Article
Public, Environmental & Occupational Health
Gabriella Yazbeck, Diana Malaeb, Hamid Shaaban, Abir Sarray El Dine, Souheil Hallit, Rabih Hallit
Summary: This study aimed to assess the rate of unidentified IBS among Lebanese adults and investigate the role of socio-demographic factors, anxiety, depression, insomnia, and eating attitudes on IBS diagnosis. A cross-sectional study was conducted using a self-reporting questionnaire distributed via social media. The study found that higher psychological distress and insomnia severity were significantly associated with higher odds of having possible unidentified IBS.
Review
Psychiatry
Shefaly Shorey, Alla Demutska, Valerie Chan, Kewin Tien Ho Siah
Summary: This study synthesized 17 qualitative studies on the experiences of adults living with IBS, highlighting the negative impacts on physical, psychological, and social aspects, and the need for future research on diverse geographical locations. Furthermore, interventions such as technology-based support, trained peer volunteers, mindfulness, and cognitive behavioural therapy are essential for supporting IBS patients. Collaboration among stakeholders is crucial for developing standardized tools and materials for accurate testing, diagnosis, assessment, treatment, and management of IBS.
JOURNAL OF PSYCHOSOMATIC RESEARCH
(2021)
Article
Gastroenterology & Hepatology
Sarah Zaza, John Alverdy
Summary: This article highlights the challenges faced by surgeons when dealing with patients suffering from IBS who present with a defined anatomic abnormality. It emphasizes the importance of a multidisciplinary approach to avoid unnecessary surgery in these patients.
JOURNAL OF GASTROINTESTINAL SURGERY
(2023)
Review
Chemistry, Medicinal
Ewa Dudzinska, Andreas M. Grabrucker, Pawel Kwiatkowski, Robert Sitarz, Monika Sienkiewicz
Summary: Visceral stimuli from the digestive tract are transmitted to the brain via nerves, causing overreaction in the brain of irritable bowel syndrome (IBS) patients. Stress and dysbiosis can lead to inflammation and gastrointestinal hypersensitivity. Treating IBS involves reducing visceral hypersensitivity and regulating the intestinal microbiota.
Review
Nutrition & Dietetics
Claudia Di Rosa, Annamaria Altomare, Vittoria Terrigno, Florencia Carbone, Jan Tack, Michele Cicala, Michele Pier Luca Guarino
Summary: Irritable bowel syndrome (IBS) is a chronic gastrointestinal disorder characterized by abdominal pain and altered bowel habits. The exact cause of IBS is not fully understood, but it is believed to involve a combination of factors such as abnormal gut motility, inflammation, increased intestinal permeability, and sensitivity. Diet and gut microbiota have also been identified as important contributors to IBS. This review examines the effects of dietary components, functional foods, prebiotics, probiotics, and symbiotics on symptoms and gut microbiota in individuals with IBS-C.
Article
Biochemistry & Molecular Biology
Isabella Gigante, Valeria Tutino, Francesco Russo, Valentina De Nunzio, Sergio Coletta, Raffaele Armentano, Alberto Crovace, Maria Gabriella Caruso, Antonella Orlando, Maria Notarnicola
Summary: The study found that a high-fat diet can improve gastrointestinal symptoms and functions in an animal model of IBS by restoring intestinal tissue damage, upregulating CB1 and CB2 receptors, and affecting glucose metabolism and intestinal membrane permeability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Karem Awad, Christian Barmeyer, Christian Bojarski, Oliver Nagel, In-Fah M. Lee, Michal R. Schweiger, Joerg-Dieter Schulzke, Roland Buecker
Summary: This study investigated the pathophysiological mechanisms of diarrhea, constipation, and antigen uptake in mixed-type irritable bowel syndrome (IBS-M). The findings showed that in IBS-M, chloride secretion was reduced and antigen permeability was increased, which contributed to a low-grade inflammation in the colon mucosa.
Article
Gastroenterology & Hepatology
Giovanni Marasco, Cesare Cremon, Maria Raffaella Barbaro, Giulia Cacciari, Francesca Falangone, Anna Kagramanova, Dmitry Bordin, Vasile Drug, Egidia Miftode, Pietro Fusaroli, Salem Youssef Mohamed, Chiara Ricci, Massimo Bellini, Mohammed Masudur Rahman, Luigi Melcarne, Javier Santos, Beatriz Lobo, Serhat Bor, Suna Yapali, Deniz Akyol, Ferdane Pirincci Sapmaz, Yonca Yilmaz Urun, Tugce Eskazan, Altay Celebi, Huseyin Kacmaz, Berat Ebik, Hatice Cilem Binicier, Mehmet Sait Bugdayci, Munkhtsetseg Banzragch Yagci, Husnu Pullukcu, Berrin Yalinbas Kaya, Ali Tureyen, Ibrahim Hatemi, Elif Sitre Koc, Goktug Sirin, Ali Riza Caliskan, Goksel Bengi, Esra Ergun Alis, Snezana Lukic, Meri Trajkovska, Keren Hod, Dan Dumitrascu, Antonello Pietrangelo, Elena Corradini, Magnus Simren, Jessica Sjoelund, Navkiran Tornkvist, Uday C. Ghoshal, Olga Kolokolnikova, Antonio Colecchia, Jordi Serra, Giovanni Maconi, Roberto De Giorgio, Silvio Danese, Piero Portincasa, Antonio Di Sabatino, Marcello Maggio, Elena Philippou, Yeong Yeh Lee, Daniele Salvi, Alessandro Venturi, Claudio Borghi, Marco Zoli, Paolo Gionchetti, Pierluigi Viale, Vincenzo Stanghellini, Giovanni Barbara
Summary: This study aimed to evaluate the prevalence of gastrointestinal symptoms and post-COVID-19 disorders of gut-brain interaction among hospitalized patients with SARS-CoV-2 infection. The results showed that patients with COVID-19 had higher rates of gastrointestinal symptoms on hospital admission and lower rates of constipation and hard stools at 12 months post-infection compared to the control group. Additionally, the rate of irritable bowel syndrome was significantly higher in patients with COVID-19 than in controls.
Article
Medicine, Research & Experimental
Haomeng Wu, Kai Zhan, Kehan Rao, Huan Zheng, Shumin Qin, Xudong Tang, Shaogang Huang
Summary: The effects of different rat models of diarrhea-predominant irritable bowel syndrome (IBS-D) on the brain-gut-microbiota (BGM) axis were evaluated in this study. The results showed that these models caused changes in brain gut peptides, cytokine levels, spinal cord neuronal activity, intestinal mucosal barrier function, and gut microbiota composition and structure.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Food Science & Technology
Mahsa Miryan, Davood Soleimani, Pejman Alavinejad, Mohammadreza Abbaspour, Alireza Ostadrahimi
Summary: This study suggests that propolis supplementation may be beneficial for reducing the severity and frequency of abdominal pain in patients with constipation subtype of irritable bowel syndrome (IBS-C) and mixed subtype of irritable bowel syndrome (IBS-M).
FOOD SCIENCE & NUTRITION
(2022)
Review
Pharmacology & Pharmacy
Jill E. Elwing, Hadi Atassi, Benjamin D. Rogers, Gregory S. Sayuk
Summary: Irritable bowel syndrome (IBS) is a multifactorial disorder with limited effectiveness of current therapies, leading to the need for novel treatment options. Future development focuses on serotonergic and endogenous opioid receptor systems, as well as emerging therapies like the endogenous cannabinoid system. The diverse etiologies of IBS present a great potential for the development of new therapies in the future.
EXPERT OPINION ON EMERGING DRUGS
(2022)
Review
Nutrition & Dietetics
Annamaria Altomare, Claudia Di Rosa, Elena Imperia, Sara Emerenziani, Michele Cicala, Michele Pier Luca Guarino
Summary: The study explores the effects of different nutritional protocols on IBS-D symptoms and intestinal microbiota variations. An ideal nutritional protocol does not yet exist for IBS-D patients, but it is crucial to consider the impact of different nutritional approaches on the composition of the intestinal microbiota for better management of this functional disorder.
Article
Plant Sciences
Zhaoqin Wang, Manwen Xu, Zheng Shi, Chunhui Bao, Huirong Liu, Cili Zhou, Yilu Yan, Chunye Wang, Guona Li, Wei Zhang, Anqi Gao, Huangan Wu
Summary: This study aimed to evaluate the effects of mild moxibustion (MM) for the treatment of irritable bowel syndrome with diarrhea (IBS-D) and compare them with placebo moxibustion. The findings suggest that mild moxibustion may be more effective than placebo moxibustion for the treatment of IBS-D, with effects lasting up to 12 weeks.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Gastroenterology & Hepatology
Michael Camilleri, Guy Boeckxstaens
Summary: This article evaluates the evidence that targeted pathophysiological mechanisms and customized treatments can be an alternative approach to treating patients with irritable bowel syndrome (IBS). The authors conducted a literature review on the mechanisms and treatments of IBS, identifying various noninvasive clinical tests that can assess the underlying mechanisms responsible for symptom generation. These mechanisms include rectal evacuation disorders, abnormal transit, visceral hypersensitivity or hypervigilance, bile acid diarrhea, sugar intolerances, barrier dysfunction, the microbiome, immune activation, and chemicals released by these mechanisms. The authors also recognized the basic molecular mechanisms contributing to these pathophysiologies, offering opportunities for interventions with medications targeted at specific food components, receptors, and potentially the microbiome. Although the evidence supporting interventions for each mechanism varies, the current state-of-the-art allows for a shift from symptom-based treatment to individualized treatment guided by pathophysiology and clinically identified biomarkers.
Article
Biotechnology & Applied Microbiology
Hao Lin, Qingqing Guo, Zhiyong Wen, Songlin Tan, Jie Chen, Lijian Lin, Pengcheng Chen, Jianquan He, Jianbo Wen, Ye Chen
Summary: Fecal microbiota transplantation (FMT) treatment effectively alleviates anxiety and depression behaviors in IBS-D patients, improves symptoms, and enhances quality of life. Additionally, FMT reduces the content of certain short-chain fatty acids (SCFAs) and decreases the abundance of specific microorganisms.
MICROBIAL CELL FACTORIES
(2021)
Letter
Psychology, Clinical
Trudie Chalder, Meenal Patel, Kirsty James, Matthew Hotopf, Rona Moss-Morris, Mark Ashworth, Katie Watts, Anthony S. David, Mujtaba Husain
PSYCHOLOGICAL MEDICINE
(2023)
Editorial Material
Psychology, Clinical
Nia Kaleycheva, Alexis E. Cullen, Robyn Evans, Tirril Harris, Timothy Nicholson, Trudie Chalder
PSYCHOLOGICAL MEDICINE
(2023)
Letter
Rehabilitation
Trudie Chalder, Abigail Smakowski, James Adamson, Tracey Turner
DISABILITY AND REHABILITATION
(2023)
Article
Psychology, Clinical
Michael Rose, Christopher D. Graham, Nicola O'Connell, Chiara Vari, Victoria Edwards, Emma Taylor, Lance M. McCracken, Aleksander Radunovic, Wojtek Rakowicz, Sam Norton, Trudie Chalder
Summary: This study aimed to investigate whether Acceptance and Commitment Therapy (ACT) could improve the quality of life in patients with chronic muscle diseases. The results showed that ACT, as an adjunct to usual care, significantly improved the quality of life and other psychological and social outcomes in these patients.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychology, Clinical
Federica Picariello, Joseph Chilcot, Trudie Chalder, David Herdman, Rona Moss-Morris
Summary: This study evaluated the psychometric properties of the Cognitive and Behavioural Responses Questionnaire (CBRQ) and its shortened version in different long-term conditions. The results showed that the CBRQ and the shortened version were reliable and valid at assessing cognitive and behavioral responses to symptoms, highlighting the questionnaire's multi-symptom, transdiagnostic properties. Further research is needed to determine the test-retest reliability, sensitivity to change, and content validity of the items.
BRITISH JOURNAL OF HEALTH PSYCHOLOGY
(2023)
Review
Clinical Neurology
Caoimhe McLoughlin, Ingrid Hoeritzauer, Veronica Cabreira, Selma Aybek, Caitlin Adams, Jane Alty, Harriet A. Ball, Janet Baker, Kim Bullock, Chrissie Burness, Barbara A. Dworetzky, Sara Finkelstein, Beatrice Garcin, Jeannette Gelauff, Laura H. Goldstein, Anika Jordbru, Anne-Catherine M. L. Huys, Aoife Laffan, Sarah C. Lidstone, Stefanie Caroline Linden, Lea Ludwig, Julie Maggio, Francesca Morgante, Elizabeth Mallam, Clare Nicholson, Mary O'Neal, Suzanne O'Sullivan, Isabel Parees, Panayiota Petrochilos, Susannah Pick, Wendy Phillips, Karin Roelofs, Rachel Newby, Biba Stanton, Cordelia Gray, Eileen M. Joyce, Marina A. J. Tijssen, Trudie Chalder, Maxanne McCormick, Paula Gardiner, Indrit Begue, Margaret C. Tuttle, Isobel Williams, Sarah McRae, Valerie Voon, Laura McWhirter
Summary: Functional neurological disorder (FND) is often overlooked and misunderstood by clinicians, despite being a common and accurately diagnosable condition based on clinical signs. People with FND face discrimination from healthcare providers, researchers, and the public, reflecting the neglect of disorders primarily affecting women. We argue that FND is a feminist issue, drawing on historical and contemporary perspectives from clinical, research, and social domains. We call for equal attention and support for FND in medical education, research, and clinical services to ensure adequate care for those affected.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Multidisciplinary Sciences
Damien Ridge, Karen Pilkington, Sheila Donovan, Elisavet Moschopoulou, Dipesh Gopal, Kamaldeep Bhui, Trudie Chalder, Imran Khan, Ania Korszun, Stephanie Taylor
Summary: This study investigates the social and cultural influences on health care interventions, focusing on psychological approaches and/or cancer care for racially minoritised patients. The findings highlight the importance of the patient-practitioner relationship, family decision-making, and interactions with non-human factors in health care. The study suggests that training on affective relationality could improve care for diverse patients.
Article
Medicine, General & Internal
Kim Poole-Wright, Ismail Guennouni, Olivia Sterry, Rachael A. Evans, Fiona Gaughran, Trudie Chalder
Summary: This systematic review and meta-analysis aimed to investigate postinfection fatigue among survivors of SARS-CoV-2 and associated factors. The results showed that a significant proportion of survivors experienced fatigue, but this fatigue reduced over time. Female gender, age, physical functioning, breathlessness, and psychological distress were frequently reported associations with fatigue.
Article
Health Care Sciences & Services
Karianne Svendsen, Lise Solberg Nes, Anders Meland, Ine Marie Larsson, Ylva M. Gjelsvik, Elin Borosund, Christine M. Rygg, Tor Age Myklebust, Kristin Reinertsen, Cecilie E. Kiserud, Helle Skjerven, Michael H. Antoni, Trudie Chalder, Ingvil Mjaaland, Linda E. Carlson, Hege R. Eriksen, Giske Ursin
Summary: This study aims to investigate the effects of using two different eHealth interventions, StressProffen-CBI and StressProffen-MBI, compared to standard treatment in breast cancer survivors. The study is a randomized controlled trial with a goal of recruiting 430 participants, and currently 428 participants have been enrolled.
JMIR RESEARCH PROTOCOLS
(2023)
Article
Respiratory System
Charles C. Reilly, Matthew Maddocks, Trudie Chalder, Katherine Bristowe, Irene J. Higginson
Summary: SELF-BREATHE is a digital breathlessness intervention that aims to improve the lives of people with chronic breathlessness. This study found that SELF-BREATHE was feasible to deliver and acceptable to patients, with users reporting improved breathlessness during daily life.
Article
Health Care Sciences & Services
Snehal M. Pinto Pereira, Roz Shafran, Manjula D. Nugawela, Laura Panagi, Dougal Hargreaves, Shamez N. Ladhani, Sophie D. Bennett, Trudie Chalder, Emma Dalrymple, Tamsin Ford, Isobel Heyman, Kelsey McOwat, Natalia K. Rojas, Kishan Sharma, Ruth Simmons, Simon R. White, Terence Stephenson
Summary: A follow-up study on children and young people (CYP) with acute COVID found that the prevalence of symptoms declined over a year. Some individuals reported adverse symptoms, such as fatigue, shortness of breath, poor quality of life, emotional difficulties, and fatigue, for the first time at six and 12 months post-infection, suggesting multiple factors contributing to these symptoms.
LANCET REGIONAL HEALTH-EUROPE
(2023)
Article
Gastroenterology & Hepatology
Calum D. Moulton, Cheryl Jordan, Bu'Hussain Hayee, Trudie Chalder
Summary: This study reveals that fatigue is common in patients with inflammatory bowel disease (IBD), yet the underlying reasons are not well-known. The study indicates that fluctuations between high activity and rest and negative thinking patterns contribute to worsening fatigue over time.
INFLAMMATORY BOWEL DISEASES
(2023)
Review
Clinical Neurology
Peter White, Susan Abbey, Brian Angus, Harriet A. Ball, Dedra S. Buchwald, Christine Burness, Alan J. Carson, Trudie Chalder, Daniel J. Clauw, Jan Coebergh, Anthony S. David, Barbara A. Dworetzky, Mark J. Edwards, Alberto J. Espay, John Etherington, Per Fink, Signe Flottorp, Beatrice Garcin, Paul Garner, Paul Glasziou, Willie Hamilton, Peter Henningsen, Ingrid Hoeritzauer, Mujtaba Husain, Anne-Catherine M. L. Huys, Hans Knoop, Kurt Kroenke, Alexander Lehn, James L. Levenson, Paul Little, Andrew Lloyd, Ira Madan, Jos W. M. van der Meer, Alastair Miller, Maurice Murphy, Irwin Nazareth, David L. Perez, Wendy Phillips, Markus Reuber, Winfried Rief, Alastair Santhouse, Tereza Serranova, Michael Sharpe, Biba Stanton, Donna E. Stewart, Jon Stone, Michele Tinazzi, Derick T. Wade, Simon C. Wessely, Vegard Wyller, Adam Zeman
Summary: Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is a disabling long-term condition of unknown cause. The recent guideline from the National Institute for Health and Care Excellence (NICE) sparked controversy by recommending against graded exercise therapy (GET) and downgrading the importance of cognitive-behavioural therapy for recovery. The anomalies in evidence processing and interpretation by the NICE committee, such as creating a new definition, omitting data, and deviating from accepted practices, contributed to this controversy.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Psychology, Clinical
L. S. Merritt Millman, Eleanor Short, Biba Stanton, Joel S. Winston, Timothy R. Nicholson, Mitul A. Mehta, Antje A. T. S. Reinders, Mark J. Edwards, Laura H. Goldstein, Anthony S. David, Matthew Hotopf, Trudie Chalder, Susannah Pick
Summary: Altered interoception may play a role in the pathophysiology of functional neurological disorder (FND), particularly in functional motor symptoms (FMS) and seizures (FS). This study found that individuals with FMS/FS displayed lower scores on specific dimensions of interoceptive sensibility compared to healthy controls. Additionally, confidence in interoceptive accuracy was associated with self-regulation, symptom severity, and impact in FMS/FS.
BEHAVIOUR RESEARCH AND THERAPY
(2023)
Article
Respiratory System
Camilla Dawson, Gemma Clunie, Felicity Evison, Sallyanne Duncan, Julie Whitney, Linzy Houchen-Wolloff, Charlotte E. Bolton, Olivia C. Leavy, Matthew Richardson, Elneima Omer, Hamish McAuley, Aarti Shikotra, Amisha Singapuri, Marco Sereno, Ruth M. Saunders, Victoria C. Harris, Neil J. Greening, Claire Marie Nolan, Dan Gower Wootton, Enya Daynes, Gavin Donaldson, Jack Sargent, Janet Scott, John Pimm, Lettie Bishop, Melitta McNarry, Nicholas Hart, Rachael A. Evans, Sally Singh, Tom Yates, Trudie Chalder, William Man, Ewen Harrison, Annemarie Docherty, Nazir Lone, Jennifer K. Quint, James Chalmers, Ling-Pei Ho, Alex Robert Horsley, Michael Marks, Krisnah Poinasamy, Betty Raman, Louise Wain, Chris Brightling, Neil PHOSP-COVID Collaborative Grp, Neil Sharma, Margaret Coffey, Amit Kulkarni, Sarah Wallace
Summary: This multicentre observational study in the UK examined the prevalence of self-reported swallowing, communication, voice, and cognitive problems in patients discharged from hospitals after COVID-19. The study found that compromised swallowing was reported by 20% of patients who had been admitted to the intensive care unit. Voice problems were reported by 34% of patients post-ICU admission. Communication compromise was reported by 23% of patients. Cognitive issues were reported by 70% of patients. These problems were associated with factors such as age, sex, social deprivation, and being a healthcare worker.
BMJ OPEN RESPIRATORY RESEARCH
(2023)
