Article
Nutrition & Dietetics
Cezary Chojnacki, Aleksandra Blonska, Paulina Konrad, Marcin Chojnacki, Marcin Podogrocki, Tomasz Poplawski
Summary: This study aimed to evaluate the urinary excretion of selected tryptophan metabolites in patients with IBS-C and IBS-D. It was found that changes in tryptophan metabolism occurred in both groups of IBS patients compared to the control group. The 5-HIAA level was correlated with abdominal symptoms and anxiety in IBS-D patients, while the concentration of kynurenines (KYN, QA) in urine was higher in IBS-C patients and correlated with depression.
Article
Nutrition & Dietetics
Cezary Chojnacki, Tomasz Poplawski, Aleksandra Blonska, Paulina Konrad, Jan Chojnacki, Janusz Blasiak
Summary: This study evaluated the efficacy of a low-FODMAP diet with a concomitant reduction in tryptophan intake for the treatment of IBS-D. The results showed that limiting tryptophan intake was more effective in improving symptoms in IBS-D patients compared to using only a low-FODMAP diet.
Article
Medicine, General & Internal
Grace L. Burns, Nicholas J. Talley, Simon Keely
Summary: Irritable bowel syndrome (IBS) is a disorder of gut-brain interaction characterized by chronic abdominal pain and altered defaecation. Research has found that small intestinal mechanosensation, altered barrier functions, and microbial imbalance are associated with IBS. The current literature suggests that the pathogenesis of IBS may involve dysfunction of the entire intestinal tract.
Article
Biochemistry & Molecular Biology
Zijuan Bi, Shisheng Zhang, Yangyang Meng, Ya Feng, Yinshu Wang, Enkang Wang, Xiangxue Pan, Ruixin Zhu, Haiting Fan, Shuhua Pang, Lixin Zhu, Jianye Yuan
Summary: The knockout of the SERT gene may lead to changes in the serotonin system, causing VH and accelerated gastrointestinal motility in female rats, which can be used as an animal model of IBS.
Article
Endocrinology & Metabolism
Ping-Huei Tseng, Han-Mo Chiu, Chia-Hung Tu, Ming-Shiang Wu, Hong-Nerng Ho, Mei-Jou Chen
Summary: Women with PCOS are more likely to have IBS and obesity, and are at higher risk of psychiatric morbidities compared to healthy women. Those with both PCOS and IBS have increased rates of sleep difficulties and psychiatric distress.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Gastroenterology & Hepatology
Giovanni Marasco, Cesare Cremon, Maria Raffaella Barbaro, Giulia Cacciari, Francesca Falangone, Anna Kagramanova, Dmitry Bordin, Vasile Drug, Egidia Miftode, Pietro Fusaroli, Salem Youssef Mohamed, Chiara Ricci, Massimo Bellini, Mohammed Masudur Rahman, Luigi Melcarne, Javier Santos, Beatriz Lobo, Serhat Bor, Suna Yapali, Deniz Akyol, Ferdane Pirincci Sapmaz, Yonca Yilmaz Urun, Tugce Eskazan, Altay Celebi, Huseyin Kacmaz, Berat Ebik, Hatice Cilem Binicier, Mehmet Sait Bugdayci, Munkhtsetseg Banzragch Yagci, Husnu Pullukcu, Berrin Yalinbas Kaya, Ali Tureyen, Ibrahim Hatemi, Elif Sitre Koc, Goktug Sirin, Ali Riza Caliskan, Goksel Bengi, Esra Ergun Alis, Snezana Lukic, Meri Trajkovska, Keren Hod, Dan Dumitrascu, Antonello Pietrangelo, Elena Corradini, Magnus Simren, Jessica Sjoelund, Navkiran Tornkvist, Uday C. Ghoshal, Olga Kolokolnikova, Antonio Colecchia, Jordi Serra, Giovanni Maconi, Roberto De Giorgio, Silvio Danese, Piero Portincasa, Antonio Di Sabatino, Marcello Maggio, Elena Philippou, Yeong Yeh Lee, Daniele Salvi, Alessandro Venturi, Claudio Borghi, Marco Zoli, Paolo Gionchetti, Pierluigi Viale, Vincenzo Stanghellini, Giovanni Barbara
Summary: This study aimed to evaluate the prevalence of gastrointestinal symptoms and post-COVID-19 disorders of gut-brain interaction among hospitalized patients with SARS-CoV-2 infection. The results showed that patients with COVID-19 had higher rates of gastrointestinal symptoms on hospital admission and lower rates of constipation and hard stools at 12 months post-infection compared to the control group. Additionally, the rate of irritable bowel syndrome was significantly higher in patients with COVID-19 than in controls.
Article
Gastroenterology & Hepatology
S. Coughlan, A. Das, E. O'Herlihy, F. Shanahan, P. W. O'Toole, I. B. Jeffery
Summary: The study conducted metagenomic sequencing of fecal Virus-Like Particles (VLPs) from 55 patients with IBS and 51 control individuals. It found significantly lower alpha diversity of viral clusters in IBS, identified core viromes in both IBS and control groups, and noted no significant covariation between the virome and the bacteriome, IBS clinical subtype, or Bile Acid Malabsorption status.
Review
Cell Biology
Tamas Kortesi, Eleonora Spekker, Laszlo Vecsei
Summary: Migraine is a complex neurovascular disorder with unclear pathophysiology and limited therapeutic options. Recent research has focused on tryptophan metabolism, which produces neuroactive molecules that affect pain processing and stress response. This review summarizes translational and clinical findings, as well as potential therapeutic options for the prevention and treatment of migraine.
Review
Physiology
Xiao-Lan Yu, Cui-Ping Li, Lian-Ping He
Summary: Several studies have shown the critical role of serotonin in the development of depression and irritable bowel syndrome. Recent research indicates that vitamin D is involved in regulating the synthesis of serotonin. This review focuses on the recent advancements in understanding the relationship between vitamin D and serotonin synthesis.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Gastroenterology & Hepatology
Michael Camilleri, Guy Boeckxstaens
Summary: This article evaluates the evidence that targeted pathophysiological mechanisms and customized treatments can be an alternative approach to treating patients with irritable bowel syndrome (IBS). The authors conducted a literature review on the mechanisms and treatments of IBS, identifying various noninvasive clinical tests that can assess the underlying mechanisms responsible for symptom generation. These mechanisms include rectal evacuation disorders, abnormal transit, visceral hypersensitivity or hypervigilance, bile acid diarrhea, sugar intolerances, barrier dysfunction, the microbiome, immune activation, and chemicals released by these mechanisms. The authors also recognized the basic molecular mechanisms contributing to these pathophysiologies, offering opportunities for interventions with medications targeted at specific food components, receptors, and potentially the microbiome. Although the evidence supporting interventions for each mechanism varies, the current state-of-the-art allows for a shift from symptom-based treatment to individualized treatment guided by pathophysiology and clinically identified biomarkers.
Article
Gastroenterology & Hepatology
Zlatan Mujagic, Melpomeni Kasapi, Daisy M. A. E. Jonkers, Isabel Garcia-Perez, Lisa Vork, Zsa Zsa R. M. Weerts, Jose Ivan Serrano-Contreras, Alexandra Zhernakova, Alexander Kurilshikov, Jamie Scotcher, Elaine Holmes, Cisca Wijmenga, Daniel Keszthelyi, Jeremy K. Nicholson, Joram M. Posma, Ad A. M. Masclee
Summary: Combining microbiome and metabolome data can distinguish between irritable bowel syndrome (IBS) patients and healthy controls. Unsupervised clustering based on fecal microbiome-metabolome data revealed distinct subsets of IBS patients. The study also found associations between altered serotonin metabolism, unfavorable stress response related to gastrointestinal symptoms, and IBS, supporting the importance of the microbiome-gut-brain axis in the pathogenesis of IBS.
Article
Medicine, General & Internal
Katsiaryna Vashkevich, Kathryn Janiuk, Nasim Maleki
Summary: This study found that irritable bowel syndrome (IBS) is significantly associated with anxiety disorders, especially in chronic pain patients with comorbid alcohol use disorders. These findings suggest that GI problems resulting from chronic alcohol use may play a key role in the comorbidity of anxiety disorders, chronic pain, and alcohol use disorders. Addressing GI problems in IBS patients with alcohol use disorders may help manage alcohol use disorders and recovery more effectively.
FRONTIERS IN MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Nayoung Kwak, Hankil Lee, Beom Kyung Kim, Yun Mi Yu, Hye-Young Kang
Summary: This study found that the risk of subsequent IBS occurrence following SSRI use was high in patients who initially took a heavy SSRI dose and those who did not have a history of psychiatric drug use.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Review
Gastroenterology & Hepatology
Arjun Gandhi, Ayesha Shah, Michael P. Jones, Natasha Koloski, Nicholas J. Talley, Mark Morrison, Gerald Holtmann
Summary: The systematic review and meta-analysis indicated that methane-positive SIBO is more prevalent in IBS, particularly in IBS-C, compared to controls, while it is less common in patients with IBD. In patients with IBD, methane-positive SIBO was significantly lower in Crohn's disease compared to ulcerative colitis. More studies are needed to establish a causal relationship due to the low quality of evidence and clinical heterogeneity in the current studies.
Article
Obstetrics & Gynecology
M. Peters, I Mikeltadze, H. Karro, M. Saare, Andres Metspalu, Andres Metspalu, Mari Nelis, Lili Milani, Georgi Hudjashov, Tonu Esko, A. Salumets, R. Magi, T. Laisk
Summary: Despite overlapping symptoms, endometriosis and IBS have different significantly associated comorbidities, related to the organ systems primarily involved in the index diagnosis.
HUMAN REPRODUCTION
(2022)
Article
Psychiatry
Tim Klaassen, Lisa Vork, Fabienne G. M. Smeets, Freddy J. Troost, Joanna W. Kruimel, Carsten Leue, Ad A. M. Masclee, Daniel Keszthelyi
Summary: This study used the experience sampling method to assess the association between stress and fullness in patients with FD and healthy controls. The results showed that patients with FD had higher average scores of fullness and stress compared to healthy controls, and stress scores were positively associated with fullness scores in patients with FD. These findings suggest that increased levels of stress may precede feelings of fullness in patients with FD.
PSYCHOSOMATIC MEDICINE
(2022)
Article
Health Care Sciences & Services
Rosel Sturkenboom, Daniel Keszthelyi, Lloyd Brandts, Zsa Zsa R. M. Weerts, Johanna T. W. Snijkers, Ad A. M. Masclee, Brigitte A. B. Essers
Summary: This study developed an algorithm for calculating utility values using the condition-specific IBS-QoL questionnaire for economic evaluations. The model chosen included the total IBS-QoL score and squared IBS-SSS, demonstrating improved performance.
QUALITY OF LIFE RESEARCH
(2022)
Article
Gastroenterology & Hepatology
Rosel Sturkenboom, Daniel Keszthelyi, Ad A. M. Masclee, Brigitte A. B. Essers
Summary: This study investigated the treatment preferences of patients with irritable bowel syndrome (IBS). The results showed that dietary intervention was the most preferred treatment option, followed by pharmacotherapy and psychotherapy. Age and other factors were found to influence treatment choices.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Maartje J. M. Hereijgers, Daniel Keszthelyi, Joanna W. Kruimel, Ad A. M. Masclee, Jose M. Conchillo
Summary: This study assesses the antroduodenal motility patterns among different etiologies of gastroparesis (GP). It identifies different motility patterns ranging from post-surgery GP to idiopathic and diabetic GP.
NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Article
Nutrition & Dietetics
Marlijne C. G. de Graaf, Corinne E. G. M. Spooren, Evelien M. B. Hendrix, Martine A. M. Hesselink, Edith J. M. Feskens, Agnieszka Smolinska, Daniel Keszthelyi, Marieke J. Pierik, Zlatan Mujagic, Daisy M. A. E. Jonkers
Summary: The study found that diet quality was lower in patients with IBD and IBS, and was associated with intestinal inflammation and gastrointestinal symptoms to varying degrees.
Article
Gastroenterology & Hepatology
Sade L. Assmann, Daniel Keszthelyi, Jos Kleijnen, Foteini Anastasiou, Elissa Bradshaw, Ann E. Brannigan, Emma Carrington, Giuseppe Chiarioni, Liora D. A. Ebben, Marc A. Gladman, Yasuko Maeda, Jarno Melenhorst, Giovanni Milito, Jean W. M. Muris, Julius Orhalmi, Daniel Pohl, Yvonne Tillotson, Mona Rydningen, Saulius Svagzdys, Carolynne J. Vaizey, Stephanie O. Breukink
Summary: The project aimed to create an evidence-based European clinical practice guideline for the diagnosis and treatment of faecal incontinence. The guidelines were created in collaboration with different medical societies and included input from a patient advisory board. The guidelines included systematic literature searches, quality assessment, and the formulation of recommendations. Overall, there were 45 recommendations on the classification, diagnosis, and management of faecal incontinence in adult patients.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2022)
Article
Gastroenterology & Hepatology
Annick M. E. Alleleyn, Daniel Keszthelyi, Nicolaas F. Rinsma, Kata Cseko, Bela Kajtar, Zsuzsanna Helyes, Bjorn Winkens, Adrian A. M. Masclee, Jose M. Conchillo
Summary: The perfusion of capsaicin in the esophagus resulted in significant pain intensity and impaired recovery of mucosal impedance. Pain response was associated with decreased mucosal impedance, suggesting capsaicin may induce esophageal pain by affecting mucosal impedance and restoration capacity.
CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Zlatan Mujagic, Melpomeni Kasapi, Daisy M. A. E. Jonkers, Isabel Garcia-Perez, Lisa Vork, Zsa Zsa R. M. Weerts, Jose Ivan Serrano-Contreras, Alexandra Zhernakova, Alexander Kurilshikov, Jamie Scotcher, Elaine Holmes, Cisca Wijmenga, Daniel Keszthelyi, Jeremy K. Nicholson, Joram M. Posma, Ad A. M. Masclee
Summary: Combining microbiome and metabolome data can distinguish between irritable bowel syndrome (IBS) patients and healthy controls. Unsupervised clustering based on fecal microbiome-metabolome data revealed distinct subsets of IBS patients. The study also found associations between altered serotonin metabolism, unfavorable stress response related to gastrointestinal symptoms, and IBS, supporting the importance of the microbiome-gut-brain axis in the pathogenesis of IBS.
Letter
Gastroenterology & Hepatology
Daniel Keszthelyi, Abraham Beckers
NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Letter
Gastroenterology & Hepatology
Sade L. Assmann, Daniel Keszthelyi, Stephanie O. Breukink
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2022)
Review
Gastroenterology & Hepatology
Michelle Bosman, Fabienne Smeets, Sigrid Elsenbruch, Jan Tack, Magnus Simren, Nicholas Talley, Bjorn Winkens, Ad Masclee, Daniel Keszthelyi
Summary: This study conducted a systematic review and meta-analysis to investigate the placebo response in pharmacological trials for functional dyspepsia (FD). The study found that the pooled placebo response rate ranged from 35.5% to 39.6% depending on the responder definition used. Lower baseline symptom scores were significantly associated with higher placebo response rates. The study suggests considering entry criteria based on symptom severity and separate reporting of core FD symptoms in future trials.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Review
Surgery
Gwen M. C. Masclee, Daniel Keszthelyi, Jose M. Conchillo, Joanna W. Kruimel, Nicole D. Bouvy, Ad A. M. Masclee
Summary: The efficacy and safety of sleeve gastrectomy and Roux-en-Y gastric bypass surgery were systematically evaluated in patients with refractory gastroparesis. Studies showed that both surgeries improved symptoms and gastric emptying in patients with refractory gastroparesis. These surgical interventions may be considered as an effective treatment option for a small group of patients when other therapies have failed.
SURGERY FOR OBESITY AND RELATED DISEASES
(2023)
Article
Nutrition & Dietetics
Marlijne C. G. de Graaf, Jean L. J. M. Scheijen, Corinne E. G. M. Spooren, Zlatan Mujagic, Marieke J. Pierik, Edith J. M. Feskens, Daniel Keszthelyi, Casper G. Schalkwijk, Daisy M. A. E. Jonkers
Summary: A Western diet high in dicarbonyls and advanced glycation endproducts (AGEs) may worsen inflammation in inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS). This study examined the intake of dicarbonyls and AGEs in the habitual diet of IBD and IBS patients and their association with intestinal inflammation. The results showed that the absolute intake of dicarbonyls and AGEs was higher in IBD and healthy control subjects compared to IBS. However, after adjusting for energy intake, only glyoxal was lower in IBD compared to IBS and healthy controls. No significant association was found between dietary dicarbonyls and AGEs and intestinal inflammation in either patient group. The findings suggest that potential harmful effects of these compounds in the diet of Dutch patients with IBD or IBS may be counteracted by anti-inflammatory components in the food matrix.
Article
Health Care Sciences & Services
Esther van Barneveld, Arianne Lim, Nehalennia van Hanegem, Frits van Osch, Lisa Vork, Joanna Kruimel, Marlies Bongers, Carsten Leue
Summary: This study aimed to evaluate the psychometric properties of an endometriosis-specific ESM tool. The results showed that the ESM tool had high validity and reliability for assessing symptoms in women with endometriosis.
JMIR FORMATIVE RESEARCH
(2023)
Article
Health Care Sciences & Services
Gwen M. C. Masclee, Ad A. M. Masclee, Joanna W. Kruimel, Jose M. Conchillo, Jedidja van Vliet, Daniel Keszthelyi
Summary: The patient hotel model can improve patient satisfaction and quality of care, as well as provide substantial financial savings for hospitals, healthcare providers, and insurance companies.
JOURNAL OF PATIENT EXPERIENCE
(2022)
Article
Psychiatry
Xiuxiu Zhao, Junlin Li, Xianhai Xie, Zhaojing Fang, Yue Feng, Yi Zhong, Chen Chen, Kaizong Huang, Chun Ge, Hongwei Shi, Yanna Si, Jianjun Zou
Summary: This study developed dynamic prediction models for postoperative delirium (POD) after cardiac surgery using machine learning algorithms. The models showed satisfactory predictive performance and were used to create online risk calculators for identifying high-risk patients and facilitating early intervention or care.
JOURNAL OF PSYCHOSOMATIC RESEARCH
(2024)
Article
Psychiatry
Miaolan Guo, Jing Su, Shaoyan Zheng, Baixin Chen
Summary: Psoriasis is associated with poor sleep quality and higher risk for sleep disturbance, especially among patients with psoriatic arthritis, severe psoriasis, shorter duration of psoriasis, and younger age. Patients with psoriasis are also more likely to experience insomnia, restless legs syndrome (RLS), and depression.
JOURNAL OF PSYCHOSOMATIC RESEARCH
(2024)
