Article
Immunology
Camilla Astley, Gleice Clemente, Maria Teresa Terreri, Camila G. Carneiro, Marcos S. Lima, Carlos Alberto Buchpiguel, Hilton Leao Filho, Ana Lucia de Sa Pinto, Clovis Artur Silva, Lucia Maria Arruda Campos, Nadia Emi Aikawa, Saulo Gil, Rosa Maria Rodrigues Pereira, Hamilton Roschel, Bruno Gualano
Summary: Exercise is safe and may improve visceral fat, physical activity levels, functionality, and physical component SF-36 in childhood-onset Takayasu Arteritis (c-TA) patients. Exercise intervention is also beneficial for improving quality of life in these patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Edoardo Fascio, Jacopo Antonino Vitale, Paolo Sirtori, Giuseppe Peretti, Giuseppe Banfi, Laura Mangiavini
Summary: This study compared the efficacy of early rehabilitation via the Virtual Reality Rehabilitation System (VRRS) with traditional rehabilitation in improving functional outcomes after total hip arthroplasty (THA). The results showed that virtual-reality-based home rehabilitation and traditional rehabilitation had similar improvements in functional outcomes, but virtual-reality-based rehabilitation had a better overall perceived effect.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Poorna Anandavadivelan, Kalle Malberg, Karin Vikstrom, Sandra Nielsen, Ulrika Holdar, Asif Johar, Pernilla Lagergren
Summary: This study found that a home-based physical activity intervention conducted 1 year after surgery for esophageal cancer can improve lower extremity muscle strength in patients, but has no significant impact on hand grip strength or muscle mass.
Article
Health Care Sciences & Services
Haneul Lee, Seon-Heui Lee
Summary: This study aimed to assess the clinical effectiveness of a personalized multicomponent home-based rehabilitation program, and the results showed that the 8-week program significantly improved balance, mobility, pain, and general health-related quality of life in patients who underwent hip surgery.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Health Care Sciences & Services
Yiwen Wang, Xingkang Liu, Weimin Wang, Yanyun Shi, Xiaojian Ji, Lidong Hu, Lei Wang, Yiquan Yin, Siyuan Xie, Jian Zhu, Jianglin Zhang, Wei Jiao, Feng Huang
Summary: This study investigated the adherence, efficacy, and safety of a wearable technology-assisted combined home-based exercise program in ankylosing spondylitis (AS) patients. The results suggest that this program can improve the clinical outcomes of AS patients with no exercise habit, with good adherence and safety profile.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2022)
Article
Geriatrics & Gerontology
Kiyotaka Uchiyama, Keika Adachi, Kaori Muraoka, Takashin Nakayama, Takuma Oshida, Marie Yasuda, Akihito Hishikawa, Hitoshi Minakuchi, Kazutoshi Miyashita, Hirobumi Tokuyama, Shu Wakino, Hiroshi Itoh
Summary: The study showed that a 6-month home-based exercise program improved aerobic capacity and HRQOL in patients with Stage 4 CKD, with potential beneficial effects on kidney function and CKD-related parameters.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2021)
Article
Clinical Neurology
Gavin Brupbacher, Thea Zander-Schellenberg, Doris Straus, Hildburg Porschke, Denis Infanger, Markus Gerber, Roland von Kanel, Arno Schmidt-Trucksaess
Summary: This study investigated the effects of a single bout of aerobic exercise performed after 2:00 pm on subsequent night's sleep in patients with depression. While the exercise did not affect sleep efficiency, it had a strong beneficial effect on mood states, including depressiveness.
Article
Clinical Neurology
Gavin Brupbacher, Thea Zander-Schellenberg, Doris Straus, Hildburg Porschke, Denis Infangerl, Markus Gerber, Roland von Kaenel, Arno Schmidt-Trucksaess
Summary: The study aimed to investigate the effects of a single bout of aerobic exercise on sleep in patients with depression. The results showed that aerobic exercise had no effect on sleep efficiency but had a strong beneficial effect on mood and did not increase adverse outcomes. These findings suggest that exercise after 02:00 pm is not detrimental for sleep, contrary to sleep hygiene recommendations.
Article
Geriatrics & Gerontology
Sara A. Suikkanen, Paula K. Soukkio, Eeva M. Aartolahti, Hannu Kautiainen, Sanna M. Kaaria, Markku T. Hupli, Sarianna Sipila, Kaisu H. Pitkala, Katriina T. Kukkonen-Harjula
Summary: The study showed that home-based physical exercise did not increase the number of days spent at home, but it prevented the deterioration of HRQoL. In the frail subgroup, intervention costs were compensated with decreased utilization of other health care and social services over 24 months.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2021)
Article
Geriatrics & Gerontology
Eun-Lee Lee, Myung Hun Jang, Byeong-Ju Lee, Sang Hun Han, Hoo Man Lee, Sang Ui Choi, Myung Jun Shin
Summary: This study aimed to examine the effects of a home-based lower-extremity strengthening exercise program on community-dwelling older women with knee osteoarthritis. The results showed that the home-based exercise program using a remote rehabilitation medical device was effective in improving lower extremity strength and function in the participants.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2023)
Article
Orthopedics
Qiao-Mei Hong, Hao-Nan Wang, Xi-Hui Liu, Wen-Qi Zhou, Xiao Zhang, Xiao-Bing Luo
Summary: This study evaluated the effects of home-based exercise and health education in patients with patellofemoral pain (PFP). The intervention group showed a greater reduction in pain and better function and muscle strength compared to the control group.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Endocrinology & Metabolism
F. Zhang, Z. Wang, H. Su, H. Zhao, W. Lu, W. Zhou, H. Zhang
Summary: This study evaluates the effectiveness of home-based resistance exercise in elder participants with osteoporosis. The results demonstrate that this mode of exercise can improve physical function, increase confidence in exercise, and reduce fear of falling. Additionally, it also improves health-related quality of life in various dimensions.
OSTEOPOROSIS INTERNATIONAL
(2022)
Article
Clinical Neurology
Hitomi Ejiri, Hiroyuki Uchida, Kenji Tsuchiya, Kazuhiko Fujiwara, Senichiro Kikuchi, Kazuki Hirao
Summary: This pilot study aimed to investigate the efficacy of a smartphone application (SPSRS) in improving depressive mood in individuals with subthreshold depression. The experimental group received the SPSRS intervention, while the control group received a YouTube intervention. Results showed a small improvement in depressive mood in the experimental group. Therefore, the SPSRS application intervention may have an immediate effect on improving depressive mood in individuals with subthreshold depression.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2023)
Article
Critical Care Medicine
Paolo Zanaboni, Birthe Dinesen, Hanne Hoaas, Richard Wootton, Angela T. Burge, Rochelle Philp, Cristino Carneiro Oliveira, Janet Bondarenko, Torben Tranborg Jensen, Belinda R. Miller, Anne E. Holland
Summary: By comparing long-term telerehabilitation and unsupervised treadmill training at home with standard care, the study found that both telerehabilitation and unsupervised training can effectively reduce hospitalizations and emergency department visits in patients with chronic obstructive pulmonary disease (COPD).
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Neurosciences
Susana Justo-Henriques, Enrique Perez-Saez, Janessa O. Carvalho, Marco Cavallo, Paula Sargaco
Summary: Cognitive difficulties are common in people with mental health issues, and home-based services such as individual cognitive stimulation (iCS) can be effective for reaching populations with accessibility challenges. This randomized controlled trial in Portugal explored the effectiveness of iCS intervention on participants with psychotic disorders and found significant improvements in cognitive functioning, depression, quality of life, and functional activities.
Article
Public, Environmental & Occupational Health
Rebecca M. Joseph, Tjeerd P. van Staa, Mark Lunt, Michal Abrahamowicz, William G. Dixon
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
(2019)
Article
Public, Environmental & Occupational Health
Ryan P. Kyle, Erica E. M. Moodie, Marina B. Klein, Michal Abrahamowicz
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2019)
Article
Public, Environmental & Occupational Health
Coraline Danieli, Sarah Cohen, Aihua Liu, Louise Pilote, Liming Guo, Marie-Eve Beauchamp, Ariane J. Marelli, Michal Abrahamowicz
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2019)
Article
Mathematical & Computational Biology
Yishu Wang, Marie-Eve Beauchamp, Michal Abrahamowicz
BIOMETRICAL JOURNAL
(2020)
Article
Cardiac & Cardiovascular Systems
Michelle Samuel, Michal Abrahamowicz, Jacqueline Joza, Marie-Eve Beauchamp, Vidal Essebag, Louise Pilote
Article
Mathematical & Computational Biology
Per Kragh Andersen, Maja Pohar Perme, Hans C. van Houwelingen, Richard J. Cook, Pierre Joly, Torben Martinussen, Jeremy M. G. Taylor, Michal Abrahamowicz, Terry M. Therneau
Summary: This paper offers guidance for researchers with mathematical background on conducting time-to-event analysis based on intensity models in observational studies. It covers basic concepts like time axis, event definition, and censoring, introduces hazard models with emphasis on the Cox proportional hazards regression model, provides check lists for fitting and assessing the model's goodness of fit, and discusses avoiding immortal time bias and prediction challenges. Examples and implementation details using R software are also included.
STATISTICS IN MEDICINE
(2021)
Article
Peripheral Vascular Disease
Pavel Hamet, Zdenka Pausova, Redha Attaoua, Camil Hishmih, Mounsif Haloui, Jean Shin, Tomas Paus, Michal Abrhamowicz, Daniel Gaudet, Lara Santucci, Theodore A. Kotchen, Allen W. Cowley, Julie Hussin, Johanne Tremblay
Summary: The study found that a single nucleotide polymorphism of the ACE2 gene was associated with hypertension in adult obese males, especially in obese males who smoked. The variant was also linked to blood pressure levels in adolescents, with an interaction with obesity present only in females. Additionally, ACE2 gene variants were associated with more severe outcomes in COVID-19 in obese, smoking males.
AMERICAN JOURNAL OF HYPERTENSION
(2021)
Article
Mathematical & Computational Biology
Michal Abrahamowicz, Marie-Eve Beauchamp, Cristiano Soares Moura, Sasha Bernatsky, Steve Ferreira Guerra, Coraline Danieli
Summary: Many applications of survival analysis focus on interval-censored events, which can lead to biased estimates. We propose a SIMEX-based correction method that improves the accuracy of estimated associations between time-varying exposures and interval-censored events.
BIOMETRICAL JOURNAL
(2022)
Editorial Material
Mathematical & Computational Biology
Michal Abrahamowicz
BIOMETRICAL JOURNAL
(2022)
Article
Rheumatology
Claire E. H. Barber, Diane Lacaille, Ruth Croxford, Cheryl Barnabe, Deborah A. Marshall, Michal Abrahamowicz, Hui Xie, J. Antonio Avina-Zubieta, John M. Esdaile, Glen S. Hazlewood, Peter Faris, Steven Katz, Paul MacMullan, Dianne Mosher, Jessica Widdifield
Summary: This study examines the association between rheumatologist access, early treatment, and ongoing care of older-onset rheumatoid arthritis (RA) and healthcare utilization and costs following diagnosis. The results show that access to rheumatologists, timely treatment, and ongoing care are associated with lower total healthcare costs at 5 years. Investments in improving access to care may lead to long-term health system savings.
JOURNAL OF RHEUMATOLOGY
(2023)
Article
Rheumatology
Claire E. H. Barber, Diane Lacaille, Ruth Croxford, Cheryl Barnabe, Deborah A. Marshall, Michal Abrahamowicz, Hui Xie, J. Antonio Avina-Zubieta, John M. Esdaile, Glen Hazlewood, Peter Faris, Steven Katz, Paul MacMullan, Dianne Mosher, Jessica Widdifield
Summary: The study found that although there were improvements in rheumatology care and treatment for RA patients over time, there are still shortcomings, particularly in the use of DMARDs. Patients in regions with higher rheumatologist supply were more likely to access care but less likely to receive timely treatment.
Article
Mathematical & Computational Biology
Liliane Manitchoko, Michal Abrahamowicz, Pascale Tubert-Bitter, Jacques Benichou, Anne C. M. Thiebaut
Summary: Cohort and nested case-control (NCC) designs are commonly used in pharmacoepidemiology to assess the effects of time-varying drug exposures on adverse event risks. Simulations comparing the two designs showed that cohort-based estimates had lower bias and greater precision than NCC estimates. NCC estimates showed bias that decreased with more controls per case and increased with higher event proportion, but bias was reduced when NCC analyses were matched on confounders. Overall, NCC estimates were similar to cohort-based estimates when ties were correctly accounted for.
BIOMETRICAL JOURNAL
(2023)
Article
Rheumatology
Michal Abrahamowicz, Maria Izabela Abrahamowicz, Peter E. Lipsky
Summary: The study developed a new Lupus Multivariable Outcome Score (LuMOS) for evaluating the treatment effectiveness of systemic lupus erythematosus (SLE). Through external validation, LuMOS demonstrated better discrimination than the SLE Responder Index-5 (SRI-5). However, further validation is needed for non-B cell-directed therapies.
ACR OPEN RHEUMATOLOGY
(2022)
Article
Rheumatology
Claire E. H. Barber, Diane Lacaille, Ruth Croxford, Cheryl Barnabe, Deborah A. Marshall, Michal Abrahamowicz, Hui Xie, J. Antonio Avina-Zubieta, John M. Esdaile, Glen Hazlewood, Peter Faris, Steven Katz, Paul MacMullan, Dianne Mosher, Jessica Widdifield
Summary: This study assessed adherence to system-level performance measures in rheumatology care for patients with rheumatoid arthritis (RA). The results showed a decline in the percentage of patients with annual visits over time. Factors such as age, gender, and healthcare resources were found to affect the likelihood of receiving ongoing rheumatology care.
ACR OPEN RHEUMATOLOGY
(2022)
Article
Mathematical & Computational Biology
Menglan Pang, Robert W. Platt, Tibor Schuster, Michal Abrahamowicz
Summary: A spline-based AFT model that does not require specification of the parametric family of event time distribution was developed, providing unbiased estimates and numerical stability in various scenarios.
STATISTICS IN MEDICINE
(2021)