucidum, also known as Lingzhi, is a widely-used herbal medicine with various pharmacological effects including antioxidant, antitumor, anti-aging, anti-liver fibrosis, and immunomodulation. Its main active components include triterpenoids, polysaccharides, sterols, peptides, and other bioactive ingredients. The triterpenoids and polysaccharides in G. lucidum have shown significant anti-liver fibrotic effects. Given the global increase in liver fibrosis cases, this review summarizes the role of G. lucidum extract in anti-liver fibrosis and its effects on fibrosis induced by different causes, providing insights for the development of G. lucidum extracts in anti-liver fibrosis treatment.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Chemistry, Applied
Arunrat Yangchum, Pranee Rachtawee, Kitlada Srichomthong, Rattaket Choeyklin, Thitiya Boonpratuang, Chawanee Thongpanchang, Masahiko Isaka
Summary: Chemical investigation of artificially cultivated fruiting bodies of Ganoderma cf. mastoporum, strain TBRC-BCC 47851, led to the discovery of three undescribed lanostane triterpenoids (1-3) and twelve known compounds. The structures of these new compounds were determined through NMR spectroscopy and mass spectrometry. However, the new compounds showed no activity in the antimalarial and antitubercular assays.
NATURAL PRODUCT RESEARCH
(2023)
Article
Plant Sciences
Arunrat Yangchum, Kitlada Srichomthong, Tuksaporn Thummarukcharoen, Sujinda Sommai, Masahiko Isaka
Summary: Seven previously unreported lanostane triterpenoids were isolated from cultivated fruiting bodies of Ganoderma wiiroense. Their structures were determined using NMR spectroscopy and mass spectrometry. Compound 7 exhibited activity against Mycobacterium tuberculosis H37Ra.
PHYTOCHEMISTRY LETTERS
(2023)
Article
Biochemistry & Molecular Biology
Yushuang Liu, Wei Liu, Miaomiao Li, Tao Yuan
Summary: Thirteen new lanostane triterpenoids and nine known compounds were isolated from the fruiting bodies of Fomitopsis pinicola. Extensive analysis of spectroscopic data and single-crystal X-ray diffraction were used to determine their structures and absolute configurations. Pinicopsic acid F and 16 alpha-hydroxy-3-oxolanosta-7,9(11),24-trien-21-oic acid showed moderate inhibitory activities against LPS-induced NO production in RAW 264.7 cells.
Article
Chemistry, Medicinal
Lin Zhou, He-Ping Chen, Xinyang Li, Ji-Kai Liu
Summary: Two triterpenes with unique 6/6/6/5/6 scaffolds, ganoaustralins A and B, were isolated from the fruiting bodies of Ganoderma australe. Their structures, absolute configurations, and biosynthetic pathways were determined, with ganoaustralin B showing weak inhibition against beta-secretase 1.
Review
Chemistry, Medicinal
Diandra A. Luz, Alana M. Pinheiro, Eneas A. Fontes-Junior, Cristiane S. F. Maia
Summary: Ganoderma lucidum, known as Ling Zhi, Reishi, and Youngzhi, is a mushroom that has been used for its antiaging properties in Asian countries for centuries. It has shown cognitive improvement through various mechanisms, including the inhibition of b-amyloid and neurofibrillary tangle formation, antioxidant effects, reduction of inflammation and apoptosis, genic expression modulation, and presence of metabolites such as triterpenes. This mushroom's properties make it a potential source for developing drugs to prevent or reverse memory disorders.
MEDICINAL RESEARCH REVIEWS
(2023)
Article
Acoustics
Cunyu Li, Yun Ma, Xin Shen, Wei Chen, Yuqing Zhou, Xinglei Zhi
Summary: This study applied ultrasonic-assisted supercritical fluid separation (USFS) to improve the safety of ganoderma lucidum spores' oil by regulating solubility and removing plasticizers. The optimal separation conditions were determined, and USFS showed great potential in pharmaceutical manufacturing.
ULTRASONICS SONOCHEMISTRY
(2023)
Article
Plant Sciences
An-An Yang, Ying-Xiang Yan, Pei-Dong Shi, Chao Yu, Yu-Zhu Feng, Meng-Ke Zhang, Liang Xing, Chen-Yu Cao, Xia Yin
Summary: Two new lanostane triterpenes, ganorbifoins A and B, along with a known compound, were isolated from Ganoderma orbiforme. Ganorbifoin A showed the best glucose uptake induction in a zebrafish-based system, while compounds 2 and 3 exhibited inhibitory effects on nitric oxide production.
PHYTOCHEMISTRY LETTERS
(2022)
Article
Plant Sciences
Malipan Sappan, Pranee Rachtawee, Kitlada Srichomthong, Thitiya Boonpratuang, Rattaket Choeyklin, Tao Feng, Ji-Kai Liu, Masahiko Isaka
Summary: Three new lanostane triterpenoids, named ganoellipsic acids A-C (1-3), along with seven known Ganoderma lanostanoids (4-10), were isolated from artificially cultivated fruiting bodies of Ganoderma ellipsoideum, strain BCC 16634. The structures of these compounds were determined by NMR spectroscopy and mass spectrometry. The absolute configuration of compound 1 at C-25 was found to be 25S using the phenylglycine methyl ester (PGME) method.
PHYTOCHEMISTRY LETTERS
(2022)
Review
Biochemistry & Molecular Biology
Mohammed Sharif Swallah, Precious Bondzie-Quaye, Yahui Wu, Adolf Acheampong, Frederick Leo Sossah, Shereen M. M. Elsherbiny, Qing Huang
Summary: Ganoderma lucidum (G. lucidum) is a traditional Asian medicine with a long history, known for its health-improving and life-extending properties. It contains bioactive metabolites such as polysaccharides, triterpenoids, and polyphenols, which have antioxidant, anti-inflammatory, anticancer, hepatoprotective, and antidiabetic activities. This mushroom species is widely used in the food industry as a nutrient supplement.
Article
Biochemistry & Molecular Biology
Rong-Wei Kou, Bing Xia, Zhi-Ju Wang, Jian-Nan Li, Jun-Ren Yang, Yu-Qi Gao, Xia Yin, Jin-Ming Gao
Summary: Ganoresinoid A from Ganoderma resinaceum exhibits anti-inflammatory, antioxidative, and anti-apoptosis activities. It inhibits the release of inflammatory cytokines and reduces cell apoptosis by suppressing TLR-4/NF-κB and MAPK signaling pathways. In addition, Ganoresinoid A has antioxidant effects by activating the Akt/GSK-3β/Nrf2 signaling pathway. These findings provide a theoretical basis for using Ganoresinoid A as a nutritional intervention for neurodegenerative diseases.
BIOORGANIC CHEMISTRY
(2022)
Article
Plant Sciences
Ngu-Truong Nhan, Phi-Hung Nguyen, Manh-Hung Tran, Phuong-Dai-Nguyen Nguyen, Dang-Thach Tran, Dao-Cuong To
Summary: Two new xanthones, delpyxanthone A and delpyxanthone B, were isolated from the stem bark of Garcinia delpyana, along with four known compounds. The isolated compounds showed significant inhibitory activity against nitric oxide production in RAW264.7 cells, suggesting their potential as anti-inflammatory agents.
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
(2021)
Article
Plant Sciences
Hoang Le Tuan Anh, Vinh Le Ba, Thi Thao Do, Van Kiem Phan, Hai Yen Pham Thi, Long Giang Bach, Manh Hung Tran, Phuong Anh Tran Thi, Young Ho Kim
Summary: A new compound, physalucoside A, along with withanolides and flavonoids, were isolated from the medicinal plantPhysalis angulata. The withanolides were found to be primarily responsible for the anti-inflammatory activity of the plant. This study suggests that withanolides hold promise as candidates for the development of new anti-inflammatory drugs.
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
(2021)
Article
Chemistry, Medicinal
Dinh-Tuan Nguyen, Dao-Cuong To, Thi-Tuyen Tran, Manh-Hung Tran, Phi-Hung Nguyen
Summary: A new coumarin and four known isoflavones were isolated from a Vietnamese medicinal plant, exhibiting potential antidiabetic properties, which opens up possibilities for further research and development of new natural inhibitors for diabetes.
JOURNAL OF NATURAL MEDICINES
(2021)
Article
Plant Sciences
Dang Thach Tran, Phi Hung Nguyen, Manh Hung Tran, Phuong Dai Nguyen Nguyen, Truong Nhan Ngu, Thi Huyen Thoa Pham, Dao Cuong To
Summary: A new flavanone glycoside, gymnosporioside (1), and three known compounds were isolated from Gymnosporia stylosa leaves. Gymnosporioside (1) was structurally elucidated using NMR, TOFMS, and CD data, while the known compounds were identified as prunin (2), acteoside (3), and isoacteoside (4). Compounds 3 and 4 showed significant inhibitory activities against LPS-induced NO production in RAW264.7 cells.
RECORDS OF NATURAL PRODUCTS
(2021)
Article
Chemistry, Medicinal
Thi Ngoc Tram Nguyen, Thanh Duy Le, Phuoc Long Nguyen, Duc Hanh Nguyen, Huynh Van Thi Nguyen, Tan Khanh Nguyen, Manh Hung Tran, Thi Hong Van Le
Summary: Aquilaria crassna is a plant cultivated for producing resinous heartwood, also known as agarwood. Its leaves are a source of herbal tea in Vietnam due to their high polyphenol content. The study isolated 7 polyphenols from the leaves, with genkwanin showing the most active alpha-glucosidase inhibition. Different leaf ages exhibited varying contents of compounds, with mangiferin being the most abundant.
NATURAL PRODUCT COMMUNICATIONS
(2022)
Article
Chemistry, Medicinal
Linh Thuy Thi Tran, Trong Nhan Le, Duc Viet Ho, Thi Hoai Nguyen, Vinh Phu Tran Pham, Kim Thuong Van Pham, Tan Khanh Nguyen, Manh Hung Tran
Summary: Cordauvarin A from Uvaria cordata shows potential as a natural therapeutic agent for gout treatment through its strong inhibition of xanthine oxidase. Further research and development are needed for clinical applications.
NATURAL PRODUCT COMMUNICATIONS
(2022)
Article
Chemistry, Medicinal
Linh Thuy Thi Tran, Nhi Yen Thi Dang, Nguyen Thao Nguyen Le, Hoai Thi Nguyen, Duc Viet Ho, Thao Thi Do, Manh Hung Tran, Tan Khanh Nguyen, Phu Tran Vinh Pham
Summary: In this study, liriodenine and lysicamine from Goniothalamus elegans Ast. were found to have anti-breast cancer activity through molecular interactions with breast cancer-related proteins. In vitro experiments confirmed their inhibitory effects on cell proliferation. These findings suggest that Goniothalamus elegans could be a potential herbal medicine for breast cancer treatment.
NATURAL PRODUCT COMMUNICATIONS
(2022)
Article
Education, Scientific Disciplines
Linh Thuy Thi Tran, Tan Khanh Nguyen, Hoai Thi Nguyen, Phu Phong Nguyen, Nhi Yen Thi Dang, Manh Hung Tran, Vinh Phu Tran Pham, Anh Tuan Le
Summary: This study investigated the morphological and microanatomical characteristics of Pogostemon auricularius collected from Quang Tri Province. The results provided important taxonomic information for this species and contributed to the taxonomic investigation of the genus Pogostemon.
Article
Chemistry, Physical
Tan Khanh Nguyen, Thao Nguyen Le Nguyen, Kiet Nguyen, Huynh Van Thi Nguyen, Linh Thuy Thi Tran, Thanh Xuan Thi Ngo, Phu Tran Vinh Pham, Manh Hung Tran
Summary: This study utilizes a machine learning algorithm-based model to discover potential anticancer compounds on the MCF-7 breast cancer cell line. The model identifies eight essential oils from Ocimum basilicum as potential candidates and analyzes their anticancer mechanisms through molecular docking simulation. These findings provide a basis for further research on the utilization of substances derived from Ocimum basilicum as a novel treatment for breast cancer.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Biochemistry & Molecular Biology
Van Ngo Thai Bich, Tan Khanh Nguyen, Thao Dao Thi Thu, Linh Thuy Thi Tran, Sa Vo Duong Nguyen, Ho Le Han, Long-Hung Dinh Pham, Trung Hoang Thanh, Van Hoa Duong, Tuan Anh Trieu, Manh Hung Tran, Phu Tran Vinh Pham
Summary: This study found that the ethyl acetate fraction extracted from Ampelopsis cantoniensis exhibited significant antibacterial activity against methicillin-resistant Staphylococcus aureus. Molecular docking and molecular dynamics methods revealed that the main compound, dihydromyricetin, could bind to the bacterial protein PBP2a at an allosteric site, thereby exerting its antibacterial effect. High performance liquid chromatography analysis confirmed dihydromyricetin as the major component of the ethyl acetate fraction. Therefore, natural products derived from Ampelopsis cantoniensis may serve as a potential therapy for methicillin-resistant Staphylococcus aureus.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Chemistry, Medicinal
Trang Thi Thu Nguyen, Trinh Thi Tuyet Nguyen, Hoang Duc Nguyen, Tan Khanh Nguyen, Phu Tran Vinh Pham, Linh Thuoc Tran, Linh Thuy Thi Tran, Manh Hung Tran
Summary: In this study, molecular docking simulation was used to evaluate the binding energy of natural secondary metabolites from Ganoderma sp. on S. aureus sortase A. The results showed that ganosinensin B and ganosinoside A had the highest binding energy and stable binding capacity to the protein. In addition, the extracts of Ganoderma sp. exhibited antibacterial activity against S. aureus. These findings provide potential candidates for developing novel drugs to treat S. aureus infection.
NATURAL PRODUCT COMMUNICATIONS
(2023)
Article
Education, Scientific Disciplines
Trang Thi Thu Nguyen, Hoang Duc Nguyen, Anh Tu Bui, Khanh Huyen Thi Pham, Kim Thuong Pham Van, Linh Thuoc Tran, Manh Hung Tran
Summary: This study identifies a wood decay mushroom, Ganoderma multipileum, associated with the dieback of Delonix regia in Vietnam through morphological analysis and genetic sequencing. The research provides the first documented evidence of Ganoderma multipileum in Vietnam and its connection to the dieback of Delonix regia.
Article
Chemistry, Multidisciplinary
Tan Khanh Nguyen, Linh Thuy Thi Tran, Trung Truong Tan, Phu Tran Vinh Pham, Linh Thuy Khanh Nguyen, Hoai Thi Nguyen, Duc Viet Ho, Manh Hung Tran
Summary: Two styryl-lactone derivatives (1 and 2) were isolated from the aerial parts of Goniothalamus elegans. Compound 1 is a newly discovered natural product, and compound 2 is reported in this plant for the first time. Both compounds showed potent cytotoxicity against cancer cell lines, with compound 1 displaying a strong binding affinity for EGFR and HER-2 proteins. ADMET predictions suggested that these compounds can be absorbed in the gastrointestinal tract and penetrate the blood-brain barrier. These findings suggest that further studies should be conducted to explore their potential as active ingredients for cancer treatment.
Article
Plant Sciences
Chuong Ngoc Nguyen, Hieu Thi Hong Nguyen, Dieu Thuong Thi Trinh, Thi Hong Van Le, Tuan Duc Nguyen, Dinh Vinh, Dao Cuong To, Loi Huynh, Manh Hung Tran
Summary: In this study, two novel secondary metabolites and eight known compounds were isolated and identified from the extract of Vietnamese Lycopodium casuarinoides. The flavonoids (2R,3R)-dihydrokaempferol and apigenin showed significant inhibitory activity against nitric oxide production, indicating potential anti-inflammatory effects. Structural variations in guaiacyl glyceryls salcolin A and salcolin B were also found to be related to their activity.
PHYTOCHEMISTRY LETTERS
(2023)
Article
Immunology
Ngu Truong Nhan, Phi Hung Nguyen, Dam Thi Bich Hanh, Dang Thi Thuy My, Nguyen Phuong Dai Nguyen, Truong Ba Phong, Nguyen Thi Mai Huong, Manh Hung Tran, Nguyen Thi Thu Tram, Dao Cuong To
Summary: The phytochemical constituents of Vietnamese Dalbergia oliveri and their inhibition of NO production were investigated in this study. As a result, nine secondary metabolites were successfully isolated from the heartwood of D. oliveri, and these compounds showed significant inhibitory effects on NO production.
EUROPEAN JOURNAL OF INFLAMMATION
(2022)
Article
Plant Sciences
Yi Zhu, Junlin Wang, Lu Tang, Yuxin Shang, Weiyi Zhao, Wei Zhang, Ping Hai, Yongbiao Zheng, Wenbo Li, Yanfang Su
Summary: One new iridoid glucoside and two new lignan glycosides, along with three known compounds, were isolated from the whole plants of Lancea tibetica. The structures were determined by spectroscopic methods and X-ray crystallographic analysis. One of the new iridoid glucosides and the known compounds exhibited moderate antioxidant activity.
PHYTOCHEMISTRY LETTERS
(2024)
Article
Plant Sciences
Yi Deng, Minghua Chen, Junming Yi, Yuguo Zheng
Summary: This study successfully designed and synthesized a series of quinazolinone derivatives containing purine molecules, and found that some compounds exhibited strong antiviral activity against tobacco mosaic virus. The findings have important implications for further development of antiviral drugs.
PHYTOCHEMISTRY LETTERS
(2024)
