Editorial Material
Biochemistry & Molecular Biology
Kristen Hege
Summary: Unexpected clinical results have revealed a new aspect in CAR design that could potentially enhance the development of more effective CAR T cell therapies.
Article
Multidisciplinary Sciences
Binhan Yu, Channing C. Pletka, B. Montgomery Pettitt, Junji Iwahara
Summary: The study presents a novel NMR-based method for validating electrostatic potentials around biomolecules, demonstrating good agreement with predictions from the Poisson-Boltzmann theory. However, certain weaknesses of the theory were also illuminated, such as discrepancies in the dependence on ionic strength and potential errors due to conformational flexibility or structural uncertainties. This NMR-based method has the potential to facilitate improvements in computational approaches for electrostatic potentials.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Sabrina Gessler, Clara Guthmann, Vera Schuler, Miriam Lilienkamp, Gerd Walz, Toma Antonov Yakulov
Summary: Acute kidney injury is a common complication of severe human diseases, and the mechanisms of repair after injury are still poorly understood. Using a zebrafish model, this study reveals the crucial role of nucleotide-dependent signaling in the cell migration process following tubular injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Jimin Park, Joy S. Zeng, Atharva Sahasrabudhe, Kyoungsuk Jin, Yoel Fink, Karthish Manthiram, Polina Anikeeva
Summary: Researchers have developed an electrochemical approach to on-demand release CO by reducing dissolved CO2, modulating signaling pathways mediated by CO receptor. By exploring the effects of CO release kinetics on neuronal signaling, and integrating components into microscale fibers, they localized CO synthesis and activated signaling cascades in targeted cells. This approach may facilitate studies of physiological processes affected by this gaseous molecular messenger.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Multidisciplinary Sciences
Kyle G. Daniels, Shangying Wang, Milos S. Simic, Hersh K. Bhargava, Sara Capponi, Yurie Tonai, Wei Yu, Simone Bianco, Wendell A. Lim
Summary: This study constructed a CAR library containing synthetic costimulatory domains and used neural networks and machine learning to decode the combinatorial grammar of CAR signaling motifs. Non-native combinations of signaling motifs were found to enhance cytotoxicity and stemness associated with tumor killing.
Review
Chemistry, Multidisciplinary
Wolfgang Maret
Summary: Humans require about 20 chemical elements for their bodies, with essential metal ions making up half of them. Non-essential metal ions are also present in our bodies due to environmental exposures, with their accumulation being accelerated by increasing pollution. The integration of specialty disciplines into a science of bioelements called metallomics has only recently been attempted, aiming to understand the interactions of life processes with most of the chemical elements in the periodic table.
APPLIED SCIENCES-BASEL
(2021)
Review
Pharmacology & Pharmacy
Shanu Jain, Kenneth A. Jacobson
Summary: Purinergic signaling, originally proposed by Geoffrey Burnstock, plays a crucial role in modulating pathways in various physiological systems. Adenosine receptors and P2 nucleotide receptors are involved in metabolic disorders, affecting specific cell types like adipocytes, skeletal muscle, liver cells, and immune cells. Selective ligands for adenosine and P2 receptors may have therapeutic potential for diabetes and obesity, but conflicting conclusions exist in drug discovery related to this topic.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Electrochemistry
Tiejun Xiao, Yun Zhou
Summary: In this paper, a nonlocal electrostatics model is developed for ions in primitive electrolyte solutions. Through a self-consistent determination of parameters, the theory can reproduce the well known multi-Yukawa electric potentials in concentrated electrolyte solutions, applicable to spherical ions, and shows good agreement with HNC theory.
ELECTROCHIMICA ACTA
(2021)
Article
Chemistry, Multidisciplinary
Deyu Yi, Jian Zhao, Lele Li
Summary: Li et al. achieved cell-selective imaging of metal ions using an enzyme-activatable DNAzyme sensor technology, allowing differentiation of metal-ion signals in tumor cells from healthy cells both in vitro and in vivo.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Biochemistry & Molecular Biology
Gene Chong, Alexander D. MacKerell
Summary: Molecular modeling and dynamics simulations were used to generate structures of Fc gamma RIIIa-Fc epsilon RI gamma complexes and study how ITAM signaling is triggered. Different spatial orientations of ITAMs upon clustering were predicted to lead to ITAM phosphorylation by Lck and subsequent Syk activity, facilitating downstream signaling.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2022)
Review
Immunology
Matthew Bell, Stephen Gottschalk
Summary: CAR T cell therapy is effective for hematological malignancies, but there is a need to improve its efficacy for solid tumors and brain tumors. Several approaches are being pursued to enhance the antitumor activity of CAR T cells, including augmenting signal 3 of T cell activation and improving the function of CAR T cells in the tumor microenvironment.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Thibault Roudaire, Marie-Claire Heloir, David Wendehenne, Aymeric Zadoroznyj, Laurence Dubrez, Benoit Poinssot
Summary: Both plants and animals possess sophisticated innate immune systems equipped with receptors to detect danger signals and initiate antimicrobial defenses through regulated cell death signaling pathways.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Endocrinology & Metabolism
Shanu Jain, Kenneth A. Jacobson
Summary: Research has shown that purinergic receptors play a vital role in regulating liver function and the development of liver diseases, suggesting potential therapeutic strategies by targeting adenosine, P2Y, and P2X receptors.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Chemistry, Analytical
Marzia Cosmi, Nathaly Gonzalez-Quinonez, Pablo Tejerina Diaz, Angel Manteca, Elisa Blanco-Gonzalez, Jorg Bettmer, Maria Montes-Bayon, Mario Corte-Rodriguez
Summary: By utilizing SP-ICP-MS and TEM techniques, the study detected the release of metallic nanoparticles from dental implants in the oral environment. The addition of mucosal bacteria significantly decreased the production of nanoparticles, indicating a potential impact on biotribocorrosion.
JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY
(2021)
Review
Biochemistry & Molecular Biology
Georgi Nikolaev, Ralitsa Robeva, Rossitza Konakchieva
Summary: The exact role of the pineal hormone melatonin in human physiology remains elusive despite numerous studies. Human body has two high-affinity melatonin receptors, MT1 and MT2, which activate different signaling pathways. Genetic polymorphisms of melatonin receptors have been implicated in various diseases. The secretion pattern and diverse effects of melatonin, along with its interactions with other signaling pathways, further contribute to the complexity of research on its role in humans.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
