Journal
JOURNAL OF RADIATION RESEARCH
Volume 53, Issue 4, Pages 570-580Publisher
OXFORD UNIV PRESS
DOI: 10.1093/jrr/rrs011
Keywords
ionizing radiation; normal endothelial cells; angiogenesis
Funding
- National Nuclear R&D Program through the National Research Foundation of Korea (NRF)
- Ministry of Education, Science and Technology [2009-0093747]
- National Research Foundation of Korea [2009-0093747] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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The purpose of the present investigation was to study the effects of ionizing radiation on endothelial cells derived from diverse normal tissues. We first compared the effects of radiation on clonogenic survival and tube formation of endothelial cells, and then investigated the molecular signaling pathways involved in endothelial cell survival and angiogenesis. Among the different endothelial cells studied, human hepatic sinusoidal endothelial cells (HHSECs) were the most radio-resistant and human dermal microvascular endothelial cells were the most radio-sensitive. The radio-resistance of HHSECs was related to adenosine monophosphate-activated protein kinase and p38 mitogen-activated protein kinase-mediated expression of MMP-2 and VEGFR-2, whereas the increased radio-sensitivity of HDMECs was related to extracellular signal-regulated kinase-mediated generation of angiostatin. These observations demonstrate that there are distinct differences in the radiation responses of normal endothelial cells obtained from diverse organs, which may provide important clues for protection of normal tissue from radiation exposure.
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