Article
Chemistry, Applied
Yu Cai, Liying Xin, Peng Sun, Hui Li, Chao Liu, Liang Fang
Summary: A temperature-sensitive multifunctional intelligent hydrogel patch has been developed for wound healing, which can accelerate wound closure through controlling drug release, providing analgesia, antioxidation, and hemostasis.
CARBOHYDRATE POLYMERS
(2023)
Article
Biochemistry & Molecular Biology
Marcel Jakubowski, Aleksandra Domke, Maria Ratajczak, Joanna Szczuka, Tomasz Buchwald, Adam Voelkel, Mariusz Sandomierski
Summary: Osteoporosis is a widespread disease. Bisphosphonates are commonly used drugs for its treatment, but they have limitations. This paper focuses on the development of a hydrogel material modified with lanthanum for sustained and slow release of Zoledronate. The research found that the hydrogel is capable of long-term release, making it suitable for implantable hydrogel or coating for local drug delivery on titanium implants.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Polymer Science
Young-Ah Kim, Jin-Oh Jeong, Jong-Seok Park
Summary: This study developed a smart drug delivery system using PAA hydrogel and electrical stimulus to efficiently deliver drugs. The PAA-silicone hydrogel, formed by combining carboxyl groups of PAA with siloxane groups of silicone, demonstrated excellent mechanical properties and cell compatibility. It can effectively control drug release rate and has potential applications in cosmetics and medical drug delivery systems.
Article
Chemistry, Applied
Ferah Comert Onder, Alper Onder, Pinar Ilgin, Hava Ozay, Ozgur Ozay
Summary: This study developed a drug carrier, poly(acrylic acid-co-2-hydroxyethyl methacrylate)/rutin (RTN hydrogel), using the natural crosslinker rutin. The RTN hydrogel exhibited in vitro biodegradability and antioxidant properties. It adsorbed a maximum of 32.96±1.83 mg/g doxorubicin (DOX) and released the drug in normal and cancer cell media. The effect on triple negative breast cancer (TNBC) cell lines was also investigated, showing promising potential as a high-impact carrier in drug distribution systems.
REACTIVE & FUNCTIONAL POLYMERS
(2023)
Article
Chemistry, Physical
Niloufar Khosravi, Leila Youseftabar-Miri, Faten Divsar, Sara Hallajian, Kaynaz Hafezi
Summary: A biocompatible and biodegradable hydrogel nanocomposite was synthesized for controlled and sustained release of gabapentin. The hydrogel composite exhibited high drug encapsulation and loading efficiency, and the drug release followed the Higuchi kinetics model and Fick-ian diffusion mechanism. The chitosan-based hydrogel showed excellent biocompatibility and thermosensitive properties, making it a promising drug carrier.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Polymer Science
Justin B. Safari, Alain M. Bapolisi, Rui W. M. Krause
Summary: This study developed a pH-sensitive chitosan-based hydrogel for controlled delivery of anti-hepatitis B drug TDF. The hydrogels showed pH and ionic strength sensitivity, with high drug encapsulation efficiency and pH-dependent drug release. Cytotoxicity studies demonstrated cytocompatibility, suggesting potential as a smart delivery system for oral anti-hepatitis B drugs.
Article
Biochemistry & Molecular Biology
Yangjin Dong, Shanshan Li, Xiaoyun Li, Xiaoying Wang
Summary: In this study, two-dimensional MXene nanosheets with high photothermal conversion efficiency and stability were successfully prepared and applied to a hydrogel drug delivery system, providing a new approach for localized cancer treatment.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Physical
Tannaz Soltanolzakerin Sorkhabi, Mehrab Fallahi Samberan, Krzysztof Adam Ostrowski, Tomasz M. Majka
Summary: The effect of SiO2 nanoparticles on the formation of PAA gel structure was investigated. The results showed that SiO2 nanoparticles played a co-crosslinking role in the formation of PAA hydrogel and the addition of toluene resulted in a macroporous structure. The water absorption capacity and amoxicillin release from the nanocomposite hydrogels were influenced by the presence of pores. The release of amoxicillin was found to be a swelling controlled-release system.
Article
Pharmacology & Pharmacy
Kangkang Li, Xinlong Zang, Mingyang Cheng, Xuehong Chen
Summary: Recent progresses in fighting against cancer include better understanding of tumor microenvironment and rapid development in nanoscale drug delivery system. Nanocarriers based on polymeric acrylic derivatives have shown high drug encapsulation rate and satisfactory therapeutic outcome in tumor treatment.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Chemistry, Multidisciplinary
Dipen Biswakarma, Nilanjan Dey, Santanu Bhattacharya
Summary: The self-assembly properties of new biocompatible, thermoreversible fluorescent hydrogels composed of amino acid residues have been reported. Different amino acid residues form different aggregated structures, and a significant gel-to-sol transition occurs in the presence of hypochlorite.
Article
Polymer Science
Fabio Pizzetti, Anna Maspes, Arianna Rossetti, Filippo Rossi
Summary: Hydrogels have shown promise in various medical applications, such as controlled drug delivery systems and tissue engineering scaffolds. Careful material design is crucial for achieving desired properties. By modifying the 3D network of agarose-carbomer hydrogels with hyaluronic acid chains as degradable cross-links, the degradation kinetics of the hydrogels can be tuned to improve tissue regrowth.
EUROPEAN POLYMER JOURNAL
(2021)
Article
Chemistry, Applied
Amilton Barbosa Botelho Junior, Denise Crocce Romano Espinosa, Jorge Alberto Soares Tenorio
Summary: Rare earth elements are critical metals due to the risk of supply interruption. Recycling of waste electrical and electronic equipment can be an alternative supply source. Aqueous media processes allow extraction and separation of elements even at low concentrations.
JOURNAL OF RARE EARTHS
(2021)
Article
Pharmacology & Pharmacy
Mariyeh Rajaei, Hamid Rashedi, Fatemeh Yazdian, Mona Navaei-Nigjeh, Abbas Rahdar, Ana M. Diez-Pascual
Summary: A promising methodology has been developed to improve drug loading performance and achieve sustained release of 5-fluorouracil (5-FU) for breast cancer treatment. A pH-sensitive and biocompatible hydrogel of chitosan/agarose/graphene oxide (CS/AG/GO) was synthesized with glyoxal as cross-linker, and 5-FU-loaded nanocomposites (NCs) of CS/AG/GO were prepared. The NCs showed high drug loading and encapsulation efficiency, and exhibited effective sustained drug release and cytotoxicity against breast cancer cells.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Mehrab Pourmadadi, Mohammadjavad Ahmadi, Fatemeh Yazdian
Summary: Nanotechnology with drug carriers has achieved significant progress in cancer treatment by mitigating the adverse effects of traditional therapies such as curcumin. Targeting tumors without harming healthy cells can be achieved with the use of chitosan. Magnetic iron oxide provides a high specific area to enhance the ability of the nano-scale vehicle to load curcumin.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Physical
Martina Klucakova, Petra Zavodska
Summary: Many pharmaceuticals can exhibit dangerous behavior in soil and water environments, and their migration ability and toxicity can be influenced by interactions with organic matter. This study focuses on the transport of two commonly used sulphonamide antibiotics, sulfamethoxazole and sulphapyridine, in hydrogels containing humic substances. The addition of humic acids into the hydrogel was found to decrease the effective diffusion coefficient of sulphapyridine and increase the effective diffusion coefficient of sulfamethoxazole. Batch sorption experiments showed similar adsorption capacities of humic acids for both antibiotics, but the desorption experiments indicated that a majority of sulphapyridine can be immobilized by interaction with humic acids while more free movable sulfamethoxazole was observed.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2023)
Review
Materials Science, Multidisciplinary
Filippo Pinelli, Marjan Saadati, Ehsan Nazarzadeh Zare, Pooyan Makvandi, Maurizio Masi, Alessandro Sacchetti, Filippo Rossi
Summary: Nanogels have emerged as highly promising biomaterials with a wide range of applications. They have been recognized as efficient drug delivery systems for in vivo applications and have also shown potential in areas such as sensing materials, catalysts, and environmental adsorbents. This study aims to enhance our understanding of their possible uses and synthesis methods by reviewing the existing literature.
INTERNATIONAL MATERIALS REVIEWS
(2023)
Article
Engineering, Chemical
Carmine Sabia, Antonio Buffo, Tommaso Casalini, Daniele L. Marchisio, Maurizio C. Barbato, Giuseppe Storti
Summary: Two different modeling approaches, including a fully detailed computational fluid-dynamics (CFD) model and a conventional three-phase, 1D compartmentalized model (SCM), were applied to simulate fluidized bed reactors for polyolefins production. The reliability of the simplified model was confirmed by comparing it with the detailed CFD model, and the results showed that the simplified approach is capable of predicting solid mixing features with good reliability, especially for non-reactive polyethylene particles.
MACROMOLECULAR REACTION ENGINEERING
(2022)
Article
Instruments & Instrumentation
Filippo Bisotti, Fabio Pizzetti, Giuseppe Storti, Filippo Rossi
Summary: Hydrogels are 3D structures of hydrophilic polymers that have gained significant importance in various applications, such as tissue engineering and drug delivery. In this study, hydrogels were synthesized using branched polyacrylic acid and aliphatic polyetherdiamine and their swelling behavior and drug release capabilities were investigated through mathematical modeling and literature models.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Review
Biotechnology & Applied Microbiology
Oystein Ovrebo, Giuseppe Perale, Jonathan P. Wojciechowski, Cecile Echalier, Jonathan R. T. Jeffers, Molly M. Stevens, Havard J. Haugen, Filippo Rossi
Summary: Musculoskeletal defects are a significant healthcare burden, particularly as the population ages. Hydrogels have emerged as a promising solution, with their high biocompatibility and potential for minimally invasive delivery. This review explores the design and clinical translation of hydrogels, with a focus on treatments for cartilage, bone, and the nucleus pulposus. The importance of acquiring high-quality pre-clinical and clinical data for successful translation is emphasized.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2022)
Editorial Material
Biochemistry & Molecular Biology
Filippo Rossi
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Filippo Pinelli, Fabio Pizzetti, Valeria Veneruso, Emilia Petillo, Michael Raghunath, Giuseppe Perale, Pietro Veglianese, Filippo Rossi
Summary: Spinal cord injury is a damaging process that occurs during an acute traumatic event, and requires a multi-target approach for treatment. Recent advances in biomaterials and drug/biomolecule combinations have shown promise in the treatment of spinal cord injuries.
Article
Chemistry, Physical
Filippo Pinelli, Marjan Saadati, Arianna Rossetti, Filippo Rossi, Alessandro Sacchetti
Summary: Nanogels are biocompatible and biodegradable colloids that show potential in drug delivery applications. However, encapsulating hydrophobic compounds in nanogels has proven to be challenging. This study investigates the chemical modification of linear polyethyleneimine (PEI) to improve the loading and release of hydrophobic drugs from nanogels. The introduction of modifications in the nanogel framework results in optimal loading and encapsulation efficiency for hydrophobic molecules.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2023)
Article
Chemistry, Multidisciplinary
Valeria Vanoli, Giovanna Massobrio, Fabio Pizzetti, Andrea Mele, Filippo Rossi, Franca Castiglione
Summary: Bijels, as bicontinuous interfacially jammed emulsion gels, have attracted increasing interest as biomaterials for controlled drug delivery. Two different bijel formulations were prepared and their structures and drug transport behavior were characterized using diffusion nuclear magnetic resonance spectroscopy. The results showed that both drug concentration and bijel formulation type influenced the drug diffusion coefficient and in vitro release profiles.
Editorial Material
Biotechnology & Applied Microbiology
Filippo Rossi, Yuta Kurashina, Hiroaki Onoe
Article
Chemistry, Physical
Giulia Camana, Mirko Tavano, Min Li, Franca Castiglione, Filippo Rossi, Francesco Cellesi
Summary: In this study, functional Pluronic F127 precursors were designed and synthesized for the preparation of thermosensitive hydrogels. The properties of these gels were compared to those obtained through free radical crosslinking of F127 diacrylate. The study provides a method for creating tailored hydrogels suitable for various biomedical applications, such as soft-tissue engineering, cell encapsulation, wound healing, and sustained delivery of therapeutic molecules.
Article
Chemistry, Physical
Omar Salmi, Simone Gelosa, Filippo Rossi, Maurizio Masi
Summary: The finished tanned leather is usually covered by a thin polymeric layer to improve its appearance and impermeabilization properties. However, this finished layer often leads to the rejection of the product by clients, and tanneries need to recover the underlying leather layer. The strong bonding between the polymeric film and leather requires a blade shaving process for separation, which also removes a layer of tanned leather and reduces its thickness. In this study, a novel separation method using cryogenic fluids, such as liquid nitrogen, was developed to freeze the polymeric layer below the glass transition temperature, allowing for easy separation without altering the tanned leather layer.
Review
Agriculture, Multidisciplinary
Roberta Magaletti, Fabio Pizzetti, Maurizio Masi, Filippo Rossi
Summary: The exponential growth of the world's population has increased the need to optimize agricultural technologies. Smart use of fertilizers, particularly slow-release fertilizers, can help ensure high productivity while avoiding pollution issues. Research has focused on materials that are cheap, environmentally friendly, and biodegradable to address the problems associated with non-renewable sources used in fertilizers.
ACS AGRICULTURAL SCIENCE & TECHNOLOGY
(2023)
Article
Polymer Science
Filippo Pinelli, Chiara Piras, Liebert Parreiras Nogueira, Filippo Rossi
Summary: One of the most persistent issues affecting people worldwide is water contamination due to indiscriminate disposal of pollutants. This study focuses on the use of porous graphene-oxide-chitosan aerogels as a sorbent material to remove harmful contaminants, particularly dyes, from water. The aerogels showed excellent adsorption ability for anionic dyes and can be regenerated and reused through alkaline and acidic treatments.
Article
Chemistry, Multidisciplinary
Sara Maria Giannitelli, Emanuele Limiti, Pamela Mozetic, Filippo Pinelli, Xiaoyu Han, Franca Abbruzzese, Francesco Basoli, Danila Del Rio, Stefano Scialla, Filippo Rossi, Marcella Trombetta, Laura Rosano, Giuseppe Gigli, Zhenyu Jason Zhang, Emanuele Mauri, Alberto Rainer
Summary: This study successfully synthesized nanogels using droplet-based microfluidics, demonstrating precise control over nanoparticle size and morphology, and validated its potential application as a drug delivery system in vitro.
Article
Polymer Science
Filippo Pinelli, Tommaso Nespoli, Filippo Rossi
Summary: Porous aerogels, formed by freeze-drying precursor hydrogels, are highly studied soft materials with key features like elasticity, swelling behavior, and micro/nanosized pores, suitable for various applications. Recent interest has focused on aerogels combining polymeric structures with graphene, enabling tuning of properties such as toughness and electrical conductivity. Chitosan graphene oxide aerogels were synthesized in this study, chemically characterized and mechanically tested, demonstrating high adsorption capacity for contaminants like anionic dyes.
