Review
Medicine, General & Internal
Lianne M. Haveman, Roelof van Ewijk, Elvira C. van Dalen, Willemijn B. Breunis, Leontien C. M. Kremer, Henk van den Berg, Uta Dirksen, Johannes H. M. Merks
Summary: Ewing sarcoma is a common bone tumor in children, with a significant recurrence rate and low survival rate despite intensive chemotherapy. High-dose chemotherapy followed by autologous haematopoietic cell transplantation may improve survival after the first recurrence of Ewing sarcoma. Further research is needed to examine the efficacy and toxicity of this treatment approach.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2021)
Article
Oncology
Eleni Gavriilaki, Athanasios Tragiannidis, Maria Papathanasiou, Sotiria Besikli, Paraskevi Karvouni, Vassiliki Douka, Eleni Paphianou, Emmanuel Hatzipantelis, Giorgos Papaioannou, Anastasia Athanasiadou, Anastasia Marvaki, Alkistis-Kira Panteliadou, Anna Vardi, Ioannis Batsis, Antonia Syrigou, Despina Mallouri, Chrysavgi Lalayanni, Ioanna Sakellari
Summary: This study aims to investigate the efficiency and safety of therapeutic methods for aplastic anemia and paroxysmal nocturnal hemoglobinuria. The study found that novel treatments are changing the field of BMF syndromes, but further research is needed to personalize algorithms.
FRONTIERS IN ONCOLOGY
(2022)
Article
Engineering, Multidisciplinary
Mohamed M. M. Elnasharty, Azhar M. Elwan
Summary: Measuring the impact of different dose rates of irradiation is difficult. This study introduces physical parameters that can measure and differentiate these effects. Promising results were obtained in discriminating dose rates using thermodynamic functions derived from dielectric parameters. This provides the ability for early medical intervention to prevent late effects.
Review
Endocrinology & Metabolism
Toshihide Mizoguchi, Noriaki Ono
Summary: Osteoblasts are the only cells capable of forming bones in vertebrates, with their main function being the production of mineralized matrix. Disruption of their regulation can lead to various bone diseases, highlighting the importance of understanding the origin of these cells for the development of novel therapeutic approaches. Recent advances in technology have provided new insights into the diverse sources of osteoblasts involved in bone formation under different conditions.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Hematology
Jessica A. Pollard, Elissa Furutani, Shanshan Liu, Erica Esrick, Laurie E. Cohen, Jacob Bledsoe, Chih-Wei Liu, Kun Lu, Maria Jose Ramirez de Haro, Jordi Sumalles, Maggie Malsch, Ashley Kuniholm, Ashley Galvin, Myriam Armant, Annette S. Kim, Kaitlyn Ballotti, Lisa Moreau, Yu Zhou, Daria Babushok, Farid Boulad, Clint Carroll, Helge Hartung, Amy Hont, Taizo Nakano, Tim Olson, Sei-Gyung Sze, Alexis A. Thompson, Marcin W. Wlodarski, Xuesong Gu, Towia A. Libermann, Alan D'Andrea, Markus Grompe, Edie Weller, Akiko Shimamura
Summary: This study investigated the feasibility and tolerability of metformin treatment in patients with Fanconi anemia (FA). The results showed that metformin is safe and tolerable in nondiabetic patients with FA and may provide therapeutic benefits.
Review
Medicine, General & Internal
Lianne M. Haveman, Roelof van Ewijk, Elvira C. van Dalen, Willemijn B. Breunis, Leontien C. M. Kremer, Henk van den Berg, Uta Dirksen, Johannes H. M. Merks
Summary: The study evaluated the effects of high-dose chemotherapy with autologous hematopoietic cell transplantation compared to conventional chemotherapy in improving outcomes for children, adolescents, and young adults with primary metastatic Ewing sarcoma. The results suggest that there may be no significant difference in event-free survival between the two treatment groups, but further research is needed to draw more definitive conclusions.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2021)
Review
Oncology
BhanuPrasad Venkatesulu, Prashanth Giridhar, Lincoln Pujari, Brian Chou, Jae Han Lee, Alec M. Block, Rituraj Upadhyay, James S. Welsh, Matthew M. Harkenrider, Sunil Krishnan, Vivek Verma, Cheng En Hsieh, Satyajit Pradhan, William Small Jr, Abhishek A. Solanki
Summary: This study provides a systematic review of the literature on the dosimetric predictors of radiation-related lymphopenia in solid malignancies. The findings suggest that optimizing radiation therapy delivery to limit dose to lymphocyte-rich structures may improve cancer-associated outcomes.
RADIOTHERAPY AND ONCOLOGY
(2022)
Review
Immunology
Natividad Cuende, Anna Vilarrodona, Elena Vuelta, Rosario Marazuela, Concha Herrera, Sergi Querol, Jacinto Sanchez-Ibanez, Mar Carmona, Antonio Gaya, Jaume Tort, Dolores Hernandez, Beatriz Dominguez-Gil
Summary: This article proposes an ethical and transparent framework for collaboration between industry and authorities in the field of SoHO-derived products. It highlights the risks associated with commodification of these products and emphasizes the importance of maintaining the principles of altruistic donation and noncommercialization of the human body. The article also suggests measures to ensure the quality, safety, and efficacy standards of tissues and cells for clinical use.
Article
Medicine, General & Internal
David I. Marks, Anna Castleton, Eduardo Olavarria, Maria Gilleece, Adele Fielding, George Mikhaeel, Matthew Beasley, Patricia Diez, Aimee Jackson, Andrea Hodgkinson, Mohamed Elhanied, Ronjon Chakraverty
Summary: This study examines the usage of T-cell depleted, reduced intensity conditioning (RIC) approach to haematopoietic cell transplantation (HCT) in adult patients with acute lymphoblastic leukaemia (ALL). The results show encouraging survival rates but high relapse rates, suggesting the need for more powerful conditioning approaches.
Article
Cardiac & Cardiovascular Systems
Jiro Ikeda, Corey A. Scipione, Sharon J. Hyduk, Marwan G. Althagafi, Jawairia Atif, Sarah A. Dick, Maneesha Rajora, Erika Jang, Takuo Emoto, Junichi Murakami, Noriko Ikeda, Hisham M. Ibrahim, Chanele K. Polenz, Xiaotang Gao, Kelly Tai, Jenny Jongstra-Bilen, Ryota Nakashima, Slava Epelman, Clinton S. Robbins, Gang Zheng, Warren L. Lee, Sonya A. MacParland, Myron Cybulsky
Summary: This study revealed that radiation exposure inhibits LDL entry into the aortic intima at baseline and the earliest stages of atherosclerosis in a mouse model of bone marrow transplantation. Single-cell transcriptomic analysis showed a redirection of LDL uptake by endothelial cells to lysosomal degradation and reverse cholesterol transport pathways, reducing lipid accumulation within the intima and impacting lesion initiation and growth.
CIRCULATION RESEARCH
(2021)
Article
Oncology
Nathan J. Schloemer, Wei Xue, Amira Qumseya, Leo Y. Luo, Susan M. Hiniker, Timothy B. Lautz, Daniel S. Rhee, Michael A. Arnold, Rajkumar Venkatramani
Summary: This study is of great significance in understanding the outcomes and prognostic factors of children with bone marrow metastatic rhabdomyosarcoma (RMS). The results show poor prognosis for these patients, indicating the need for therapy deintensification or early pursuit of novel treatments/approaches.
PEDIATRIC BLOOD & CANCER
(2023)
Article
Endocrinology & Metabolism
Huda M. Elsharkasi, Suet C. Chen, Lewis Steell, Shuko Joseph, Naiemh Abdalrahaman, Christie McComb, Blair Johnston, John Foster, Sze Choong Wong, S. Faisal Ahmed
Summary: This study investigates the role of 3T-MRI in assessing musculoskeletal health in children and young people. The results provide insights into the relationships between bone, muscle, and bone marrow, and highlight the importance of MRI as a non-invasive method for comprehensive evaluation of musculoskeletal health in growing individuals.
ENDOCRINE CONNECTIONS
(2022)
Article
Endocrinology & Metabolism
Huda M. Elsharkasi, Suet C. Chen, Lewis Steell, Shuko Joseph, Naiemh Abdalrahaman, Christie McComb, Blair Johnston, John Foster, Sze Choong Wong, S. Faisal Ahmed
Summary: This study explores the role of 3T-MRI in assessing musculoskeletal health in children and young people. The results show associations between bone, muscle, and bone marrow parameters with age and gender, highlighting the importance of MRI as a non-invasive method for comprehensive musculoskeletal health assessment in growing individuals.
ENDOCRINE CONNECTIONS
(2022)
Review
Cardiac & Cardiovascular Systems
Seth J. Rotz, Thomas D. Ryan, Salim S. Hayek
Summary: Hematopoietic stem cell transplantation is a potentially curative treatment for various diseases, but it can also lead to significant cardiovascular complications that require pre-transplant evaluation.
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
(2021)
Article
Hematology
YunZu Michele Wang, Michaela Loveless, Erica Miller, Adam S. Nelson, Parinda A. Mehta, Stella M. Davies, Kasiani C. Myers
Summary: The long-term outcomes of adults with Fanconi anaemia have improved with advances in stem cell transplantation and improved follow-up and screening guidelines. The phenotype of survivors may differ from typical presentation of the disease. Endocrine complications and the development of solid tumors complicate adulthood for these patients. Further analysis is needed to characterize the phenotype of untransplanted adults with Fanconi anaemia.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)