Article
Neurosciences
Kylie Isenburg, Thomas M. Morin, Maya L. Rosen, David C. Somers, Chantal E. Stern
Summary: Studies have found that certain brain regions are activated during attentional deployment via long-term memories. We conducted an analysis of task-based functional connectivity to study the communication between these brain regions underlying long-term memory guided attention. Our results showed that different subnetworks, such as default mode, cognitive control, and dorsal attention, contribute differently to long-term memory guided attention, and the connectivity at the network level shifts based on attentional demands. We also found specific nodes within these subnetworks that play a crucial role in facilitating long-term memory guided attention.
Article
Neurosciences
Jasmin M. Kizilirmak, Joram Soch, Hartmut Schuetze, Emrah Duezel, Hannah Feldhoff, Larissa Fischer, Lea Knopf, Anne Maass, Matthias Raschick, Annika Schult, Renat Yakupov, Anni Richter, Bjoern H. Schott
Summary: The default mode network (DMN) shows decreased activity during demanding tasks and increased activity during rest. In young healthy adults, increased DMN activity during memory encoding predicts later forgetting; however, this association is attenuated in older adults, and in some cases, increased DMN activity predicts remembering. This study examines the relationship between DMN activity during encoding and at rest in young and older adults, and finds that older adults have lower resting-state DMN activity and reduced task-related deactivations. Higher resting-state DMN activity is associated with better memory performance in older adults, emphasizing the importance of maintaining DMN modulation in old age.
HUMAN BRAIN MAPPING
(2023)
Article
Neurosciences
Joram Soch, Anni Richter, Hartmut Schuetze, Jasmin M. Kizilirmak, Anne Assmann, Lea Knopf, Matthias Raschick, Annika Schult, Anne Maass, Gabriel Ziegler, Alan Richardson-Klavehn, Emrah Duezel, Bjorn H. Schott
Summary: Subsequent memory paradigms separate brain responses based on memory performance during later retrieval, with fMRI typically showing activations in certain brain structures. This study suggests that using parametric models, especially with non-linear transformations of memory confidence ratings, can better explain fMRI signal variance during encoding, providing a framework for improving models of encoding-related activations and applying them to memory-impaired individuals.
Article
Neurosciences
Ziang Gao, Xixiang Chen, Rong Xiang, Wei Zhang, Lu Tan, Wenjun Fan, Peiqiang Liu, Hao Lv, Yu Xu
Summary: This study used resting-state functional magnetic resonance imaging to discover functional changes in brain activity in patients with allergic rhinitis, including hypoactivity in the precuneus and hyperactivity in the anterior cingulate cortex. These changes were significantly correlated with symptom scores and quality of life measures. Further investigation into brain activity in allergic rhinitis patients may provide new insights for clinical interventions.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Neurosciences
Ye-Lim Lim, Davis J. Lang, Rachel A. Diana
Summary: Episodic memories are coded neurally via the hippocampus and surrounding medial temporal lobe cortex. Similarity in voxel patterns in the hippocampus can predict later memory retrieval, but the cognitive goals during encoding might also affect the neural representations. This study found that variable cognitive tasks during encoding improved memory retrieval and altered the relationship between pattern similarity and memory success in the hippocampus.
Article
Multidisciplinary Sciences
James B. Heald, Mate Lengyel, Daniel M. Wolpert
Summary: This article presents a theory of motor learning based on the principle that memory creation, updating, and expression are controlled by a single computation-contextual inference. The theory reveals that adaptation in motor learning can occur through creating and updating memories, as well as changing the expression of existing memories. The theory also predicts new phenomena and confirms them experimentally.
Article
Clinical Neurology
Corey Loo, Andy C. H. Lee, Bradley R. Buchsbaum
Summary: Research suggests that brain structures involved in working memory are not static, but gradually develop distinct multivoxel activity patterns through repetition, indicating a cross-trial persistence in working memory structures.
FRONTIERS IN NEUROLOGY
(2021)
Article
Neurosciences
Long Tang, Toshimitsu Takahashi, Tamami Shimada, Masayuki Komachi, Noriko Imanishi, Yuji Nishiyama, Takashi Iida, Yukio Otsu, Shigeru Kitazawa
Summary: The human brain distinguishes among past, present, and future time points, with sentences evoking presence activating the bilateral precuneus more strongly. This activation occurs regardless of differences in verb tense systems across languages, suggesting the precuneus serves as a key region for time perception.
Article
Neurosciences
Xin Xu, Xue Li, Xu Qi, Xi Jiang, Haoyang Xing, Xiaoqi Huang, Qiyong Gong
Summary: Resting-state functional magnetic resonance imaging (RS-FMRI) was used to evaluate the effects of intermittent theta burst stimulation (iTBS) and continuous theta burst stimulation (cTBS) on intrinsic brain activity in the precuneus. The results showed that iTBS decreased functional connectivity in the bilateral precuneus, while cTBS decreased functional connectivity in the bilateral insula and increased it in the thalamus.
HUMAN BRAIN MAPPING
(2023)
Article
Neurosciences
Aki Tsuchiyagaito, Masaya Misaki, Obada Al Zoubi, Martin Paulus, Jerzy Bodurka
Summary: This study demonstrated the potential positive impact of connectivity-based real-time fMRI neurofeedback in reducing rumination and improving mood by normalizing brain functional connectivity associated with rumination.
HUMAN BRAIN MAPPING
(2021)
Article
Neurosciences
Barbara Tomasino, Ilaria Del Negro, Riccardo Garbo, Gian Luigi Gigli, Serena D'Agostini, Maria Rosaria Valente
Summary: Using functional magnetic resonance imaging (fMRI), researchers found that imagining fatigue-related multisensory sensations activates brain regions involved in first-person perspective, multisensory integration, and mental imagery networks.
HUMAN BRAIN MAPPING
(2022)
Article
Neurosciences
Julia Jablonowski, Michael Rose
Summary: The incidental acquisition of multimodal associations is crucial for everyday memory functions. This study found that the ventral and dorsal posterior parietal regions have different functional recruitment in multimodal memory processing, and these differences are directly related to the associative process.
HUMAN BRAIN MAPPING
(2022)
Article
Multidisciplinary Sciences
Chris B. Martin, Bryan Hong, Rachel N. Newsome, Katarina Savel, Melissa E. Meade, Andrew Xia, Christopher J. Honey, Morgan D. Barense
Summary: The act of remembering everyday experiences affects our perception of the world, future thinking, and self-perception. However, the ability to recall specific details and relive the past tends to decline with age. To address this, a smartphone application called HippoCamera was developed to help older adults enhance their episodic memory. By repeatedly reactivating memories of real-world events, participants experienced improved recollection and more positive emotions. These benefits were observed shortly after the intervention and even after a 3-month delay.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
David J. Halpern, Shannon Tubridy, Lila Davachi, Todd M. Gureckis
Summary: Over 40 years of research have shown associations between neuroimaging signals during memory encoding tasks and future memory performance. However, the interpretation of these subsequent memory effects (SMEs) is still unclear. Previous studies did not control for potential confounders of these effects. In this study, a large fMRI dataset was collected and adjusted for known confounding variables. The results suggest that existing neuroimaging measures may not have the precision and specificity to reliably predict subsequent memory.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Multidisciplinary Sciences
Byung-Hoon Kim, Min-Kyeong Kim, Hye-Jeong Jo, Jae-Jin Kim
Summary: Social anxiety is prevalent among young adults, and machine learning models using brain functional radiomic features can successfully predict its level.
SCIENTIFIC REPORTS
(2022)
Article
Clinical Neurology
Jessica Stark, Daniela J. Palombo, Jasmeet P. Hayes, Kelly J. Hiersche, Alexander N. Hasselbach, Scott M. Hayes
Summary: The study identified significant associations between AD biomarkers, neurotrophic growth factors, education, and stress with specific domains of cognitive function (including episodic memory, executive function, processing speed, and language). Biological metrics were found to be more strongly related to cognition than chronological age in older adults with MCI.
JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY
(2022)
Article
Psychology, Biological
Paul C. Bogdan, Matthew Moore, Illia Kuznietsov, Justin D. Frank, Kara D. Federmeier, Sanda Dolcos, Florin Dolcos
Summary: The study demonstrates that in the process of behavioral change, individuals are influenced by both direct feedback and social observation. Through an experiment using a role-swapping version of the Ultimatum Game, EEG data revealed different neural correlates for the two forms of behavioral change, suggesting that frontal midline theta oscillations may play a role in predicting behavioral changes linked to direct feedback.
Article
Neurosciences
Lea Waller, Susanne Erk, Elena Pozzi, Yara J. Toenders, Courtney C. Haswell, Marc Buettner, Paul M. Thompson, Lianne Schmaal, Rajendra A. Morey, Henrik Walter, Ilya M. Veer
Summary: HALFpipe is an open-source, user-friendly tool developed within the ENIGMA consortium, aiming to facilitate reproducible analysis of task-based and resting-state fMRI data through uniform preprocessing, quality assessment, feature extraction, and group-level statistics. It provides state-of-the-art preprocessing and extends fMRIPrep functionality with additional steps, along with generating interactive quality assessment webpages and numerous post-processing functions for individual subject analysis.
HUMAN BRAIN MAPPING
(2022)
Article
Neurosciences
Heather C. Bouchard, Delin Sun, Emily L. Dennis, Mary R. Newsome, Seth G. Disner, Jeremy Elman, Annelise Silva, Carmen Velez, Andrei Irimia, Nicholas D. Davenport, Scott R. Sponheim, Carol E. Franz, William S. Kremen, Michael J. Coleman, M. Wright Williams, Elbert Geuze, Inga K. Koerte, Martha E. Shenton, Maheen M. Adamson, Raul Coimbra, Gerald Grant, Lori Shutter, Mark S. George, Ross D. Zafonte, Thomas W. McAllister, Murray B. Stein, Paul M. Thompson, Elisabeth A. Wilde, David F. Tate, Aristeidis Sotiras, Rajendra A. Morey
Summary: Mild traumatic brain injury (mTBI) is common in military personnel and is associated with age-related neurodegenerative disorders affecting white matter in the brain. Non-negative matrix factorization (NMF) was used to detect covarying patterns of fractional anisotropy (FA) associated with mTBI in a large dataset of military Veterans. The study showed significant age-dependent differences in WM alterations between Veterans with and without TBI, highlighting the importance of considering age in assessing the effects of mTBI.
HUMAN BRAIN MAPPING
(2022)
Article
Clinical Neurology
Molly Monsour, Emily Clarke-Rubright, Wil Lieberman-Cribbin, Christopher Timmins, Emanuela Taioli, Rebecca M. Schwartz, Samantha S. Corley, Anna M. Laucis, Rajendra A. Morey
Summary: The impact of climate change-induced sea level rise and tropical cyclone exposure on mental illness symptom prevalence is explored. Exposure to high-intensity tropical cyclones is found to be associated with increased risk of mental illness symptoms. Severe and widespread impacts on mental health are observed due to sea level rise and storm surges.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Clinical Neurology
Emma Clark, Saurab Faruque, Cedric Mutebi, Newton V. Nagirimadugu, Alyssa Kim, Malavika Mahendran, Elaine Sullo, Rajendra Morey, Robert W. Turner
Summary: This systematic review aimed to synthesize recent literature on the relationship between mild traumatic brain injury (mTBI) and Alzheimer's disease and related dementias (ADRD). Of the eight relevant articles identified, four showed a significant relationship between mTBI and disease outcomes, highlighting the need for future research on this causal relationship. Future studies should standardize definitions and methodologies to produce more reliable and comprehensive results.
JOURNAL OF NEUROLOGY
(2022)
Article
Psychiatry
Meghan E. Pierce, Jasmeet Hayes, Bertrand Russell Huber, Andreas Jeromin, Catherine B. Fortier, Jennifer R. Fonda, Heather Lasseter, Lauren Chaby, Regina McGlinchey, William Milberg
Summary: This study explored the relationships between plasma biomarkers, clinical, and medical comorbidities in a sample of post-9/11 veterans. The findings suggest that close blast exposure is associated with increased inflammation and decreased GFAP levels, which may be related to deployment-related psychopathology.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Psychology, Clinical
Sarah Prieto, Jena N. Moody, Kate E. Valerio, Jasmeet P. Hayes
Summary: This study examined the association between PTSD symptom severity, number of stressors experienced, and cognitive outcomes in US Vietnam War Veterans. The results showed that higher PTSD symptom severity was associated with poorer cognitive outcomes, while the number of reported stressors was not related to cognitive outcomes.
JOURNAL OF TRAUMATIC STRESS
(2022)
Article
Psychology, Clinical
Eamonn Kennedy, Emily L. Dennis, Hannah M. Lindsey, Terri deRoon-Cassini, Stefan Du Plessis, Negar Fani, Milissa L. Kaufman, Nastassja Koen, Christine L. Larson, Sarah Laskowitz, Lauren A. M. Lebois, Rajendra A. Morey, Mary R. Newsome, Cori Palermo, Nicholas J. Pastorek, Abigail Powers, Randall Scheibel, Soraya Seedat, Antonia Seligowski, Dan J. Stein, Jennifer Stevens, Delin Sun, Paul Thompson, Maya Troyanskaya, Sanne J. H. van Rooij, Amanda A. Watts, Carissa W. Tomas, Wright Williams, Frank G. Hillary, Mary Jo Pugh, Elisabeth A. Wilde, David F. Tate
Summary: This study uses a multisite mega analysis to derive quantitative recommendations for equating scores across measures of PTSD severity. The results suggest that harmonization and covariate adjustments can significantly improve inference of scores across different instruments.
Article
Psychology, Experimental
Florin Dolcos, Paul C. Bogdan, Margaret O'Brien, Alexandru D. Iordan, Anna Madison, Simona Buetti, Alejandro Lleras, Sanda Dolcos
Summary: Emotional well-being depends on the successful use of coping strategies to regulate affective responses. This study found that self-guided focused attention can reduce the impact of unpleasant pictures on negative emotions, suggesting that attentional control is important for improving emotional well-being.
Article
Psychiatry
Adam Fijtman, Ashley Clausen, MarciaKauer-Sant Anna, Rajendra Morey
Summary: This study investigated the association between trauma exposure and suicide attempt in Veterans with bipolar disorder. The results showed that individuals with bipolar disorder who experienced physical assault and childhood sexual abuse were more likely to have a history of suicide attempts. These findings highlight the importance of assessing previous trauma exposure when identifying Veterans at risk for bipolar disorder.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Neurosciences
Delin Sun, Viraj R. Adduru, Rachel D. Phillips, Heather C. Bouchard, Aristeidis Sotiras, Andrew M. Michael, Fiona C. Baker, Susan F. Tapert, Sandra A. Brown, Duncan B. Clark, David Goldston, Kate B. Nooner, Bonnie J. Nagel, Wesley K. Thompson, Michael D. De Bellis, Rajendra A. Morey
Summary: This study used unsupervised machine learning to successfully identify spatial patterns of cortical thickness variation at the vertex level, which are not constrained by neuroanatomical features. The findings suggest that age-appropriate cortical thinning is faster in younger drinkers and slower in older drinkers, with the strongest effect observed in heavy drinkers.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Neurosciences
Emily L. Dennis, Mary R. Newsome, Hannah M. Lindsey, Maheen Adamson, Tara A. Austin, Seth G. Disner, Blessen C. Eapen, Carrie Esopenko, Carol E. Franz, Elbert Geuze, Courtney Haswell, Sidney R. Hinds II, Cooper B. Hodges, Andrei Irimia, Kimbra Kenney, Inga K. Koerte, William S. Kremen, Harvey S. Levin, Rajendra A. Morey, John Ollinger, Jared A. Rowland, Randall S. Scheibel, Martha E. Shenton, Danielle R. Sullivan, Leah D. Talbert, Sophia I. Thomopoulos, Maya Troyanskaya, William C. Walker, Xin Wang, Ashley L. Ware, John Kent Werner, Wright Williams, Paul M. Thompson, David F. Tate, Elisabeth A. Wilde
Summary: Traumatic brain injury (TBI) in military populations can lead to disruptions in brain structure and function, causing cognitive and psychological dysfunction. A study conducted a mega-analysis of neuroimaging and clinical data from military personnel and veterans, finding that deployment-related TBI is associated with increased left lateralization in the cingulum, a white matter tract. This effect was primarily observed in individuals whose worst injury occurred before age 40.
HUMAN BRAIN MAPPING
(2023)
Article
Genetics & Heredity
Jasmeet Pannu Hayes, Meghan E. Pierce, Emma Brown, David Salat, Mark W. Logue, Julie Constantinescu, Kate Valerio, Mark W. Miller, Richard Sherva, Bertrand Russell Huber, William Milberg, Regina McGlinchey
Summary: The aim of this study was to investigate cortical thinning associated with genetic risk for Alzheimer's disease (AD) in middle-aged military veterans. The findings suggest that higher genetic risk for AD is associated with accelerated cortical thinning, particularly in the right hemisphere inferior parietal cortex. Additionally, plasma tau levels are related to cortical thinning, while mild traumatic brain injury and posttraumatic stress disorder are not.
NEUROLOGY-GENETICS
(2023)
Article
Psychiatry
Sarah E. Prieto, Kate N. Nolan, Jena M. Moody, Scott P. Hayes, Jasmeet Hayes
Summary: Chronic stress is a risk factor for dementia, and in this study, it was found that posttraumatic stress disorder (PTSD) symptom severity is associated with accelerated cognitive decline in older adults. This association remained significant even after adjusting for Alzheimer's disease biomarkers. It highlights the importance of treating PTSD to maintain cognitive function in aging adults.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Psychiatry
Yafit Levin, Rahel Bachem, Dorit Brafman, Menachem Ben-Ezra
Summary: Negative symptoms of schizophrenia have been overlooked, and this study found an association between negative symptoms and the risk of dissociative disorder, independently of depression and anxiety symptoms. It is important to consider both negative symptoms and dissociative symptoms in clinical practice to better understand their interaction.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Review
Psychiatry
Roland Mergl, Sarah M. Quaatz, Vanessa Lemke, Antje-Kathrin Allgaier
Summary: Women who have had miscarriages or stillbirths have an increased risk for depressive symptoms and disorders, with a wide range of prevalence rates. However, depressive symptoms tend to diminish over time.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Hai-Yang Wang, Lin Zhang, Bei-Yan Guan, Shi-Yao Wang, Cui-Hong Zhang, Ming-Fei Ni, Yan-Wei Miao, Bing-Wei Zhang
Summary: This study investigates the association between cognitive reappraisal and panic disorder (PD), and finds that PD patients have weakened functional connectivity between the prefrontal cortex (PFC) and the amygdala, which is associated with the severity of PD symptoms. Additionally, cognitive reappraisal is negatively correlated with PD severity, and the PFC-amygdala functional connectivity plays a mediating role in this association.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Yanqiang Tao, Xinyuan Zou, Qihui Tang, Wenxin Hou, Shujian Wang, Zijuan Ma, Gang Liu, Xiangping Liu
Summary: Depression and anxiety are prevalent mental disorders among adolescents. The study utilized network analysis to examine the symptom dimension of depression and anxiety in different age groups of adolescents. The results indicated that different age groups have different key symptoms and bridging symptoms, highlighting the importance of targeting specific symptoms at different stages of adolescence in treatment to alleviate the comorbidity of anxiety and depression.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Philip J. Batterham, Aliza Werner-Seidler, Bridianne O'Dea, Alison L. Calear, Kate Maston, Andrew Mackinnon, Helen Christensen
Summary: Screening for psychological distress in adolescents is important, and the Distress Questionnaire-5 (DQ5) is a reliable measure for this purpose. The study found that DQ5 had good fit to a unidimensional construct, strong criterion and predictive validity, and sensitivity to change. The brevity and ease of interpretation of DQ5 make it suitable for screening in schools.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Xiaoli Liu, Qianqian Chen, Fang Cheng, Wenhao Zhuang, Wenwu Zhang, Yiping Tang, Dongsheng Zhou
Summary: This study found working memory defects in adolescents with major depressive disorder compared to healthy controls based on mean oxy-hemoglobin changes, which can be useful for distinguishing adolescents with MDD from healthy controls.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Anders Nordahl-Hansen, Hugo Cogo-Moreira, Sareh Panjeh, Daniel S. Quintana
Summary: This article aims to determine empirically-derived effect size thresholds associated with psychotherapy for depressive disorders by calculating the effect size distribution. The findings indicate that the observed effect size thresholds are larger than the suggested guidelines, which has implications for interpreting study effects and planning future research.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Guangli Zhao, Liyong Yu, Peixin Chen, Keli Zhu, Lu Yang, Wenting Lin, Yucai Luo, Zeyang Dou, Hao Xu, Pan Zhang, Tianmin Zhu, Siyi Yu
Summary: This study investigated the neural mechanisms underlying emotional attention bias in patients with CID using ERP and rs-FC approaches. The results revealed abnormalities in attention processing and connectivity in the emotion-cognition networks of CID patients. This study provides a neural basis for understanding attention bias in CID.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Seungyeon Lee, Sora Mun, Jiyeong Lee, Hee-Gyoo Kang
Summary: Major depressive disorder is a prevalent condition worldwide, but the proportion of patients receiving treatment has not increased. Biomarkers related to drug-treatment responses can be used to monitor the effectiveness of medication. Serum protein levels were compared among patients with depression who received medication, those who did not, and a control group. Eight biomarkers were identified, which can be used to monitor the effectiveness of drug treatment.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Alfredo L. Sklar, Fang -Cheng Yeh, Mark Curtis, Dylan Seebold, Brian A. Coffman, Dean F. Salisbury
Summary: This study investigated semantic verbal fluency (SVF) impairments in first-episode psychosis patients within the schizophrenia spectrum. The findings revealed disruptions in both functional and structural connectivity in these patients, as well as an association between enhanced connectivity in the right hemisphere and worse SVF performance and longer disease duration.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Maksymilian Rejek, Blazej Misiak
Summary: This study investigates the association of the exposome score (ES) with psychosis risk in a non-clinical population. The results show that the ES is associated with the extended psychosis phenotype, suggesting its potential to identify individuals who may benefit from further psychosis risk assessment.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)