Article
Psychiatry
Cassie Overstreet, Jason C. DeViva, Ananda Amstadter, Elissa McCarthy, Steven M. Southwick, Robert H. Pietrzak
Summary: This study focused on resilience and potentially protective factors in U.S. veterans, using a novel analytic approach to operationalize resilience. Results showed the importance of resilience and identified potentially modifiable psychosocial factors. The study demonstrated the utility of the DBPR approach and generated insights for future prevention and treatment efforts.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Psychology, Clinical
Sigal Zilcha-Mano, Xi Zhu, Amit Lazarov, Benjamin Suarez-Jimenez, Liat Helpman, Yoojean Kim, Carly Maitlin, Yuval Neria, Bret R. Rutherford
Summary: The study used a data-driven approach to identify structural brain markers of resilience, especially in regions implicated in trauma exposure such as the thalamus and rostral middle frontal gyrus.
DEPRESSION AND ANXIETY
(2022)
Review
Psychology, Multidisciplinary
Angela L. Richardson, Matthew W. Gallagher
Summary: The study conducted a meta-analytic review on the relationship between gratitude and PTSD, finding a moderate, negative association between gratitude and PTSD severity. Results suggest further research may be needed to explore how gratitude works as a protective factor or intervention for reducing PTSD.
JOURNAL OF HAPPINESS STUDIES
(2021)
Editorial Material
Psychology, Biological
Lisa M. Shin, Samuel R. Sommers
Summary: Increased exposure to media coverage of traumatic events is linked to greater symptoms of post-traumatic stress, especially in youth with specific patterns of brain activation that may make them more vulnerable to trauma.
NATURE HUMAN BEHAVIOUR
(2021)
Review
Psychology, Multidisciplinary
Laura J. Long
Summary: This paper reviews the relationship between hope and PTSD, as well as broader functioning after a trauma, including potential mechanisms and factors impacting these relationships, and the role of hope as a mechanism of change in PTSD interventions.
CURRENT OPINION IN PSYCHOLOGY
(2022)
Article
Psychology, Clinical
Grace C. George, Taylor J. Keding, Sara A. Heyn, Ryan J. Herringa
Summary: This longitudinal study explored functional brain changes in pediatric PTSD, revealing increased hippocampal activation to threat in persistent PTSD youth compared to typically developing youth. The remitted group showed patterns more similar to typically developing youth, with increasing hippocampal connectivity to the visual cortex during threat stimuli. These findings suggest potential biomarkers for improving the treatment of pediatric PTSD.
DEPRESSION AND ANXIETY
(2022)
Article
Medicine, General & Internal
Lisa A. Brenner, Jeri E. Forster, Jaimie L. Gradus, Trisha A. Hostetter, Claire A. Hoffmire, Colin G. Walsh, Mary Jo Larson, Kelly A. Stearns-Yoder, Rachel Sayko Adams
Summary: This study aimed to identify the associations of military-related traumatic brain injury (TBI) with suicide and new-onset mental health conditions. The findings showed that soldiers with a history of TBI had higher rates of new-onset mental health conditions and were at greater risk of suicide. These results highlight the need for increased efforts to address the cumulative risk associated with multiple military-related exposures.
Article
Public, Environmental & Occupational Health
Xiaofei Mao, Pengfei Luo, Fengzhan Li, Fan Zhang, Jianguo Zhang, Wenxi Deng, Ziqiang Li, Tianya Hou, Wei Dong
Summary: This study aimed to investigate the prevalence and correlates of post-traumatic stress disorder (PTSD) among Chinese nurses during the normalisation stage of COVID-19 pandemic prevention and control measures. The results showed that the prevalence of PTSD among Chinese nurses was 26.4%, and marital status, social support, and resilience were factors associated with PTSD. Chinese hospital management should intervene to improve resilience and social support for nurses to reduce symptoms of PTSD.
JOURNAL OF GLOBAL HEALTH
(2023)
Article
Education, Scientific Disciplines
Katrin Jaradeh, Francesco Sergi, Coleen Kivlahan, Cesar Nava Gonzales, Mar Cury, Triveni DeFries
Summary: This study describes the implementation of trauma-informed care principles in a student-run asylum clinic, highlighting the importance of these principles in supporting individuals seeking asylum during forensic medical evaluations. The clinic completed 160 evaluations over a three-year period, with positive feedback from participants. Future research should focus on assessing secondary trauma and resilience within these clinics.
Article
Clinical Neurology
Mrithula S. Babu, Sabrina J. Chan, Tsachi Ein-Dor, Sharon Dekel
Summary: This study found that nearly two thirds of women who gave birth during the COVID-19 pandemic reported childbirth-related psychological growth, with greater appreciation of life being the most common outcome. There were no significant differences in the prevalence of psychological growth between deliveries during or before the pandemic. It was also found that in deliveries during the pandemic, childbirth-related acute stress was linked with elevated psychological growth, which in turn was associated with lower posttraumatic stress symptoms and better mother-infant bonding.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychiatry
Carole E. Siegel, Eugene M. Laska, Ziqiang Lin, Mu Xu, Duna Abu-Amara, Michelle K. Jeffers, Meng Qian, Nicholas Milton, Janine D. Flory, Rasha Hammamieh, Bernie J. Daigle, Aarti Gautam, Kelsey R. Dean, Victor Reus, Owen M. Wolkowitz, Synthia H. Mellon, Kerry J. Ressler, Rachel Yehuda, Kai Wang, Leroy Hood, Francis J. Doyle, Marti Jett, Charles R. Marmar
Summary: The study identified two clinical subtypes of PTSD in veterans using machine learning methods and blood biomarkers, showing that one subtype (S2) had more severe symptoms compared to the other subtype (S1) and healthy controls. Multi-omic blood markers were effective in distinguishing between these subtypes and healthy controls, with methylation, micro RNA, and lactate markers showing a biological role in symptom severity.
TRANSLATIONAL PSYCHIATRY
(2021)
Review
Behavioral Sciences
Reihaneh Ahmadi, Sama Rahimi-Jafari, Mahnaz Olfati, Nooshin Javaheripour, Farnoosh Emamian, Mohammad Rasoul Ghadami, Habibolah Khazaie, David C. Knight, Masoud Tahmasian, Amir A. Sepehry
Summary: Posttraumatic stress disorder (PTSD) is strongly associated with insomnia, and the prevalence of insomnia in PTSD patients is high. Screening and managing insomnia in PTSD patients are of great importance.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Psychology, Clinical
Romain Colle, Khalil El Asmar, Celine Verstuyft, Pierre-Marie Lledo, Francoise Lazarini, Kenneth Chappell, Eric Deflesselle, Abd El Kader Ait Tayeb, Bruno Falissard, Emmanuelle Duron, Samuel Rotenberg, Jean-Francois Costemale-Lacoste, Denis J. David, Florence Gressier, Alain M. Gardier, Thomas Hummel, Laurent Becquemont, Emmanuelle Corruble
Summary: The study found significant differences in olfactory performance between depressed patients and healthy controls, but after venlafaxine treatment, some patients showed improvements in olfaction, which were mediated by the alleviation of depressive symptoms.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Marcela Konjevod, Gordana Nedic Erjavec, Matea Nikolac Perkovic, Jorge Saiz, Lucija Tudor, Suzana Uzun, Oliver Kozumplik, Dubravka Svob Strac, Neven Zarkovic, Nela Pivac
Summary: Posttraumatic stress disorder (PTSD) is a severe neuropsychiatric disorder that can develop in individuals exposed to severe stress or trauma. Metabolomic analysis has revealed altered metabolites that may differentiate between PTSD patients and healthy individuals, potentially shedding light on the pathogenesis of PTSD.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Neurosciences
Tom Salomon, Adi Cohen, Daniel Barazany, Gal Ben-Zvi, Rotem Botvinik-Nezer, Rani Gera, Shiran Oren, Dana Roll, Gal Rozic, Anastasia Saliy, Niv Tik, Galia Tsarfati, Ido Tavor, Tom Schonberg, Yaniv Assaf
Summary: The study suggests that the brains of healthy individuals may undergo transient volumetric changes related to stress and anxiety during the COVID-19 pandemic. These changes decrease over time following the lifting of lockdown measures, indicating that intense experiences associated with the pandemic play a role.
Article
Psychology, Clinical
Alan E. Kazdin, Chi-Shin Wu, Irving Hwang, Victor Puac-Polanco, Nancy A. Sampson, Ali Al-Hamzawi, Jordi Alonso, Laura Helena Andrade, Corina Benjet, Jose-Miguel Caldas-de-Almeida, Giovanni de Girolamo, Peter de Jonge, Silvia Florescu, Oye Gureje, Josep M. Haro, Meredith G. Harris, Elie G. Karam, Georges Karam, Viviane Kovess-Masfety, Sing Lee, John J. McGrath, Fernando Navarro-Mateu, Daisuke Nishi, Bibilola D. Oladeji, Jose Posada-Villa, Dan J. Stein, T. Bedirhan Ustun, Daniel V. Vigo, Zahari Zarkov, Alan M. Zaslavsky, Ronald C. Kessler
Summary: Antidepressant medications (ADMs) are widely used for a variety of conditions, not only depression and anxiety. The usage rate of ADMs is higher in high-income countries compared to low- and middle-income countries, and newer ADMs are more frequently used in high-income countries. Among users, 58.8% perceive ADMs to be very effective and 28.3% perceive them to be somewhat effective, with these proportions being higher in low- and middle-income countries than in high-income countries.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychology, Clinical
Glenn Kiekens, Penelope Hasking, Ronny Bruffaerts, Jordi Alonso, Randy P. Auerbach, Jason Bantjes, Corina Benjet, Mark Boyes, Wai Tat Chiu, Laurence Claes, Pim Cuijpers, David D. Ebert, Arthur Mak, Philippe Mortier, Siobhan O'Neill, Nancy A. Sampson, Dan J. Stein, Gemma Vilagut, Matthew K. Nock, Ronald C. Kessler
Summary: Non-suicidal self-injury (NSSI) is common among college students and is a behavioral marker of various common mental disorders.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Clinical Neurology
Jon E. Grant, Richard A. Bethlehem, Samuel R. Chamberlain, Tara S. Peris, Emily J. Ricketts, Joseph O'Neill, Darin D. Dougherty, Dan Stein, Christine Lochner, Douglas W. Woods, John Piacentini, Nancy J. Keuthen
Summary: This study found that there are differences in brain structure among different subtypes of Trichotillomania (TTM), which may have implications for understanding clinical presentations and treatment response.
Article
Clinical Neurology
Harry Fagan, Edward Jones, David S. Baldwin
Summary: The orexin system is involved in regulating various biological functions and dysfunctional orexin system is linked to depression. Orexin receptor antagonists (ORAs) have been developed for insomnia treatment and have potential as treatments for major depressive disorder (MDD). Pre-clinical studies suggest a possible antidepressant effect of systemic DORA treatment, but the evidence from selective ORAs is conflicting. Only a few randomized controlled trials have shown significant differences between ORAs and placebo in the treatment of MDD.
Article
Psychology, Developmental
Sara Bertolin, Pino Alonso, Ignacio Martinez-Zalacain, Jose M. Menchon, Susana Jimenez-Murcia, Justin T. Baker, Nuria Bargallo, Marcelo Camargo Batistuzzo, Premika S. W. Boedhoe, Brian P. Brennan, Jamie D. Feusner, Kate D. Fitzgerald, Martine Fontaine, Bjarne Hansen, Yoshiyuki Hirano, Marcelo Q. Hoexter, Chaim Huyser, Neda Jahanshad, Fern Jaspers-Fayer, Masaru Kuno, Gerd Kvale, Luisa Lazaro, Mafalda Machado-Sousa, Rachel Marsh, Pedro Morgado, Akiko Nakagawa, Luke Norman, Erika L. Nurmi, Joseph O'Neill, Ana E. Ortiz, Chris Perriello, John Piacentini, Maria Pico-Perez, Roseli G. Shavitt, Eiji Shimizu, Helen Blair Simpson, S. Evelyn Stewart, Sophia I. Thomopoulos, Anders Lillevik Thorsen, Susanne Walitza, Lidewij H. Wolters, Paul M. Thompson, Odile A. van den Heuvel, Dan J. Stein, Carles Soriano-Mas
Summary: The results of the study suggest that higher cortical thickness in specific right prefrontal cortex regions may play an important role in the response to cognitive-behavioral therapy in children with OCD.
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2023)
Article
Pediatrics
Carlyle McCready, Sadia Haider, Francesca Little, Mark P. Nicol, Lesley Workman, Diane M. Gray, Raquel Granell, Dan J. Stein, Adnan Custovic, Heather J. Zar
Summary: This study aimed to describe the developmental trajectories of childhood wheezing in South Africa and the UK. Four wheeze phenotypes were identified in the South African cohort: never, early transient, late onset, and recurrent. All-cause lower respiratory tract infection and respiratory syncytial virus infection were associated with recurrent wheeze.
LANCET CHILD & ADOLESCENT HEALTH
(2023)
Article
Public, Environmental & Occupational Health
Danielle Giovenco, Audrey Pettifor, Linda-Gail Bekker, Lindsey M. Filiatreau, Tao Liu, Morayo Akande, Katherine Gill, Millicent Atujuna, Dan J. Stein, Caroline Kuo
Summary: This study examined the interest of adolescents in oral PrEP and its association with perceived parental support and PrEP stigma. The results showed that a significant percentage of adolescents were interested in using PrEP and believed that their parents would support them. However, low parental support and high PrEP stigma were associated with reduced interest in PrEP among adolescents. Therefore, interventions should focus on improving communication between adolescents and parents regarding sexual health and effective HIV prevention tools.
Review
Neurosciences
A. Prag, K. A. Donald, E. Weldon, S. L. Halligan, D. J. Stein, S. Malcolm-Smith
Summary: Child development is influenced by maternal characteristics, but there is limited research on this topic in Sub-Saharan Africa. This scoping review aims to assess the nature and extent of observational assessments of dyadic interactions and explore the risks and outcomes associated with maternal sensitivity in this context. The research findings highlight the need for more culturally sensitive and rigorous studies in this field.
ACTA NEUROPSYCHIATRICA
(2023)
Article
Neurosciences
Olivia Wootton, Shareefa Dalvie, Rae MacGinty, Linda Ngqengelele, Ezra S. Susser, Ruben C. Gur, Dan J. Stein
Summary: This study examined the relationship between within-individual variability (WIV) and clinical and demographic variables in people with schizophrenia in South Africa. The results showed that increased WIV in performance speed was associated with a diagnosis of schizophrenia, older age, lower education level, and lower overall functioning. Increased WIV in accuracy was associated with younger age. Therefore, studying WIV can provide additional insights into cognitive dysfunction in schizophrenia in resource-limited settings.
ACTA NEUROPSYCHIATRICA
(2023)
Article
Psychiatry
Dan J. Stein, Alan E. Kazdin, Richard J. Munthali, Irving Hwang, Meredith G. Harris, Jordi Alonso, Laura Helena Andrade, Ronny Bruffaerts, Graca Cardoso, Stephanie Chardoul, Giovanni de Girolamo, Silvia Florescu, Oye Gureje, Josep Maria Haro, Aimee N. Karam, Elie G. Karam, Viviane Kovess-Masfety, Sing Lee, Maria Elena Medina-Mora, Fernando Navarro-Mateu, Jose Posada-Villa, Juan Carlos Stagnaro, Margree ten Have, Nancy A. Sampson, Ronald C. Kessler, Daniel V. Vigo
Summary: This study aimed to investigate the extent and predictors of treatment coverage for PTSD in high-income countries (HICs) and low- and middle-income countries (LMICs). The results showed that only a small percentage of respondents received adequate pharmacotherapy or psychotherapy, with lower treatment coverage in LMICs.
Article
Biochemistry & Molecular Biology
Anna Kotsakis Ruehlmann, Sara Sammallahti, Andrea P. Cortes Hidalgo, Kelly M. Bakulski, Elisabeth B. Binder, Megan Loraine Campbell, Doretta Caramaschi, Charlotte A. M. Cecil, Elena Colicino, Cristiana Cruceanu, Darina Czamara, Linda Dieckmann, John Dou, Janine F. Felix, Josef Frank, Siri E. Haberg, Gunda Herberth, Thanh T. Hoang, Lotte C. Houtepen, Anke Huls, Nastassja Koen, Stephanie J. London, Maria C. Magnus, Giulia Mancano, Rosa H. Mulder, Christian M. Page, Katri Raikkonen, Stefan Roeder, Rebecca J. Schmidt, Tabea S. Send, Gemma Sharp, Dan J. Stein, Fabian Streit, Johanna Tuhkanen, Stephanie H. Witt, Heather J. Zar, Ana C. Zenclussen, Yining Zhang, Lea Zillich, Rosalind Wright, Jari Lahti, Kelly J. Brunst
Summary: Prenatal maternal stressful life events are associated with adverse neurodevelopmental outcomes in offspring. This meta-analysis examined the association between maternal stressful life events during pregnancy and DNA methylation in cord blood. Children whose mothers reported higher levels of cumulative maternal stressful life events during pregnancy exhibited differential methylation of specific genes implicated in neurodevelopment, neurodegeneration, immune and cellular functions, regulation of global methylation levels, metabolism, and schizophrenia risk. These findings provide novel insights into potential mechanisms of neurodevelopment in offspring.
MOLECULAR PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Willem B. Bruin, Yoshinari Abe, Pino Alonso, Alan Anticevic, Lea L. Backhausen, Srinivas Balachander, Nuria Bargallo, Marcelo C. Batistuzzo, Francesco Benedetti, Sara Bertolin Triquell, Silvia Brem, Federico Calesella, Beatriz Couto, Damiaan A. J. P. Denys, Marco A. N. Echevarria, Goi Khia Eng, Sonia Ferreira, Jamie D. Feusner, Rachael G. Grazioplene, Patricia Gruner, Joyce Y. Guo, Kristen Hagen, Bjarne Hansen, Yoshiyuki Hirano, Marcelo Q. Hoexter, Neda Jahanshad, Fern Jaspers-Fayer, Selina Kasprzak, Minah Kim, Kathrin Koch, Yoo Bin Kwak, Jun Soo Kwon, Luisa Lazaro, Chiang-Shan R. Li, Christine Lochner, Rachel Marsh, Ignacio Martinez-Zalacain, Jose M. Menchon, Pedro S. Moreira, Pedro Morgado, Akiko Nakagawa, Tomohiro Nakao, Janardhanan C. Narayanaswamy, Erika Nurmi, Jose C. Pariente Zorrilla, John Piacentini, Maria Pico-Perez, Fabrizio Piras, Federica Piras, Christopher Pittenger, Janardhan Y. C. Reddy, Daniela Rodriguez-Manrique, Yuki Sakai, Eiji Shimizu, Venkataram Shivakumar, Blair H. Simpson, Carles Soriano-Mas, Nuno M. Sousa, Gianfranco Spalletta, Emily R. Stern, S. Evelyn Stewart, Philip Szeszko, Jinsong Tang, Sophia Thomopoulos, Anders L. Thorsen, Yoshida Tokiko, Hirofumi Tomiyama, Benedetta Vai, Ilya M. Veer, Ganesan Venkatasubramanian, Nora C. Vetter, Chris Vriend, Susanne Walitza, Lea Waller, Zhen Wang, Anri Watanabe, Nicole Wolff, Je-Yeon Yun, Qing Zhao, Wieke A. van Leeuwen, Hein J. F. van Marle, Laurens A. van de Mortel, Anouk van der Straten, Ysbrand D. van der Werf, Paul M. Thompson, Dan J. Stein, Odile A. van den Heuvel, Guido A. van Wingen
Summary: Current knowledge about functional connectivity in obsessive-compulsive disorder (OCD) is based on small-scale studies, limiting the generalizability of results. A mega-analysis of data from 1024 OCD patients and 1028 healthy controls revealed widespread abnormalities in functional connectivity in OCD, including global hypo-connectivity and few hyper-connections mainly with the thalamus. Classification performances based on resting-state connectivity were poor, indicating that it is not an accurate biomarker for identifying individual patients.
MOLECULAR PSYCHIATRY
(2023)
Review
Public, Environmental & Occupational Health
Livio Tarchi, Giuseppe Pierpaolo Merola, Ottone Baccaredda-Boy, Francesca Arganini, Emanuele Cassioli, Eleonora Rossi, Mario Maggi, David S. Baldwin, Valdo Ricca, Giovanni Castellini
Summary: The purpose of this systematic review was to investigate the adverse effects of SSRIs on sexual function and determine if these effects persist after discontinuation. The review found limited evidence of sexual dysfunction following SSRI discontinuation and was unable to establish a cause-effect relationship. However, it highlighted the need for further research to explore the relationship between SSRI exposure and persistent sexual dysfunction and to develop new treatment options.
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
(2023)
Article
Oncology
Dakotah Feil, Sarina Abrishamcar, Grace M. M. Christensen, Aneesa Vanker, Nastassja Koen, Anna Kilanowski, Nadia Hoffman, Catherine J. J. Wedderburn, Kirsten A. A. Donald, Michael S. S. Kobor, Heather J. J. Zar, Dan J. J. Stein, Anke Huls
Summary: This study found that exposure to indoor air pollution during pregnancy is associated with neurodevelopmental delay in infants, and DNA methylation might explain this link. Through high-dimensional mediation analysis methods, differentially methylated CpG sites and genes that mediate the association between indoor air pollution and neurodevelopmental delay were identified. The findings suggest that DNA methylation may mediate the association between prenatal PM10 exposure and cognitive neurodevelopment.
CLINICAL EPIGENETICS
(2023)
Article
Psychiatry
Sheri-Michelle Koopowitz, Karen Thea Mare, Marilyn Lake, Christopher du Plooy, Nadia Hoffman, Kirsten A. Donald, Susan Malcolm-Smith, Lynne Murray, Heather J. Zar, Peter Cooper, Dan J. Stein
Summary: This study investigated the effects of dialogic book-sharing on language development, neurocognitive function, and socio-emotional domains in 3.5-year-old children from low-income South African communities. The results showed no significant differences between the intervention and control groups after 4 months post-intervention.
COMPREHENSIVE PSYCHIATRY
(2024)
