Review
Biochemistry & Molecular Biology
Martyna Bayassi-Jakowicka, Grazyna Lietzau, Ewelina Czuba, Aleksandra Steliga, Monika Waskow, Przemyslaw Kowianski
Summary: The nucleus accumbens (NAc) plays a crucial role in both reward processes and central nervous system diseases. Understanding its diverse functions requires a combination of morphological and functional studies, as well as research on its connections, neuroplasticity, and neurotransmitter systems.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Psychology, Clinical
Wei Lei, Kezhi Liu, Guangxiang Chen, Serenella Tolomeo, Cuizhen Liu, Zhenlei Peng, Boya Liu, Xuemei Liang, Chaohua Huang, Bo Xiang, Jia Zhou, Fulin Zhao, Rongjun Yu, Jing Chen
Summary: This study found that patients with Internet gaming disorder (IGD) have impaired reinforcement learning and blunted reward prediction error (RPE) signals in the brain reward system, as well as hyperconnectivity between regions of the reward system. These results suggest that reinforcement learning deficits may be crucial characteristics of IGD pathophysiology.
PSYCHOLOGICAL MEDICINE
(2022)
Review
Public, Environmental & Occupational Health
Francesca Dossi, Alessandra Buja, Laura Montecchio
Summary: This systematic review examines the association between religiosity or spirituality and emerging internet addictions. The majority of the studies reviewed support a possible role for religiosity as a protective factor and suggest a potential link between religiosity and lower rates of internet gaming addiction among adolescents.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Health Care Sciences & Services
Jianxia Lu, Qinhan Zhang, Na Zhong, Jin Chen, Yujia Zhai, Lei Guo, Chunlei Lu, Tianzhen Chen, Zhongli Jiang, Hui Zheng
Summary: This study explored the differences in internet use symptom networks between internet addiction (IA) group and non-addiction group. The inability to stop being online is identified as a key symptom of internet addiction, closely related to the inability to control the intention to play games.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2022)
Article
Sport Sciences
Yu Zhou, Graham Finlayson, Xudong Liu, Qichen Zhou, Tianze Liu, Chenglin Zhou
Summary: The study examined the effects of acute moderate-intensity dance and aerobic exercise on drug craving, appetite, prefrontal neural activation to food cues, and food reward in women with methamphetamine dependence. Results showed that both interventions reduced subjective craving for drugs and increased implicit wanting and relative preferences for high-calorie savory foods. The findings suggest that moderate-intensity exercise can be used as a therapeutic intervention to restore the balance between drug and nondrug rewards.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2021)
Review
Pharmacology & Pharmacy
Xiaohang Che, Jialing Cai, Yueyang Liu, Tianyu Xu, Jingyu Yang, Chunfu Wu
Summary: This article discusses the role of oxytocin in treating drug addiction, including its effects on drug reward, stress responses, and social impairments. Studies have shown that oxytocin administration can alleviate drug-induced neurobehavioral changes and be beneficial in reducing substance use disorders of various drugs.
PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Neurosciences
Stevenson Desmercieres, Virginie Lardeux, Jean-Emmanuel Longueville, Myriam Hanna, Leigh Panlilio, Nathalie Thiriet, Marcello Solinas
Summary: The newly developed PSS procedure provides a quantifiable breakpoint to measure animals' propensity to continue working for a reward despite progressively increasing electric shock intensity. The break point is sensitive to hunger and changes in the qualitative incentive value of the reward, and it shows differences compared to the traditional PR procedure.
Article
Psychology, Clinical
Mingli Liu, Daifeng Dong, Jia Xiao, Cong Lai, Aixia Zhuang, Yan Wang
Summary: This study found that both behavioral inhibition system (BIS) and behavioral approach system (BAS) were positively associated with the risk of internet addiction (IA) in adolescents, and grit-perseverance moderated the associations between BIS, BAS, and IA.
PSYCHOLOGY RESEARCH AND BEHAVIOR MANAGEMENT
(2022)
Article
Clinical Neurology
Wanling Zhang, Jianlin Pu, Ruini He, Minglan Yu, Liling Xu, Xiumei He, Ziwen Chen, Zhiqin Gan, Kezhi Liu, Youguo Tan, Bo Xiang
Summary: This study found that internet addiction among adolescents is associated with demographic characteristics, family environment, and psychological factors. Negative psychological factors play an important role in different types of behavioral addictions.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Psychiatry
Hao Chen, Guijun Dong, Kefeng Li
Summary: Internet addiction (IA) is a psychiatric disorder that has seen a significant increase during the COVID-19 pandemic. IA damages brain functions, but exercise has been found to have beneficial effects in improving cognitive levels affected by IA. This review examines the neurobiological mechanisms of IA and its impact on reward, execution, and decision-making systems in the brain. Additionally, it explores the research on exercise intervention for IA and its effects on improving brain function. The study emphasizes the need to consider internal and external factors when designing exercise prescriptions to combat IA and provides future research directions for targeted exercise interventions.
FRONTIERS IN PSYCHIATRY
(2023)
Review
Psychology, Multidisciplinary
Peter Andre Busch, Stephen McCarthy
Summary: This article presents a systematic review of existing research on problematic smartphone use (PSU), analyzing 293 studies to develop an overview model in the field of PSU. The findings cover demographic factors, explanations for smartphone use, consequences of PSU, and strategies for correcting PSU. Future research directions are proposed, focusing on seven key research questions for investigation.
COMPUTERS IN HUMAN BEHAVIOR
(2021)
Review
Substance Abuse
Yuan-Wei Yao, Jin-Tao Zhang, Xiao-Yi Fang, Lu Liu, Marc N. Potenza
Summary: The study estimated the aggregated effect sizes of reward-related decision-making deficits in IGD and found that these deficits were consistently associated with the disorder. Different decision-making situations showed similar effects, with larger effects observed for pure-gain and mixed compared to pure-loss decision-making.
Review
Biochemistry & Molecular Biology
Megana Sundar, Devon Patel, Zachary Young, Kah-Chung Leong
Summary: Recent research suggests that oxytocin may reduce addictive behaviors by directly affecting the glutamatergic system, in addition to its established effects on dopamine. This new perspective provides insight into the potential use of oxytocin as a therapeutic target for addiction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Michelle Ren, Shahrdad Lotfipour
Summary: Communication between the brain and gut bacteria affects drug and addiction behaviors. Researchers investigated the impact of gut microbiota on fentanyl reinforcement and reward by depleting gut bacteria in adult male and female rats using antibiotics and allowing them to self-administer fentanyl. The results showed that antibiotic treatment increased fentanyl self-administration in males, but not females, at the lowest reinforcement schedule. Both males and females treated with antibiotics self-administered higher amounts of fentanyl at higher reinforcement schedules. Replenishing microbial metabolites restored normal fentanyl self-administration levels, indicating a significant relationship between gut microbiome and opioid use.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Marlene Cervantes, Robert G. Lewis, Maria Agnese Della-Fazia, Emiliana Borrelli, Paolo Sassone-Corsi
Summary: The circadian clock and metabolism are closely linked, relying on interactions between organ systems for proper timing. Substance use disrupts communication between organs and alters rhythmic activities. This study finds that alterations in dopamine signaling in the brain can affect circadian metabolism in peripheral organs. Drugs like cocaine that increase dopamine levels disrupt circadian metabolic profiles in the liver, especially when dopamine D2 receptors are lost.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Guangheng Dong, Xiao Lin, Yanbo Hu, Chunming Xie, Xiaoxia Du
SCIENTIFIC REPORTS
(2015)
Article
Biotechnology & Applied Microbiology
Du Lei, Jun Ma, Jilei Zhang, Mengxing Wang, Kaihua Zhang, Fuqin Chen, Xueling Suo, Qiyong Gong, Xiaoxia Du
BIOMED RESEARCH INTERNATIONAL
(2015)
Article
Neurosciences
Guangheng Dong, Yifen Zhang, Jiaojing Xu, Xiao Lin, Xiaoxia Du
FRONTIERS IN NEUROSCIENCE
(2015)
Article
Clinical Neurology
Jilei Zhang, Jingjing Su, Mengxing Wang, Ying Zhao, Qian Yao, Qiting Zhang, Haifeng Lu, Hui Zhang, Shuo Wang, Ge-Fei Li, Yi-Lan Wu, Feng-Di Liu, Yan-Hui Shi, Jianqi Li, Jian-Ren Liu, Xiaoxia Du
JOURNAL OF HEADACHE AND PAIN
(2016)
Article
Clinical Neurology
Jilei Zhang, Yi-Lan Wu, Jingjing Su, Qian Yao, Mengxing Wang, Ge-Fei Li, Rong Zhao, Yan-Hui Shi, Ying Zhao, Qiting Zhang, Haifeng Lu, Shuai Xu, Zhaoxia Qin, Guo-Hong Cui, Jianqi Li, Jian-Ren Liu, Xiaoxia Du
JOURNAL OF HEADACHE AND PAIN
(2017)
Article
Psychology, Developmental
Yi Qiao, Bin Xie, Xiaoxia Du
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2012)
Article
Multidisciplinary Sciences
Du Lei, Jun Ma, Xiaoming Shen, Xiaoxia Du, Guohua Shen, Wei Liu, Xu Yan, Gengying Li
Article
Multidisciplinary Sciences
Mengxing Wang, Kaihua Zhang, Jilei Zhang, Guangheng Dong, Hui Zhang, Xiaoxia Du
Article
Neurosciences
Min Wang, Yanbo Hu, Ziliang Wang, Xiaoxia Du, Guangheng Dong
NEUROSCIENCE LETTERS
(2019)
Article
Multidisciplinary Sciences
Kaihua Zhang, Paola Rigo, Xueyun Su, Mengxing Wang, Zhong Chen, Gianluca Esposito, Diane L. Putnick, Marc H. Bornstein, Xiaoxia Du
SCIENTIFIC REPORTS
(2020)
Article
Clinical Neurology
Zhaoxia Qin, Hang Qu, Huai-Bin Liang, Qichen Zhou, Wei Wang, Min Wang, Jian-Ren Liu, Xiaoxia Du
Summary: A study using resting-state functional magnetic resonance imaging found differences in effective connectivity among regions in the trigeminal vascular system between patients with migraine without aura (MWoA) and healthy controls. These results provide further evidence of the involvement of disturbed trigeminovascular nociceptive pathways in the pathophysiology of migraine.
Article
Psychiatry
Zhengjie Zhang, Shizhen Wang, Xiaoxia Du, Yanyan Qi, Lingxiao Wang, Guang-heng Dong
Summary: This study investigates the brain responses of individuals with internet gaming disorder (IGD) to positive and negative events during real gaming, revealing deficits in regulating game craving, maladaptive gaming behaviors, and negative emotions among IGD individuals. These findings provide direct evidence for the underlying neural features of IGD and can guide prevention and treatment efforts.
JOURNAL OF BEHAVIORAL ADDICTIONS
(2023)
Article
Neurosciences
Hui Pan, Qi Huang, Shiyu Ban, Xiaoxia Du, Jingjing Su, Jianren Liu
NEUROSCIENCE LETTERS
(2020)
Article
Psychology, Multidisciplinary
Lingxiao Wang, Lingdan Wu, Yifan Wang, Hui Li, Xiaoyue Liu, Xiaoxia Du, Guangheng Dong
FRONTIERS IN PSYCHOLOGY
(2017)
Article
Psychology, Multidisciplinary
Yifen Zhang, Xiao Lin, Hongli Zhou, Jiaojing Xu, Xiaoxia Du, Guangheng Dong
FRONTIERS IN PSYCHOLOGY
(2016)
Article
Psychiatry
Yafit Levin, Rahel Bachem, Dorit Brafman, Menachem Ben-Ezra
Summary: Negative symptoms of schizophrenia have been overlooked, and this study found an association between negative symptoms and the risk of dissociative disorder, independently of depression and anxiety symptoms. It is important to consider both negative symptoms and dissociative symptoms in clinical practice to better understand their interaction.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Review
Psychiatry
Roland Mergl, Sarah M. Quaatz, Vanessa Lemke, Antje-Kathrin Allgaier
Summary: Women who have had miscarriages or stillbirths have an increased risk for depressive symptoms and disorders, with a wide range of prevalence rates. However, depressive symptoms tend to diminish over time.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Hai-Yang Wang, Lin Zhang, Bei-Yan Guan, Shi-Yao Wang, Cui-Hong Zhang, Ming-Fei Ni, Yan-Wei Miao, Bing-Wei Zhang
Summary: This study investigates the association between cognitive reappraisal and panic disorder (PD), and finds that PD patients have weakened functional connectivity between the prefrontal cortex (PFC) and the amygdala, which is associated with the severity of PD symptoms. Additionally, cognitive reappraisal is negatively correlated with PD severity, and the PFC-amygdala functional connectivity plays a mediating role in this association.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Yanqiang Tao, Xinyuan Zou, Qihui Tang, Wenxin Hou, Shujian Wang, Zijuan Ma, Gang Liu, Xiangping Liu
Summary: Depression and anxiety are prevalent mental disorders among adolescents. The study utilized network analysis to examine the symptom dimension of depression and anxiety in different age groups of adolescents. The results indicated that different age groups have different key symptoms and bridging symptoms, highlighting the importance of targeting specific symptoms at different stages of adolescence in treatment to alleviate the comorbidity of anxiety and depression.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Philip J. Batterham, Aliza Werner-Seidler, Bridianne O'Dea, Alison L. Calear, Kate Maston, Andrew Mackinnon, Helen Christensen
Summary: Screening for psychological distress in adolescents is important, and the Distress Questionnaire-5 (DQ5) is a reliable measure for this purpose. The study found that DQ5 had good fit to a unidimensional construct, strong criterion and predictive validity, and sensitivity to change. The brevity and ease of interpretation of DQ5 make it suitable for screening in schools.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Xiaoli Liu, Qianqian Chen, Fang Cheng, Wenhao Zhuang, Wenwu Zhang, Yiping Tang, Dongsheng Zhou
Summary: This study found working memory defects in adolescents with major depressive disorder compared to healthy controls based on mean oxy-hemoglobin changes, which can be useful for distinguishing adolescents with MDD from healthy controls.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Anders Nordahl-Hansen, Hugo Cogo-Moreira, Sareh Panjeh, Daniel S. Quintana
Summary: This article aims to determine empirically-derived effect size thresholds associated with psychotherapy for depressive disorders by calculating the effect size distribution. The findings indicate that the observed effect size thresholds are larger than the suggested guidelines, which has implications for interpreting study effects and planning future research.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Guangli Zhao, Liyong Yu, Peixin Chen, Keli Zhu, Lu Yang, Wenting Lin, Yucai Luo, Zeyang Dou, Hao Xu, Pan Zhang, Tianmin Zhu, Siyi Yu
Summary: This study investigated the neural mechanisms underlying emotional attention bias in patients with CID using ERP and rs-FC approaches. The results revealed abnormalities in attention processing and connectivity in the emotion-cognition networks of CID patients. This study provides a neural basis for understanding attention bias in CID.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Seungyeon Lee, Sora Mun, Jiyeong Lee, Hee-Gyoo Kang
Summary: Major depressive disorder is a prevalent condition worldwide, but the proportion of patients receiving treatment has not increased. Biomarkers related to drug-treatment responses can be used to monitor the effectiveness of medication. Serum protein levels were compared among patients with depression who received medication, those who did not, and a control group. Eight biomarkers were identified, which can be used to monitor the effectiveness of drug treatment.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Alfredo L. Sklar, Fang -Cheng Yeh, Mark Curtis, Dylan Seebold, Brian A. Coffman, Dean F. Salisbury
Summary: This study investigated semantic verbal fluency (SVF) impairments in first-episode psychosis patients within the schizophrenia spectrum. The findings revealed disruptions in both functional and structural connectivity in these patients, as well as an association between enhanced connectivity in the right hemisphere and worse SVF performance and longer disease duration.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Maksymilian Rejek, Blazej Misiak
Summary: This study investigates the association of the exposome score (ES) with psychosis risk in a non-clinical population. The results show that the ES is associated with the extended psychosis phenotype, suggesting its potential to identify individuals who may benefit from further psychosis risk assessment.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
