Article
Clinical Neurology
Axel Fogaca Rosado, Laura Menegatti Bevilacqua, Eduardo Luiz Gasnhar Moreira, Manuella Pinto Kaster
Summary: This study aimed to evaluate if variability in baseline flexibility can enable differences in coping strategies, changes in neuroplasticity, and behavioral outcomes in responses to chronic social defeat stress (CSDS). The results showed that animals with high behavioral flexibility exhibited changes in their coping strategies during the CSDS protocol, and they also displayed higher dendritic complexity in certain cortical areas. Moreover, high flexibility was associated with better emotional responses and motivation. However, exposure to CSDS reversed the beneficial effects of high flexibility in male mice.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2023)
Article
Parasitology
Damira Avgustinovich, Anna Kovner, Elena Kashina, Natalia Shatskaya, Galina Vishnivetskaya, Natalia Bondar, Maria Lvova
Summary: The study found that the combination of chronic Opisthorchis felineus infection and repeated social defeat stress had adverse effects on both the liver and brain of mice. Mice exposed to both adverse factors exhibited disturbances in the startle response behaviorally.
INTERNATIONAL JOURNAL FOR PARASITOLOGY
(2021)
Article
Neurosciences
Wenjuan Hou, Shuying Huang, Lu Li, Xing Guo, Zhixiong He, Shufeng Shang, Ziyan Jia, Lizi Zhang, Yishan Qu, Caihong Huang, Yin Li, Yitong Li, Zijian Lv, Fadao Tai
Summary: Chronic social stress can lead to psychological diseases. Oxytocin has been found to modulate the effects of chronic social defeat stress on emotional and social behaviors, but its role in mediating the effects of CSDS on emotional and social abnormalities is still unclear. Repeated administration of oxytocin during CSDS prevented the decrease of oxytocin receptors in the nucleus accumbens in females, but had no effect on males.
Article
Multidisciplinary Sciences
Alisson Pinto de Almeida, Alicia Moraes Tamais, Carolina Zerbini, Fernando Falkenburger Melleu, Newton Sabino Canteras, Simone Cristina Motta
Summary: This study reveals the neural mechanisms involved in mediating social defensive responses. The dorsal pre-mammillary nucleus projects to the rostral dorsomedial PAG, and through ascending paths mediated by the cuneiform nucleus, it influences prosencephalic circuits to mediate passive social defensive responses. This study provides further support for the role of the PAG in the modulation of behavioral responses.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2023)
Article
Behavioral Sciences
Jun Kawanokuchi, Ken Takagi, Nobuyuki Tanahashi, Teruhisa Yamamoto, Nobuyuki Nagaoka, Torao Ishida, Ning Ma
Summary: The study examined the preventive and therapeutic effects of acupuncture on depression model mice, revealing that acupuncture can restore reduced expression of neurotrophic factors induced by stress and that this effect occurs earlier than that of antidepressants.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Yuta Yoshida, Yuhei Yajima, Kina Kawakami, Shin-ichi Nakamura, Takamitsu Tsukahara, Katsutaka Oishi, Atsushi Toyoda
Summary: Identifying early stress biomarkers is crucial in preventing mood and anxiety disorders. This study found changes in salivary miRNAs and metabolites in mice subjected to subchronic and mild social defeat stress, with one miRNA, miR-208b-3p, upregulated, possibly linked to myocardial infarction. Pathway analyses suggested that energy metabolism pathways were significantly related to the miRNAs affected by sCSDS in saliva.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Risako Fujikawa, Jun Yamada, Kyoko M. Iinuma, Shozo Jinno
Summary: The study aims to understand the potential effects of chronic social defeat stress and genistein on neuron-microglia interactions in the mouse hippocampus. The findings suggest that genistein may partially alleviate stress-related symptoms and modulate neuron-microglia signaling via chemokines and neurotrophic factors in the hippocampus.
Article
Behavioral Sciences
David M. Lyons, Sarah Ayash, Alan F. Schatzberg, Marianne B. Muller
Summary: Laboratory mouse models play a crucial role in bridging the gap between basic neuroscience and applied stress research. This study examines the ecological validity of social defeat stressors in mouse models of emotional vulnerability and resilience. It was found that the majority of the reviewed reports (95%) focus on males, and many reports (71%) discuss vulnerability and resilience. Limited ecological validity leads to increased vulnerability and decreased resilience. Elements of limited ecological validity include repeated exposure to defeat stressors without opportunities to avoid or escape from pre-screened aggressive conspecifics, which is not representative of naturalistic conditions. Research is needed to establish causality and determine if ecologically valid stressors can build resilience in both sexes of mice.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Neurosciences
Mikio Yoshida, Sho Hasegawa, Masayuki Taniguchi, Akihiro Mouri, Chiharu Suzuki, Akira Yoshimi, Takayoshi Mamiya, Norio Ozaki, Yukihiro Noda
Summary: Juveniles are more sensitive to stress, and exposure to stress can prolong psychiatric symptoms and cause treatment resistance. This study found that memantine can attenuate impaired social behavior in juveniles by regulating the NMDA receptor and ERK1/2 signaling activation mechanism.
Article
Behavioral Sciences
Toshinori Yoshioka, Daisuke Yamada, Riho Kobayashi, Eri Segi-Nishida, Akiyoshi Saitoh
Summary: Adult hippocampal neurogenesis is closely related to depressive disorders, and psychological stress can decrease cell survival rate in the hippocampus of mice, influencing the validity of emotional stress in animal models of depression.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Neurosciences
Yu-Fen Lin, Kao Chin Chen, Yen Kuang Yang, Ya-Hsin Hsiao
Summary: CRMP5 expression in the hippocampus was increased in stress-susceptible mice compared to control and stress-resilient mice, with a negative correlation between CRMP5 levels and social interaction ratio. Lowering hippocampal CRMP5 levels improved social interactions in stress-susceptible mice, while overexpression of CRMP5 induced social avoidance behaviors. Furthermore, increased CRMP5 expression also elevated serum corticosterone concentrations in stress-susceptible and CRMP5-treated mice. These findings shed light on how CRMP5 may contribute to susceptibility to social stress and suggest potential therapeutic targets for stress disorders in humans.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Neurosciences
Lanmin Guo, Zhi-mei Jiang, Rui-xue Sun, Wei Pang, Xue Zhou, Mei-ling Du, Meng-xiang Chen, Xinyue Lv, Jing-tao Wang
Summary: The social defeat stress model is commonly used to study depression and anxiety disorder, but the mechanism of neuronal loss is still unclear. In this study, a social defeat stress model was established in mice, and the impact on the structure of hippocampal neurons was evaluated using various techniques. The results showed that social defeat stress disrupts homeostasis in the hippocampus and affects the integrity of mitochondria, resulting in inhibited neuronal development and growth. These findings provide important insights into the mechanisms of neuronal development and the development of new strategies to combat depression and anxiety disorder.
BRAIN RESEARCH BULLETIN
(2022)
Article
Biochemistry & Molecular Biology
Atsushi Toyoda, Kina Kawakami, Yuto Amano, Hideaki Nishizawa, Shin-ichi Nakamura, Takahiro Kawase, Yuta Yoshida, Hodaka Suzuki, Takamitsu Tsukahara
Summary: Psychosocial stress leads to mental illnesses and increases the risk of health problems. This study investigated the effects of psychosocial stress on the histopathological features of organs and tissues in a mouse model. Results showed increased cardiac fibrosis and elevated plasma putrefactive substances in the stressed mice. These findings suggest that this mouse model could be useful for studying the pathophysiology of psychosocial stress and heart failure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Behavioral Sciences
Kyle J. Brymer, Erin Y. Kulhaway, John G. Howland, Hector J. Caruncho, Lisa E. Kalynchuk
Summary: Repeated corticosterone injections in rats lead to cognitive deficits and depression-like behavior, highlighting the importance of considering cognitive impairments in assessing depression. Corticosterone significantly affects body weight, immobility in the forced swim test, startle amplitudes, and object recognition memory, suggesting a complex phenotype induced by chronic stress.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Psychiatry
Christopher S. Stauffer, Tyler E. Morrison, Nathan K. Meinzer, David Leung, Jessica Buffington, Evan G. Sheh, Thomas C. Neylan, Aoife O'Donovan, Joshua D. Woolley
Summary: Co-occurring PTSD and AUD is common and treatment options are limited. Intranasal oxytocin administration may be effective in reducing symptoms, but dosage is important. This study found that oxytocin 20 IU had no effect on startle reactivity in co-occurring patients, while oxytocin 40 IU increased startle reactivity.
PSYCHIATRY RESEARCH
(2022)
Article
Oncology
Ashley Ojeaga, Ernest Alema-Mensah, Desiree Rivers, Ijeoma Azonobi, Brian Rivers
JOURNAL OF CANCER EDUCATION
(2019)
Article
Health Care Sciences & Services
Mechelle D. Claridy, Benjamin Ansa, Francesca Damus, Ernest Alema-Mensah, Selina A. Smith
QUALITY OF LIFE RESEARCH
(2018)
Article
Environmental Sciences
Elizabeth O. Ofili, Laura E. Schanberg, Barbara Hutchinson, Felix Sogade, Icilma Fergus, Phillip Duncan, Joe Hargrove, Andre Artis, Osita Onyekwere, Wayne Batchelor, Marcus Williams, Adefisayo Oduwole, Anekwe Onwuanyi, Folake Ojutalayo, Jo Ann Cross, Todd B. Seto, Henry Okafor, Priscilla Pemu, Lilly Immergluck, Marilyn Foreman, Ernest Alema Mensah, Alexander Quarshie, Mohamed Mubasher, Almelida Baker, Alnida Ngare, Andrew Dent, Mohamad Malouhi, Paul Tchounwou, Jae Lee, Traci Hayes, Muna Abdelrahim, Daniel Sarpong, Emma Fernandez-Repollet, Stephen O. Sodeke, Adrian Hernandez, Kevin Thomas, Anne Dennos, David Smith, David Gbadebo, Janet Ajuluchukwu, B. Waine Kong, Cassandra McCollough, Sarah R. Weiler, Marc D. Natter, Kenneth D. Mandl, Shawn Murphy
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2019)
Article
Public, Environmental & Occupational Health
Priscilla Pemu, Robina Josiah Willock, Ernest Alema-Mensah, Latrice Rollins, Michelle Brown, Bethany Saint Clair, Elizabeth Olorundare, Atuarra McCaslin, Tabia Henry Akintobi, Alexander Quarshie, Elizabeth Ofili
ETHNICITY & DISEASE
(2019)
Review
Public, Environmental & Occupational Health
Elizabeth Armstrong-Mensah, Kim Ramsey-White, Ernest Alema-Mensah
FRONTIERS IN PUBLIC HEALTH
(2019)
Article
Environmental Sciences
Michelle Brown, Elizabeth O. Ofili, Debbie Okirie, Priscilla Pemu, Cheryl Franklin, Yoon Suk, Alexander Quarshie, Mohamed Mubasher, Charles Sow, Valerie Montgomery Rice, David Williams, Michael Brooks, Ernest Alema-Mensah, Dominic Mack, Daniel Dawes
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2019)
Article
Public, Environmental & Occupational Health
Joffi E. Musonge-Effoe, Ernest Alema-Mensah, Valery S. Effoe, Femi Akinnawo, Lee Caplan
PREVENTIVE MEDICINE
(2020)
Meeting Abstract
Hematology
Tom Adamkiewicz, Mohamed Mubasher, Folashade Omole, Melvin R. Echols, Jason Payne, Tennille Leak-Johnson, Jan Morgan-Billingslea, Kathy Pines, Deborah A. Sundal, Shira Krebs, Eric Chang, Jennifer A. Afranie-Sakyi, Eric Flenaugh, Judith Volcy, Marlene Garcia, Teclemichael Tewolde, Adel Driss, Olusola Gbinigie, Chad Evans, Marques Harvey, Ernest Alema-Mensah, Dennis Bryan, Charlye D. Majett, Herman Alfred Taylor
Article
Environmental Sciences
Mohamed Mubasher, Kimberly Lawson, Priscilla Pemu, Thomas Pearson, Jeffrey Engler, Adriana Baez, Jonathan K. Stiles, Maritza S. Salazar, Lee S. Caplan, Keith Green, Meldra Hall, Muhammed Y. Idris, Ernest Alema-Mensah, Yulia A. Levites Strekalova, Winston E. Thompson, Alexander Quarshie, Elizabeth Ofili
Summary: This study aims to enhance the research careers of Early-Stage Investigators (ESIs) by implementing a Nested Cluster Randomization (NCR) design and recruiting 220 ESIs for grant applications. The diversity of participants, including various ethnicities, genders, and disciplines, was highlighted in the study. Challenges were encountered during recruitment/retention, DN intervention implementation, and the impact of the COVID-19 pandemic, requiring adjustments and innovations to overcome these obstacles.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Health Care Sciences & Services
Muhammed Y. Idris, Ernest Alema-Mensah, Elizabeth Olorundare, Mohammad Mohammad, Michelle Brown, Elizabeth Ofili, Priscilla Pemu
Summary: This study aims to compare the content of conversations between patient-coach pairs that achieved their self-management goals and those that did not. The context is a clinical implementation study of diabetes self-management behavior change using Health360x within the practices of the Morehouse Choice Accountable Care Organization in the Atlanta metro area.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2022)
Article
Public, Environmental & Occupational Health
Elizabeth A. Armstrong-Mensah, Kim Ramsey-White, Ernest Alema-Mensah, Barbara A. Yankey
Summary: In the United States, there are higher education institutions that offer undergraduate degrees in public health. However, it is unclear if these institutions provide adequate preparation for students to enter the public health workforce or pursue higher education. Regardless of the goals, undergraduate public health students need curricula that adequately prepare them for well-defined careers in public health.
FRONTIERS IN PUBLIC HEALTH
(2022)
Meeting Abstract
Psychiatry
Kofi Kondwani, Jill Barber, Delores Williams, Sudjata Aya, Ernest Alema-Mensah
PSYCHOSOMATIC MEDICINE
(2020)
Meeting Abstract
Clinical Neurology
D. Davis, T. Tewolde, F. Akinnawo, E. Alema-Mensah, K. Paul, K. Clark
Article
Computer Science, Information Systems
Hossein Estiri, Jeffrey G. Klann, Sarah R. Weiler, Ernest Alema-Mensah, R. Joseph Applegate, Galina Lozinski, Nandan Patibandla, Kun Wei, William G. Adams, Marc D. Natter, Elizabeth O. Ofili, Brian Ostasiewski, Alexander Quarshie, Gary E. Rosenthal, Elmer V. Bernstam, Kenneth D. Mandl, Shawn N. Murphy
JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION
(2019)
Meeting Abstract
Clinical Neurology
C. Branson, S. Bissonnette, T. Tewolde, E. Alema-Mensah, M. Saint-Hilaire
MOVEMENT DISORDERS
(2019)
Article
Psychiatry
Yafit Levin, Rahel Bachem, Dorit Brafman, Menachem Ben-Ezra
Summary: Negative symptoms of schizophrenia have been overlooked, and this study found an association between negative symptoms and the risk of dissociative disorder, independently of depression and anxiety symptoms. It is important to consider both negative symptoms and dissociative symptoms in clinical practice to better understand their interaction.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Review
Psychiatry
Roland Mergl, Sarah M. Quaatz, Vanessa Lemke, Antje-Kathrin Allgaier
Summary: Women who have had miscarriages or stillbirths have an increased risk for depressive symptoms and disorders, with a wide range of prevalence rates. However, depressive symptoms tend to diminish over time.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Hai-Yang Wang, Lin Zhang, Bei-Yan Guan, Shi-Yao Wang, Cui-Hong Zhang, Ming-Fei Ni, Yan-Wei Miao, Bing-Wei Zhang
Summary: This study investigates the association between cognitive reappraisal and panic disorder (PD), and finds that PD patients have weakened functional connectivity between the prefrontal cortex (PFC) and the amygdala, which is associated with the severity of PD symptoms. Additionally, cognitive reappraisal is negatively correlated with PD severity, and the PFC-amygdala functional connectivity plays a mediating role in this association.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Yanqiang Tao, Xinyuan Zou, Qihui Tang, Wenxin Hou, Shujian Wang, Zijuan Ma, Gang Liu, Xiangping Liu
Summary: Depression and anxiety are prevalent mental disorders among adolescents. The study utilized network analysis to examine the symptom dimension of depression and anxiety in different age groups of adolescents. The results indicated that different age groups have different key symptoms and bridging symptoms, highlighting the importance of targeting specific symptoms at different stages of adolescence in treatment to alleviate the comorbidity of anxiety and depression.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Philip J. Batterham, Aliza Werner-Seidler, Bridianne O'Dea, Alison L. Calear, Kate Maston, Andrew Mackinnon, Helen Christensen
Summary: Screening for psychological distress in adolescents is important, and the Distress Questionnaire-5 (DQ5) is a reliable measure for this purpose. The study found that DQ5 had good fit to a unidimensional construct, strong criterion and predictive validity, and sensitivity to change. The brevity and ease of interpretation of DQ5 make it suitable for screening in schools.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Xiaoli Liu, Qianqian Chen, Fang Cheng, Wenhao Zhuang, Wenwu Zhang, Yiping Tang, Dongsheng Zhou
Summary: This study found working memory defects in adolescents with major depressive disorder compared to healthy controls based on mean oxy-hemoglobin changes, which can be useful for distinguishing adolescents with MDD from healthy controls.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Anders Nordahl-Hansen, Hugo Cogo-Moreira, Sareh Panjeh, Daniel S. Quintana
Summary: This article aims to determine empirically-derived effect size thresholds associated with psychotherapy for depressive disorders by calculating the effect size distribution. The findings indicate that the observed effect size thresholds are larger than the suggested guidelines, which has implications for interpreting study effects and planning future research.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Guangli Zhao, Liyong Yu, Peixin Chen, Keli Zhu, Lu Yang, Wenting Lin, Yucai Luo, Zeyang Dou, Hao Xu, Pan Zhang, Tianmin Zhu, Siyi Yu
Summary: This study investigated the neural mechanisms underlying emotional attention bias in patients with CID using ERP and rs-FC approaches. The results revealed abnormalities in attention processing and connectivity in the emotion-cognition networks of CID patients. This study provides a neural basis for understanding attention bias in CID.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Seungyeon Lee, Sora Mun, Jiyeong Lee, Hee-Gyoo Kang
Summary: Major depressive disorder is a prevalent condition worldwide, but the proportion of patients receiving treatment has not increased. Biomarkers related to drug-treatment responses can be used to monitor the effectiveness of medication. Serum protein levels were compared among patients with depression who received medication, those who did not, and a control group. Eight biomarkers were identified, which can be used to monitor the effectiveness of drug treatment.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Alfredo L. Sklar, Fang -Cheng Yeh, Mark Curtis, Dylan Seebold, Brian A. Coffman, Dean F. Salisbury
Summary: This study investigated semantic verbal fluency (SVF) impairments in first-episode psychosis patients within the schizophrenia spectrum. The findings revealed disruptions in both functional and structural connectivity in these patients, as well as an association between enhanced connectivity in the right hemisphere and worse SVF performance and longer disease duration.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Maksymilian Rejek, Blazej Misiak
Summary: This study investigates the association of the exposome score (ES) with psychosis risk in a non-clinical population. The results show that the ES is associated with the extended psychosis phenotype, suggesting its potential to identify individuals who may benefit from further psychosis risk assessment.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
