Full central neurokinin-1 receptor blockade is required for efficacy in depression: evidence from orvepitant clinical studies

Substance P Causes Seizures in Neurocysticercosis

(2012) Prema Robinson et al.   PLoS Pathogens

The Columbia–Suicide Severity Rating Scale: Initial Validity and Internal Consistency Findings From Three Multisite Studies With Adolescents and Adults

(2011) Kelly Posner et al.   AMERICAN JOURNAL OF PSYCHIATRY

A pharmacokinetic PET study of NK1 receptor occupancy

(2011) Stefano Zamuner et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Exploratory Analyses of Efficacy Data From Major Depressive Disorder Trials Submitted to the US Food and Drug Administration in Support of New Drug Applications

(2011) Ni A. Khin et al.   JOURNAL OF CLINICAL PSYCHIATRY

A Randomized, Double-Blind, Placebo-Controlled, 8-Week Study of Vilazodone, a Serotonergic Agent for the Treatment of Major Depressive Disorder

(2011) Arif Khan et al.   JOURNAL OF CLINICAL PSYCHIATRY

Results From 2 Randomized, Double-Blind, Placebo-Controlled Studies of the Novel NK1 Receptor Antagonist Casopitant in Patients With Major Depressive Disorder

(2011) Emiliangelo Ratti et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

Discovery and Biological Characterization of (2R,4S)-1′-Acetyl-N-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-2-(4-fluoro-2-methylphenyl)-N-methyl-4,4′-bipiperidine-1-carboxamide as a New Potent and Selective Neurokinin 1 (NK1) Receptor Antagonist Clinical Candidate

(2011) Romano Di Fabio et al.   JOURNAL OF MEDICINAL CHEMISTRY

Review of Pharmacological Treatment in Mood Disorders and Future Directions for Drug Development

(2011) Xiaohua Li et al.   NEUROPSYCHOPHARMACOLOGY

Potentiation of the anticonvulsant efficacy of sodium channel inhibitors by an NK1-receptor antagonist in the rat

(2010) Mikhail Kalinichev et al.   EPILEPSIA

Evidence for Efficacy and Tolerability of Vilazodone in the Treatment of Major Depressive Disorder

(2009) Karl Rickels et al.   JOURNAL OF CLINICAL PSYCHIATRY

Reliability and Validity of the Massachusetts General Hospital Cognitive and Physical Functioning Questionnaire

(2009) Maurizio Fava et al.   PSYCHOTHERAPY AND PSYCHOSOMATICS

Redefining Affective Disorders: Relevance for Drug Development

(2008) Steven D Targum et al.   CNS Neuroscience & Therapeutics